Mukazindikira kuti muli ndi khansa, mumamva mantha ambiri komanso kudabwa. Kenako, madokotala akamalankhula za chithandizochi, mumamva mankhwala ambiri atsopano ndi mawu atsopano omwe simukuwamvetsa. Nthawi zina, mukapanda kumvetsetsa bwino zinthuzi, mantha anu amawonjezeka kwambiri. Avastin ndi mankhwala osiyana pang'ono omwe amagwiritsidwa ntchito pochiza khansa . Chifukwa chake lero, tiyeni tikambirane za mankhwala otchedwa Avastin (Bevacizumab) m'njira yosavuta yomwe mungamvetse.
Choyamba, tiyeni tiwone zomwe mankhwala oletsa angiogenesis awa ali.
Kuti timvetse izi, tiyeni tigwiritse ntchito chitsanzo chosavuta. Tangoganizirani chotupa cha khansa ngati udzu woipa womwe ukumera m'munda mwathu. Kodi udzu uwu umafunika chiyani kuti ukule ndikufalikira m'munda wonse? Umafunikira madzi. Mofananamo, chotupa cha khansa chimafunikanso magazi kuti chikule ndikufalikira ku ziwalo zina za thupi.
Kotero khansa iyi ndi yochenjera kwambiri. Imatumiza "chizindikiro" ku thupi lathu kuti lipeze magazi omwe likufunikira ndikukulitsa mitsempha yatsopano yamagazi . Monga momwe chomera cha udzu chimakulira mapaipi atsopano pansi pa nthaka kuti abweretse madzi. Mankhwala otchedwa angiogenesis inhibitors amaletsa kukula kwa mitsempha yatsopano yamagazi iyi. Izi zikutanthauza kuti, amaletsa "mitsempha yamagazi" yomwe imapita ku khansa. Kenako, magazi akatayika, khansayo singathe kukula kapena kufalikira.
Ndiye kodi Avastin (Bevacizumab) imagwira ntchito bwanji?
Avastin ndi mankhwala omwe ali m'gulu la Angiogenesis inhibitor lomwe takambirana pamwambapa. Kunena zoona, iyi ndi mankhwala omwe ali mu gulu lapadera lotchedwa Monoclonal antibody .
Tsopano mwina mukudabwa kuti monoclonal antibody ndi chiyani. Mwachidule, ndi puloteni yopangidwa mwapadera yopangidwa mu labotale, yofanana ndi ma antibodies omwe thupi lathu limapanga mwachilengedwe kuti lilimbane ndi matenda. Chinthu chapadera pa izi ndichakuti sichikhudza maselo onse m'thupi monga mankhwala a chemotherapy wamba, koma chimakhudza maselo a khansa okha mu chithandizo cholunjika .
Avastin imagwiritsa ntchito VEGF (Vascular Endothelial Growth Factor)Molekyulu. Tinanena kale kuti khansa imatumiza "chizindikiro" kuti ipange mitsempha yatsopano yamagazi, ndipo chizindikiro chimenecho ndi VEGF. Chomwe Avastin amachita ndichakuti imalumikiza ku molekyulu iyi ya VEGF ndikuyiletsa kugwira ntchito. Zili ngati "kuzimitsa" chizindikirocho. VEGF ikasiya kugwira ntchito, mitsempha yatsopano yamagazi siimapanga, ndipo khansa imataya zakudya zake.
Kodi ndikufunika chemotherapy ngati nditatenga Avastin?
Inde, vutoli ndi vuto kwa anthu ambiri. Ngakhale kuti Avastin ndi mankhwala ochiritsira okha, sagwira ntchito yokha . Ali ngati wothandizira. Wochita sewero wamkulu mu nkhaniyi, yemwe ndi chemotherapy, akufunikabe.
Chemotherapy ndi mtundu wamphamvu wa mankhwala omwe amapha maselo omwe amagawikana mofulumira (monga maselo a khansa). Avastin amagwira ntchito pothandiza chemotherapy.
Koma chabwino kwambiri n’chakuti, Avastin ikaphatikizidwa ndi mankhwala a chemotherapy, zotsatira za mankhwala a chemotherapy zimakhala zopambana kwambiri. Izi zikutanthauza kuti, mankhwala awiriwa akaphatikizidwa, nkhondo yolimbana ndi khansa imakhala yamphamvu kwambiri. Mwa kuchepetsa magazi kupita ku chotupa, mankhwala a chemotherapy amapha maselo a khansa.
Ndi mitundu iti ya khansa yomwe imachiritsidwa ndi Avastin?
Avastin imavomerezedwa pa mitundu yambiri ya khansa . Komabe, si mankhwala onse a khansa. Dokotala wanu adzasankha ngati mankhwalawa ndi oyenera kwa inu kutengera mtundu wa khansa yomwe muli nayo, gawo lake, komanso thanzi lanu lonse.
Gome ili m'munsimu likuwonetsa mitundu yodziwika bwino ya khansa yomwe Avastin imagwiritsidwa ntchito.
| Mtundu wa khansa | Mfundo zofunika |
|---|---|
| Khansa ya Colon kapena Rectal | Amagwiritsidwa ntchito kwambiri ngati khansa yafalikira ku ziwalo zina za thupi (metastatic). Nthawi zambiri imaperekedwa pamodzi ndi mankhwala a chemotherapy monga 5-fluorouracil (5-FU) kapena capecitabine (Xeloda) . |
| Khansa ya M'mapapo | Amagwiritsidwa ntchito pa mitundu ina ya khansa ya m'mapapo yoopsa. |
| Khansa ya Impso | Amagwiritsidwa ntchito pochiza khansa ya impso yofalikira. |
| Khansa ya M'chiberekero | Amagwiritsidwa ntchito ngati mankhwala a khansa ya m'chiberekero. |
| Khansa ya pachibelekero | Amagwiritsidwa ntchito pa khansa ya pachibelekero yomwe yabwereranso kapena kufalikira. |
| Glioblastoma | Uwu ndi mtundu wa khansa ya muubongo, ndipo chithandizochi chingaperekedwe ngati khansayo yabwereranso. |
Kodi Avastin si yoperekedwa chifukwa cha khansa ya m'mawere?
Ngakhale kuti Avastin kale inkagwiritsidwa ntchito pochiza khansa ya m'mawere, kafukufuku wamtsogolo adatsimikizira kuti zoopsa za zotsatirapo zake zinali zazikulu kuposa ubwino wa mankhwalawa. Chifukwa chake, mabungwe monga FDA ku United States savomerezanso kugwiritsa ntchito Avastin pa khansa ya m'mawere.
Kodi Avastin ingachiritse khansa ya m'matumbo kwathunthu?
Ayi. Avastin si mankhwala "amatsenga" omwe angachiritse khansa kwathunthu. Komabe, mayesero azachipatala awonetsa kuti mankhwalawa amatha kutalikitsa moyo wa odwala kwambiri . Mwachitsanzo, kafukufuku wina wapeza kuti odwala omwe adalandira Avastin ndi chemotherapy amakhala ndi moyo wautali pafupifupi miyezi 5 kuposa omwe adalandira chemotherapy yokha. Tikudziwa kuti nthawi ino ndi yamtengo wapatali kwa munthu amene akumenyana ndi khansa.
Kodi zotsatirapo zoyipa za Avastin ndi ziti?
Monga mankhwala aliwonse amphamvu, Avastin imatha kukhala ndi zotsatirapo zake. Komabe, si aliyense amene amamwa mankhwalawa amene amakumana ndi zotsatirapo zake . Komabe, ndikofunikira kwambiri kudziwa izi. Izi zidzakuthandizani kuzindikira zizindikiro zilizonse ndikudziwitsa dokotala wanu nthawi yomweyo.
Pansipa pali zina mwa zotsatirapo zoyipa komanso zofala zomwe zingachitike.
| Zotsatira zoyipa za Avastin | |
|---|---|
| Zotsatira zoyipa | Zoyenera kudziwa pa izi |
| Zotsatirapo zoyipa zomwe ziyenera kufotokozedwa kwa dokotala nthawi yomweyo | |
| Kuboola kwa m'mimba | Uwu ndi matenda oopsa kwambiri. Zizindikiro zake zingakhale kupweteka kwambiri m'mimba, kutentha thupi, komanso nseru. Pangafunike opaleshoni. |
| Kutuluka magazi mkati | Izi zingayambitse matenda oopsa monga sitiroko. |
| Kuchira kwa bala mochedwa | Dokotala amasamala kwambiri popereka mankhwalawa asanayambe opaleshoni kapena atangomaliza opaleshoni. |
| Kulephera kwa Mtima | Chiwopsezo chimakhala chachikulu makamaka akamwedwa limodzi ndi mankhwala ena a chemo omwe amakhudza mtima. |
| Kuwonongeka kwa impso | Zizindikiro monga kuchuluka kwa mapuloteni mu mkodzo zingachitike. |
| Zotsatira zina zofala (dziwitsani dokotala) | |
| Kuthamanga kwa Magazi Kwambiri | Ndikofunikira kuyang'anira kuthamanga kwa magazi pafupipafupi panthawi ya chithandizo. |
| Kutopa | Izi ndi zotsatira zoyipa zomwe zimachitika chifukwa cha mankhwala a chemotherapy. |
| Magazi amaundana m'mitsempha | Dziwani zizindikiro monga kutupa kwa miyendo ndi kupweteka. |
| Kutsegula m'mimba, mutu, kusowa chilakolako cha chakudya, zilonda pakamwa | Izi nthawi zambiri zimakhala zotsatirapo zoyipa zomwe zingathetsedwe. |
| Magazi mu mkodzo | Muyenera kudziwitsa dokotala wanu nthawi yomweyo ngati muwona izi. |
Chofunika kwambiri n’chakuti, ngati muli ndi zizindikiro izi, musaganize kuti, “Izi si kanthu.” Uzani dokotala wanu kapena dipatimenti yoyenera ya chipatala komwe mukulandira chithandizo nthawi yomweyo. Mukanena mwachangu, zimakhala zosavuta kusamalira vutoli.
Uthenga Wopita Nawo Kunyumba
- Avastin (Bevacizumab) si mankhwala achikhalidwe a chemotherapy. Ndi mankhwala ochizira omwe amaletsa kupangika kwa mitsempha yamagazi yomwe imapereka magazi ku maselo a khansa.
- Mankhwalawa nthawi zambiri sagwiritsidwa ntchito okha. Amaperekedwa pamodzi ndi chemotherapy kuti awonjezere mphamvu yake.
- Izi zimagwiritsidwa ntchito pa mitundu ina ya khansa, monga khansa ya m'matumbo, mapapo, impso, ndi mazira.
- Popeza zotsatirapo zoyipa zimatha kuchitika, ndikofunikira kuuza dokotala wanu nthawi yomweyo za zizindikiro zilizonse zachilendo mukalandira chithandizo.
- Ngati inu kapena wokondedwa wanu mwapatsidwa mankhwala a Avastin ngati mankhwala a khansa, onetsetsani kuti mwakambirana ndi dokotala wanu mafunso kapena nkhawa zanu zilizonse . Adzatha kukupatsani chidziwitso cholondola kwambiri.
Avastin, Bevacizumab, khansa, chithandizo cha khansa, chemotherapy, angiogenesis inhibitor, mankhwala a khansa, zotsatirapo zake, pilika prathikara, anathuru abada, chithandizo cha khansa sinhala
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