Kodi chakudya chatsekeredwa m'mimba? Tiyeni tiphunzire za zinthu zoyambitsa prokinetic

Nthawi zina tikadya, m'mimba mwathu mumamva kukhuta komanso kutupa, eti? Zimamveka ngati chakudya sichikutsika m'mimba mwathu. Kapena timamva kusasangalala monga kutopa nthawi zonse, kutentha pamtima, komanso kusanza. Chifukwa chimodzi cha izi chingakhale chakuti dongosolo lanu logaya chakudya, kutanthauza matumbo anu, limachedwa pang'ono. Lero, tikulankhula za gulu lapadera la mankhwala omwe amabwera kudzathandiza nthawi ngati zimenezi.

Mwachidule, kodi Prokinetic Agents awa ndi chiyani?

Mankhwala otchedwa prokinetic agents ndi mtundu wa mankhwala omwe amalimbikitsa minofu ya m'mimba mwanu kuti ichepetse, kapena "ikankhire," ndikuthandizira kusuntha chakudya mosavuta.

Tangoganizirani, tikameza chakudya, minofu yochokera ku mmero kupita m'mimba ndi m'matumbo imangogwedezeka ndikupumula ngati mafunde, ndikukankhira chakudya patsogolo. Timachitcha kuti njira yodzidzimutsa ya peristalsis . Zili ngati kufinya ndi kufinya china chake mkati mwa chubu ndikuchitumiza patsogolo. Chifukwa chakuti njirayi imachitika bwino, thupi lathu limatha kuyamwa michere yomwe limafunikira kuchokera ku chakudya.

Komabe, ngati pazifukwa zina njira yoyendera iyi yafooka, chakudya chingakhale m'mimba kwa nthawi yayitali. Izi zingayambitse kusasangalala monga kudzimbidwa, kudzimbidwa, ndi kutentha pamtima. Pamenepo ndi pomwe mankhwala otchedwa Prokinetic Agents amathandizira kupatsa matumbo athu "kankhira" pang'ono ndikubwezeretsa njira imeneyo.

Kodi mankhwalawa amagwira ntchito bwanji m'thupi?

Mankhwala a prokinetic amagwira ntchito polimbikitsa mitsempha m'matumbo athu, zomwe zimapangitsa kuti minofu igwire ntchito. Izi zimachita zinthu zingapo zofunika:

• Zimawonjezera kupindika kwa m'mero: Izi zimapangitsa kuti chakudya chilowe m'mimba mwachangu.
• Limbitsani Lower Esophageal Sphincter (LES): Ichi ndi "chipata" pakati pa mmero ndi m'mimba. Pamene chifooka, asidi m'mimba amatha kubwerera m'mimba. Ichi ndi chomwe timachitcha kutentha pamtima, kapena GERD . Mankhwala a prokinetic amalimbitsa chipata ichi ndikuletsa asidi kuti asabwerere m'mwamba.
• Zimawonjezera kupweteka kwa m'mimba: Izi zimathandiza kuti chakudya m'mimba chiziyenda mofulumira kupita m'matumbo ang'onoang'ono. M'mimba mukamatuluka madzi mwachangu, mwayi woti chibwererenso m'mimba umakhala wochepa.
• Amachepetsa nthawi yomwe imatenga kuti m'mimba mutulutse chakudya: Izi zimathandizanso kwambiri poletsa matenda monga GERD omwe atchulidwa pamwambapa.

Kodi mankhwala a prokinetic amagwiritsidwa ntchito pa matenda otani?

Mankhwala amtundu uwu nthawi zambiri amalimbikitsidwa ndi madokotala ngati njira zina zothandizira sizinathandize, chifukwa izi zitha kukhala ndi zotsatirapo zina.

Kodi mitundu ikuluikulu ya mankhwala a prokinetic ndi iti?

Mankhwalawa akhoza kugawidwa m'magulu awiri akuluakulu kutengera momwe amagwirira ntchito: Agonists ndi Otsutsa .

• Agonists: Izi zimagwira ntchito ngati ma neurotransmitters m'thupi lathu ndipo zimachita zomwezo zomwezo. Izi zikutanthauza kuti, zimatumiza uthenga ku minofu ya m'matumbo kuti ichepetse.
• Otsutsa: Izi zimagwira ntchito poletsa mankhwala omwe amanyamula mauthenga a mitsempha omwe amachepetsa ntchito ya matumbo kuti asafike pa mitsempha. Izi zikutanthauza kuti, amaletsa uthenga womwe umapangitsa matumbo "kuchepetsa liwiro."

Pali mitundu ingapo ya mankhwala pansi pa izi:

• Mankhwala oletsa dopamine: Dopamine, mankhwala omwe amapezeka mu ubongo ndi m'matumbo, amachepetsa ntchito ya matumbo. Mankhwalawa amagwira ntchito poletsa ntchito ya dopamine. Zitsanzo: Metoclopramide, Domperidone .
• Ma serotonin agonists: Amagwira ntchito ngati mankhwala otchedwa serotonin ndipo amalimbikitsa matumbo kugwira ntchito bwino. Zitsanzo: Prucalopride .
• Motilin agonists: Motilin ndi mankhwala omwe amalamulira kupweteka kwa matumbo athu ang'onoang'ono. Umu ndi momwe mankhwalawa amagwirira ntchito. Chodabwitsa n'chakuti, gululi lili ndi maantibayotiki monga Erythromycin .
• Mankhwala oletsa kutupa: Amachita ngati acetylcholine wa neurotransmitter ndipo amachititsa kuti minofu ya m'matumbo igwidwe. Zitsanzo: Bethanechol, Neostigmine .

Chofunika Kwambiri: Zotsatirapo zoyipa za mankhwalawa

Madokotala amangopereka mankhwala amenewa ngati njira zina zothandizira zalephera, ndipo nthawi zambiri amaperekedwa pa mlingo wochepa komanso kwa nthawi yochepa.

Zotsatira zoyipa zomwe zimawonedwa kawirikawiri:

• Kuwawa kwam'mimba
• Kusanza ndi kusanza
• Kutsegula m'mimba
• Maso osawoneka bwino
• Mutu
• Kutopa kwambiri, kugona tulo
• Kuvutika maganizo ndi nkhawa

Zotsatirapo zoyipa zomwe muyenera kuzisamala nazo:

Zizindikiro zimenezi n’zofunika kwambiri. Ngati mukukumana ndi zizindikiro zimenezi mukumwa mankhwala a prokinetic, muyenera kudziwitsa dokotala wanu nthawi yomweyo.

• Dystonia: Iyi ndi matenda omwe minofu ya thupi imakokana mosalamulirika, monga khosi kukokedwa mbali imodzi, maso akukwera mmwamba, kapena lilime likutuluka.
• Kusuntha kosafunikira kwa ziwalo za nkhope (Tardive Dyskinesia): Uwu ndi vuto lomwe lingachitike mutamwa mankhwala kwa nthawi yayitali. Mbali zina za nkhope, monga pakamwa, lilime, ndi nsagwada, zimasuntha mosadzifunira. Vutoli nthawi zina silikhala bwino ngakhale mutasiya kumwa mankhwalawo.
• Mavuto a mtima: Mankhwala ena, makamaka Domperidone , angayambitse kugunda kwa mtima kosakhazikika (arrhythmias) ndi matenda a mtima. Pachifukwa ichi, kugwiritsa ntchito mankhwalawa kwaletsedwa m'maiko ena.

Chifukwa cha zoopsa izi, ngati dokotala wanu akukupatsani mankhwala awa , kambiranani naye mosamala za ubwino ndi kuipa kwake. Onetsetsani kuti mwauza dokotala wanu za matenda ena aliwonse omwe muli nawo komanso mankhwala ena aliwonse omwe mukumwa.