Icyo ugomba kumenya ku rukingo rugezweho rwo kurwanya cholesterol (PCSK9 Inhibitors)

Ese nawe urimo urwana n'ikibazo cya cholesterol ? Wenda urimo gufata imiti wahawe na muganga wawe, ukagenzura indyo yawe , ndetse ugakora siporo. Ariko biragoye kugabanya urugero rwa cholesterol yawe, si byo se? Hari igihe, uko wagerageza kose, urugero rwa cholesterol mbi mu mubiri wawe rushobora kuguma hejuru. Muri iyi nkuru, tugiye kuvuga ku bwoko bushya bw'imiti ishobora gufasha abantu nk'abo.

Mu magambo make, izi PCSK9 Inhibitors ni iki?

Ibi bishobora kumvikana nk'izina rigoye, ariko bikora mu buryo bworoshye cyane. Indangagaciro za PCSK9 ni ubwoko bw'imiti igabanya cholesterol. By'umwihariko, zibanda kuri cholesterol ya LDL (Low-Density Lipoprotein) , ari yo "cholesterol mbi" yangiza imibiri yacu. Hari abantu bagira cholesterol nyinshi mu buzima bwabo bwose. Kuri abo bantu, ubu bwoko bw'imiti bushobora kuba ingirakamaro cyane.

Noneho reka turebe icyo izina `PCSK9` risobanura. `PCSK9` ni ubwoko bwihariye bwa poroteyine ikorwa n'umwijima wacu. Izina ry'iyi poroteyine ni `proprotein convertase subtilisin/kexin type 9`. Icyo ikora ni ukugenzura ibintu byitwa `LDL receptors` mu mubiri wacu. Ubushakashatsi bw'abaganga bwagaragaje ko iyo umubiri w'umuntu usanzwe ukora poroteyine nyinshi ya `PCSK9`, uwo muntu aba afite amahirwe menshi yo kugira cholesterol nyinshi .

Ni nde ukeneye uyu muti?

Iki ni ikibazo cy'ingenzi cyane. Kubera ko uyu muti udahabwa abantu bose bafite cholesterol nyinshi. Muri rusange hari ibintu bibiri by'ingenzi muganga ashobora kukwandikira uyu muti wa 'PCSK9 inhibitor':

1. Iyo cholesterol idagenzurwa n'indi miti: Niba usanzwe ukoresha indi miti igabanya cholesterol, nka `(statins)` ariko urugero rwa cholesterol yawe rukiri hejuru, ushobora gufata uyu muti nk'intambwe ikurikiraho.

2. Mu ndwara zimwe na zimwe zishingiye ku ngirabuzimafatizo: Hari abantu bafite ikibazo cy’umubiri wabo cya cholesterol nyinshi. Ibi byitwa "hypercholesterolemia yo mu muryango" mu buvuzi.Uyu muti kandi ufasha cyane abantu bafite iyi ndwara.

Uyu muti ukora ute imbere mu mubiri?

Kugira ngo tubisobanukirwe neza, reka dufate urugero ruto.

Tekereza ko umubiri wawe ufite "amaboko afata cholesterol." Tuyita "receptors za LDL." Izi "receptors" ziboneka cyane cyane ku buso bw'uturemangingo tw'umwijima wacu. Izi "maboko" zifata cholesterol mbi ireremba mu maraso (cholesterol ya LDL) zikayijyana mu mwijima. Hanyuma umwijima ucagagura iyo cholesterol ukayikura mu mubiri. Iyi ni inzira isanzwe.

Ariko hari akantu gato kabi hano. Iyo ni poroteyine ya `(PCSK9)` twavuze mbere. Iyi poroteyine ya `PCSK9` ikora nk'umukasi. Icyo ikora ni ugusenya amaboko afata cholesterol, ni ukuvuga `receptors za LDL`, no kugabanya imikorere yayo. Iyo poroteyine ya `PCSK9` yiyongera mu mubiri, umubare w'`intoki` zifata cholesterol uragabanuka. Hanyuma cholesterol mbi mu maraso ntishobora gukurwaho n'umwijima ngo ikusanyirize mu maraso.

Noneho ushobora kuba usobanukiwe icyo umuti wa `PCSK9 inhibitor` ukora. Mu by’ukuri, uyu muti ubuza poroteyine ya `PCSK9` ikora nk'umukasi. Ibyo bivuze ko, iyo uyu muti ufashwe, poroteyine ya `PCSK9` idashobora gusenya ibyo biganza bifata cholesterol (receptors za LDL).

Hanyuma se bigenda bite?

• Hariho receptors za LDL zikora cyane.
• Izi "ntoki" zikora zifata cholesterol mbi nyinshi mu maraso zikayigeza mu mwijima.
• Umwijima ukuraho iyo cholesterol mu mubiri.

Ingaruka zabyo ni ukugabanuka gukomeye k'urugero rwa cholesterol mbi mu maraso yawe.

Uyu muti ufite akamaro kangana iki? Kandi ni ubuhe bwoko bwawo?

Imiti igabanya ubukana bwa PCSK9 ni ubwoko bw'imiti byagaragaye ko ifite akamaro kanini kuri bamwe. Ubushakashatsi bumwe bwagaragaje ko iyi miti ishobora kugabanya urugero rwa cholesterol mbi (LDL cholesterol) kugeza kuri 70% ndetse ikaba inagabanya ibyago byo kurwara indwara z'umutima ku kigero cya kimwe cya gatatu.

Hari ubwoko bubiri bwa `PCSK9 inhibitors` bukoreshwa cyane muri iki gihe muri Sri Lanka no ku isi:

• `Alirocumab` (izina ry'ikirango: Praluent®)
• `Evolocumab` (izina ry'ikirango: Repatha®)

Ufata umuti ute?

Iki si ikinini cyo gufata buri munsi. `PCSK9 inhibitors` zitangwa nk'urushinge.Ubusanzwe uzakenera kubona uru rukingo buri byumweru bike cyangwa buri mezi make, nk'uko byagenwe na muganga wawe.

Mu gihe ufata ubu buvuzi, muganga wawe azajya apima amaraso buri gihe kugira ngo arebe neza uko umuti ukora. Hari igihe uyu muti ushobora gutangwa wonyine, ubundi ugatangwa hamwe n'undi usanzwe ufata, nka statin.

Ni izihe nyungu n'ingaruka mbi zishobora kubaho?

Kimwe n'indi miti iyo ari yo yose, uyu muti ushobora kugira ibyiza ndetse n'ingaruka mbi. Nyamara, abantu benshi ntibagira ingaruka mbi zikomeye.

Ese umuti wonyine urahagije? Oya, iki ni kimwe mu bigize gahunda nini.

Ibi ni ingenzi cyane. Waba ufata imiti igabanya cholesterol cyangwa indi miti igabanya ububabare bw'umutima, ni kimwe mu bigize gahunda yawe rusange yo kuvura. Hari ibindi bintu byinshi ushobora gukora kugira ngo urinde ubuzima bw'umutima wawe, uretse kwishingikiriza ku miti.

• Indyo nziza: Kurya amavuta make, isukari n'umunyu, no kurya imboga nyinshi, imbuto, imboga n'ibiribwa birimo fibre nyinshi.
• Imyitozo ngororamubiri: Kora imyitozo ngororamubiri ifasha umutima wawe gukora imyitozo ngororamubiri, nko kugenda n'amaguru, kwiruka cyangwa kugendera ku igare, nibura iminsi mike mu cyumweru.
• Kugabanya stress: Kuruhuka mu mutwe wawe binyuze mu bintu nko gutekereza cyane no gukora yoga.
• Gusinzira neza: Gusinzira nibura amasaha 7-8 buri joro.
• Irinde kunywa itabi: Niba unywa itabi, rireke burundu.

Uzabona umusaruro mwiza cyane niwahuza izi mpinduka mu mibereho n'imiti.

Ibikoresho bibuza PCSK9, cholesterol, cholesterol, cholesterol ya LDL, indwara z'umutima, indwara zo gucika kw'imitsi, hypercholesterolemia yo mu muryango, statin, Alirocumab, Evolocumab