Wakambonzwa nezve acetylcholine here, kana (ACh)? Pamwe chiremba wako akakuudza nezvazvo, kana kuti wakamboverenga nezvazvo pane imwe nzvimbo. Ikemikari diki asi inokosha kwazvo mumuviri wedu. Yakafanana nekapositi kadiki kanotakura mameseji mumuviri wedu. Saka, nhasi tichataura nezve acetylcholine nenzira iri nyore yaunogona kunzwisisa.
Chii chinonzi Acetylcholine?
Zvichitaurwa zviri nyore, acetylcholine ineurotransmitter . Funga nezvazvo, uropi hwako hunofanira kutumira mameseji madiki emagetsi kuti ufambe ruoko rwako, ufunge, uyeuke chimwe chinhu, zvese izvi. Acetylcholine imutumwa wemakemikari anobatsira kutakura mameseji iwayo kuburikidza nemasero etsinga .
Izvi zvinonziwo " excitatory " neurotransmitter . Unoziva here kuti chii ichocho? "Chinomutsa" tsinga dzeropa, kureva kuti, chinodzikurudzira, uye chinoita kuti "dzitumire" mameseji nekukurumidza. Zvakafanana nekugogodza pamusuwo wemunhu akarara woti, "Heino, tora tsamba iyi."
Zita rekuti acetylcholine rinobva pazvinhu zviviri zvinoriumba. Chimwe chikamu che acetyl . Izvi zvinobva muchinhu chinonzi acetyl coenzyme A, chinogadzirwa neshuga glucose. Chimwe chikafu chinonzi choline . Choline inowanikwa muzvipenyu zvemazai, soya, chiropa, miriwo, nembeu. Choline inogadzirwawo muchiropa chedu.
Acetylcholine inobatanidzwa mumabasa akawanda akakosha mumuviri wedu, kunyanya kufamba kwetsandanyama nekuzvidira.Izvi zvinoita basa guru muzviito zvedu zvekuziva, zvakaita sekufambisa makumbo nemakumbo uye kufamba. Zvinokurudzira masero etsinga mutsandanyama dzedu, zvichiita kuti azvimbike. Kwete izvozvo chete, asi zvakakoshawo kumasero etsinga muuropi hwedu, uye kune maitiro akaita sekurangarira, kufunga, uye kudzidza.
Acetylcholine (ACh) inoshanda sei?
Acetylcholine inochengetwa kumagumo emasero etsinga, kusvika meseji yada kutumirwa. Kana "chiratidzo" chasvika chekutumira meseji, acetylcholine iyi yakachengetwa inosunungurwa. Kana yangoburitswa, inofamba ichipinda mumukaha mudiki pakati pemasero maviri etsinga. Mukaha uyu unonzi synaptic cleft .
Mushure mekuyambuka synaptic cleft, kune mhando mbiri dzemareceptor anogona kusunganidzwa paari acetylcholine. Idzi ndeidzi:
- Nicotinic receptors
- Zvigamuchidzo zveMuscarinic
Mushure mekusunga kune aya mareceptor, meseji yemakemikari inofamba ichienda kune imwe tsinga. Mushure mekunge meseji yatumirwa, acetylcholine inosara musynaptic cleft haingoparare. Imwe enzyme inonzi acetylcholinesterase inouya yopwanya iyi acetylcholine kuita zvikamu zvayo, choline neacetate. Zvadaro zvikamu izvi zvakaputsika zvinotorwazve, zvodzokororwa, uye zvinoshandiswa kutakura imwe meseji yemakemikari. Sisitimu inoshanda zvikuru!
Chii chinoitika kuacetylcholine (ACh)?
Acetylcholine ine mabhenefiti akawanda kumuviri wedu. Ngatitarisei makuru acho.
| Rudzi rwemugamuchiri | Mabasa makuru |
|---|---|
| Zvigamuchidzo zveMuscarinic | |
| Nicotinic receptors (Nicotinic) |
|
Marudzi ese ari maviri emareceptor anobatanidzwa mundangariro dzedu. Kureva kuti, akakosha pakurangarira kwenguva refu, kurangarira kwenguva pfupi, kuumbwa kwendangariro, kubatana kwadzo, uye kudzoreredzwa kwadzo. Mukati meuropi, acetylcholine inobatanidzwa mune zvimwe zvinhu. Inokurudzira kukurudzira, kufarira/kutarisisa, kudzidza, uye kurara kweREM (danho rekurara kwatinorota).
Ndezvipi zvinhu zvinoitika kana huwandu hweacetylcholine (ACh) hukadzikira?
Kushomeka kweacetylcholine mumuviri kunogona kukonzera zvirwere zvakasiyana-siyana. Zvikuru pane izvi ndeizvi:
- Chirwere cheAlzheimer : Vanhu vane chirwere cheAlzheimer havana acetylcholine yakakwana muuropi hwavo. Nekuda kweizvozvo, kurasikirwa nendangariro chiratidzo chikuru.
- Lambert-Eaton myasthenic syndrome : Chirwere ichi chinokonzerwa nekuderera kwekuburitswa kweacetylcholine kubva mumasero etsinga.
- Myasthenia gravis : Ichi chirwere chinokonzerwa ne autoimmune chinoita kuti tsandanyama dzemapfupa dzishaye simba nekukurumidza mushure mekushandisa kakawanda.
Zvakakosha:Kana uine chimwe chezviratidzo izvi, enda kuna chiremba nekukasika. Usazviongorore wega.
Ndeipi mishonga inoshandiswa kurwisa acetylcholine (ACh)?
Mishonga inodzivirira cholinesterase imhando yemishonga inoshanda nekumisa enzyme inopwanya acetylcholine uye kuwedzera mashandiro emareceptor eacetylcholine. Inoshandiswa kurapa chirwere cheAlzheimer ne myasthenia gravis. Donepezil (Aricept®), Rivastigmine (Exelon®), uye Galantamine (Razadyne®) ndedzimwe dzemishonga iyi.
Ndezvipi zvekudya zvine choline, iyo inobatsira kugadzira acetylcholine (ACh)?
Choline, chinhu chinovaka muviri chinoshanduka kuita acetylcholine, chinowanikwa muzvikafu zvakawanda. Semuenzaniso:
- Chiropa chemombe
- Mazai (kunyanya mazamu)
- Nyama yepamusoro-soro
- Soya dzakakangwa, bhinzi dzemumagaba
- Zamu rehuku rakagochwa
- Hove dzeCod `(Cod)`
- Quinoa yakabikwa
- Howa hweshiitake hwakabikwa, broccoli yakabikwa uye Brussels sprouts
- Mukaka (1%) `(Mukaka (1%)`, yogati yevanilla isina mafuta `(yogati yevanilla isina mafuta)`
Edza kuwedzera zvekudya izvi mukudya kwako. Kudya kwakaringana kwakakosha zvikuru kuti uve nehupenyu hwakanaka.
Mharidzo Yekuenda Nayo Kumba
Saka, ikozvino ungangove wava kunzwisisa kuti acetylcholine (ACh) ineurotransmitter inokosha zvikuru pakushanda kwehuropi hwedu, ndangariro, uye mashandiro emuviri akadai sekuoma kwetsandanyama. Kana huwandu hwayo hukadzikira, matambudziko ekurangarira uye zvirwere zvine chekuita netsandanyama zvinogona kuitika. Chinhu chakakosha ndechekuti, kana uine matambudziko ehutano, taura nachiremba nezvazvo. Usaende kunorapwa zvichibva pafungidziro. Ramba uine hutano hwakanaka!
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