Tiyeni tiphunzire za Aromatase Inhibitors zomwe zimagwiritsidwa ntchito pochiza khansa ya m'mawere.

Dokotala wanu akakuuzani inu kapena munthu amene mumamudziwa kuti ali ndi khansa ya m'mawere, mwina anatchula kuti mankhwala a mahomoni ndi njira yochizira. Mungakhale ndi nkhawa pang'ono mukamva izi. Koma musadandaule. Lero tikulankhula za mtundu wa mankhwala othandiza kwambiri omwe amaperekedwa kwa anthu omwe ali ndi maselo a khansa omwe amakhudzidwa ndi hormone ya estrogen (Estrogen Receptor-Positive kapena ER+). Izi zimatchedwa Aromatase Inhibitors.

Mwachidule, kodi Aromatase Inhibitors awa ndi chiyani?

Chabwino, tiyeni tikambirane izi. Mankhwala oletsa a Aromatase, kapena AI mwachidule, ndi gulu la mankhwala omwe amagwiritsidwa ntchito kwambiri pochiza mahomoni. Amagwiritsidwa ntchito pochiza khansa ya m'mawere ya ER+, makamaka kwa amayi omwe atsala pang'ono kusamba .

Tsopano, taonani, estrogen ndi mahomoni ofunikira kwambiri m'matupi athu, makamaka pa thanzi la kubereka la akazi. Komabe, kwa maselo ena a khansa ya m'mawere, estrogen iyi imakhala ngati chakudya. Izi zikutanthauza kuti, pamene estrogen ilipo, maselo a khansa amakula mofulumira.

Apa ndi pomwe mankhwala a AI amabwera. Zimene mankhwalawa amachita ndikuletsa enzyme yotchedwa aromatase m'thupi lathu. Enzyme iyi ya aromatase imasintha mahomoni ena kukhala estrogen. Chifukwa chake, pamene mankhwalawa aletsa enzyme ya aromatase kugwira ntchito, kuchuluka kwa estrogen m'thupi kumachepa. Kenako maselo a khansa amataya "chakudya" chawo, amasiya kukula, ndipo khansa imawongoleredwa. Kodi mukumvetsa?

Mwachidule, zomwe mankhwalawa amachita ndikuletsa maselo a khansa kuti asapeze "mafuta" omwe amafunikira.

Kodi mankhwalawa amalimbikitsidwa pazochitika ziti?

Pali zochitika zingapo zomwe dokotala wanu angakulimbikitseni chithandizo cha "AI" ichi:

• Ngati mwachitidwa opaleshoni ya khansa ya m'mawere ya ER+, mankhwalawa amaperekedwa kuti achepetse chiopsezo chobwereranso kwa khansa .
• Ngati khansa yafalikira ku ma lymph nodes apafupi.
• Ngati khansa yafalikira ku ziwalo zina za thupi (monga mapapo, mafupa, ubongo, chiwindi), timaitcha khansa yofalikira.
• Ngati muli ndi khansa ya ER+ musanayambe kusamba. Pakadali pano, mazira anu akupangabe estrogen, kotero mutha kupatsidwa mankhwala ena owongolera hormone ya estrogen pamodzi ndi mankhwala a AI.
• Ngati mwamuna atenga khansa ya m'mawere ya ER+. (Inde, amuna nawonso amadwala khansa ya m'mawere, ndipo ali ndi estrogen yochepa m'matupi awo).
• Kafukufuku wina wasonyeza kuti anthu omwe ali pachiwopsezo chachikulu chotenga khansa ya m'mawereMankhwalawa akuti amathandiza kuchepetsa chiopsezo chimenecho, koma sanavomerezedwe ndi boma.

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Mitundu yodziwika kwambiri ya aromatase inhibitors

Pali mitundu ingapo ya mankhwala a "AI" awa pamsika. Dokotala wanu adzasankha omwe akuyenererani bwino matenda anu.

Kodi ndingapeze bwanji chithandizochi ndipo chimatenga nthawi yayitali bwanji?

Mankhwala a "AI" awa ndi piritsi lomwe muyenera kumwa tsiku lililonse . Nthawi zina, chithandizo chimayamba ndi mankhwalawa. Nthawi zina, dokotala wanu angakupatseni mankhwala ena otchedwa tamoxifen kwa zaka zingapo kenako n’kukusinthirani ku mankhwala a "AI".

Kawirikawiri, chithandizochi chimapitilira kwa zaka pafupifupi zisanu . Pakatha zaka zisanu, ngati mulibe zizindikiro za khansa ndipo mayeso ali bwino, mutha kusiya chithandizocho.

Komabe, kafukufuku wina wasonyeza kuti khansa ikhoza kubwereranso pakatha zaka 20 kuchokera pamene chithandizo chaperekedwa. Izi zimatchedwa 'kubwereranso mochedwa'. Chifukwa chake, ndikofunikira kwambiri kukambirana momasuka ndi dokotala wanu za zoopsa zomwe zingachitike chifukwa cha vuto lanu.

Ubwino wa chithandizo ndi zotsatirapo zake zomwe zingatheke

Ubwino waukulu wa chithandizochi ndi wakuti chimatha kuchiritsa khansa ya m'mawere ya ER+. Kafukufuku wasonyeza kuti 95% ya anthu omwe amalandira chithandizo cha AI ichi atachitidwa opaleshoni sadzachira khansa yawo mkati mwa zaka 5. Nkhani yabwino kwambiri imeneyo, eti?

Koma, monga mankhwala ena onse, iyi ikhoza kukhala ndi zotsatirapo zake. Chifukwa, monga tafotokozera kale, estrogen ndi mahomoni omwe amathandizanso kuti mafupa ndi mtima wathu zikhale zathanzi. Chifukwa chake, mukachepetsa milingo ya estrogen ndi AI, zotsatirapo zina zimatha kuchitika.

Kodi mungatani kuti muthane ndi zotsatirapo zake?

Musachite mantha ndi zotsatirapo izi. Chofunika kwambiri ndikulankhula ndi dokotala wanu za izo. Makamaka ngati zinthu monga kupweteka kwa mafupa ndi kwakukulu, simuyenera kupirira nazo. Dokotala wanu angakupatseni mayankho. Mwachitsanzo:

• Mankhwala ochepetsa ululu, makamaka NSAIDs (monga ibuprofen), angaperekedwe.
• Ngati zikukuvutani kupirira, mutha kusintha mtundu wina wa AI m'malo mwa AI yomwe mukugwiritsa ntchito pano.
• Nthawi zina, tamoxifen ingalowe m'malo mwa AI.

Chofunika kwambiri ndi kudziwitsa dokotala wanu za vuto lililonse, m'malo mopanga zisankho nokha.

Kodi ndi liti pamene muyenera kulankhula ndi dokotala?

Pazochitika zotsatirazi, onetsetsani kuti mwalankhula ndi dokotala wanu.

• Ngati zotsatira zake zili zoipa kwambiri kuposa momwe mumayembekezera.
• Ngati mankhwala omwe dokotala wapereka sapereka mpumulo uliwonse ku zotsatirapo zake.
• Ngati muwona zizindikiro za kubwereranso kwa khansa (monga ziphuphu zatsopano, kupweteka kosalekeza, kupuma movutikira) , funsani dokotala wanu zizindikiro zomwe muyenera kuziyang'anira.