Nta kintu kibabaza cyane nko kubona umubyeyi wacu ugeze mu za bukuru, data, nyirakuru, cyangwa nyirarume twibagirwa buri kimwe buhoro buhoro. Guhera ku kwibagirwa utuntu duto kugeza ku kutibuka abo turi bo cyangwa abana bacu, indwara ya Alzheimer ni indwara ituma twese tutagira icyo twimarira nk'umuryango. None se, byagenda bite se umucyo muto w'izuba ugaragaye hagati mu gicu cyijimye? Bite se haramutse habayeho inkuru ivuga ku muti mushya ushobora kugabanya ukwiyongera kwa Alzheimer? Uyu munsi tugiye kuvuga ku bushakashatsi bushya bwazanye icyizere nk'iki.
Donanemab ni iki? Ikora ite?
Mu magambo make, Donanemab ni umuti mushya urimo gukorwaho ubushakashatsi kugira ngo uvure indwara ya Alzheimer. Ukorwa n'ikigo cy'imiti cya Eli Lilly.
Ubu, impamvu nyamukuru itera indwara ya Alzheimer ifatwa nk'iy'ubwiyongere bwa poroteyine mbi yitwa amyloid plaques mu bwonko. Kimwe n'ingese zibaho mu miyoboro y'amazi, izi poroteyine ziteranira hagati y'uturemangingo tw'imitsi mu bwonko kandi zikabangamira imikorere yatwo. Uko igihe kigenda gihita, ibi nibyo bitera ibimenyetso nko gutakaza kwibuka no kugorwa no gutekereza.
Umuti wa Donanemab wibasira by’umwihariko iyi miyoboro yitwa amyloid plaques. Iyo uyu muti uhawe umubiri, ujya mu bwonko, ukamenya iyi miyoboro ya poroteyine idakenewe, hanyuma ugatangira kuyikuraho. Ibi bikora nk'umuti uvura antibody . Ishingiro rya siyansi ni uko gusukura ubwonko muri ubu buryo, bishobora kugabanya ikwirakwira ry'indwara.
Ibisubizo by'ubu bushakashatsi byagenze neza cyane ku buryo Eli Lilly yitegura gusaba Ikigo gishinzwe ibiribwa n'imiti muri Amerika (FDA) kwemeza uyu muti ku mugaragaro.
Ibisubizo bitangaje byagaragajwe n'ubushakashatsi
Ubu si ubushakashatsi ubwo aribwo bwose gusa. Ubu ni igerageza ryakozwe ku buryo butaziguye, ritagaragara ku mpande zombi, rigenzurwa na placebo . Ni ukuvuga ko abarwayi bagabanyijwemo amatsinda abiri, itsinda rimwe rigahabwa umuti nyawo, irindi tsinda rigahabwa umuti w'impimbano udafite ikintu gikora (placebo). Ariko umurwayi cyangwa itsinda rishinzwe kuvura ntabwo bazi uwo ari we wese. Ubu buryo budufasha gupima ubushobozi nyakuri bw'uwo muti nta kubogama.
Reka turebe bimwe mu byavuye muri ubu bushakashatsi. Ibi bigaragaza uburyo ibi bishobora kugira ingaruka ku buzima bw'abarwayi ba Alzheimer.
| Ivumburwa ry'ingenzi | Ibisobanuro by'ibyavuye mu bushakashatsi |
|---|---|
| Ibimenyetso ntibirushaho kwiyongera | 47% by'abafashe donanemab nta bimenyetso byagaragaye nyuma y'umwaka umwe, ugereranyije na 29% gusa by'abafashe placebo. |
| Kugabanya umuvuduko w'indwara | Ugereranyije n'abafashe placebo, abafashe Donanemab bagabanutseho 35% mu muvuduko w'indwara ziyongera. |
| Ubushobozi bwo gukora imirimo ya buri munsi | Ubushobozi bwo gukora imirimo ya buri munsi nko gusiga no guteka icyayi wenyine bwagabanutseho 40% . Ibi ni ihumure rikomeye ku murwayi ndetse no ku muryango. |
| Ingaruka zo gukomeza kuzamuka mu cyiciro gikurikira cy'indwara | Abafashe Donanemab bagabanyije ibyago byo kugera ku cyiciro gikurikiraho kandi gikomeye cy’iyi ndwara ku kigero cya 39% . |
| Urwego rwa amyloid mu bwonko | Ndetse no mu mezi 6 gusa uhereye igihe atangiye kuvurwa, urugero rwa amyloid plaques mu bwonko bw'abarwayi rwaragabanutse cyane. |
Ubushakashatsi bwakorewe ku barwayi bari mu ntambwe za mbere z'iyi ndwara. Banashyizwe mu byiciro hakurikijwe urwego rwabo rwa tau, indi poroteyine ipima ubukana bw'iyi ndwara. Igitangaje ni uko n'abarwayi bafite indwara zikomeye kandi bafite urugero rwo hejuru rwa tau babonye inyungu zimwe na zimwe zivuye muri uyu muti.
Turabizi kandi ingaruka mbi.
Kimwe n'indi miti iyo ari yo yose, hari ingaruka zimwe na zimwe zivugwa. Mu gihe tuvuga ku byiringiro, tugomba kuba inyangamugayo kuri izi ngaruka.
Ingaruka nyamukuru zigaragara kuri uyu muti ni indwara yitwa ARIA (Amyloid-Related Imaging Abnormalities) . Muri make, iki ni ukubyimba by'igihe gito cyangwa kuva amaraso mu bwonko. Bikekwa ko bifitanye isano no gukuraho amyloid.
- 24% by'abafashe DonanemabUbwonko bwarabyimbye, ariko abantu 6% gusa ni bo bagaragaje ibimenyetso.
- Kuva amaraso make byagaragaye ku barwayi bagera kuri 31% (ibi byanagaragaye kuri 14% by'abafashe placebo).
Igishimishije ni uko inyinshi muri izi ndwara za ARIA ziba zoroheje cyangwa ziringaniye kandi zishobora gukira cyangwa gukomezwa n'ubuvuzi bukwiye.
Ariko, ntitwagombye kwibagirwa iki kintu. Ikibabaje ni uko muri ubu bushakashatsi hagaragaye impfu eshatu zifitanye isano n’iyi ndwara ya ARIA. Ibi bitwereka uburyo kugenzura kwa muganga ari ngombwa cyane mu gihe ukoresha umuti ukomeye nk’uwo.
Impuguke zivuga iki kuri ibi?
Abaganga b'indwara z'imitsi hirya no hino ku isi bishimiye ibi bisubizo. Bamwe bavuga bati: "Ubu twinjiye mu gihe cyo kuvura indwara ya Alzheimer."
Impuguke imwe yagize iti: "Nyuma y'imyaka myinshi y'ubushakashatsi butagenze neza, ubu turi kubona ibisubizo bihoraho bigaragaza ko gukuraho amyloid bishobora guhindura uko indwara igenda."
Ikindi kintu cyihariye kuri uyu muti ni uburyo utangwa. Ubushakashatsi bwagaragaje ko iyo poroteyine mbi ya amyloid mu bwonko imaze kugabanuka ku rugero runaka, uyu muti ushobora guhagarikwa . Kuvura byahagaze ku barwayi 52% mu mwaka umwe, naho 72% mu mezi 18. Ibi ni nko "gutuma indwara igabanuka" no kuyireba nta kuvurwa. Ibi bishobora kuba inyungu nini ku barwayi ndetse no ku giciro cy'ubuvuzi.
Ariko impuguke zimwe na zimwe ziracyafite amakenga. Bati: "Ibi bisubizo bisa neza cyane, ariko tugomba kureba amakuru yose. Hari ingaruka zikomeye, kandi tugomba kumenya byinshi ku buryo bigira ingaruka ku barwayi."
Ubutumwa bwo kujyana mu rugo
- Donanemab si umuti w’indwara ya Alzheimer, ahubwo ni umuti ugabanya cyane ukwiyongera kw’iyi ndwara, kandi ugatanga icyizere gikomeye cy’ejo hazaza.
- Ibi bikora binyuze mu gukuraho utunyangingo twangiza tw’ubwonko twirundanya mu bwonko.
- Ibi bifasha abarwayi, cyane cyane mu ntangiriro z'indwara, kugumana kwibuka no gukora imirimo ya buri munsi igihe kirekire.
- Kubyimba ubwonko no kuva amaraso make (ARIA)Hari ibyago byo kugira ingaruka mbi zikomeye, bityo rero niba uhisemo kuvurwa, bigomba gukorwa ukurikiranwe na muganga cyane.
- Uyu muti uracyari mu cyiciro cy’ubushakashatsi. Bizafata igihe mbere yuko uboneka ngo ukoreshwe muri Sri Lanka. Kubwibyo, niba hari umuntu wo mu muryango wawe ugaragaza ibimenyetso bya Alzheimer, ikintu cyiza wakora ni ukubonana na muganga wujuje ibisabwa vuba bishoboka no gusaba inama.
💬 Comments (0)
Kwipimisha kanseri y'ibere, kwisuzuma no kwirinda byakozwe byoroshye. Kanseri y'ibihaha
Ishyirireho intego ya calorie hanyuma ubare itariki yo kugabanya ibiro.