Masero enyu machena eropa akaderera zvine ngozi here? Izvozvo zvinoreva agranulocytosis here? Ngatitaurei nezvazvo!

Unogara uchirwara here? Unonzwa usina simba uye wakaneta here kunyangwe kwenguva diki? Dzimwe nguva izvi zvinogona kukonzerwa nekudzikira kwekudzivirira kwemuviri wako, kureva ma neutrophils, rudzi rwemasero machena eropa. Nhasi tiri kutaura nezvechirwere chakakomba asi chinorapika chinonzi agranulocytosis . Usazvidya moyo, zvakakosha kuziva izvi.

Chii chinonzi agranulocytosis?

Zvichitaurwa zviri nyore, Agranulocytosis chirwere chinoisa upenyu panjodzi apo huwandu hwemasero machena eropa anonzi ma neutrophils mumuviri wedu hunoderera kusvika padanho rakaderera. Waizviziva here kuti masero machena eropa akafanana nemasoja ari muimmune system yedu? Ndiwo anotidzivirira kubva kuhutachiona hunokonzera zvirwere. Kana huwandu hwema neutrophils aya hukadzikira, muviri wedu unova nyore kubatwa nehutachiona. Kunyangwe utachiona husingawanzotikuvadza zvakanyanya hunogona kutiita kuti tirware. Fungidzira, kana chikwata chemauto chakakosha muuto redu chikangoerekana chanyangarika, kunyange muvengi mudiki hachingave dambudziko guru here? Izvi zvakafanana. Zita rekuti "agranulocytosis" rinobva pashoko rekuti granulocytes . Ma granulocytes imhando yemasero machena eropa. Ane ma enzymes anoparadza utachiona. Kune marudzi matatu ema granulocytes: Neutrophils , Eosinophils, uye Basophils . Ma Neutrophils ndiwo masero machena eropa akawanda kwazvo mumiviri yedu. Ndosaka vanachiremba vachiyedza mazinga e neutrophil kuti vaongorore agranulocytosis. Izvi dzimwe nguva zvinonzi granulocytopenia .

Ndeupi musiyano uripo pakati peNeutropenia neAgranulocytosis?

Zvese izvi zvine chekuita nekuderera kwema neutrophils. Zvisinei, agranulocytosis ndiyo mhando yakanyanya ye neutropenia .

• Neutropenia chirwere chinokonzerwa nekuti huwandu hwema neutrophils muropa hunenge hwakaderera pane hwakajairika. Vanhu vane ma neutrophils ari pasi pe1,500 pa microliter (mL) yeropa vanonzi vane neutropenia.
• Agranulocytosis ndiyo danho rekupedzisira uye rine njodzi huru, apo huwandu hwema neutrophil hunoderera pasi pe100 pa microliter yeropa. Wanzwisisa here? Iyi ndiyo mhando yakanyanya ye neutropenia.

Pane mhando dzeagranulocytosis here?

Ehe, izvi zvinogona kuuya nenzira mbiri huru: 1. Agranulocytosis inoberekwa nhaka:Izvi zvinokonzerwa nechirwere chemajini. Kureva kuti, pane dambudziko nemajini anobatsira muviri wedu kugadzira ma neutrophils. Chirwere ichi chinonyanya kukanganisa vacheche nevana vadiki. 2. Acquired agranulocytosis: Izvi zvinogona kuva nezvikonzero zvakawanda. Zvisinei, kazhinji (inenge 70% yenguva!) zvinokonzerwa nemhedzisiro yemishonga yatinotora. Rudzi urwu runonyanya kuitika muvanhu vakuru.

Dambudziko iri rakajairika zvakadii?

Ichi chirwere chisingawanzoitiki. Paavhareji, vanhu vanosvika vanomwe pazviuru zana vanowana chirwere ichi gore rega rega. Saka musatya zvisina kufanira, asi zvakakosha kuti muzive.

Ndezvipi zviratidzo zveAgranulocytosis?

Muchiitiko ichi, zviratidzo zvikuru zvine chekuita nehutachiona. Izvi zvinogona kutanga kamwe kamwe, kana kuti zvinogona kuwedzera zvishoma nezvishoma nekufamba kwenguva. Ona kana zviratidzo izvi zvichinzwika sekunge zvakajairika kwauri:

• Kunzwa fivha, kunzwa dzihwa uye kudedera.
• Kurova kwemoyo kwakanyanya uye kufema kwakanyanya.
• Kunzwa sekuti hauna hupenyu uye kuneta zvakanyanya.
• Huro inorwadza (pharyngitis), kudzikira kwemazino, kubuda ropa mumatadza.
• Maronda mumuromo nemuhuro, zvichiita kuti zviomere kumedza chikafu nekunwa.
• Kuderera kweBP kamwe kamwe (hypotension), dzungu, kupera simba, uye pamwe kurasikirwa nepfungwa.

Kana uine zviratidzo zvakadai, kunyanya kana zvikaitika kakawanda, unofanira kutsvaga rubatsiro rwechiremba.

Sei agranulocytosis ichiitika? Ndezvipi zvikonzero?

Chikonzero chikuru cheizvi kudzikira kune njodzi kwehuwandu hwemasero machena eropa anonzi ma neutrophils mumuviri wedu. Pane zvikonzero zviviri zvinogona kukonzera izvi:

• Miviri yedu haigadziri ma neutrophils akakwana kuti ashande zvakanaka.
• Zvikasadaro, ma neutrophils mumuviri anoparadzwa, kana kuti anofa nguva isati yakwana.

Zvino ngationei kuti zvikonzero chaizvo zveizvi ndezvipi.

Agranulocytosis inogarwa nhaka

Muizvi, pane dambudziko rine jini rinobatsira kugadzira ma neutrophils. Iri idambudziko rinowanikwa pakuzvarwa (congenital). Semuenzaniso, kana tikatora Kostmann syndrome , kana congenital agranulocytosis , chirwere chisingawanzoitiki, vacheche vachangoberekwa vanowanzova nehutachiona, fivha, kuzvimba, uye matambudziko emapfupa.

Kuwanikwa kweagranulocytosis

Panogona kunge paine zvikonzero zvakawanda zveizvi. Ngationei kuti ndezvipi:

• Mimwe mishonga: Ichi ndicho chikonzero chinowanzoitika . Mimwe mishonga inorwisa mabhakitiriya , mishonga yekurwisa pfungwa , uye mishonga yethyroid inogona kukonzera chirwere ichi.
• Zvirwere zve autoimmune : Izvi zvirwere umo masoja emuviri anorwisa masero emuviri. Mienzaniso inosanganisira lupus ne rheumatoid arthritis .
• Zvirwere zveBone Morrow uye Matambudziko eBone Morrow: Semuenzaniso , aplastic anemia . Bone Morrow ndipo panogadzirwa masero edu eropa.
• Kenza: Kenza dzinokanganisa mumongo wemapfupa, kunyanya leukemia .
• Kurapa Gomarara (Chemotherapy): Kurapa uku kunogona kuparadza masero ane hutano pamwe chete nema neutrophils.
• Kusangana nezvinhu zvine chepfu kana makemikari: Kusangana nezvinhu zvakaita se lead kana mercury kwenguva refu.
• Utachiona: Utachiona hwakanyanya hwakadai semarariya , TB , uye Rocky Mountain spotted fever .
• Kushaikwa kwezvinovaka muviri: Kushaikwa kwezvinovaka muviri zvakakosha zvakaita seVitamin B12 neFolate.

Ndiani ari panjodzi huru yechirwere ichi?

Vakadzi vane mukana wekuwana chirwere ichi kupfuura varume. Uyewo, agranulocytosis inogona kukanganisa chero ani zvake wezera ripi zvaro. Zvisinei, vanhu vanotevera vari panjodzi huru:

• Vanhu vari kurapwa nekenza vachishandisa chemotherapy .
• Vanhu vane zvirwere zve autoimmune zvakaita se lupus ne rheumatoid arthritis .
• Vanhu vanotora mimwe mishonga, yakaita seClozapine (Clozaril®) , mushonga wekurapa pfungwa , Trimethoprim/sulfamethoxazole (Bactrim™) , uye Methimazole (Tapazole®), mushonga wethyroid.

Ndezvipi zvinetso zvinogona kuitika nekuda kweagranulocytosis?

Dambudziko iri rinogona kukonzera hutachiona hunogara huripo kana kuti hunogara kwenguva refu (hutachiona husingaperi).

Kana agranulocytosis ikaramba iripo kwemavhiki anopfuura matatu kusvika mana, pane mukana we100% wekutapukirwa nehutachiona.

Kana ikasarapwa, sepsis inogona kukonzera chirwere chakakomba, chinouraya chinonzi sepsis. Sepsis chirwere chakakomba chinopararira mumuviri wese. Vanhu vane makore anopfuura 65 kana avo vane mamwe matambudziko ehutano, akadai sechirwere chemwoyo, chirwere cheitsvo, kana chirwere chemapapu, vari panjodzi huru yekusangana nematambudziko aya.

Unoona sei izvi?

Chiremba anoongorora sei agranulocytosis? Kazhinji vanotevera matanho aya:

• Kuverengwa Kweropa Rakazara (CBC) uye musiyano: Kuongororwa uku kunotarisa mhando dzakasiyana dzemasero muropa rako, kunyanya huwandu hwema neutrophils. Kuverengwa kwemasero asina kukwana (ANC) ari pasi pe100 pa microliter yeropa kunoonekwa seagranulocytosis. (Kukosha kwakajairika kwemunhu ane hutano kwakakura kupfuura 1,500.)
• Kuongororwa kwemapfupa emubofu uye aspirate: Dzimwe nguva, bvunzo iyi inogona kuitwa kuti ione kuti mapfupa ako ari kugadzira sei ma neutrophils.
• Zviratidzo nenhoroondo yezvekurapa: Chiremba achakubvunza nezvezviratidzo zvako, mishonga yaunotora, hutachiona hwauchangobva kuwana, uye chero kusangana nemakemikari.
• Kuongororwa kwemajini: Kana paine fungidziro yekuti pane chirwere chemajini, kuongororwa kwemajini kunogona kuitwa kuti chisimbiswe. Izvi zvinogona kusanganisira kuongororwa kweganda kana kuongororwa ropa.

Ndezvipi zvinorapwa izvi?

Mashoko akanaka ndeekuti kune nzira dzekurapa chirwere ichi, agranulocytosis. Kurapa kunoenderana nechikonzero chacho.

• Kumisa Mushonga Unokonzera: Kana mushonga uri kukonzera zviratidzo zvako, chinhu chekutanga chekuita ndechekurega kuutora zvakachengeteka sezvakarairwa nachiremba wako. Usamborega kutora mushonga usina kubvunza chiremba.
• Mishonga inorwisa mabhakitiriya: Kana uine hutachiona, chiremba wako achakupa mishonga yakakodzera yekurwisa mabhakitiriya nemimwe mishonga yekuderedza zviratidzo.
• Granulocyte colony-stimulating factor (G-CSF): Rudzi urwu rwejekiseni runogona kupihwa kuti muviri ugadzire ma neutrophils nekukurumidza. Mienzaniso inosanganisira mishonga yakaita seFilgrastim (Neupogen®) , Pegfilgrastim (Neulasta®) , uye Lenograstim (Granocyte®) .
• Mishonga Inodzivirira Kurwara: Kana chirwere ichi chakakonzerwa nechirwere che autoimmune, mishonga inodzvinyirira masoja emuviri, yakadai sePrednisone, inogona kupihwa.
• Kuisirwa mapfupa emupfupa: Kana mamwe marapirwo akasabudirira, ungangoda kuisirwa mapfupa emupfupa. Mukuita izvi, uchapihwa mapfupa emupfupa kubva kune anopa hutano. Izvi zvichabatsira muviri wako kugadzira ma neutrophils ane hutano zvakare.
• Kudzivirira hutachiona: Izvi zvakakosha zvikuru. Vanhu vane chirwere ichi vanofanira kungwarira zvikuru kuti vasatapurirwe hutachiona.
• Gara uchigeza maoko ako nesipo zvakanaka.
• Dzivisa nzvimbo dzine vanhu vakawanda sezvinobvira.
• Pfeka chifukidziro chechiso/mask paunenge uchibuda panze.
• Taura nachiremba wako nezvezvimwe zvaungaita kuti udzivise kurwara.

Ndichakurumidza sei kupora mushure mekurapwa?

Nguva yekupora inoenderana nechikonzero chehuwandu hwenyu hwema neutrophil hwakaderera uye kuoma kwechirwere ichi. Kana chiri mhedzisiro yemushonga, zvinogona kutora vhiki kusvika mavhiki matatu kuti huwandu hwenyu hwema neutrophil hudzokere pahwakajairika mushure mekunge marega kutora mushonga.

Izvi zvinogona kudzivirirwa here?

Dzimwe nguva, agranulocytosis haigone kudzivirirwa zvachose. Zvisinei, kana uri kutora mushonga unogona kuderedza ma neutrophils ako (semuenzaniso, chemotherapy, mimwe mishonga yepfungwa), zvakakosha kutaura nachiremba wako uye kuongororwa mazinga ako e neutrophils nguva nenguva. Kana uri kugamuchira chemotherapy yekenza, chiremba wako anogona kukurudzira jekiseni reG-CSF kuti ribatsire kuwedzera kugadzirwa kwe neutrophil.

Chii chiri tarisiro yemunhu ane agranulocytosis?

Kunyange zvazvo iri chirwere chinorapika, mhedzisiro yacho inogona kusiyana kubva pamunhu kusvika pamunhu. Kana kurapwa kwakakodzera, kana mushonga unoderedza ma neutrophils ukamiswa, chirwere ichi chinowanzopera.

Zvisinei, kana zvikasarapwa, hutachiona hwakakomba uye kunyange rufu zvinogona kuitika. Kana huwandu hwema neutrophil hukaramba huri padanho rine njodzi, njodzi yekutapukirwa nematambudziko inowedzera. Izvi zvinonyanya kuitika kuvanhu vane makore anopfuura makumi matanhatu nemashanu uye avo vane zvirwere (zvakadai sechirwere cheitsvo, chemwoyo, kana chemapapu).

Unofanira kuona chiremba rini?

Agranulocytosis chirwere chinoisa upenyu panjodzi. Saka, zvakakosha kuti uongororwe chirwere uye kurapwa nekukasika. Enda kuna chiremba nekukasika kana uine chimwe chezviratidzo izvi:

• Kana ukarwara nezvirwere nguva nenguva.
• Kana chirwere ichi chikatora nguva yakareba kuti chipore.
• Kana ukava nezviratidzo zvehutachiona zvakaita sefivha, dzihwa, kana kurwadziwa pahuro.

Kana uine chirwere che autoimmune kana kuti uri kutora mishonga inoderedza ma neutrophils ako, usarega kuongororwa nachiremba. Kuongororwa nachiremba wako nguva dzose kunogona kukubatsira kutarisa huwandu hwema neutrophils ako uye kubatsira kudzivirira hutachiona.

Zvinhu zvakakosha zvatinofanira kurangarira (Mharidzo Yekuenda Kumba)

Zvakanaka, ngatitaurei zvimwe zvezvinhu zvakakosha kubva pane zvatataura nezvazvo:

• Agranulocytosis chirwere chakakomba asi chinorapika umo masero machena eropa anodzikira zvakanyanya anonzi ma neutrophils.
• Kana uine zviratidzo zvakaita sezvirwere zvinogara zvichiitika, fivha, kana kurwadziwa pahuro, enda kuna chiremba nekukasika.
• Izvi zvinogona kukonzerwa nemimwe mishonga, zvirwere zve autoimmune, uye kurapwa kwegomarara.
• Kurapa kunogona kusanganisira kumisa mushonga unokuvadza, mishonga inorwisa mabhakitiriya, jekiseni reG-CSF, uye pamwe kuisirwa mubofu.
• Kuzvidzivirira kubva kuzvirwere kwakakosha zvikuru. Unogona kuzvidzivirira nekuita zvinhu zviri nyore zvakaita sekugeza maoko ako nguva nenguva uye kupfeka masiki paunenge uri paruzhinji.
• Kana uri panjodzi yeizvi (semuenzaniso, kana ukatora mimwe mishonga), usarega kuenda kuna chiremba.

Ndinovimba ruzivo urwu ruchakubatsira. Ramba uine hutano hwakanaka!