Tangoganizirani kuti gawo limodzi lokha la thupi lanu, mwachitsanzo mkono, mwendo, kapena dera linalake la khungu, limakula mofulumira kwambiri kuposa ena onse. Uwu ndi vuto losowa kwambiri lomwe anthu ena amabadwa nalo. Mwachidule, timatcha gulu la matenda awa kuti PIK3CA-Related Overgrowth Spectrum, kapena PROS . Ichi ndi chinthu chomwe chimayambitsa mavuto ambiri kwa munthu amene amachiwona, komanso munthu amene amachiwona. Lero, m'nkhaniyi, tikambirana za PROS iyi ndi chiyani komanso za Vijoice, mankhwala oyamba ovomerezeka makamaka pa vutoli.
Kodi ubwino ndi chiyani kwenikweni?
Mwachidule, PROS ndi vuto lomwe limayamba chifukwa cha majini. Tonsefe tili ndi majini m'thupi lathu omwe amalamulira kukula, kugawikana, ndi kufa kwa maselo. `PIK3CA` ndi jini imodzi yofunika kwambiri. Ganizirani jini iyi ngati `switch` yomwe imalamulira kukula kwa maselo athu.
Komabe, mwa munthu amene ali ndi PROS, pali vuto, kapena kusintha kwa majini a `PIK3CA`. Izi zimapangitsa kuti `switch` ikhale pamalo a `on`. Kenako puloteni yomwe ikukambidwa imayamba kugwira ntchito mofulumira kwambiri komanso mopitirira muyeso. Zotsatira zake, ziwalo zina za thupi, mwachitsanzo khungu, mitsempha yamagazi , mafupa , ndi ubongo, zimayamba kukula mosalamulirika.
Chofunika kwambiri ndichakuti PROS sikhudza ziwalo zonse za thupi. Zitha kusiyana kuchokera ku gawo limodzi la thupi kupita ku lina, komanso kuchokera kwa munthu ndi munthu. Chifukwa chake, zizindikiro zake zimakhala zosiyanasiyana kwambiri.
Mpaka pano, panalibe mankhwala athunthu a PROS. Mankhwalawa ankayang'ana kwambiri pa kuthana ndi zizindikiro. Mwachitsanzo, mankhwala ochizira ululu, kuyabwa, ndi khunyu, komanso opaleshoni yochotsa zotupa zosazolowereka. Komabe, panali chiopsezo chakuti zotupazo zimerenso pambuyo pa opaleshoni.
Kodi mankhwala a Vijoice (alpelisib) amagwira ntchito bwanji?
Apa ndi pomwe mankhwala a Vijoice amayambira. Vijoice ndiye mankhwala oyamba omwe amayambitsa PROS, kusinthasintha kwa ntchito komwe kumachitika chifukwa cha kusintha kwa majini.
Chomwe chimagwira ntchito mu izi ndi alpelisib . Mankhwalawa amagwiritsidwa ntchito pa mitundu ina ya khansa ya m'mawere . Chifukwa chake ndi chakuti, ndiMaselo a khansa amakula chifukwa cha kugwira ntchito mopitirira muyeso kwa njira ya PIK3, monga momwe zilili mu PROS.
Kotero chomwe Vijoice amachita ndikutseka njira ya PIK3, yomwe imagwira ntchito ngati 'switch' yomwe yakhala pamalo 'okhala'. Izi zimachepetsa kukula kwa maselo kosazolowereka, zimachepetsa kukula kwa minofu yomwe ikukula kale, komanso zimawongolera zizindikiro.
Kodi ubwino wa mankhwalawa ndi wotani?
Kafukufuku wochitidwa pa mankhwalawa (EPIK-P1 ndi EPIK-P3) wasonyeza ubwino waukulu kwa odwala.
| Phindu | Kufotokozera kosavuta |
|---|---|
| Zomera zazing'ono (mabala) | Zapezeka kuti anthu ambiri omwe adamwa mankhwalawa adachepetsa kuchuluka kwa zotupa zamafuta (lipomas) ndi zolakwika za mitsempha yamagazi ndi 20% kapena kuposerapo. |
| Kufunika kochepa kwa opaleshoni | Pafupifupi 70% ya ana ndi 90% ya akuluakulu omwe amatenga Vijoice sanafunike opaleshoni. |
| Kuchepetsa zizindikiro | Odwala anena kuti zizindikiro monga kupweteka, kuyabwa, ndi kutopa zachepa kwambiri. |
| Kupangitsa ntchito za tsiku ndi tsiku kukhala zosavuta | Pafupifupi 81% ya odwala omwe adachita nawo kafukufukuyu adanenanso kuti luso lawo lochita zinthu zatsiku ndi tsiku komanso moyo wawo unali wabwino poyerekeza ndi momwe adachitira asanayambe kumwa mankhwalawa. |
Chofunika: Zotsatirazi sizingakhale zofanana kwa aliyense. Lankhulani ndi dokotala wanu ngati mankhwalawa ndi oyenera kwa inu komanso ubwino ndi zoopsa zake.Ndi bwino kulankhula nawo ndi kusankha.
Kodi zotsatirapo zoyipa kwambiri ndi ziti ndipo mungathane nazo bwanji?
Monga mankhwala ena aliwonse, Vijoice ingayambitse zotsatirapo zoyipa . Komabe, zambiri mwa izi zimakhala zochepa kapena zochepa ndipo zimatha kuthandizidwa.
| Zotsatira zoyipa | Momwe mungasamalire ndi zomwe muyenera kulabadira |
|---|---|
| Kutsegula m'mimba | Imwani madzi ambiri monga madzi ndi madzi akumwa. Ngati mukumva zizindikiro monga kutsegula m'mimba kwambiri, kupweteka m'mimba, kapena magazi kapena ntchofu m'chimbudzi chanu, uzani dokotala wanu nthawi yomweyo . |
| Kusowa madzi m'thupi | Kutsegula m'mimba kungayambitse kutaya madzi m'thupi. Samalani ndi zizindikiro monga chizungulire kwambiri, kutopa, komanso kuchepa kwa kukodza. Izi zingakhudze impso zanu, choncho uzani dokotala nthawi yomweyo. |
| Zilonda pakamwa (Stomatitis) | Zilonda pakamwa ndi ululu zingachitike. Pewani kutsuka pakamwa ndi mowa. Tsukani pakamwa panu ndi madzi ofunda amchere. Pewani zakudya zokometsera komanso zamchere. |
| Kuwonjezeka kwa shuga m'magazi (hyperglycemia) | Dokotala wanu adzayang'ana kuchuluka kwa shuga m'magazi mwanu musanayambe kumwa mankhwalawa komanso panthawi ya chithandizo chanu. Uzani dokotala wanu ngati muli ndi zizindikiro monga ludzu lochuluka, kukodza pafupipafupi, kapena kutopa. Anthu omwe ali ndi matenda a shuga ayenera kusamala kwambiri ndi izi. |
| Kuchepetsa tsitsi (Alopecia) | Tsitsi limatha kutayika kapena kuonda panthawi ya chithandizo. Gwiritsani ntchito shampu zofewa. Lankhulani ndi dokotala wanu za izi. |
Kodi pangakhale mavuto ndi mankhwala ena?
Inde. Vijoice imatha kuyanjana ndi mankhwala ena. Mwachidule, mankhwala ena amatha kuchepetsa mphamvu ya Vijoice. Vijoice imathanso kusintha mphamvu ya mankhwala ena.
Mwachitsanzo, mankhwala monga carbamazepine a khunyu, rifampin a chifuwa chachikulu, ndi mankhwala azitsamba monga St. John's wort angathandize pankhaniyi.
Choncho, musanayambe kumwa mankhwalawa, ndikofunikira kuuza dokotala wanu za mankhwala onse omwe mukumwa (kuphatikizapo mavitamini, mankhwala azitsamba, ndi mankhwala ochepetsa ululu) kuti athe kusintha kulikonse kofunikira.
Uthenga Wopita Nawo Kunyumba
- ZOTHANDIZA ndi vuto losowa kwambiri lomwe ziwalo za thupi zimakula molakwika chifukwa cha kusintha kwa majini otchedwa `PIK3CA`.
- Vijoice (alpelisib) ndiye mankhwala oyamba ovomerezeka kuti agwire ntchito yomwe imayambitsa matendawa.
- Izi zingathandize kuchepetsa kukula kosazolowereka, kuchepetsa kufunika kochitidwa opaleshoni, komanso kukonza moyo wabwino.
- Zotsatirapo monga kutsegula m'mimba, shuga wambiri m'magazi, ndi zilonda pakamwa zimatha kuchitika, ndipo ndikofunikira kwambiri kuzithetsa ndikudziwitsa dokotala.
- Ndikofunikira kudziwitsa dokotala wanu za mankhwala ena onse omwe mukumwa. Musayambe kapena kusiya kumwa mankhwala aliwonse popanda upangiri wa dokotala.
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