Kana vanachiremba vakasimbisa kuti iwe kana mumwe munhu ari pedyo newe ane kenza yemazamu, zvinonetsa kutaura kutya kwako nekuzvidya mwoyo kwaunonzwa. Panguva imwe chete, kana vanachiremba vachitaura nezvebvunzo dzakasiyana-siyana uye marapirwo , zvinogona kuoma kunzwisisa mazwi iwayo. Imwe bvunzo yaunowanzo kunzwa ndeyebvunzo yeIHC. Kunyangwe zita racho ringanzwika serakaoma zvishoma, usatya . Iyi bvunzo yakakosha zvikuru inobatsira chiremba wako kusarudza mushonga wakanakisa wekenza yako. Nhasi, tichataura nezvazvo nenzira iri nyore, nenzira yaunogona kunzwisisa.
Chii chinonzi bvunzo yeIHC?
Zvichitaurwa zviri nyore, IHC (Immunohistochemistry) ibvunzo yakakosha inoratidza rudzi chairwo rwemasero ekenza yako. Haasi ese magomarara emazamu akafanana. Mamwe magomarara anoshandisa mahormone mumiviri yedu kuti akure. Mamwe anovimba nemamwe mapuroteni kuti akure. Saka kana wangoziva chaizvo kuti ndezvipi zvinhu zviri kubatsira kenza yako kukura, chiremba wako anogona kunanga zvinhu izvozvo ozvirapa.
Bvunzo yeIHC inonyanya kutarisa zvinhu zviviri:
1. Mahormone Receptors : Miviri yedu inobereka mahormone anonzi estrogen neprogesterone. Mamwe masero ekenza yemazamu ane nzvimbo dzakakosha pamusoro pawo dzinonzi mareceptors uko mahormone aya anogona kunamatira. Kana mahormone aya akabatana, masero ekenza anogamuchira chiratidzo chekukura. Kana masero ako ekenza aine mahormone receptors aya, anonzi "hormone receptor-positive."
2. Mapuroteni eHER2: `(HER2)` imwe puroteni inobatsira kudzora kukura kwemasero. Zvisinei, mamwe masero ekenza yemazamu anogadzira puroteni iyi ye`HER2` yakawandisa. Izvi zvinonzi "HER2-positive". Ichi ndicho chikonzero nei kenza ichikura nekukurumidza.
Chinangwa chikuru chebvunzo iyi ndechekuona kuti chii chiri kukonzera kenza yako, ndiko kuti, chii chiri kukonzera kukura kwayo. Zvadaro, tinogona kukupa mishonga inomisa "kudya" ikoko.
Bvunzo iyi yeIHC inoitwa sei?
Kuongororwa uku kunoda sampuli yemasero ako egomarara . Izvi zvinowanzo torwa kubva pachidimbu chenyama chinotorwa panguva yekuongorora kenza kuti zvionekwe kuti gomarara riripo here kana kuti panguva yekuvhiyiwa kuti gomarara ribviswe.
Zvadaro chidimbu ichi chetishu chinotumirwa kurabhoritari, ndiko kuti, kurabhoritari. Ipapo, chimwe chinhu chinonakidza chinoitika:
- Nyanzvi dziri murabhoritari dzichawedzera kemikari yakakosha musampuli yemasero ako ekenza. Izvi zvinoshandisa rudzi rweprotein yakagadzirwa murabhoritari. Aya anonzi ``antibodies''.
- Aya ma `(antibodies)` akagadzirwa kuti abatanidzwe chete kuma `(Estrogen)`, `( Progesterone )` kana `(HER2)` receptors. Kungofanana neburi rekiyi rinokwana kiyi.
- Kana masero ako egomarara aine mareceptor aya, ma antibodies iwayo acharamba aripo uye anonamira paari.
- Zvadaro, kana imwe kemikari ikaiswa pane izvi, masero ane masoja ekudzivirira chirwere anochinja ruvara .
- Nyanzvi yezvirwere , kana kuti histologist, inotarisa nyama yacho pasi pemaikorosikopu uye inoverenga kana paine masero akachinja ruvara uye kuti mangani aripo.
Iyi ndiyo nzira yaunogona kuziva nayo kana kenza yako iri `HER2-positive`, `hormone receptor-positive`, kana kuti `zvose zviri zviviri hazvina`.
Unonzwisisa sei zviri mumushumo webvunzo?
Kana wawana mushumo wako wekuongororwa kweIHC, zvinogona kutyisa kuona nhamba nemashoko ari pairi. Asi chinonyanya kukosha kugara pasi nachiremba wako motaura zvakajeka nezvese zviri mumushumo . Heino maitiro anowanzo taurwa mhedzisiro:
Mhedzisiro yeHER2
Mhedzisiro ye `HER2` inowanzo kupihwa senhamba.
| Mhedzisiro | Zvinoreva |
|---|---|
| 0 kana 1+ | Izvi zvinoreva kuti kenza yako haina HER2-negative . Izvi zvinoreva kuti masero ekenza haana HER2 receptors kana kuti ane huwandu hwakaderera kwazvo hwemasero aya. |
| 2+ | Ichi chirwere "chemuganhu" kana kuti chisingazivikanwe . Hazvigoneki kutaura zvechokwadi kana bundu iri riri HER2-positive kana kuti risina kunaka. Muzviitiko zvakadaro, chiremba anogona kukurudzira bvunzo yakasimba, inonzi FISH test (Fluorescence In Situ Hybridization). |
| 3+ | Izvi zvinoreva kuti kenza yako ine HER2-positive . Izvi zvinoreva kuti masero ekenza ane maHER2 receptors akawanda. |
Hormone Receptor (ER/PR) Migumisiro
Mhedzisiro iyi inogona kutaurwa nenzira dzakasiyana-siyana:
- Sechikamu (0% - 100%): Chikamu chemasero ekenza zana ane mahormone receptors.
- Nhamba kubva pa0 kusvika pa3: 0 zvinoreva kuti hapana mareceptor. 1, 2, na3 zvinoratidza mareceptor akaderera, apakati, uye akakwira, zvichiteerana.
- "Allred score" (0-8): Kana chibodzwa ichi chakakwira, huwandu hwemareceptors uye kujeka kwawo kunowedzera.
- "Zvakanaka" kana "Zvakaipa": "Zvakanaka" zvinoreva kuti kune mareceptor. Kunyangwe paine mashoma se1% emareceptor, achiri kunzi "Akanaka." Saka, zvakakosha kuziva huwandu kana mamakisi.
Dzimwe nguva mhedzisiro yacho inogona kunge isiriyo. Kana uine kusava nechokwadi, usambozeza kukumbira chiremba wako kuti aongororezve mushumo nemumwe "nyanzvi yezvirwere" kana kuti adzokorore bvunzo yacho.
Mhedzisiro yeIHC inokanganisa sei kurapwa kwako?
Ichi ndicho chinhu chinonyanya kukosha. Chiremba wekenza achasarudza nzira yakanakisisa yekurapa iwe zvichibva pane zvakabuda muongororo yeIHC.
| Rudzi rwegomarara (zvichibva pamigumisiro yeIHC) | Kurapa kunoenderana |
|---|---|
| HER2-positive | Kurapa kwakanangana, uko kunonangana neproteni yeHER2, kunoshanda zvikuru kune rudzi urwu. |
| HER2-isina kunaka | Rudzi urwu runogona kukura zvishoma nezvishoma kupfuura kenza ine HER2. Mishonga inorapwa neHER2 haishande kune rudzi urwu. Saka chiremba wako anogona kusarudza mamwe marapirwo, akadai sechemotherapy kana hormone therapy. |
| Hormone receptor-positive (ER+ uye/kana PR+) | Kurapa nehomoni kunoshanda zvikuru parudzi urwu rwegomarara. Mishonga iyi inoderedza huwandu hweestrogen mumuviri kana kudzivirira masero egomarara kuti asawane estrogen. |
| Hormone-isina receptor | Gomarara iri rinowanzo kurumidza kukura. Kurapwa nemahormone hakugoni kukanganisa izvi. Saka, mamwe marapirwo, akadai se chemotherapy, anodiwa. |
| Katatu-positive | Izvi zvinoreva kuti zvese zvitatu izvi zvine positive: `(Estrogen), `(Progesterone), uye `HER2.` Vanhu ava vanogona kupihwa kurapwa kwemahormone uye kurapwa kwakanangana neHER2. |
| Katatu-negative | Izvi zvinoreva kuti zvinhu zvitatu izvi hazvina kunaka. Izvi zvinowanzokura nekukurumidza. Sezvo mishonga yehormone kana HER2-targeted isingashande pakuita izvi, zvinhu zvakaita sekuvhiyiwa, chemotherapy, uye radiation ndizvo zvinonyanya kushandiswa. |
Mharidzo Yekuenda Nayo Kumba
- Bvunzo yeIHC inzira yakakosha inoshandiswa pakuronga kurapwa kwegomarara remazamu. Usatye zita racho.
- Izvi zvinonyanya kusarudza kana kenza yako inoenderana nemahormone (ER/PR positive) uye kana HER2 inoenderana nemapuroteni (HER2 positive).
- Zvichibva pamhedzisiro yebvunzo iyi, chiremba wako achakwanisa kusarudza mushonga unoshanda zvakanyanya kwauri, pasina migumisiro yakawanda.
- Kana wagamuchira mushumo wako wekuongororwa, kumbira chiremba wako kuti akutsanangurire izwi rega rega nenhamba dziri mariri kuitira kuti unzwisise zvakajeka. Usatya kubvunza mibvunzo.
- Kana usina chokwadi nezvemhedzisiro, taura nachiremba wako nezvekuwana mumwe munhu anoongorora kana kudzokorora bvunzo. Zvakakosha kuti utore chikamu chakakosha mukuita sarudzo pamusoro pehutano hwako.
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