Kodi ziphuphu zimenezi pakhosi ndi m'khwapa ndi ziti? Tiyeni tiphunzire za matenda a Rosai-Dorfman!

Ndi zachilendo kumva mantha pang'ono tikaona kusintha m'thupi lathu, sichoncho? Makamaka ngati tiwona ziphuphu zazing'ono pakhosi pathu, m'khwapa, kapena m'mimba, timaganiza kuti, 'Ichi ndi chiyani?' Lero tikambirana za vuto losowa lomwe lingayambitse ziphuphu zotere, koma anthu ambiri sanamvepo za izi. Izi zimatchedwa Matenda a Rosai-Dorfman.

Kodi mukudziwa kuti matenda a Ross-Dorffman (RDD) ndi chiyani?

Mwachidule, matupi athu ali ndi mtundu wa maselo oyera a m'magazi otchedwa histiocytes . Awa ali ngati apolisi m'thupi lathu, omwe amalimbana ndi majeremusi omwe amayambitsa matenda, ndipo ndi gawo lofunika kwambiri la chitetezo chathu chamthupi. Komabe, ma histiocytes awa akakula kwambiri, amatchedwa matenda a Ross-Dorffmann (RDD). Izi si khansa kwenikweni (yoipa) , kutanthauza kuti si matenda oopsa omwe amafalikira kuchokera mbali imodzi ya thupi kupita ku ina. Komabe, maselowa akamasonkhana mopitirira muyeso, timatha kumva kusasangalala komanso zizindikiro.

Nthawi zambiri, ma histiocyte ochulukirapowa amasonkhana m'ma lymph nodes m'khosi mwathu. Kenako amatupa ngati zotupa m'khosi. Madokotala nthawi zina amatcha kutupa kwa ma nodes `(lymphadenopathy).` Koma sikungakhudze khosi lokha, komanso ma nodes m'zigawo zina za thupi. Nthawi zina, kuwonjezera pa ma nodes, maselowa amathanso kusonkhana m'zigawo zina za thupi (extranodal sites).

Matendawa amatchedwanso `sinus histiocytosis yokhala ndi massive lymphadenopathy`. Uwu ndi matenda osowa omwe ali m'gulu la `non-Langerhans cell histiocytosis`.

Kodi mitundu ikuluikulu ya matenda a Ross-Dorffmann (RDD) ndi iti?

Matendawa sakhudza aliyense mofanana. Anthu ena amakhala ndi kutupa pamalo amodzi, pomwe ena amakhala ndi kutupa m'malo angapo. Komanso, ma histiocyte amenewa amatha kudziunjikira osati m'mabowo okha komanso m'zigawo zina za thupi. Umu ndi momwe amagawidwira.

• Matenda a Ross-Dorffmann (Osaoneka ndi Mafinya) (Classic/Nodal RDD): Uwu ndi mtundu wofala kwambiri. Umakhudza makamaka kutupa kwa mafinya m'khosi. Komabe, zizindikiro zimatha kusiyana malinga ndi kuchuluka kwa mafinya omwe akhudzidwa.
• Extranodal RDD: Mu mtundu uwu, ma histiocyte amenewa amasonkhana m'maselo ena osati ma lymph nodes. Khungu limakhudzidwa kwambiri. Izi zimatchedwa cutaneous RDD (CRDD) . Kuphatikiza apo, vutoli lingakhudze sinuses zathu, maso ndi zikope, mafupa, ndi dongosolo lapakati la mitsempha (CNS) - kutanthauza ubongo ndi msana. Nthawi zina dongosolo lopumira ndi dongosolo la m'mimba zimathanso kukhudzidwa.

Pafupifupi 40% ya anthu omwe ali ndi RDD akhoza kukhala ndi maselo a histiocyte awa omwe amasonkhanitsidwa m'mbali zina za thupi, kuwonjezera pa ziphuphu, monga mwanenera.

Ndani amene ali ndi mwayi waukulu wopeza matendawa?

Matenda a Ross-Dorffmann amakhudza kwambiri ana, achinyamata, ndi achinyamata . Nthawi zambiri amapezeka mwa anthu azaka za m'ma 20. Komabe, anthu azaka za m'ma 70 nawonso adanenedwa kuti ali ndi matendawa.

RDD, yomwe imakhudza machende, imapezeka kwambiri mwa amuna ochokera ku Africa. Koma vuto la khungu lomwe latchulidwa kale lakuti "CRDD" limapezeka kwambiri mwa akazi ochokera ku Asia. "CRDD" imapezeka kwambiri mwa anthu azaka za m'ma 20, 30, ndi 40.

Kodi matenda a Ross-Dorfman ndi osowa bwanji?

Uwu ndi matenda osowa kwambiri . Umakhudza munthu m'modzi pa anthu 200,000. Mwachitsanzo, ku United States, milandu yatsopano pafupifupi 100 imanenedwa chaka chilichonse. Izi zikutanthauza kuti ku Sri Lanka, matendawa ndi ochepa kwambiri.

Kodi zizindikiro za matenda a Rose-Dorfman (RDD) ndi ziti?

Zizindikiro zomwe mumakumana nazo zimadalira komwe ma histiocyte ochulukirapo amasonkhana m'thupi lanu. Ngati ma lymph nodes omwe ali m'khosi mwanu ndi omwe akhudzidwa, zizindikiro zanu zitha kukhala zochepa kapena kusakhalapo. Komabe, ngati maselowa asonkhana ndikusokoneza ntchito ya chiwalo, zizindikiro zanu zitha kukhala zoopsa kwambiri.

Zizindikiro zakale (zotupa)

Ma histiocyte nthawi zambiri amasonkhana m'mitsempha ya khosi. Chifukwa chake, chizindikiro chofala kwambiri ndikuwoneka ngati pali ziphuphu zotupa komanso zopanda ululu mbali zonse ziwiri za khosi . Mungakumbukire momwe nthawi zina mumakhalira ndi chotupa chaching'ono m'khosi mwanu mukakhala ndi chimfine kapena chimfine, sichoncho? Inde, koma sizingakhale zopweteka. Komabe, kutengera komwe kuli minofu yokhudzidwa, kutupako kumathanso kukhala m'malo ena.

Madera akuluakulu a kutupa omwe angachitike chifukwa cha kuchuluka kwa ma histiocytes ndi awa:

• Khosi lanu
• Malo okulira
• Makhwapa
• Pakati pa chifuwa (mediastinum)

Simungakhale ndi zizindikiro zina kupatula kutupa, kapena mutha kukhala ndi zizindikiro monga:

• Malungo
• Khungu lotumbululuka
• Kutopa kwambiri
• Thukuta la usiku
• Mphuno yotuluka madzi
• Kuchepetsa thupi kosamveka bwino

Zizindikiro zakunja kwa nodial

Matenda a Rose-Dorffmann (`CRDD`) amatha kukhudza khungu ndipo amatha kuonekera kulikonse m'thupi. Matumbo amenewa, omwe amapangidwa ndi magulu a maselo a histiocyte, nthawi zambiri amakula pang'onopang'ono. Zizindikiro zomwe zingawoneke pakhungu ndi izi:

• Matumbo athyathyathya kapena okwezeka
• Mafinya odzaza ndi mafinya kapena olimba
• Ziphuphu zachikasu, zofiirira, zofiira, kapena zofiirira
• Ikhoza kufalikira pakhungu lonse kapena kufalikira kudera limodzi lokha.

Ngati ma histiocyte ochulukirapowa akhudza chiwalo china kapena dongosolo la thupi, zizindikiro zosiyanasiyana zimatha kuchitika. Mwachitsanzo, ngati RDD ikhudza maso, ingayambitse kuwona kawiri. Ngati ikhudza dongosolo la mitsempha, ingayambitse khunyu. Ngati ikhudza mapapo, ingayambitse chifuwa chosatha. Mofananamo, zizindikiro zimasiyana malinga ndi dera lomwe lakhudzidwa.

Kodi n’chiyani chimayambitsa matenda a Ross-Dorffman (RDD)?

Asayansi sakudziwabe chomwe chimayambitsa matendawa. Popeza RDD imakhudza munthu aliyense mosiyana, pakhoza kukhala zifukwa zingapo. Mwachitsanzo, kafukufuku waposachedwapa akusonyeza kuti vuto la khungu la ``CRDD`` limayamba chifukwa cha zinthu zina zomwe zimayambitsa RDD wamba.

Ofufuza posachedwapa apeza kuti kusintha kwa majini ena kumapezeka m'mitundu ina ya RDD kupatula CRDD. Kusintha kumeneku kungayambitse maselo kukula mosalamulirika.

Anthu ambiri omwe ali ndi RDD ali ndi vutoli limodzi ndi matenda ena. Chifukwa chake, pakhoza kukhala kulumikizana pakati pa matenda amenewo ndi RDD. Kafukufuku wowonjezereka akufunika pankhaniyi.

RDD yapezeka kuti ikugwirizana ndi izi:

• Matenda opatsirana ndi mavairasi: Zitsanzo zake ndi monga herpes, kachilombo ka Epstein-Barr, cytomegalovirus, ndi kachilombo ka HIV.
• Khansa: Hodgkin lymphoma, non-Hodgkin lymphoma, ndi khansa ya pakhungu monga cutaneous clear-cell sarcoma. (Koma kumbukirani, RDD si khansa.)
• Matenda a Autoimmune: Lupus, Juvenile Idiopathic Arthritis, Autoimmune Hemolytic Anemia.

Kodi matenda a Ross-Dorffman (RDD) amapezeka bwanji?

Dokotala wanu adzachita kaye mayeso akuthupi ndikufunsani za zizindikiro zanu. Adzafufuza zizindikiro za RDD, monga kutupa kwa glands ndi ziphuphu pakhungu. Adzafunsanso za mbiri yanu yachipatala kuti aone ngati muli ndi matenda enaake okhudzana ndi RDD.

Komanso, dokotala akhoza kuchita mayeso awa:

• Njira zojambulira: Kutengera mtundu wa minofu yomwe ikukayikiridwa kuti ili ndi ma histiocyte, dokotala angalamule kuti apimidwe X-ray, ultrasound, MRI, CT, PET, PET/CT, kapena fupa. Izi zingagwiritsidwe ntchito kuona zomwe zili mkati mwa thupi.
• Mayeso a magazi: Mayeso angapo a magazi, monga kuwerengera magazi onse (CBC) ndi gulu lonse la kagayidwe kachakudya, angachitike kuti awone kusintha komwe kukuchitika m'thupi.
• Biopsy: Iyi ndi mayeso ofunikira kwambiri.Izi zimaphatikizapo kutenga chitsanzo chaching'ono cha minofu yomwe yakhudzidwa (monga lymph node yotupa) ndikuwunika maselowo pogwiritsa ntchito maikulosikopu kuti awone ngati ali ndi mawonekedwe a RDD. Kuyeza kumeneku kungathenso kudziwa ngati matenda ena akuyambitsa kukula kwa maselo osadziwika bwino.

Kodi matenda a Ross-Dorffmann (RDD) amachiritsidwa bwanji?

Nthawi zina, RDD imatha kuchira mwadzidzidzi popanda chithandizo chilichonse. Izi zikutanthauza kuti matendawa adzachira okha. Komabe, nthawi yomwe imatenga ndi yovuta kuneneratu. Zingatenge miyezi kapena zaka kuti achire. Komabe, nthawi zina, sangachoke okha, kapena angabwererenso. Ngati sanalandire chithandizo, matendawa angakule kwambiri.

Chithandizo chomwe mudzalandire chidzadalira momwe RDD yakukhudzirani.

• Kuyang'anitsitsa: Ngati mulibe zizindikiro zomwe zikukhudza kwambiri moyo wanu, dokotala wanu angasankhe kuyang'anira vuto lanu. Izi zikufanana ndi njira yodikira mwatcheru.
• Opaleshoni: Ziphuphu zimatha kuchotsedwa mwa opaleshoni. Ngati muli ndi `CRDD` (cutaneous RDD), kapena ngati ziphuphuzo zikutseka njira yanu yopumira kapena zikukhudza msana wanu, opaleshoni ikhoza kuchitidwa.
• Chithandizo cha radiation: Ngati opaleshoni singathe kuchotsa ma histiocytes, chithandizo cha radiation chingaperekedwe. Izi zimaphatikizapo kugwiritsa ntchito makina kuwongolera kuwala kwa radiation ku maselo, kuwawononga.
• Chemotherapy: Ngati matendawa ndi aakulu, kapena ngati njira zina zothandizira, monga opaleshoni, sizinachepetse zizindikiro, chemotherapy ingaganizidwe. Izi zikuphatikizapo kugwiritsa ntchito mankhwala omwe amapha maselo omwe amakula mofulumira, monga maselo a khansa.
• Corticosteroids: Mankhwala a Corticosteroids, monga prednisone, amatha kuchepetsa kutupa kwa mafupa ndikuchepetsa zizindikiro. Awa ndi mtundu wa mankhwala omwe amachepetsa kutupa.
• Chithandizo cha Immunotherapy: Mankhwalawa amathandiza chitetezo cha mthupi lanu kupeza ndikuwononga maselo ochulukirapo a histiocyte bwino kwambiri.

Kodi tsogolo la munthu amene ali ndi matenda a Ross-Dorffman (RDD) ndi lotani?

Kuyezetsa matenda anu kumadalira zinthu zingapo. Chiwerengero cha maselo omwe akhudzidwa, komwe ma histiocyte ochulukirapo m'thupi lanu ali, komanso momwe mumayankhira bwino chithandizo. Nthawi zambiri, RDD imatha yokha. Komabe, nthawi zina, chithandizo chimafunika, kapena mavuto akuluakulu angachitike.

Kawirikawiri, maselo okhudzidwa akachepa, zotsatira zake zimakhala zabwino.Ngati pali extranodal RDD, yomwe imakhudza khungu, chifuwa, kapena njira yopumira yapamwamba, zotsatira zake zimakhala zabwino. Komabe, ngati ma histiocyte alipo m'njira yopumira yapansi, impso, kapena chiwindi, vutoli likhoza kukhala loipa pang'ono.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga?

Musaiwale kulankhula ndi dokotala wanu za izi, chifukwa ndikofunikira kwambiri kuti mumvetse bwino za matenda anu:

• "Dokotala, ndi ziwalo ziti za thupi langa zomwe zakhudzidwa ndi vuto langa la RDD?"
• "Kodi ndiyenera kuyesedwanso zithunzi (monga ma scan) kapena magazi?"
• "Kodi ndikufunika chithandizo, kapena n'zotheka kuti vuto langa la RDD litha lokha?"
• "Ndiyenera kuda nkhawa bwanji ndi vutoli la RDD?"
• "Ndi chithandizo chiti chabwino kwambiri chomwe dokotala amandilangiza?"
• "Ndi zotsatirapo ziti zomwe ndingayembekezere pambuyo pa chithandizo?"
• "Kodi pali mwayi wotani woti vuto langa la RDD lidzabwerenso nditalandira chithandizo?"
• "Ndiyenera kubwera kangati kudzandiona kuti ndili ndi vuto?"

Kodi matenda a Ross-Dorffman (RDD) ndi khansa?

Ayi. Ili ndi funso lomwe anthu ambiri amafunsa. Matenda a Rose-Dorffman si khansa (yoipa) . Izi zikutanthauza kuti, safalikira kuchokera mbali imodzi ya thupi kupita ku ina monga khansa (malignancy). Komabe, ziphuphu zomwe zimachitika chifukwa cha RDD zimatha kukhudza ziwalo, kusokoneza ntchito yawo, ndikuyambitsa mavuto. Dokotala wanu ndiye munthu wabwino kwambiri wodziwa momwe matenda anu a RDD akukhudzira thupi lanu komanso ngati muyenera kuda nkhawa nawo.

Ndani anatulukira matenda a Ross-Dorffman (RDD)?

Ndi bwino kudziwa izi. Mu 1965, wasayansi wotchedwa Pierre Paul Louis Lucien Destombes adapeza zizindikiro za RDD mwa odwala anayi. Kenako, mu 1969, asayansi awiri otchedwa Juan Rosai ndi Ronald Dorfman adafufuza gulu lina la odwala omwe ali ndi zizindikiro zofanana. Matendawa tsopano amadziwika kuti matenda a Rosai-Dorfman, kuphatikiza mayina awo. Kawirikawiri, amatchedwanso matenda a Rosai-Dorfman-Destombes, polemekeza asayansi onse atatu.

Pomaliza, zinthu zoti muzikumbukira (Uthenga Wopita Nawo Kunyumba)

Matenda a Ross-Dorffmann (RDD) akhoza kukhala ovuta kuwazindikira chifukwa ndi osowa kwambiri ndipo amakhudza munthu aliyense mosiyana . Palibe malangizo amodzi ochiritsira RDD. Ndicho chifukwa chake ndikofunikira kulankhula momasuka ndi dokotala wanu, kumvetsetsa matenda anu, komanso kudziwa njira zomwe mungasankhire chithandizo.

Mwina muli ndi RDD yochepa yomwe ingathetse yokha. Kapena, mungafunike njira zosiyanasiyana zochiritsira. Funsani dokotala wanu momwe dongosolo lanu la chithandizo ndi zotsatira zomwe mukuyembekezera zidzagwirizanitsidwire ndi vuto lanu.

Kumbukirani kuti simuli nokha . Mukakumana ndi vuto losowa chonchi, ndikofunikira kwambiri kutsatira malangizo a dokotala ndikukhala olimba m'maganizo. Ngati muli ndi mafunso kapena kukayikira kulikonse, kambiranani ndi dokotala wanu. Musachite mantha, chifukwa kudziwa bwino matendawa ndiye chida chabwino kwambiri cholimbana ndi zinthu zotere.

Matenda a Rosai -Dorfman, RDD, histiocytes, lymphadenopathy, ziphuphu pakhosi, matenda a pakhungu, CRDD, matenda osowa, chitetezo chamthupi