Unonzwawo here kurwadziwa mudumbu, kunzwa kupisa mudumbu, kana gastritis kana uchinwa mishonga inonyaradza marwadzo yawakanyorerwa nachiremba wako yekurwadziwa kwemajoini, kurwadziwa kwemusana, kana mamwe marwadzo? Iri idambudziko rinowanzoitika kuvanhu vazhinji. Zvinonetsa zvikuru kuva nerimwe dambudziko mushure mekutora mushonga wekuderedza marwadzo. Asi waizviziva here kuti kune mhando yakakosha yemishonga inogona kuderedza marwadzo emudumbu uye kudzora marwadzo? Kirasi iyoyo yemishonga inonzi COX-2 inhibitors . Nhasi tiri kutaura nezvazvo.
Chii chinonzi COX-2 Inhibitors? Ngatizvinzwisise zviri nyore.
Mishonga inodzivirira COX-2 inotorwa kubva mumhuri imwe chete yemishonga inoderedza marwadzo inozivikanwa seNSAIDs ( Nonsteroidal Anti-inflammatory Drugs) . Mishonga yaunowanzo shandisa, yakaita seIbuprofen , Diclofenac, uye Naproxen , ndeyeboka iri reNSAIDs. Basa guru remishonga iyi nderekuderedza marwadzo, kuderedza kuzvimba, uye kuderedza fivha.
Saka chii chakakosha nezvemishonga iyi inodzivirira COX-2? Kuti tinzwisise izvozvo, tinofanira kutanga tatarisa kuti NSAID inoshanda sei mumuviri wedu.
"Vashandi" vaviri vari mumuviri wedu: COX-1 naCOX-2
Fungidzira kuti mukati memiviri yedu mune rudzi rwe enzyme inonzi Cyclooxygenase ( COX ). Idzi dzakafanana nevashandi vadiki vanoita mabasa akasiyana-siyana mumiviri yedu. Kune mhando mbiri dzevashandi ava veCOX.
1. COX-1: Uyu mushandi "akanaka". Basa rake guru nderekuchengetedza mukati medumbu redu neura. Inobatsira kugadzira jira rinodzivirira dumbu kubva kumaacids ekugaya chikafu chatinodya nekunwa. Inobatanidzwawo mukuita kwekugwamba kweropa .
2. COX-2: Izvi zvinowanzova "zvinokonzeresa matambudziko." Kana paine kukuvara, hutachiona, kana kukuvara kwemuviri wedu, zvinoenda ikoko zvogadzira makemikari anonzi prostaglandins . Aya maprostaglandins ndiwo anokonzera kurwadziwa, kuzvimba, uye fivha. Kunyangwe ichi chiri chidziviriro mumuviri, muzvirwere zvisingaperi zvakaita searthritis, izvi zvinoramba zvichikonzera kurwadziwa.
Zvino tarisai, patinotora mushonga unowanzo shandiswa weNSAID seIbuprofen, mushonga iwoyo unopinda mumuviri wovhara munhu akanaka (COX-1) nemunhu akaipa (COX-2), zvichireva kuti vese vanomira kushanda. Nekuti COX-2 yavharwa, kurwadziwa nekuzvimba zvinodzikira. Izvo zvakanaka. Asi nekuti COX-1 yavharwa, dziviriro yemudumbu inomiswawo, uye mikana yekuzvimba mudumbu, gastritis, uye kunyange maronda emudumbu inowedzera.
Kuti vagadzirise dambudziko iri, masayendisiti akawana mishonga inonzi COX-2 inhibitors. Mishonga iyi yakaita sema snipers. Painopinda mumuviri, inonanga zvakananga mushandi weCOX-2 anonetsa. Mushandi akanaka weCOX-1 haapindiri chero chinhu. Inongoita basa rayo chete.
Saka, kunyange hazvo dumbu richiramba richidzivirirwa, enzyme yeCOX-2 chete, iyo inokonzera kurwadziwa nekuzvimba, ndiyo inodziviswa. Zvichitaurwa zviri nyore, mukana mukuru weCOX-2 inhibitors ndewekuti inodzora marwadzo uku ichideredza migumisiro yemudumbu.
Mishonga inodzivirira COX-2 inonyanya kushandiswa pazvirwere zvipi?
Rudzi urwu rwemushonga runokurudzirwa navanachiremba pakurapa zvirwere zvakasiyana-siyana zvinorwadza uye zvinozvimba. Heano mamwe emishonga mikuru.
| Dambudziko rehutano | Tsananguro iri nyore |
|---|---|
| Osteoarthritis | Marwadzo nekuzvimba kwemapfupa kunoitika kana tsinga iri pakati pemapfupa ichipera nekukura kana zvimwe zvikonzero. Kazhinji zvinokanganisa majoini akaita semabvi nehudyu. |
| Rheumatoid Arthritis | Kuzvimba kusingaperi uye kurwadziwa kwakanyanya kunoitika kana chikanganiso mumasoja emuviri chikarwisa majoini. |
| Arthritis yeVechidiki | Zvirwere zveArthritis muvana vadiki. |
| Ankylosing Spondylitis | Chirwere chinonyanya kukonzera kuti majoini emusana azvimbe uye, nekufamba kwenguva, abatana, zvichikonzera kuomarara. |
| Kurwadziwa Kwekuenda Kumwedzi / Dysmenorrhea | Kudzora marwadzo akanyanya emudumbu anokonzerwa nekuenda kumwedzi kuvakadzi. |
| Kurwadziwa kwenguva pfupi | Inoshandiswawo pakurwadziwa kwenguva pfupi, kwakadai sekukuvara kwemitambo, kurwadziwa mushure mekuvhiyiwa, uye kurwadziwa mushure mekubviswa kwezino. |
Pamusoro pezvo, mishonga iyi inogona kushandiswawo kune zvimwe zvirwere zvakaita segout uye migraine, zvichienderana nesarudzo yachiremba.
Ndezvipi zvinodzivirira COX-2 zvinoshandiswa muSri Lanka nepasi rose?
Mushonga unonyanya kushandiswa weCOX-2 inhibitor pasi rose uye muSri Lanka iCelecoxib . Ungave wakambonzwa nezvawo uchishandisa zita rekuti Celebrex® .
Pamusoro pezvo, mimwe mishonga inodzivirira COX-2 yakaita seEtoricoxib (Arcoxia®) neParecoxib (Dynastat®) inoshandiswawo munyika dzakasiyana-siyana pasi rose.
Asi unofanirawo kuziva izvi. Makore akati wandei apfuura, mamwe mishonga inodzivirira COX-2, yakaita seRofecoxib (Vioxx®) neValdecoxib (Bextra®) , yaive pamusika. Zvisinei, zvidzidzo zvakazotevera zvakawana kuti mishonga iyi yakawedzera zvakanyanya njodzi yekurwara nemoyo uye sitiroko kana ikashandiswa kwenguva refu. Yakakonzerawo vamwe vanhu kuti vabatwe nezvirwere zveganda zvakakomba. Nekuda kwezvikonzero izvi, mishonga iyi yakabviswa pamusika.
Chidzidzo chakakosha chatinogona kudzidza kubva muzviitiko izvi ndechekuti hapana mushonga wekurwadziwa unofanirwa kushandiswa kwenguva refu pasina kurairwa nachiremba . Mushonga wega wega une zvakanakira nezvawo. Chiremba wako chete ndiye anogona kusarudza mushonga wakakodzera uye wakachengeteka kwauri.
Ndingatora mushonga uyu sei? Ndinofanira kuutora kwenguva yakareba sei?
Mishonga inodzivirira COX-2 inowanzo shandiswa semapiritsi, asi inogonawo kuwanikwa semushonga unonwiwa.
Marwadzo anotanga kudzikira mukati meawa imwe chete mushure mekunwa mushonga uyu.Zvisinei, zvinogona kutora mazuva mashoma kuti uwane mabhenefiti ese ekudzivirira kuzvimba, akadai sekuderedza kuzvimba.
Nguva yaunofanira kutora mushonga uyu inoenderana nemamiriro ako ehutano.
- Kune marwadzo enguva pfupi (senge mazuva mashoma kana mavhiki maviri): Zvinokurudzirwa nguva dzose kutora mushonga wakaderera unoshanda kwenguva pfupi .
- Kune chirwere chenguva refu chakadai searthritis: Chiremba wako achaongorora nhoroondo yako yese yehutano, mimwe mishonga yaunotora, uye kunyange zvabuda muongororo yeropa kana zvichidikanwa, kuti aone kana zvakachengeteka kuti urambe uchitora mushonga uyu.
Chinhu chinonyanya kukosha ndechekuti ugare uchitora mushonga wawakanyorerwa nachiremba wako, sezvawakanyorerwa, uye kwenguva yakatarwa. Kana uine zvinokunetsa, iva nechokwadi chekuti wataura nachiremba wako usati warega mushonga kana kuchinja mushonga wacho.
Ndezvipi njodzi nemigumisiro yeCOX-2 inhibitors?
Sezvatakambokurukura, mukana mukuru wemishonga iyi ndeyekuti haina simba rakawanda padumbu nemudumbu. Asi izvi hazvirevi kuti haina njodzi. Mimwe migumisiro inogona kuitika, kunyanya kana ikatorwa yakawanda uye kwenguva yakareba.
Njodzi mbiri huru:
1. Njodzi yekurwara nemoyo nestroke: Mishonga yese yeNSAID, kusanganisira COX-2 inhibitors, inogona kuwedzera njodzi yekurwara nemoyo nestroke kusvika pamwero wakati. Njodzi iyi yakakura zvakanyanya kune vanhu vatova nezvinhu zvinokonzera chirwere chemwoyo, zvakaita seBP yakakwira uye cholesterol yakakwira.
2. Matambudziko emudumbu nemudumbu: Kunyangwe zvisingawanzoitiki seNSAIDs dzenguva dzose, zvinodzivirira COX-2 zvinogona kukonzera kubuda ropa mudumbu uye maronda mune vamwe vanhu. Njodzi iyi yakanyanya kukwira kune vakwegura nevaya vanotora mimwe mishonga inokonzera kuzvimba mudumbu.
Mimwe migumisiro inogona kuitika:
| Sisitimu yemuviri | Migumisiro inogona kuitika |
|---|---|
| Sisitimu yekugaya chikafu | Kuzvimba, kurwadziwa mudumbu, kuda kurutsa, kurutsa, manyoka, kuvimbiwa, uye chirungurira. |
| Mwoyo netsinga dzeropa | Kukwira kweropa (BP), kurova kwemoyo nekukurumidza kana kusina kurongeka (Palpitations), kashoma kurwara nemoyo kana sitiroko. |
| Itsvo | Kusashanda zvakanaka kweitsvo, kuzvimba kwemakumbo (edema) nekuda kwekuungana kwemvura nemunyu mumuviri, uye kuwedzera kwehuwandu hwepotassium muropa. |
| Sisitimu yetsinga | Musoro, dzungu. |
Havasi vese vanowana migumisiro yese yakanyorwa pane iyi rondedzero. Kana ukaona chimwe chezviratidzo izvi kana kuona chimwe chinhu chisingawanzoitiki, taurira chiremba wako nekukasika.
Ndiani asingafaniri kutora mushonga uyu?
Vamwe vanhu vane mamwe matambudziko ehutano havakodzeri kushandisa COX-2 inhibitors. Chiremba wako achafunga nezvese izvi asati akupa mushonga.
Vanhu vasingafaniri kutora mishonga inhibitor yeCOX-2:
- Kana wakambova nestroke kare.
- Kana uri kugadzirira kana kuti uchangobva kuvhiyiwa coronary artery bypass.
- Kana uine chirwere cheitsvo chakakomba kana kuti chiropa chako chisina kushanda zvakanaka.
- Kana wakamborwara neasthma kana kuti wakamborwara zvakanyanya mushure mekutora aspirin kana imwe NSAID.
- Kana uine allergy nemishonga inorwisa mabhakitiriya ye sulfonamide.
Avo vanofanira kungwarira zvikuru:
- Kana uchitova nemaronda mudumbu kana kubuda ropa.
- Kana uri mumwedzi mitatu yekupedzisira yekuzvitakura.
- Kana uri amai vanoyamwisa.
Kana uine chimwe chezvirwere izvi, unofanira kuudza chiremba wako.
Zviratidzo zvekunyevera zvinoda kurapwa nekukurumidza!
Kana ukaona chimwe chezviratidzo zvinotevera paunenge uchitora mishonga inhibitor yeCOX-2, rega kutora mushonga wacho wobva waona chiremba wako nekukasika kana kuenda kuchipatara chiri pedyo newe (ETU).
- Zviratidzo zvematambudziko echiropa: weti yakasviba, kuneta kwakanyanya, ganda kana maziso anotsvuka, tsvina ine ruvara rwakajeka, kurwadziwa mudumbu.
- Zviratidzo zvekubuda ropa: kurutsa ropa, kurutsa kunoita sekofi yakakuyiwa, ropa riri mutsvina kana tsvina nhema, ropa muweti, matadza anobuda ropa, uye mavanga ari nyore.
- Zviratidzo zvematambudziko eitsvo: kutadza kuita weti, kudzikira kwehuwandu hweweti, ropa muweti, kuwedzera uremu kamwe kamwe.
- Zviratidzo zvekurwara zvakanyanya: mapundu eganda, kuvaviwa, kuoma kufema, kufemereka, kuzvimba kwechiso, miromo, kana rurimi.
- Zviratidzo zvechirwere chemwoyo: kudzvanya kurwadziwa muchipfuva, kurwadziwa kupararira kuruoko rweruboshwe, shaya, kana kumusana, kuoma kufema, kudikitira.
- Zviratidzo zvestroke: kusanzwa kumeso, ruoko, kana gumbo, kuoma kutaura, uye musoro wakakomba kamwe kamwe.
Mharidzo Yekuenda Nayo Kumba
- COX-2 inhibitors imhando chaiyo yemishonga inoderedza marwadzo (NSAID) ine migumisiro mishoma mudumbu.
- Izvi zvinoshandiswa pakurapa arthritis, kurwadziwa panguva yekuenda kumwedzi, nezvimwe zvirwere zvinorwadza.
- Kusiyana nemishonga inorwadza nguva dzose, mishonga iyi inongonanga enzyme yeCOX-2 chete, iyo inokonzera marwadzo, uye haikanganisi enzyme yeCOX-1, iyo inodzivirira dumbu.
- Pasinei nekubatsira kwayo, mishonga iyi inogonawo kuwedzera njodzi yekubatwa nechirwere chemwoyo uye sitiroko kusvika pamwero wakati. Saka, zvakakosha kuishandisa chete kana yapihwa mazano nachiremba.
- Usambofa watora mushonga uyu muhuwandu hwakanyanya kana kwenguva yakareba kupfuura yawakarairwa usina kurairwa nachiremba.
- Kana ukaona zviratidzo zvisingawanzoitiki, tsvaga rubatsiro rwechiremba nekukasika.
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