Kerendia imapereka mpumulo kwa anthu omwe ali ndi matenda a shuga ndi impso (CKD)

Tikudziwa kuti anthu omwe ali ndi matenda a shuga ali pachiwopsezo cha matenda ena angapo , kuphatikizapo mavuto a impso ndi mtima. Ngakhale kuti pali mankhwala osiyanasiyana ochepetsa chiopsezochi, anthu ambiri omwe ali ndi matenda a shuga amatha kudwala matenda a impso osatha (CKD) pakapita nthawi. Ngati muli ndi matenda a shuga ndi CKD, muli ndi mwayi waukulu wopeza mavuto aakulu azaumoyo. Komabe, mankhwala otchedwa Kerendia, omwe adavomerezedwa mu 2021, angathandize kuchepetsa zoopsazi kwa anthu ena.

Kodi Kerendia imathandiza bwanji anthu omwe ali ndi matenda a shuga ndi impso?

Ngati muli ndi matenda a shuga a mtundu wachiwiri, shuga wambiri m'magazi pakapita nthawi ukhoza kuwononga ziwalo zosiyanasiyana m'thupi. Makamaka, izi zimakhudza impso mwa anthu ambiri. Impso zomwe zawonongeka mwanjira imeneyi sizingagwire ntchito bwino. Matendawa amatchedwa Matenda a Impso Osatha (CKD) . Pakapita nthawi, vutoli limakula pang'onopang'ono ndipo lingayambitse kulephera kwa impso. Shuga wambiri m'magazi amawononganso mtima ndi mitsempha yamagazi (dongosolo la mtima). Izi zimawonjezera chiopsezo cha matenda oopsa monga sitiroko, kuukira kwa mtima, ndi kulephera kwa mtima. Chifukwa impso sizikugwira ntchito bwino, anthu omwe ali ndi CKD nawonso ali pachiwopsezo chachikulu chotenga matenda a mtima. Chifukwa chake, munthu amene ali ndi matenda a shuga, CKD, ndi matenda a mtima pamodzi ali pachiwopsezo chachikulu cha imfa. Mwa kulamulira shuga m'magazi ndi kuthamanga kwa magazi, mutha kuchepetsa kuwonongeka kwa mtima wanu, mitsempha yamagazi, ndi impso. Koma mukamachita izi, pali mankhwala omwe angathandize kuteteza impso zanu kuti zisawonongeke kwambiri. Kerendia ndi imodzi mwa mankhwala apadera. Kerendia imagwira ntchito mosiyana pang'ono kuti ipewe kuwonongeka kwa mtima wanu ndi impso. Chosakaniza chogwira ntchito mu piritsi iyi ndi finerenone . Imagwira ntchito potseka cholandirira chotchedwa mineralocorticoid receptor (MR) mu impso zanu, mtima, ndi mitsempha yamagazi. Cholandirira ichi cha MR chingakhale chogwira ntchito mopitirira muyeso mwa anthu omwe ali ndi matenda ashuga. Mwa kutseka cholandirira ichi, Kerendia imathandiza impso zanu kuchotsa sodium (mchere) m'magazi anu. Imathandizanso kuchepetsa kutupa ndi zipsera (fibrosis) mumtima mwanu ndi mitsempha yamagazi. Mukachimwa kwa nthawi yayitali, mutha kuchepetsa chiopsezo chanu cha mavuto aakulu azaumoyo.

Kodi ndiyenera kugwiritsa ntchito bwanji mankhwalawa?

Kerendia ndi piritsi lomwe lingatengedwe kamodzi patsiku ndi chakudya kapena popanda chakudya. Ngati mukuvutika kumeza piritsi lonse, mutha kuliphwanya ndikusakaniza ndi madzi pang'ono kapena chakudya chofewa monga applesauce. Komabe, muyenera kumwa nthawi yomweyo mutasakaniza. Mukayamba kumwa Kerendia, dokotala wanu adzayang'ana kuchuluka kwa potaziyamu m'magazi mwanu nthawi zonse. Chifukwa chake, muyenera kuonetsetsa kuti mukupita kukayezetsa magazi tsiku lililonse lomwe dokotala wanu wakuuzani. Kutengera kuchuluka kwa potaziyamu m'magazi mwanu, dokotala wanu angakulangizeni kuti muwonjezere kapena kuchepetsa mlingo wa mankhwala, kapena kusiya kumwa mankhwalawa kwa masiku angapo. Ngati mwaphonya mlingo, imwani mwamsanga mukakumbukira. Koma pokhapokha ngati uli mkati mwa tsiku lomwe mwaphonya mlingo. Ngati mukukumbukira tsiku lotsatira, musamwe mlingo womwe mwaphonya. Kumwa mlingo wowirikiza kawiri kungapangitse chiopsezo cha zotsatirapo zoyipa.

Ndi mayeso ati omwe achitika pa mankhwalawa?

Tsopano mwina mukudabwa kuti mankhwalawa ndi odalirika bwanji komanso ndani amene wagwiritsa ntchito. Tiyeni tiwone maphunziro omwe achitika pa mankhwalawa. Mayeso awiri akuluakulu achitika kuti aone momwe Kerendia ilili yotetezeka komanso yogwira mtima mwa akuluakulu omwe ali ndi matenda a shuga ndi CKD. Avereji ya zaka za omwe adatenga nawo mbali mu mayesowa inali pafupifupi zaka 64.

Mfundo zofunika zokhudza omwe adachita nawo mayesowa:

• Onse anali ndi matenda a shuga amtundu wachiwiri komanso CKD .
• Ngakhale ena adapezeka kale ndi matenda a mtima , palibe amene anali ndi zizindikiro panthawi yoyezetsa.
• Aliyense anali kugwiritsa ntchito mankhwala omwe ankayenera kuteteza impso .
• 97% ankagwiritsa ntchito mankhwala oletsa shuga m'magazi .
• Mankhwala a Kerendia anayerekezeredwa ndi placebo , piritsi lopanda mphamvu lomwe silinagwire ntchito. Palibe amene ankadziwa ngati akupeza mankhwala enieni kapena piritsi lopanda mphamvu.

Chimodzi mwa mayesero amenewa chinayesa kuchuluka kwa mavuto akuluakulu a impso omwe anachitika pamene ankamwa mankhwalawa.

• Anthu omwe ali ndi matenda aakulu a impso.
• Anthu omwe ali ndi vuto la impso.
• Anthu omwe anamwalira chifukwa cha mavuto a impso.

Kuyesa kwina kunayesa kuchuluka kwa matenda oopsa a mtima omwe anachitika. Izi ndi izi:

• Anthu omwe adadwala sitiroko kapena matenda a mtima .
• Anthu omwe amagonekedwa m'chipatala chifukwa cha matenda a mtima.
• Anthu omwe adamwalira chifukwa cha matenda a mtima.

Kodi zotsatira za mayesowo ndi ziti?

Mavuto a impso: Mu kafukufukuyu, womwe unatenga zaka pafupifupi 2.5, anthu omwe adatenga Kerendia anali ndi mavuto ochepa a impso poyerekeza ndi omwe adatenga placebo. Izi zikutanthauza kuti anthu ena anali ndi mwayi wochepa wokhala ndi mavuto akuluakulu a impso, monga kulephera kwa impso, kulephera kwa impso, kapena kufa chifukwa cha matenda a impso. Mavuto a mtima: Mu kafukufukuyu, womwe unatenga zaka pafupifupi 3.5, anthu omwe adatenga Kerendia analinso ndi mavuto ochepa a mtima poyerekeza ndi omwe adatenga placebo. Izi zikutanthauza kuti anthu ena anali ndi mwayi wochepa wokhala ndi mavuto akuluakulu a mtima, monga sitiroko, matenda a mtima, kugonekedwa m'chipatala chifukwa cha matenda a mtima, kapena imfa.

Zotsatirapo zake ndi momwe mungathanirane nazo?

Monga mankhwala ena aliwonse, Kerendia ingayambitse zotsatira zina zoyipa. Chofunika kwambiri ndi kuchuluka kwa potaziyamu m'magazi. Ndicho chifukwa chake dokotala wanu amafufuza magazi anu nthawi zonse. Simungamve kusiyana kwakukulu mukamagwiritsa ntchito mankhwalawa. Izi zili choncho chifukwa ntchito yake yayikulu ndikuchepetsa kuchuluka kwa kuwonongeka kuchokera mkati. Chifukwa chake, ngakhale mutamva bwino, musasiye kumwa mankhwala popanda upangiri wa dokotala. Kerendia, finerenone, matenda a shuga, matenda a impso, matenda osatha a impso, CKD, matenda a mtima, Sri Lanka