Enspryng ndi NMOSD: Dziwani za matenda osowa awa (Neuromyelitis Optica Spectrum Disorder)

Kodi mwadzidzidzi mwaona kusintha kwa masomphenya anu, kupweteka kwa maso, kapena dzanzi kapena kufooka kwa miyendo yanu? Zingakhale zina. Lero tikulankhula za vuto lomwe silili lofala kwambiri m'dziko lathu, koma ndikofunikira kwambiri kulidziwa. Ndi Neuromyelitis Optica Spectrum Disorder , kapena NMOSD mwachidule. Ili ndi matenda odziyimira pawokha omwe amakhudza kwambiri maso anu ndi msana wanu.

Kodi NMOSD ndi chiyani? Kodi Enspryng imagwira ntchito bwanji?

Mwachidule, NMOSD ndi pamene chitetezo cha mthupi lanu, chomwe chimatiteteza ku matenda, chimayamba molakwika kuukira maselo anu athanzi. Makamaka, thupi lanu limayamba kupanga ma antibodies motsutsana ndi puloteni inayake mu dongosolo lanu la mitsempha yotchedwa `aquaporin-4 (AQP4).'

Kuukira kumeneku kumayambitsa kutupa, kapena kutupa, kuzungulira mitsempha yanu ya maso (mitsempha yomwe imanyamula mauthenga pakati pa diso lanu ndi ubongo wanu) ndi msana. Pamene izi zikupitirira, zingayambitse kulephera kuona bwino komanso kuvutika kuyenda.

Palibe mankhwala a NMOSD pakadali pano. Chithandizochi cholinga chake ndi kuchepetsa kutupa, kuwongolera zizindikiro , komanso kupewa kubwereranso kwa matendawa.

Apa ndi pomwe Enspryng imagwira ntchito. Enspryng ndi mankhwala atsopano achilengedwe. Mankhwalawa angathandize kupewa NMOSD kuti isabwererenso, makamaka ngati muli ndi ma antibodies a anti-AQP4 omwe tidakambirana kale m'magazi anu.

Enspryng imagwira ntchito potseka puloteni ina m'thupi lathu yotchedwa ``interleukin-6 (IL-6).`` Chifukwa puloteni iyi yotchedwa IL-6 imagwiranso ntchito pa kutupa komwe kumachitika chifukwa cha ma antibodies a anti-APQ4. Chifukwa chake IL-6 ikatsekedwa, kutupa kumachepa, zizindikiro zimawongoleredwa, ndipo matendawa amatha kuchepetsedwa.

Kodi ndiyenera kugwiritsa ntchito bwanji mankhwalawa?

Enspryng ndi jakisoni woperekedwa pansi pa thupi . Nthawi zambiri amaperekedwa m'mimba kapena pakati pa ntchafu.

• Jakisoni atatu oyamba ayenera kuperekedwa milungu iwiri iliyonse.
• Pambuyo pake, muyenera kungoyigunda kamodzi pamwezi.

Ndikofunikira kwambiri kukumbukira masiku enieni omwe muyenera kulandira jakisoni awa. Ikani chikumbutso pa kalendala kapena pafoni yanu. Ngati mwaphonya jakisoni, muyenera kulankhula ndi dokotala wanu za zomwe mungachite kenako.

Musadandaule, dokotala wanu adzakuphunzitsani momwe mungadzipatsire jakisoni, komwe mungamupatsire, komanso momwe mungasinthire malo nthawi iliyonse. Nthawi zonse muzisamba m'manja bwino musanamupatsire jakisoni.

Kodi ndiyenera kusunga bwanji mankhwalawo?

Mankhwalawa ayenera kusungidwa mufiriji . Koma musawasunge mufiriji. Komanso, musagwedeze mankhwalawo. Tulutsani mankhwalawo mphindi 30 musanapereke jakisoni ndipo mulole kuti afike kutentha kwa chipinda. Musatenthetse mankhwalawo mu microwave kapena ndi madzi otentha.

Kodi mankhwala awa afufuzidwa bwanji?

Kafukufuku awiri akuluakulu achitika kuti aone chitetezo ndi kugwira ntchito kwa Enspryng. Izi zikuyerekeza Enspryng ndi placebo, mankhwala omwe alibe chogwiritsira ntchito. Apa ndi pamene tingathe kudziwa ngati mankhwalawa ndi othandiza kapena owopsa.

Ophunzira onse mu kafukufukuyu anali ndi NMOSD, mbiri yakale yobwereranso m'mbuyo, komanso zigoli pakati pa 0 ndi 6.5 pa Expanded Disability Status Scale (EDSS), sikelo yomwe imayesa kuchuluka kwa kulumala kwawo. (Zigoli za EDSS za 0 zikutanthauza kuti palibe kulumala, 6.5 zikutanthauza kuti pali zolepheretsa zina pakuyenda.)

Kafukufukuyu makamaka adayang'ana nthawi yomwe matendawa adatenga kuti abwererenso. Kuphatikiza apo, chidwi chidaperekedwa ku kusintha kwa `Visual Analog Scale (VAS)`, komwe kumayesa ululu, ndi `Functional Assessment of Chronic Illness Therapy (FACIT)`, komwe kumayesa kutopa.

Kodi zotsatira za kafukufukuyu ndi ziti?

Mu maphunziro onse awiriwa, odwala omwe ankatenga Enspryng anali ndi kubwereranso kochepa kwambiri poyerekeza ndi omwe ankatenga placebo. Izi zikutanthauza kuti Enspryng ingachepetse zizindikiro zanu komanso kuchuluka kwa kubwereranso.

Komabe, odwala omwe analibe ma antibodies a anti-AQP4 sanapindule kwambiri ndi Enspryng poyerekeza ndi placebo.

Kodi mungatani kuti muthane ndi zotsatirapo zake ngati zitachitika?

Zotsatira zoyipa kwambiri za mankhwalawa ndi matenda a m'mphuno ndi pakhosi, mutu, nseru, ziphuphu pakhungu, gastritis, kutopa, ndi kupweteka kwa miyendo kapena mafupa. Uzani dokotala wanu ngati muli ndi chilichonse mwa izi.

Matenda

Pali chiopsezo chowonjezeka pang'ono chotenga matenda ofala kapena oopsa mukamagwiritsa ntchito Enspryng. Uzani dokotala wanu ngati mukulandira chithandizo cha matenda. Komanso, uzani dokotala wanu nthawi yomweyo ngati muli ndi zizindikiro zotsatirazi:

• Chimfine, kupweteka kwa thupi, malungo, kupweteka pakhosi, chifuwa chosatha
• Kufiira kwa khungu kapena kutupa
• Kusokonezeka m'mimba, kutsegula m'mimba
• Kupsa mtima mukakodza kapena kufuna kukodza pafupipafupi

Ziphuphu

Uzani dokotala wanu ngati mukuyamba kutupa pakhungu pamene mukumwa mankhwalawo. Ngati kutupako kwafalikira mwadzidzidzi m'thupi lanu lonse, pitani kuchipatala mwamsanga.

Izi si zotsatirapo zokha zomwe zingachitike. Ngati muli ndi zizindikiro zilizonse zomwe zikukuvutitsani, lankhulani ndi dokotala wanu za izo.

Ndi mayeso ati omwe ayenera kuchitidwa musanayambe chithandizo komanso panthawi ya chithandizo?

Musanayambe Enspryng, dokotala wanu adzayesa magazi angapo kuti aone momwe chiwindi chanu chikugwira ntchito, chiwindi cha mtundu wa B, chifuwa chachikulu, kapena matenda ena. Mayesowa angafunike kubwerezedwa panthawi ya chithandizo. Chifukwa chake ndikofunikira kwambiri kuti mayeso anu achitike pa nthawi yake.

Kodi pangakhale mavuto ndi mankhwala ena?

Palibe mgwirizano waukulu womwe wanenedwa pakati pa Enspryng ndi chakudya kapena mankhwala ena. Komabe, ndikofunikira kuuza dokotala wanu za mankhwala onse omwe mukumwa (kuphatikizapo mankhwala a matenda ena, mavitamini, mankhwala azitsamba, ndi zowonjezera). Izi zingathandize kupewa zotsatirapo zilizonse zosafunikira.