Ese nawe ufite ikibazo cy'amaraso? Reka tuvuge kuri CMML (Chronic Myelomonocytic Leukemia)!

Ese wigeze wumva indwara yitwa `CMML` cyangwa Leukemia idakira ya Myelomonocytic? Birashoboka ko atari byo. Kuko ni ubwoko budasanzwe bwa kanseri y'amaraso. Ariko ni ingenzi cyane kuri twe kubimenya. Kuko bigira ingaruka ku buryo umubiri wacu ukora amaraso. Reka tubiganireho mu buryo bworoshye, mu buryo ushobora gusobanukirwa.

CMML ni iki? Reka tubisobanukirwe mu buryo bworoshye!

Mu magambo make, umwongo w'amagufwa yawe - igice kimeze nk'ikinyabutabire kiri mu magufwa yawe - ni cyo gikora amaraso. Umuntu urwaye CMML aba afite ubwoko bwinshi bw'uturemangingo tw'amaraso tw'umweru twitwa monocytes . Utu turemangingo tw'amaraso tudasanzwe twirukana uturemangingo tw'amaraso dutukura, uduce duto tw'amaraso , n'utundi turemangingo tw'amaraso tw'umweru dufite ubuzima bwiza dukeneye. Tekereza nk'ibyatsi bibi mu busitani byirukana ibiti bizima.

Abaganga bashyira iyi ndwara mu cyiciro cya Myeloproliferative neoplasm/Myelodysplastic syndrome (MPN/ MDS ). Nubwo ibi bishobora gusa n'aho ari uruhurirane rugoye rw'amagambo, mu by'ukuri bivuze:

• Indwara ya Myeloproliferative Neoplasm (MPN): Iki ni igihe umwongo w'amagufwa yawe ukora ubwoko bwinshi bw'uturemangingo tw'amaraso. Iyo habayeho ubwoko bumwe gusa, amaraso arahungabana kandi amaraso ntakore neza.
• Indwara ya Myelodysplastic (MDS): Iyi ni indwara aho uturemangingo tw’amaraso twakozwe n’umusemburo w’amagufwa tuba tumeze nabi kandi tukagira imiterere mibi . By’umwihariko, aho kugira uturemangingo tw’amaraso tuzima kandi dukuze, tubyara uturemangingo twinshi tudakuze twitwa uturemangingo tw’amaraso.

CMML rimwe na rimwe ishobora gukura buhoro buhoro. Ariko rimwe na rimwe ishobora kuba yihuta gato kandi ikagira ubukana bukabije. Muganga wawe azagusobanurira uburyo bwo kuvura bushobora kugenzura imikurire yayo.

Ni ibihe bimenyetso bya CMML? Ese nawe urabifite?

Ibimenyetso bya CMML ntibikunze kugaragara. Hari igihe isuzuma ry'amaraso ari ryo ribanza. Nubwo ibimenyetso byagaragaye, akenshi biza buhoro buhoro. Reba niba ibi bimenyetso bisa n'ibisanzwe kuri wewe:

• Kumva unaniwe kandi ufite intege nke igihe cyose: Ibi biterwa no kugabanuka k'uturemangingo dutukura tw'amaraso, ari byo kubura amaraso .
• Indwara n'indwara zikunze kugaragara:Ibi biterwa no kugabanuka k'uturemangingo tw'amaraso twera, ari byo byitwa neutropenia.
• Kuva amaraso kenshi mu mazuru, bigahinduka ubururu nubwo haba hari igisebe gito: Ibi biterwa no kugabanuka kwa platelets, aribyo byitwa thrombocytopenia.
• Splenomegali : Kwaguka k'agace k'umugongo, gaherereye mu gice cyo hejuru ibumoso cy'inda yawe.
• Hepatomegali : Kwaguka k'umwijima.
• Kugabanya ibiro mu buryo budasanzwe.
• Kubira ibyuya nijoro.
• Kubabara amagufwa.
• Umuriro.

Wibuke ko atari buri wese ufite ibi bimenyetso ufite CMML. Ariko niba ibi bimenyetso bikomeje, ni byiza kujya kwa muganga.

Ese hari impamvu yihariye itera CMML?

Abashakashatsi ntibaramenya neza icyatera CMML. Ariko, basanze hari impinduka nyinshi mu ngirabuzimafatizo zifitanye isano n'iyi ndwara. Niba urwaye CMML, ushobora kuba ufite impinduka mu ngirabuzimafatizo zirenze imwe. Zimwe mu mpinduka zikunze kugaragara mu ngirabuzimafatizo zirimo:

• `TET2`
• `SRSF2`
• `ASXL1`
• `RAS` (iyi ni yo ikunze kugaragara cyane)

Muganga wawe azakubwira byinshi kuri iyi gene.

Ni nde uri mu kaga gakomeye ko kurwara CMML?

Hari ibintu byinshi bishobora kugira ingaruka ku iterambere rya CMML:

• Imyaka: Ingaruka zo kurwara iyi ndwara ziyongera uko ugenda ukura. Impuzandengo y'imyaka yo kuyirwara ni hagati y'imyaka 73 na 75. Ibi bivuze ko kimwe cya kabiri cy'abayirwaye baba bari munsi y'imyaka 73, naho ikindi gice kikaba kiri hejuru y'imyaka 75.
• Igitsina: CMML ikunze kugaragara cyane mu bagabo kurusha abagore.
• Uburyo bwo kuvura kanseri mbere: Hafi umuntu umwe ku icumi barwaye CMML yigeze guhabwa imiti igabanya ubukana bwa kanseri cyangwa imirasire. Ariko abaganga batanga ubwo buryo bwo kuvura gusa iyo inyungu z'ubuvuzi zirenze ibyago byo kurwara kanseri mu gihe kizaza.

Ni izihe ngorane zindi zishobora kubaho muri iki kibazo?

Abantu babiri kuri icumi barwaye CMML bazarwara indi kanseri ikomeye y'amaraso yitwa acute myeloid leukemia (AML). Vugana na muganga wawe ku byago byawe byo kurwara AML ukurikije uko wabibonye n'ibintu bishobora gutera ibyago.

Ni gute abaganga bapima CMML?

Muganga wawe azabaza ibimenyetso byawe kandi afate amateka y'ubuzima bwawe. Hanyuma azakora ibizamini byinshi kugira ngo arebe uturemangingo tw'amaraso yawe. Ibi bizamini bishobora kuba birimo:

• Umubare wuzuye w'amaraso (CBC): Niba umubare wa monocytes uri hejuru cyane (monocytosis), bishobora kuba ikimenyetso cya CMML.
• Gupima amaraso mu buryo butunguranye: Iyo urebye hakoreshejwe mikorosikopi, ibi bishobora kuba ikimenyetso cya CMML, iyo urebye ukoresheje mikorosikopi, iyo urebye ukoresheje monocytes, iyo urebye ukoresheje mikorosikopi, iyo urebye ukoresheje monocytes, iyo urebye ukoresheje microscope, ibi bishobora kuba ikimenyetso cya CMML.
• Kubagwa kw'umusemburo w'amagufwa: Hari igihe muganga ashobora gufata urugero ruto rw'umusemburo w'amagufwa akawupima muri laboratwari kugira ngo arebe niba nta monocytes zidasanzwe zihari.
• Gupima imiterere y’uturemangingo: Abaganga banashakisha impinduka mu ngirabuzimafatizo zifitanye isano n’izindi kanseri z’amaraso. Ibi bituma bamenya izindi ndwara zifite ibimenyetso bisa n’ibyavuye mu gupima amaraso.

Ni ibihe byiciro bya CMML?

Abaganga bagena aho CMML yakwirakwiriye, cyangwa ubukana bwayo (gupima kanseri), hashingiwe ku mubare w'uturemangingo tw’amaraso n’umusemburo w’amagufwa. Ibi byiciro bibiri ni ibi bikurikira:

• CMML-1: Uturemangingo turi munsi ya 4 kuri 100 mu maraso yawe ni two turemangingo. Uturemangingo turi munsi ya 9 kuri 100 mu musokoro wawe ni two turemangingo turi munsi ya 100.
• CMML-2: Uturemangingo turi hagati ya 5 na 19 kuri 100 mu maraso yawe ni two turemangingo tw’amaraso. Uturemangingo turi hagati ya 10 na 19 kuri 100 mu musokoro w’amagufwa yawe ni two turemangingo tw’amaraso.

Muri iki cyiciro ni bwo muganga wawe azagena uburyo bwo kuvura bukubereye kandi bufite akamaro kurusha ubundi.

Ni ubuhe buryo bwo kuvura CMML?

Ubwa mbere, ushobora gukenera kuvurwa kugira ngo umenye neza ko ufite uturemangingo tw’amaraso duhagije kandi dufite ubuzima bwiza. Ibi bishobora kuba birimo imiti yo kongera umubare w’uturemangingo tw’amaraso cyangwa guterwa amaraso buri gihe. Ibi bishobora kandi kuba kimwe mu bikorwa byo kuvura indwara zigabanya ububabare kugira ngo hagenzurwe ibimenyetso.

Ubundi buryo bwo kuvura bwibasira CMML ni ubu:

• Gutera uturemangingo tw’umurabyo two mu bwoko bwa Allogeneic: Ubu ni bwo buryo bwonyine bwo kuvura CMML burundu . Ariko, ntabwo bukwiriye buri wese. Bushobora kandi guteza ingorane zishobora guterwa n’ubuzima nk’indwara ya graft-versus-host.
• Ubwinshi bw'imiti ikoresha imiti igabanya ubukana bw'imiti itera indwara ya kanseri itera kanseri y'imiti ...
• Igeragezwa ry'ubuvuzi:Iyo ubundi buryo bwo kuvura budafashije, muganga wawe ashobora kukugira inama yo kwitabira igerageza ry’ubuvuzi. Ubu bushakashatsi burimo gukora iperereza ku kamaro k’uburyo bushya bwo kuvura (urugero: uburyo bwo kuvura bugamije, uburyo bwo kuvura ubudahangarwa bw’umubiri) kuri CMML.

Ni ryari ngomba kubonana na muganga?

Uzakenera kujya kwa muganga wawe buri gihe (ubusanzwe rimwe mu kwezi kugeza rimwe mu mezi atandatu). Ni ingenzi cyane ko ukomeza gahunda nk'izi. Muri izi gahunda, muganga wawe azabaza ibimenyetso byawe, akore ibizamini by'amaraso, arebe uko ubuvuzi bwawe bukora, kandi akore impinduka zikenewe.

Hagati aho, niba ugize ingaruka mbi zitunguranye kandi zikomeye ziturutse ku kuvurwa kwawe , vugana na muganga wawe ako kanya . Muganga wawe azakubwira ibimenyetso ugomba kwitondera, bitewe n'ubuvuzi urimo guhabwa.

Ni iki wakwitega mu gihe ubana n'iki kibazo?

Igipimo cy’igihe cy’ubuzima ku muntu wafashwe na CMML ni hagati y’umwaka umwe n’imyaka itatu. Na none, "igipimo cy’igihe" ni igipimo cyo hagati. Ibi bivuze ko kimwe cya kabiri cy’abaturage bashobora kugira igihe cyo kubaho gito n’igice cy’igihe cyo kubaho kirekire. Ariko, hari ibintu byinshi bigena igihe cy’ubuzima bwawe. Muri byo harimo:

• Ibisubizo by'ibipimo by'amaraso: Umubare w'uturemangingo tw'amaraso yawe ushobora gutanga ibimenyetso by'uko uzabaho. Umubare w'uturemangingo twa monocyte, uturemangingo twa blast, n'uturemangingo twa platelet ni ingenzi. Igipimo cya hemoglobine yawe nacyo ni ingenzi muganga wawe akunze gusuzuma.
• Impinduka mu ngirabuzimafatizo: Impinduka zimwe na zimwe mu ngirabuzimafatizo, urugero nk'impinduka mu ngirabuzimafatizo ya `ASXL1`, zifitanye isano n'impinduka mbi kurushaho.
• Inshuro zo guterwa amaraso: Keretse niba ukeneye guterwa amaraso kenshi kugira ngo usubize uturemangingo tw'amaraso yawe ku buzima, umusaruro wawe uba mwiza.

Isuzuma ryawe riterwa kandi n'uko indwara yawe ikomeza kugera kuri `AML` (leukemia y'imitsi ikaze). Ibi birashoboka cyane niba ufite `CMML-2`.

Nakora iki kugira ngo nkomeze kugira ubuzima bwiza kandi nkomere?

Niba ufite CMML, kimwe mu bintu byiza ushobora gukora ni ukwita ku buzima bwawe mu buryo bwose bushoboka . Muri iki gihe, ni ngombwa kurya ibiryo bifite intungamubiri no gusinzira bihagije. Kuringaniza hagati yo gukora cyane no kuruhuka bihagije nabyo ni ingenzi. Guhuza n'abandi babana na kanseri ni uburyo bwiza bwo kurwanya irungu. Vugana n'umuvuzi w'indwara ufite uburambe mu gukorana n'abarwayi ba kanseri.

Kanseri ishobora gutuma umuntu yumva adafite icyo akora, ariko ibuka ko ugifite ububasha ku buzima bwawe.Kandi hari uburyo bwo kugufasha.

Kubana na CMML ntabwo byoroshye. Ibisubizo byawe biterwa n'ibintu byinshi bikuranga. Saba muganga wawe gusobanura ibyo bintu n'uburyo bigira ingaruka ku mibereho yawe. Sobanukirwa uburyo bwo kuvurwa kugira ngo wizere ko ubuvuzi uhisemo buzagera ku ntego zawe.

Ubutumwa bw'ingenzi cyane bwo kujyana mu rugo

CMML ni indwara ikomeye. Ariko niba uyizi, ugakorana na muganga wawe, ugahabwa ubuvuzi bukwiye, kandi ugahindura imibereho yawe neza, ushobora kugerageza kubaho neza n'iyi ndwara. Ntugacike intege. Umuryango wawe, inshuti zawe, n'abaganga barahari kugira ngo bagufashe. Ntabwo uri wenyine. Niba ufite ikibazo cyangwa impungenge, ntutinye kubaza muganga wawe. Ni uburenganzira bwawe.

` CMML, Leukemia idakira ya Myelomonocytic, Kanseri y'amaraso, Umwobo w'amagufwa, Monocytes, Ibimenyetso, Uburyo bwo kuvura