Mankhwala atsopano ochizira kuvutika maganizo: Zimene muyenera kudziwa zokhudza Auvelity

Kuvutika maganizo ndi vuto lomwe limapangitsa moyo kukhala wamdima komanso wovuta. Ngati mukuvutika ndi izi, mwina simukupeza mpumulo wochuluka monga momwe mukuganizira ndi mankhwala omwe mukugwiritsa ntchito pano. Chifukwa chake, pakadali pano, mitundu yatsopano ya mankhwala yabweranso kuti ichiritse kuvutika maganizo. Lero tikulankhula za mankhwala otchedwa `Auvelity` omwe abweretsa chiyembekezo chatsopano. Uwu ndi mankhwala omwe adavomerezedwa ku United States mu 2022 ndipo amagwiritsidwa ntchito pa matenda a Major Depression Disorder.

Kodi Auvelity ndi chiyani? Imagwira ntchito bwanji?

Mwachidule, `Auvelity` ndi kuphatikiza kwa mankhwala awiri. Izi zikutanthauza kuti pali mitundu iwiri ya mankhwala mu piritsi limodzi. Ndi `dextromethorphan` ndi `bupropion`. Taganizirani izi ngati kugwira ntchito ngati gulu. Anthu awiri ogwira ntchito limodzi amagwiritsa ntchito mankhwala oposa mmodzi okha.

• Bupropion : Iyi ndi mankhwala omwe amagwiritsidwa ntchito kale pochiza kuvutika maganizo . Imagwira ntchito powonjezera kuchuluka kwa mankhwala muubongo mwathu otchedwa `dopamine` ndi `norepinephrine`, omwe amakhudza momwe timamvera.
• Dextromethorphan : Mwina mukudziwa bwino izi. Mankhwala ena a chifuwa amakhala ndi mankhwalawa. Komabe, mankhwalawa apezekanso kuti amakhudza mankhwala muubongo omwe amagwirizana ndi malingaliro.

Choncho, mankhwala awiriwa akaphatikizidwa , amathandiza kwambiri kuchepetsa zizindikiro za kuvutika maganizo kuposa bupropion yokha.

Kodi kupambana kwa mankhwalawa kunayesedwa bwanji?

Asanapereke mankhwala aliwonse kwa anthu, amayesa momwe alili otetezeka komanso ogwira mtima. Maphunziro awiri ofanana azachipatala achitika pa `Auvelity`. Mu izi, njira yapadera idagwiritsidwa ntchito poyesa kuopsa kwa kuvutika maganizo. Imatchedwa ``Montgomery-Asberg Depression Rating Scale (MADRS).`` Ili ngati mafunso. Mumafunsidwa mafunso 10 okhudza zinthu monga chisoni, mavuto ogona, ndi kudzimva kuti ndinu wolakwa ndipo mumapatsidwa zigoli. Mutha kupereka zigoli kuyambira 0 mpaka 60. Zigoli zikakwera, mumavutikanso kwambiri. Kuchepa kwa zigoli mutamwa mankhwala kumatanthauza kuti matendawa akuchira. Maphunzirowa adaphatikizapo anthu azaka zapakati pa 18-65 omwe ali ndi kuvutika maganizo kwambiri. Komabe, anthu omwe ali ndi matenda ena amisala (monga `bipolar disorder`, `psychotic disorder`), anthu omwe ali pachiwopsezo chachikulu chodzipha, komanso anthu omwe ali ndi khunyu sanaphatikizidwe.

Kodi zotsatira za maphunzirowa ndi ziti?

Zotsatira zake n’zolimbikitsa kwambiri. Mankhwala otchedwa `Auvelity` anali othandiza kwambiri pochepetsa zizindikiro za kuvutika maganizo kuposa placebo ndi `bupropion` zokha. Izi zikutanthauza kuti zigoli za `MADRS` zinali zochepa mwa anthu omwe adamwa `Auvelity` kuposa omwe adamwa mankhwala ena.

Kodi Auvelity ingagwirizane ndi mankhwala ena? (Kuyanjana kwa Mankhwala)

Iyi ndi gawo lofunika kwambiri . Inde, Auvelity imatha kuyanjana ndi mankhwala ena omwe mukumwa. Chifukwa chake, muyenera kuuza dokotala wanu za mankhwala onse omwe mukumwa, kuphatikizapo mankhwala ogulitsidwa kunja kwa chipatala, mavitamini, komanso mankhwala a Ayurvedic.

Matenda oopsa otchedwa Serotonin Syndrome

Ngati Auvelity itengedwa limodzi ndi mankhwala ena oletsa kuvutika maganizo omwe amawonjezera kuchuluka kwa serotonin m'thupi, ingayambitse kuwonjezeka kosafunikira kwa serotonin yomwe imapezeka mu ubongo. Izi zimatchedwa Serotonin Syndrome. Izi ndi zoopsa zomwe zingawononge moyo. Ngati mukumva zizindikiro izi, pitani ku chipatala chapafupi cha Emergency Department (ETU). Payenera kukhala kusiyana kwa masiku 14 pakati pa kumwa mankhwala oletsa kuvutika maganizo a MAOI ndi kumwa Auvelity.

Zotsatira zina

• Ndi mankhwala owonjezera dopamine: `Auvelity` imawonjezera dopamine muubongo. Chifukwa chake ikamwedwa ndi mankhwala ena owonjezera dopamine (monga mankhwala ena a matenda a Parkinson), kuchuluka kwa dopamine kumatha kukwera kwambiri, zomwe zimayambitsa kusakhazikika, kunjenjemera,Kuyenda kungakhale kovuta.
• Ndi Mowa: Kumwa mowa kuyenera kupewedwa kapena kuchepetsedwa kwambiri mukamwa `Auvelity`. Kumwa mowa pamodzi kumawonjezera chiopsezo cha khunyu .
• Mankhwala a mtima: Kugwira ntchito kwa mankhwala a mtima monga digoxin kungasinthidwe ndi Auvelity. Ndikofunikira kudziwitsa dokotala wanu za izi.
• Mankhwala ena omwe amasweka ndi chiwindi: Chiwindi chathu chili ngati fakitale yomwe imaswa mankhwala. Kuchuluka kwa mankhwala kumakhudza dongosolo la enzyme lotchedwa `cytochrome P450 (CYP450)` mu dongosololi. Izi zitha kusintha momwe mankhwala ena omwe mumamwa amagwirira ntchito.

Kodi mankhwalawa amagwiritsidwa ntchito bwanji ndipo zotsatira zake ndi ziti?

`Auvelity` ndi mankhwala operekedwa ndi dokotala okha. Mlingo wamba ndi piritsi limodzi patsiku kwa masiku atatu oyamba, kenako piritsi limodzi kawiri patsiku (kupatula maola 8).

Zotsatirapo zomwe zingakhalepo ndi zinthu zomwe muyenera kusamala nazo

• Kuthamanga kwa magazi: Dokotala wanu angakuuzeni kuti muyeze kuthamanga kwa magazi nthawi zonse.
• Chizungulire: Mankhwalawa angayambitse chizungulire. Choncho, samalani poyendetsa galimoto, kugwiritsa ntchito makina, komanso kuchita zinthu zomwe zingakhudze kugwa.
• Zotsatira zake pa maso: Uzani dokotala wanu ngati mukumva kupweteka kwa maso, kufiira, kapena kusintha kwa masomphenya.
• Kusintha kwa khalidwe: Anthu ena angasokonezeke maganizo, kuona kapena kumva zinthu zomwe palibe (kuona zinthu m'maganizo), komanso kuvutika kuzindikira zenizeni.
• Kugwidwa ndi khunyu: Chiwopsezochi chimawonjezeka ngati mutamwa ndi mowa. Ngati mukukumana ndi khunyu mukumwa mankhwala, siyani kumwa mankhwalawo nthawi yomweyo ndipo uzani dokotala wanu.
• Amayi oyembekezera ndi oyamwitsa: Mankhwalawa si otetezeka panthawi ya mimba kapena kuyamwitsa. Ngati mukukonzekera kutenga pakati, muli ndi pakati, kapena mukuyamwitsa, dziwitsani dokotala wanu nthawi yomweyo.

Chidziwitso chapadera chokhudza malingaliro ofuna kudzipha

Monga mankhwala ena ochizira kuvutika maganizo, Auvelity ingawonjezere pang'ono chiopsezo cha maganizo kapena zochita zodzipha mwa anthu ena, makamaka kumayambiriro kwa chithandizo.Izi zimachitika kwambiri pakati pa achinyamata. Ngati inu kapena wina m'banja mwanu ali ndi malingaliro awa, musakhale nokha.

• Imbani 1926 (National Mental Health Helpline) nthawi yomweyo.
• Kapena, pitani ku Chipatala cha Emergency Treatment Unit (ETU) chapafupi.
• Uzani dokotala wanu za izi nthawi yomweyo.

Ichi si chinthu chobisa. Ndikofunikira kwambiri kupeza thandizo mwachangu. Kuchuluka kwa nkhawa, kuvutika maganizo, thanzi la maganizo, kupsinjika maganizo, dextromethorphan, bupropion, serotonin syndrome, kupsinjika maganizo, zotsatirapo zake