Kerendia ifasha abafite diyabete n'indwara z'impyiko (CKD)

Tuzi ko abantu barwaye diyabete bashobora kurwara izindi ndwara zitandukanye, harimo n'ibibazo by'impyiko n'umutima. Nubwo hari imiti itandukanye yo kugabanya ibi byago, abantu benshi barwaye diyabete bashobora kurwara indwara zidakira z'impyiko (CKD) uko igihe kigenda gihita. Niba urwaye diyabete na CKD, ushobora kugira ibibazo bikomeye by'ubuzima. Ariko, umuti witwa Kerendia, wemejwe mu 2021, ushobora gufasha kugabanya izi ngaruka kuri bamwe.

Ni gute Kerendia ifasha abantu barwaye diyabete n'indwara z'impyiko?

Niba urwaye Diyabete yo mu bwoko bwa 2, isukari nyinshi mu maraso uko igihe kigenda gihita ishobora kwangiza ingingo zitandukanye mu mubiri. By’umwihariko, ibi bigira ingaruka ku mpyiko ku bantu benshi. Impyiko zangiritse muri ubu buryo ntizishobora gukora neza. Iyi ndwara yitwa indwara idakira y’impyiko (CKD) . Uko igihe kigenda gihita, iyi ndwara irushaho gukomera kandi ishobora gutera impyiko kunanirwa. Isukari nyinshi mu maraso yangiza kandi umutima n’imitsi (imitsi y’umutima). Ibi byongera ibyago byo kurwara indwara zikomeye nko gucika intege kw’imitsi, gutera k’umutima, no kunanirwa k’umutima. Kubera ko impyiko zidakora neza, abantu bafite CKD nabo bashobora kurwara indwara z’umutima. Bityo, umuntu urwaye diyabete, CKD, n’indwara z’umutima hamwe aba ari mu kaga gakomeye ko gupfa. Mu kugenzura isukari n'umuvuduko w'amaraso mu maraso, ushobora kugabanya kwangirika k'umutima, imiyoboro y'amaraso n'impyiko. Ariko mu gihe ubikora, hari imiti ishobora gufasha kurinda impyiko zawe kwangirika kurushaho. Kerendia ni umwe mu miti yihariye. Kerendia ikora mu buryo butandukanye gato kugira ngo ikumire kwangirika k'umutima n'impyiko. Ikintu gikora muri iki gipimo ni finerenone . Ikora mu kuziba receptor yitwa mineralocorticoid receptor (MR) mu mpyiko, umutima, n'imiyoboro y'amaraso. Iyi MR receptor ishobora gukora cyane ku bantu barwaye diyabete. Mu kuziba iyi receptor, Kerendia ifasha impyiko zawe gukuramo sodium (umunyu) mu maraso yawe. Ifasha kandi kugabanya kubyimba no gutera inkovu (fibrosis) mu mutima no mu miyoboro y'amaraso. Iyo uyifashe igihe kirekire, ushobora kugabanya ibyago byo kugira ibibazo bikomeye by'ubuzima.

Uyu muti nkwiye kuwukoresha nte?

Kerendia ni ikinini gishobora gufatwa rimwe ku munsi uri mu biryo cyangwa utariye. Niba ufite ikibazo cyo kumira ikinini cyose, ushobora kugisya ukagivanga n'amazi make cyangwa ibiryo byoroshye nka applesauce. Ariko, ugomba kugifata ako kanya nyuma yo kugivanga. Umaze gutangira gufata Kerendia, muganga wawe azasuzuma urugero rwa potasiyumu mu maraso yawe buri gihe. Kubwibyo, ugomba kujya gupimwa amaraso buri munsi muganga wawe akubwira. Bitewe n'urugero rwa potasiyumu mu maraso yawe, muganga wawe ashobora kukugira inama yo kongera cyangwa kugabanya urugero rw'umuti, cyangwa guhagarika gufata umuti mu minsi mike. Niba wasibye dose, fata vuba uko wibuka. Ariko gusa niba ari mu munsi wa dose wasibye. Niba wibuka umunsi ukurikiyeho, ntufate dose wasibye. Gufata dose ebyiri bishobora kongera ibyago byo kugira ingaruka mbi.

Ni ibihe bipimo byakozwe kuri uyu muti?

Noneho ushobora kuba wibaza uburyo uyu muti wizewe n'uwawukoresheje. Reka turebe ubushakashatsi bwakozwe kuri wo. Hakozwe ibizamini bibiri bikomeye kugira ngo harebwe uburyo Kerendia ifite umutekano kandi ikora neza ku bantu bakuru barwaye diyabete na CKD. Impuzandengo y'imyaka y'abitabiriye ibi bizamini yari hafi imyaka 64.

Amakuru y'ingenzi ku bitabiriye ikizamini:

• Bose bari bafite diyabete yo mu bwoko bwa 2 na CKD .
• Nubwo bamwe bari barasanzwe barwaye indwara y'umutima , nta n'umwe wari ufite ibimenyetso ubwo bakoraga ikizamini.
• Buri wese yakoreshaga umuti wagombaga kurinda impyiko .
• 97% bakoresheje imiti yo kugenzura isukari mu maraso .
• Umuti wa Kerendia wagereranyijwe n'umuti witwa placebo , ikinini cy'impimbano kitagira ingaruka. Nta muntu wari uzi niba bari kubona umuti nyakuri cyangwa ikinini cy'impimbano.

Imwe muri izi geragezwa yapimye ibibazo bikomeye by’impyiko byagaragaye mu gihe cyo gufata uyu muti. Ni ukuvuga:

• Abantu bafite indwara zikomeye cyane z'impyiko.
• Abantu bafite ikibazo cy'impyiko.
• Abantu bapfuye bazize ibibazo by'impyiko.

Ikindi kizamini cyapimye umubare w'indwara zikomeye z'umutima n'imitsi zabaye. Ni ukuvuga:

• Abantu barwaye indwara yo mu bwonko cyangwa indwara y'umutima .
• Abantu bari mu bitaro kubera indwara z'umutima.
• Abantu bapfuye bazize ibibazo by'umutima.

Ibisubizo by'ibizamini ni ibihe?

Ibibazo by'impyiko: Mu bushakashatsi bwamaze imyaka igera kuri 2.5, abantu bafata Kerendia bari bafite ibibazo bike bikomeye by'impyiko ugereranyije n'abafashe placebo. Ibi bivuze ko hari abantu batari bafite amahirwe menshi yo kugira ibibazo bikomeye by'impyiko, nko kunanirwa kw'impyiko, kunanirwa kw'impyiko, cyangwa gupfa bazize indwara z'impyiko. Ibibazo by'umutima: Mu bushakashatsi bwamaze imyaka igera kuri 3.5, abantu bafata Kerendia nabo bari bafite ibibazo bike bikomeye by'umutima ugereranyije n'abafashe placebo. Ibi bivuze ko hari abantu batari bafite amahirwe menshi yo kugira ibibazo bikomeye by'umutima, nko gucika intege kw'imitsi, gutera k'umutima, kujyanwa mu bitaro kubera indwara z'umutima, cyangwa urupfu.

Ingaruka mbi n'uburyo bwo kuzirwanya?

Nk’uko bimeze ku muti uwo ari wo wose, Kerendia ishobora gutera ingaruka zimwe na zimwe. Impamvu nyamukuru ni ukwiyongera k’umusemburo wa potasiyumu mu maraso. Niyo mpamvu muganga wawe azagusuzuma buri gihe. Ushobora kumva nta tandukaniro rinini ufite mu gihe ukoresha uyu muti. Ibi biterwa nuko inshingano yawo nyamukuru ari ukugabanya umuvuduko w'ibyangiritse imbere mu mubiri. Kubwibyo, nubwo waba wumva umeze neza, ntugahagarike gufata umuti utabanje kugirwa inama na muganga. Kerendia, finerenone, diyabete, indwara y'impyiko, indwara zidakira z'impyiko, CKD, indwara y'umutima, Siri Lanka