Impyiko zawe ziri mu ngingo z'ingenzi cyane mu mubiri wawe. Ariko, rimwe na rimwe impinduka mu buvuzi bw'umubiri wawe zishobora kuzitera ingaruka mbi. Imwe muri izo ndwara ni immunoglobulin A nephropathy y'ibanze, cyangwa nk'uko tuyita gusa, IgA Nephropathy ( IgA Nephropathy ). Ibi bibaho iyo ubwoko bw'umubiri witwa IgA bwishyize hamwe mu mpyiko zawe, bigatuma zibyimba kandi zikabuza gukora neza. Uyu munsi, turaganira kuri iki kibazo n'umuti wihariye witwa Tarpeyo.
Tarpeyo ikora ite?
Muri make, IgA Nephropathy itangira iyo umubiri wawe utangiye gukora antibodies zidasanzwe za IgA (IgA1). Mu bihe bisanzwe, antibodies zikora nk'abarinzi b'ubudahangarwa bw'umubiri wawe, zikakurinda abakwibasira nka bagiteri na virusi.
Ariko, muri iki kibazo, hari inenge idasobanutse neza mu basirikari bashinzwe kurwanya indwara za IgA bakorwa. Izi basirikari bashinzwe kurwanya indwara zigaragara ko zifite inenge zihurira hamwe mu matsinda manini. Ubudahangarwa bw'umubiri bwawe bubona izi mfuruka nk'ikibazo, bigatera intambara mu mpyiko zawe. Ibi bitera ububyimbirwe ( ububyimbirwe ) mu bice byoroshye byo kuyungurura by'impyiko zawe, bizwi nka glomeruli. Uko igihe kigenda gihita, ubu bubyimbirwe butera inkovu, byangiza impyiko.
Ingaruka zabyo ni uko impyiko zawe zirwana no kuyungurura amaraso neza no kuyakuramo imyanda. Bityo, amaraso na poroteyine —bitagomba kuba biriho—bitangira kuva mu nkari zawe. Iyo ibi byangiritse bikomeje, bishobora gutuma impyiko zinanirwa gukora neza, bigasaba dialyse cyangwa gusimbuzwa impyiko .
Ushobora kutabona ububabare bukabije mu ntangiriro z'iyi ndwara. Ariko, uko impyiko zikomeza kwangirika, ushobora kubona ibimenyetso bikurikira.
| Ibimenyetso | Ibisobanuro |
|---|---|
| Amaraso mu nkari | Inkari zawe zishobora kugaragara nk'umutuku cyangwa ibara ry'umutuku. |
| Inkari zifite ifuro | Akenshi biterwa na poroteyine nyinshi mu nkari. |
| Kubyimba (Edema) | Ushobora kubona ibibyimba mu biganza byawe, mu birenge, mu tuguru, cyangwa mu maso, cyane cyane mu gitondo. |
| Umuvuduko ukabije w'amaraso | Umuvuduko ukabije w'amaraso ni ikintu gikunze kugaragara. |
| Umunaniro | Kumva unaniwe cyangwa unaniwe buri gihe. |
| Kubabara mu nda yo hasi/umugongo | Kubabara mu gice cyo hasi cy'umugongo. |
Ubusanzwe ubuvuzi busanzwe bukubiyemo kuvura ibimenyetso nk'umuvuduko ukabije w'amaraso no gukoresha imiti igenzura ubudahangarwa bw'umubiri, nka imiti igabanya ubudahangarwa bw'umubiri na corticosteroids. Ariko, gukoresha imiti isanzwe igihe kirekire akenshi bishobora gutera ingaruka mbi zitari ngombwa.
Aha niho Tarpeyo igaragara cyane. Tarpeyo ni corticosteroid, ariko umwihariko wayo ni uko ikora neza aho izi antibodies za IgA ziteye ikibazo zikomoka - ileum, igice cyihariye cy'amara yawe. Mu kwibanda kuri ako gace, Tarpeyo igabanya umusaruro wa IgA1 idakora neza, bityo ikagabanya ububyimbirwe n'ibyangiritse ku mpyiko zawe mu gihe igabanya ibyago byo kugira ingaruka mbi ku mubiri zijyanye na steroid gakondo.
Ukwiye gukoresha uyu muti ute?
Tarpeyo iza mu bwoko bwa kapsule. Ugomba kuyifata buri gitondo, nibura isaha imwe mbere y'uko urya.
- Ntukamene, ntukarye cyangwa ngo ujanjagure kapsule. Igomba kumira yose.
- Irinde kurya imbuto z'umuhondo cyangwa kunywa umutobe w'imbuto z'umuhondo mu gihe ufata uyu muti. Tuzaganira ku mpamvu zabyo vuba.
Icy'ingenzi cyane: Ntugahagarike gufata uyu muti utabanje kugisha inama muganga wawe. Iyo ukoresheje imiti ya corticosteroids nka Tarpeyo igihe kirekire, umubiri wawe ukora imisemburo ya steroide igabanuka. Iyo uyihagaritse mu buryo butunguranye, umubiri wawe ushobora kutagira steroide zihagije, bigatuma ugira ibimenyetso byo kuyireka nko kunanirwa cyane, kubabara imitsi, isesemi, umuvuduko w'amaraso uri hasi, cyangwa kuribwa umutwe. Kubwibyo, niba umuti ukeneye guhagarika, ugomba kugabanya (kugabanya buhoro buhoro dose) . Muganga wawe azaguha gahunda ikwiye yo kubikoresha.
Ni gute uburambe bw'uyu muti bwizweho?
Mu bushakashatsi bw'ingenzi bwakozwe ku mutekano n'ubushobozi bwa Tarpeyo, bwagereranyijwe n'umuti wa placebo—ikinini kitagira umuti ufatika—kugira ngo hamenyekane itandukaniro nyaryo mu buvuzi.
Abitabiriye ubu bushakashatsi bose bari bafite IgA Nephropathy hamwe na poroteyine nyinshi mu nkari zabo kandi bari basanzwe bakoresha imiti igabanya umuvuduko w'amaraso nka ACE inhibitors cyangwa ARBs.
Abitabiriye batoranijwe hashingiwe kuri ibi bikurikira:
- Igipimo cya poroteyine ku nkari (UPCR): Iki gipimo cy'ingano ya poroteyine iva mu nkari mu masaha 24.
- Igipimo cy’isesengura rya glomerular (eGFR): Ibi bipima uburyo impyiko zawe zikora neza. Abitabiriye inama bagize ikibazo cy’imikorere y’impyiko cyoroheje kugeza kiringaniye.
Muri ubwo bushakashatsi, bamwe mu bitabiriye amahugurwa bahawe Tarpeyo mu gihe cy'amezi 9, abandi bahabwa placebo. Nyuma y'amezi 9, ubuvuzi bwarahagaritswe, maze abitabiriye amahugurwa bakurikiranwa mu gihe cy'andi mezi 15.
Ni izihe nyungu zigaragazwa n'ubushakashatsi?
Ubushakashatsi bwagaragaje ko abarwayi bafata Tarpeyo bahuye n’ikibazo cyo kugabanuka k’imikorere y’impyiko buhoro cyane ugereranije n’abafashe placebo. Iyi nyungu yabayeho nyuma yo kurangiza amasomo y’ubuvuzi y’amezi 9.
Kugabanuka kwa poroteyine mu nkari (poroteyine mu nkari)
Mu mpera z'amezi 9, abarwayi bafashe ikarita ya Tarpeyo babonye igabanuka rya 35% rya poroteyine mu nkari, mu gihe abari mu itsinda rya placebo babonye igabanuka rya 5% gusa. Ikigaragara ni uko iri terambere ryakomeje kugaragara mu gihe cy'amezi 24 yo kwitabwaho.
| Igihe ntarengwa | Tarpeyo (Kugabanya UPCR%) | Placebo (Kugabanya UPCR%) |
|---|---|---|
| Amezi 3 | 5% | 4% |
| Amezi 6 | 24% | 8% |
| Amezi 9 | 35% | 5% |
| Amezi 24 | 34% | 4% |
Imikorere y'impyiko (eGFR)
Ku mezi 24, abarwayi bavuwe na Tarpeyo bagaragaje igabanuka rito cyane ry’imikorere y’impyiko ugereranije n’abari kuri placebo. Agaciro ka (+) kerekana iterambere ry’imikorere y’impyiko, mu gihe agaciro ka (-) kerekana ko impyiko zigenda zigabanuka.
| Igihe ntarengwa | Tarpeyo (Impinduka ya eGFR) | Placebo (Impinduka ya eGFR) |
|---|---|---|
| Amezi 9 | + 1.5 mL/iminota/1.73 m2 | – 4.0 mL/iminota/1.73 m2 |
| Amezi 24 | – 5.3 mL/iminota/1.73 m2 | – 11.2 mL/iminota/1.73 m2 |
Ubu bushakashatsi bwerekana ko gukoresha Tarpeyo mu gihe cy'amezi 9 bishobora gufasha kugabanya iterambere ry'impyiko. Ibi bifasha mu gucunga ibimenyetso no gutinza gutangira kwangirika kw'impyiko. Ariko, wibuke ko ibisubizo bya buri muntu bishobora gutandukana.
Uburyo bwo Kugenzura no Kurinda Ingaruka Zibi
Kubera ko Tarpeyo ikora mu guhindura ubudahangarwa bw'umubiri, uba ufite ibyago byinshi byo kwandura.Ushobora kwandura ibicurane, umuriro, cyangwa indwara zo mu nzira y'inkari. Nyamuneka irinde guhura n'abantu barwaye indwara zandura nka inzoka cyangwa iseru. Uburyo bwiza bwo kwirinda kwandura ni ugukaraba intoki kenshi no kwirinda kwegerana n'abarwayi. Ganira n'umuganga wawe gahunda yo gukingira. Niba ubonye kimwe muri ibi bimenyetso bikurikira by'ubwandu, nyamuneka hamagara muganga wawe cyangwa usure ishami ryihutirwa ako kanya:
- Umuriro cyangwa ubukonje
- Kubabara umubiri
- Inkorora
- Umunaniro ukabije
- Kuribwa umutwe bidashira
- Ihinduka ry'amaso cyangwa urujijo
- Uduheri tubabaza
Tarpeyo ishobora kandi gutera kubyimba kw'amazi cyangwa umuvuduko w'amaraso uzamuka. Ganira na muganga wawe ku mibereho myiza, harimo n'imirire n'imyitozo ngororamubiri. Kugabanya umunyu, kugumana amazi meza, no gukora imyitozo ngororamubiri yoroheje nko kugenda n'amaguru bishobora gufasha mu kubyimba no kubungabunga umuvuduko w'amaraso.
Izindi ngaruka mbi zikunze kugaragara zishobora kuba zirimo isesemi, kubabara mu nda, kuribwa mu mitsi, ibiheri, no kuribwa umutwe. Niba urwaye ibiheri, tekereza gukoresha imiti isukura neza n'imiti igabanya ubushyuhe idafite amavuta nk'igice cy'ibikorwa byawe byo kwita ku ruhu.
Uru si urutonde rwuzuye rw'ingaruka zose zishobora kubaho. Niba ufite impungenge ku bimenyetso urimo kubona, nyamuneka gana muganga wawe.
Igenzura rikenewe
Muganga wawe azagutegeka ibizamini buri gihe kugira ngo asuzume uko umubiri wawe witabira imiti. Muri rusange ibi birimo:
- Gukurikirana umuvuduko w'amaraso
- Isuzuma ry'inkari kugira ngo harebwe urugero rwa poroteyine
- Gupima amaraso kugira ngo bigenzure imikorere y'impyiko
- Gupima amaraso kugira ngo harebwe niba hari Hepatite B
Ibiyobyabwenge bishobora gutera
Imiti imwe n'imwe n'ibiribwa bishobora kubangamira imikorere ya Tarpeyo. Ni ngombwa kumenyesha muganga wawe ibyo ufata byose, harimo na vitamine n'inyongeramusaruro z'ibimera. Itondere cyane ibi bikurikira:
- Imiti imwe n'imwe irwanya udukoko n'imiti irwanya udukoko (urugero: clarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole (Nizoral))
- Imiti imwe ikoreshwa mu kuvura agakoko gatera SIDA
- Umutobe w'imbuto z'umuzabibu cyangwa imbuto z'umuzabibu
Uru si urutonde rwuzuye. Buri gihe menyesha itsinda ry'abaganga amakuru ajyanye n'ibintu byose unywa.
Kubona imiti yawe
Tarpeyo ni umuti wihariye ukoreshwa mu ndwara runaka. Ushobora kutaboneka muri farumasi zose zo mu gace utuyemo. Muri rusange, iyi miti itangwa binyuze muri farumasi zo mu bitaro cyangwa farumasi zihariye. Muganga wawe wo muri Nirogi Lanka azagufasha kumenya inzira yo kubona imiti yawe n'aho ishobora guturuka.
Ibintu by'ingenzi ugomba kwitaho
- IgA Nephropathy ni indwara aho ubudahangarwa bw'umubiri bwawe bwangiza impyiko zawe mu buryo butaziguye.
- Tarpeyo ni uburyo bwo kuvura bugamije kugabanya ikorwa ry’uturemangingo twa IgA twangiza twihariye dutera iyi ndwara.
- Nyamuneka fata uyu muti nk'uko muganga wawe yabigutegetse. Ntukigere uhagarika umuti cyangwa ngo uhindure ingano yawo utabanje kugisha inama muganga wawe.
- Witondere ibyago byinshi byo kwandura. Niba ugaragaje ibimenyetso nk'umuriro cyangwa inkorora idashira, shaka ubufasha bwa muganga vuba.
- Komeza kuvugana neza n'itsinda ryawe ry'ubuvuzi muri Nirogi Lanka kandi urebe neza ko warangije ibizamini byose bya laboratwari byasabwe ku gihe.
- Ni ngombwa ko umenyesha muganga wawe indi miti, vitamine, cyangwa inyunganiramirire y’ibimera urimo gufata ubu, kuko bishobora kugira ingaruka ku buvuzi bwawe.
IgA Nephropathy, Tarpeyo, indwara z'impyiko, poroteyine muririya, eGFR, corticosteroid, ubudahangarwa bw'umubiri
