Ese hari ikibazo kiri mu turemangingo tw’amaraso twera? Reka twige kuri Histiocytosis mu magambo make!

Ese wari uzi ko rimwe na rimwe ubwoko bumwe na bumwe bw'uturemangingo mu mibiri yacu butangira kwitwara mu buryo butandukanye? Imwe muri izo ndwara zidasanzwe yitwa Histiocytosis. Ibi bishobora kumvikana nk'ibiteye ubwoba kuri wewe, ariko ntugahangayike. Reka tubiganireho mu buryo bworoshye kandi bwumvikana.

Histiocytosis ni iki? Mu magambo make...

Umubiri wawe ufite ubwoko bw'uturemangingo tw'amaraso tw'umweru twitwa histiocytes. Muri utwo turemangingo tw'amaraso tw'umweru, hari ubwoko bwihariye bw'uturemangingo twitwa histiocytes . Utwo turemangingo ni nk'abarinzi b'umubiri wacu. Ni two turwanya mikorobe zitera indwara zitwa pathogens - virusi , bagiteri , na fungi - kandi tugafasha ubudahangarwa bwacu bw'umubiri kugumana ubuzima bwiza.

Ariko, hari igihe izi selile za histiocyte zitangira gukura mu buryo budasanzwe, ni ukuvuga ko zihinduka " mutant " . Hanyuma, izi selile za histiocyte zidasanzwe zikura cyane kandi zikiyongera mu bice bitandukanye by'umubiri wacu. Iyo ziyongera cyane, ubudahangarwa bwacu bw'umubiri bushobora kugira ibibazo. Ikintu cy'ingenzi ni uko kubyimba , ni ukuvuga indwara isa n'iy'ibibyimba, biba mu ngingo z'umubiri. Uku kubyimba rimwe na rimwe bishobora kwangiza ingingo zacu.

Izi selile zidasanzwe za histiocyte zishobora kwibumbira mu turemangingo twa lymph (zitwa kandi nodes za lymph), uruhu, amagufwa, ibihaha, umwijima, urwagashya, cyangwa ahandi hantu hose mu mubiri wawe. Hari igihe bigira ingaruka ku gice kimwe cy'umubiri wawe. Ibi tubyita 'système imwe' . Hari igihe bishobora kugira ingaruka ku bice byinshi by'umubiri wawe. Ibi tubyita 'système nyinshi' .

Igikuru ni uko histiocytosis atari kanseri . Ariko, rimwe na rimwe ishobora kwitwara nk'indwara ya kanseri ikagaragaza ibimenyetso bisa na kanseri. Niyo mpamvu ari indwara isaba kwitabwaho by'umwihariko. Kubera ko ibimenyetso byayo bitandukanye bitewe n'umuntu ku giti cye kandi uburemere bw'indwara bukaba butandukanye, rimwe na rimwe bishobora kugorana gusuzuma histiocytosis vuba.

Ni ubuhe bwoko bw'ingenzi bwa histiocytosis?

Noneho ushobora kuba usobanukiwe icyo histiocytosis ari cyo. Mu by'ukuri hari ubwoko bwabyo burenga 100. Ariko hari ubwoko butatu bw'ingenzi tubona kandi tuvugaho kenshi. Reka tubirebe.

1. Histiocytosis y'uturemangingo twa Langerhans (LCH):

• Ubu ni bwo bwoko bukunze kugaragara bwa histiocytosis.
• Iyi ndwara ikunze kwibasira abana bato . Ifata abana bari hagati ya 5 na 9 muri buri miliyoni.
• Akenshi, ibi ntabwo ari ibintu bikomeye cyane, kandi bishobora kuba byoroshye nko "kutagira ibimenyetso" . Ariko, ni ngombwa kwibuka ko mu bihe bimwe na bimwe, ibi bishobora kuba bikomeye ndetse bikaba byanashyira ubuzima mu kaga.

2. Indwara ya Erdheim-Chester (ECD):

• Ubwo bwoko bw’indwara bwibasira cyane abantu bakuru .
• Ibi nabyo ni ibintu bidasanzwe cyane .
• Kimwe na LCH, ECD ishobora kuva ku yoroheje kugeza ku ikomeye kandi ishobora gushyira ubuzima mu kaga.

3. Indwara ya Rosai-Dorfman (RDD):

• Kimwe na LCH, RDD ikunze kugaragara cyane mu bana , ariko ishobora no kugaragara no mu bantu bakuru.
• Ibi nabyo ni gake cyane. Abantu bagera ku bihumbi magana abiri basanzwe barwaye iyi ndwara.
• Ubwoko bw'ingenzi bw'ibi ni 'classical RDD' . Iki ni cyo gihe utunyangingo twa lymph (glands) twawe tubyimba.
• Ubundi bwoko ni 'extranodal RDD' . Muri ibi, ingingo zitari lymph nodes zirafatwa n'ingaruka. Ibi bivuze ko uturemangingo twa histiocyte twinshi dushobora kwirunda mu ruhu, mu magufwa, cyangwa ahandi hantu.

Ni gake gashoboka gute iyi ndwara yitwa Histiocytosis?

Yego, nkuko nabivuze mbere, indwara ya histiocytosis ni indwara idakunze kugaragara . Mu by'ukuri, ubwoko bwayo bwa kanseri bukabije bugira uruhare ruri munsi ya 1% bya kanseri zose zigaragara mu turemangingo tworoshye no mu tunyangingo tw'imitsi. Bityo rero ushobora kwiyumvisha ukuntu ibi bidakunze kugaragara.

Ni ibihe bimenyetso bya Histiocytosis?

Noneho reka turebe ibimenyetso bigaragara muri iyi ndwara ya histiocytosis. Ibi bimenyetso bishobora gutandukana bitewe n'umuntu ku wundi . Impamvu y'ibi ni uko ingingo n'imitsi aho uturemangingo twa histiocyte twinshi twirundanyirije, nk'uko nabivuze, hamwe n'urugero rwangiritse kuri iyo mitsi, bigira ingaruka kuri ibi.

Dore bimwe mu bimenyetso ushobora kubona (kandi hashobora kuba hari n'ibindi):

• Uduheri ku ruhu : Ibi bishobora kugaragara cyane cyane mu bice by'ubwoya byo mu mutwe w'abana bato (tubyita 'cradle cap' ) cyangwa mu gice cy'ingofero.
• Umuriro .
• Umunaniro, umunaniro .
• Umutwe.
• Inkorora cyangwa guhumeka nabi .
• Kugabanya ibiro mu buryo budasanzwe .
• Kubabara amagufwa .
• Utudomo tw’imitsi tubyimbye (ibi nibyo bivuze kubyimba).
• Guhinduka kw'amaso cyangwa kubyimba amaso .
• Kwihagarika inkari kenshi no kugira inyota nyinshi .
• Utubyimba tw'uruhu (tushobora no kugaragara ku mboni z'amaso).
• Kugorwa no gutekereza cyangwa kwibuka ibintu .
• Ibibazo byo kuringaniza no guhuza ibikorwa .

Ibimenyetso bibaho bite? Bitewe n'aho histiocytes zihurira!

Ibi bimenyetso biterwa n'aho uturemangingo twa histiocyte twikusanyiriza mu mubiri. Ahantu nyamukuru ho kwikusanyiriza hatandukanye bitewe n'ubwoko bwa histiocytosis.

Ahantu hashobora kwibasirwa na histiocytosis ya selile ya Langerhans (LCH):

• Igufwa
• Uruhu
• Utunyangingo tw'imitsi (lymph nodes)
• Umwijima
• Umugongo
• Umunwa
• Ibihaha
• Uturemangingo tw'imitsi yo hagati (ni ukuvuga ubwonko n'umugongo)

Uduce dushobora kwibasirwa n'indwara ya Erdheim-Chester (ECD):

• Amagufwa maremare (cyane cyane mu maguru)
• Amaso
• Uturemangingo tw'imitsi yo hagati
• Ibihaha
• Umutima
• Imitsi y'amaraso
• Impyiko
• Ingingo ziri inyuma y'inda (tuzita 'retroperitoneum' )

Uduce dushobora kwibasirwa n'indwara ya Rosai-Dorfman (RDD):

• Uduce tw’umurabyo (cyane cyane mu ijosi, ariko dushobora no kugaragara ahandi)
• Uruhu
• Urugingo rworoshye
• Uburyo bwo hejuru bwo guhumeka
• Igufwa
• Retroperitoneum (ingingo ziri inyuma y'inda)
• Amaso

Ni iki gitera Histiocytosis?

Abahanga mu bya siyansi ntibaramenya neza icyatera histiocytosis, ariko basanze ishobora kuba ifitanye isano n'impinduka mu miterere y'uturemangingo .

Mu magambo make, buri selile mu mubiri wacu ifite ibikoresho bya genetike, cyangwa amabwiriza. Aya mabwiriza agena uko utwo turemangingo tugomba kwitwara. Rero, iyo habayeho impinduka muri aya mabwiriza, byitwa mutations, selile zitangira kwitwara mu buryo budasanzwe. Urugero, mutation ya genetike ishobora gutuma selile nka histiocyte yigana ubwayo igatangira gukwirakwira mu buryo butunguranye.

Kumenya izi mpinduka mu ngirabuzimafatizo byatumye abashakashatsi bahanga uburyo bushya bwo kuvura histiocytosis. Ubu buryo bukora mu gukumira impinduka mbi mu turemangingo zituma uturemangingo twa histiocyte dukura mu buryo butunguranye.

Ni gute wasuzuma indwara ya histiocytosis?

Niba ukeka ko ufite indwara ya histiocytosis, muganga wawe azabanza agukorere isuzuma ry’umubiri maze akubaze amateka y’ubuzima bwawe. Hanyuma, azahitamo ibizamini byo gukora hashingiwe ku bimenyetso byawe n’ingingo zikekwaho kuba zaragize ingaruka kuri iyo ndwara.

Dore bimwe mu bizamini ushobora gukora:

• Uburyo bwo gufata amashusho :
• Muganga wawe ashobora gutumiza isuzuma ryihariye ryitwa FDG PET / CT scan . Ibi bishobora kugaragaza ibintu nk'ibibyimba mu mubiri wose.
• Byongeye kandi , ibizamini nka CT scan, MRI scan, gupima amagufwa, gupima ultrasound scan, X-ray, cyangwa echocardiogram (gupima umutima).

• Ibizamini byo muri laboratwari :
• Muganga wawe azapima ingero z'amazi, nk'amaraso cyangwa inkari zawe, kugira ngo arebe niba hari ibimenyetso bya histiocytosis.
• Umubare w'uturemangingo tw'amaraso yawe urasuzumwa. Bashaka kandi imisemburo cyangwa poroteyine runaka igaragaza uko ingingo zawe zakora. Iyo urugingo rudakora neza, bishobora kugaragaza ko hari histiocytes nyinshi muri urwo rugingo.

• Ikizamini cya Biopsy `(Biopsy)` :
• Icyo ibi bikora ni uko muganga afata icyitegererezo cy'ingingo akagisuzuma akoresheje mikorosikopi kugira ngo arebe niba ufite histiocytosis.
• Ireba kandi impinduka zihariye za gene zijyanye na histiocytosis.
• Hari igihe, iyo bidashoboka ko hakorwa biopsy, ibintu bigize imiterere y'uturemangingo mu maraso yawe bishobora gupimwa. Ibi byitwa 'biopsy y'amazi' .

Ni ubuhe buryo bwo kuvura Histiocytosis?

Uburyo bwo kuvura histiocytosis buterwa n'ibintu byinshi . By'umwihariko:

• Uko ibimenyetso byawe bikomeye .
• Waba ufite igisebe kimwe cyangwa byinshi (ibi ni ahantu hadasanzwe mu mubiri).
• Ibi 'bisebe' biri he ku mubiri ?
• Niba ibi bibyimba ari kanseri cyangwa atari yo .

Abaganga bahitamo uburyo bwo kuvura bashingiye kuri ibi bintu. Dore uburyo bumwe na bumwe bwo kuvura:

• Itegereze kandi utegereze : Niba histiocytosis yawe idakabije kandi nta bimenyetso bikomeye ufite, muganga wawe ashobora kukubwira gusa ko ugomba kwitondera uburwayi bwawe.
• Kubaga: Iyo uturemangingo twa histiocyte twakusanyije mu gice kimwe cy'umubiri gusa, hashobora kubagwa kugira ngo icyo gice gikurweho.
• Ubuvuzi bushingiye ku mirasire : Ibi bikubiyemo gukoresha imashini kugira ngo iyobore imirasire ifite ingufu nyinshi ku bisebe. Iyi mirasire yica uturemangingo tudasanzwe kandi igatinza gukura kwa kanseri. Hari igihe ubuvuzi bushingiye ku mirasire bushobora no kugabanya ibimenyetso.
• Ubwivumbure (buzwi kandi nka 'chimotherapie') : Ibi bikubiyemo kohereza imiti mu maraso yawe kugira ngo isenye uturemangingo tw’uburozi bw’ibimera byakwirakwiriye mu mubiri wawe. Abaganga bakugira inama yo gukoresha 'chimotherapie' gusa iyo uturemangingo tw’uburozi bw’ibimera byakwirakwiriye mu mubiri wawe wose.
• Corticosteroids : Imiti nka prednisone iri muri iki cyiciro. Iyi miti ishobora kugabanya ububyimbirwe bujyana na histiocytosis. Iyi miti ishobora gutangwa yonyine cyangwa hamwe n'indi miti, nka chemotherapy.
• Ubudahangarwa bw'umubiri : Ibi bikora binyuze mu gukomeza ubudahangarwa bw'umubiri wawe, bikagufasha kumenya no gusenya uturemangingo twangiza, nka za histiocytes zidasanzwe.
• Ubuvuzi bwihariye : Ubu buvuzi bukoreshwa ku ndwara za histiocytosis zifitanye isano n'impinduka zimwe na zimwe mu ngirabuzimafatizo.

Ese Histiocytosis ishobora gukira burundu?

Biragoye kuvuga 'yego' cyangwa 'oya' kuri ibi, kuko biterwa n'imimerere. Abantu benshi bafite indwara ya histiocytosis bajya mu cyo bita 'durable remission'. Ni ukuvuga ko bagenda nta bimenyetso cyangwa ibimenyetso by'indwara.

Hari ubwoko bumwe na bumwe bwa histiocytosis, cyane cyane iyo histiocytes ziri ahantu hamwe mu mubiri, zishobora gukira burundu hakoreshejwe kubagwa . Muganga wawe azagukurikirana kugira ngo arebe niba zisubiramo.

Ariko, niba ubwoko bwa histiocytosis ufite budashobora gukira burundu, muganga wawe azakugira inama yo kugufasha guhangana n’iyo ndwara.

Ni iki giteganyijwe kuri iyi ndwara?

Uburyo indwara yawe ikwirakwira biterwa n'ibintu byinshi. Kuri bamwe, histiocytosis igenda ikira ubwayo nta kuvurwa . Urugero, abantu bagera kuri 40% barwaye RDD bakira batavuwe. Nanone, iyo LCH ifashe igice kimwe cy'umubiri gusa (tuyita 'localized LCH') , akenshi igenda ikira ubwayo.

Ariko, mu bindi bihe, histiocytosis isaba kuvurwa cyane no kwitabwaho cyane, haba ku bana no ku bakuru.Mu bihe bikomeye cyane, histiocytosis ishobora kwangiza ingingo ndetse ikaba yanashyira ubuzima mu kaga .

Kubwibyo, ni byiza kubaza muganga wawe ibyerekeye indwara yawe.

Ese Histiocytosis ishobora kwirindwa? Ingaruka zishobora kugabanuka gute?

Mu by'ukuri, nta buryo bwo kwirinda indwara ya histiocytosis buhari , ariko kuvura bishobora kugufasha kwihanganira ibimenyetso byawe.

Ariko hari ikintu kimwe. Kureka kunywa itabi bishobora kugabanya ibyago byo kurwara kanseri y'ibihaha ya LCH (Langerhans cell histiocytosis). Kureka kunywa itabi cyangwa kuguma utanywa itabi nabyo bishobora kunoza uburyo ukira imiti. Niba ukeneye ubufasha bwo kureka kunywa itabi, baza muganga wawe ku byerekeye gahunda zo kohereza abantu kureka kunywa itabi.

Ni ibihe bibazo ngomba kubaza muganga wanjye?

Niba waranduye histiocytosis, ni ibisanzwe kugira ibibazo byinshi mu mutwe wawe. Ni ngombwa kuganira na muganga wawe kuri ibi byose no gusobanukirwa neza uburwayi bwawe. Dore bimwe mu bibazo ushobora kubaza:

• Ni ubuhe bwoko bwa histiocytosis mfite?
• Ese nkeneye kuvurwa?
• Ni ubuhe buryo bwo kuvura usaba?
• Ni izihe ngaruka mbi zishobora guterwa mu gihe cyo kuvurwa?
• Ni izihe ngaruka zishobora guterwa n'ubuvuzi?
• Ese indwara yanjye irakira burundu?

Ubutumwa bwa nyuma bwo kujyana mu rugo

Mu magambo make, histiocytosis ni izina rihabwa itsinda ry’indwara zidasanzwe z’amaraso ziterwa no kwiyongera cyane kwa histiocytes, ubwoko bw’uturemangingo tw’amaraso twera, mu ngingo. Zimwe muri izi ndwara zishobora kuba zoroshye cyane, nta bimenyetso bitanga, mu gihe izindi zishobora kuba zikomeye ku buryo zishobora gushyira ubuzima mu kaga .

Umuntu wese ufite histiocytosis aba afite histiocytes nyinshi mu ngingo ze, bigatera kubyimba. Ariko, ibimenyetso, uburyo bwo kuvura, n'ingaruka z'iyi ndwara birashobora gutandukana cyane, ndetse no mu bantu bafite ubwoko bumwe bwa histiocytosis .

Muganga wawe ni we muntu mwiza wo gusobanukirwa indwara yawe n'imimerere yihariye iyikikije. Rero, kugira ngo usobanukirwe neza uburyo bwo kuyisuzuma n'uburyo bwo kuyivura, ntugatinye kubaza ibibazo. Ganira na muganga wawe ku kintu cyose kiri mu mutima wawe.

Histiocytosis , Uturemangingo tw'amaraso tw'umweru, Histiocytes, Ubudahangarwa bw'umubiri, LCH, ECD, RDD, Ibimenyetso, Uburyo bwo kuvura