Une nyota nguva dzose uye uri kuita weti kanenge ka20 pazuva here? Ndiwo here Arginine Vasopressin Disorders / Diabetes Insipidus?

Une nyota isingatsungiririki here? Unonzwa sekunge haugone kunwa mvura yakakwana here? Unofanirawo kuenda kuchimbuzi kakawanda pazuva, dzimwe nguva kunyange kamwe chete kana kaviri paawa? Kana uchifanira kumuka husiku kuti uite weti usina kurara zvakanaka, ichi hachisi chinhu chekurerutsa. Nhasi tichataura nezvechirwere chisingawanzoitiki asi chinorapika chinoratidza zviratidzo zvakafanana. Kare, ichi chainzi 'Diabetes Insipidus'.

Chii chinonzi Arginine Vasopressin Disorder?

Zvichitaurwa zviri nyore, chirwere ichi chinoitika kana muviri wako uchigadzira weti yakawandisa. Izvi zvinoreva kuti muviri wako haugone kuchengetedza mvura yakakwana. Chikonzero chikuru cheizvi idambudziko rehomoni inonzi Arginine Vasopressin (AVP) . Vanachiremba vanodanawo homoni iyi kuti ``AVP`` kuti Antidiuretic Hormone (ADH) . Homoni iyi ``AVP`` inoita basa rakakosha mukuchengetedza huwandu hwemvura mumuviri hwakaenzana kuburikidza neitsvo dzedu.

Kune mhando mbiri huru dzemamiriro ezvinhu aya:

1. Kushaikwa kweAVP (AVP-D): Izvi zvinoitika kana muviri wako usingagadzire hormone yeAVP yakakwana.

2. Kusagona kushanda zvakanaka kweAVP (AVP-R): Izvi zvinoitika kana itsvo dzako dzisisapindure zvakanaka nehomoni inonzi AVP. Izvi zvinoreva kuti kunyangwe homoni iyi iripo, itsvo hadziishandise.

Ndezvipi zviratidzo zvechirwere ichi?

Zviratidzo zvikuru zvekushaya AVP uye kuramba AVP ndeizvi:

• Kuda kuita weti nguva nenguva: Chiratidzo chikuru cheizvi kumuka kuti uite weti kwete masikati chete asiwo husiku (Nocturia) .
• Kuburitsa weti yakawanda ine ruvara rwakareruka kana ine mvura: Kazhinji, munhu anoburitsa weti iri pakati pe1 ne3 litre pazuva. Zvisinei, munhu ane chirwere ichi anogona kubvisa weti inosvika 20 litres pazuva. Fungidzira kuti yakawanda sei!
• Nyota yakawandisa (Polydipsia): Kunzwa sekuti hausi kudzima nyota yako zvisinei nekuti unonwa mvura yakawanda sei.

Zviratidzo izvi chiratidzo chakasimba chekuti pane chimwe chinhu chisina kushanda zvakanaka mumuviri wako. Zvakakosha kutsvaga rubatsiro rwechiremba nekukurumidza.

Zviratidzo izvi zvinobata sei vana vadiki?

Kana chirwere ichi chikaitika kuvana vadiki, zviratidzo zvacho zvinogona kunge zvakasiyana zvishoma. Zvimwe zvacho zvinosanganisira:

• Kushaya mvura yakakwana mumuviri.
• Kuzvimba.
• Kurutsa.
• Kugara uchirwara nefivha.
• Kuratidza hunhu hwekushatirwa uye hwekutsamwa.
• Kukura kuri kuderera / Kukundikana kukura.

Kana vacheche kana vana vadiki vaine zviratidzo izvi, vanofanira kuonekwa nachiremba nekukasika.

Sei matambudziko aya e arginine vasopressin achiitika?

Zvikonzero zvakasiyana-siyana, zvichienderana nerudzi rwambotaurwa.

Zvikonzero zvekushaikwa kweAVP `(AVP-D)`

Kare yainzi central diabetes insipidus , izvi zvinokonzerwa nekushaikwa kwehomoni inonzi arginine vasopressin (AVP). Iyi ndiyo mhando inonyanya kuwanikwa.

Izvi zvinogona kunge zvichikonzerwa ne:

• Kukuvadzwa kwehypothalamus kana pituitary gland (izvi zvikamu zvakakosha zveuropi zvinodzora mahormone). Kukuvadzwa uku kunogona kuitika nekuvhiyiwa kana kukuvara kwemusoro.
• Mimwe misiyano yemajini (Musiyano wemajini wakagarwa nhaka)
• Kuumbwa kwebundu .
• Kuzvimba / Granulomas inokonzerwa nezvimwe zvirwere, zvakaita se sarcoidosis kana TB.
• Dzimwe nguva, chikonzero chingasawanikwe (idiopathic) . Izvi zvinoreva kuti muinenge hafu yevarwere, chikonzero chacho hachizivikanwe.

Zvikonzero zvekusagona kushandisa AVP (AVP-R)

Rudzi urwu rwaimbonzi nephrogenic diabetes insipidus . Muchiitiko ichi, pituitary gland inogadzira hormone inonzi AVP, asi itsvo hadzipindure zvakanaka.

Pane zvikonzero zvinoverengeka zveizvi:

• Kumwe kuchinja kwemajini.
• Nzira yeweti yakavharika .
• Kushandisa mimwe mishonga kwenguva refu, kunyanya lithium .
• Kuwedzera kwecalcium muropa (Hypercalcemia) .
• Kushomeka kwepotassium muropa (Hypokalemia) .

Rudzi rwakakosha runoitika panguva yekuzvitakura

Izvi zvinonzi Gestational Arginine Vasopressin Disorder (gAVP-d) . Izvi hazviwanzoitiki. Munguva yekuzvitakura, placenta inoburitsa enzyme yakawandisa inopwanya hormone yeAVP.

Une mukana wekuva nechirwere ichi, nekuda kwechimwe chikonzero :

• Kana wakatakura mapatya kana vana vakawanda .
• Kana uine chirwere chinokanganisa mashandiro echiropa, senge preeclampsia kana HELLP syndrome .

Mashoko akanaka ndeekuti chirwere ichi che 'gAVP-d' chinowanzo pera mavhiki maviri kusvika matatu mushure mekusununguka.

Ndezvipi zvinetso zvechirwere ichi?

Dambudziko guru reAVP-D neAVP-R nderekushaya mvura mumuviri , kunova kurasikirwa nemvura nemaelectrolyte anodiwa kuti muviri ushande zvakanaka.

Kazhinji unogona kudzora kubuda kweweti yako nekunwa mvura yakawanda kupfuura yaunoda, asi kana usingadaro, unogona kupera mvura mumuviri nekukurumidza.

Kushaya mvura mumuviri kunogona kuisa upenyu panjodzi. Kana uine zviratidzo zvekupererwa nemvura mumuviri, zvakaita sedzungu, kuda kurutsa, kana kuneta zvakanyanya, enda kuchipatara chiri pedyo nekukurumidza.

Vanachiremba vanoona sei izvi?

Nekuti zviratidzo zvekunzwa nyota nguva dzose uye kuita weti zvinogonawo kukonzerwa nezvimwe zvirwere zvakajairika, vanachiremba vanotanga vabvisa zvimwe zvirwere pavanoongorora `AVP-D` kana `AVP-R`. Kana uine zviratidzo izvi, chiremba wako angangoda kuongororwa kakawanda.

Pakuongorora chirwere ichi, zvakakosha kuona kana chiri `AVP-D` kana `AVP-R` uye kuti chii chinokonzera.

Kuongororwa kwezvirwere

• Kuongororwa kwekushaya mvura: Iyi ndiyo nzira yakavimbika yekuongorora AVP-D kana AVP-R. Uchatariswa zvakanyanya panguva yekuongororwa uku, sezvo izvi zvinogona kukonzera kupera mvura mumuviri. Kuongororwa uku kunosanganisira kusanwa mvura kwemaawa akati wandei uye kuona kuti muviri wako unopindura sei. Kana uine chirwere ichi, ucharamba uchibuda weti yakawanda ine mvura, ine ruvara rwakajeka. Kana usina chirwere ichi, uchangobuda weti shoma yero yakasviba, yakaomeswa.
• Kuongororwa kweropa reCopeptin: Copeptin ichibereko chehomoni inonzi AVP.
• Kuongororwa kweshuga muropa: Izvi zvinoitirwa kutarisa chirwere cheshuga, icho chine zviratidzo zvakafanana.
• Kuongororwa kweweti: Izvi zvinoedza osmolality ( huwandu hweweti) uye ketones muweti.
• Miedzo yekufungidzira yakaita seMRI scans (MRI - Magnetic Resonance Imaging): Izvi zvinoitirwa kuona kana paine kukuvara kwepituitary gland kana hypothalamus.

Mishonga iyi inonzi `AVP-D` ne`AVP-R` inorapwa sei?

Kurapwa kunoenderana nekuti une `AVP-D` here kana `AVP-R`. Pasinei nekurapwa kwacho, zvakakosha kunwa mvura yakawanda kuti usapere mvura mumuviri.

Kurapa kweAVP-D (Kushomeka)

Desmopressin ndiyo mushonga mukuru wekurapa AVP-D. Mushonga unoshanda zvakafanana nehomoni AVP. Unogona kutorwa nenzira dzakasiyana (semuenzaniso, semushonga wekupfapfaidza mhino, sepiritsi).

Dzimwe nguva Desmopressin inoshandiswa padambudziko repamuviri risingawanzoitiki ``(gAVP-d)''. Zvisinei, dzimwe nguva panguva yekuzvitakura, inogona kudzorwa nekunwa mvura yakawanda.

Kurapa kweAVP-R (Resistance)

Kurapa `AVP-R` kwakaoma zvishoma. Dzimwe nguva nzira dzinoverengeka dzinofanira kushandiswa pamwe chete. Semuenzaniso:

• Mishonga yeThiazide diuretics(Kunyangwe iyi iri mhando yemishonga inowedzera weti, inoshanda zvakasiyana mumamiriro ezvinhu aya)
• Mishonga inodzivirira kuzvimba isiri yesteroidal (NSAIDs)

Kana chirwere che `AVP-R` chichikonzerwa nemushonga wauri kutora, chiremba wako anogona kukwanisa kurapa chirwere chacho nekukuchinjira kune mumwe mushonga.

Ndinofanira kuona chiremba rini?

Kana uine `AVP-D` kana `AVP-R`, zvakakosha kuti ugare uchiona chiremba wako kuti akupe mazano. Nenzira iyi, chiremba wako anogona kuita bvunzo dzekutarisa mamiriro ako uye kuona kuti kurapwa kwako kuri kushanda nemazvo.

Ungawana zvichibatsira kubvunza chiremba wako mibvunzo iyi:

• Ndine `AVP-D` kana `AVP-R` here?
• Chikonzero cheizvi chii?
• Chirwere ichi chisingaperi (chinogara kwenguva refu) here kana kuti ndechenguva pfupi?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Ndinofanira kunwa mvura yakawanda sei pazuva?
• Chii chimwe chandingaita kuti ndigadzirise mamiriro ezvinhu aya?
• Mhuri yangu iri panjodzi yekubatwa nechirwere che arginine vasopressin here?

Chii chandingatarisira kana ndiine `AVP-D` kana `AVP-R`?

Maonero (mhedzisiro) ezvirwere zve `AVP-D` ne `AVP-R` anowanzova akanaka. Kana ukashandisa mushonga wakakodzera uye ukanwa mvura yakakwana, haufanirwe kuva nematambudziko akakomba.

Zvisinei, vanhu ava vari panjodzi huru yekusangana nematambudziko:

• Vacheche
• Vanhu vane makore anopfuura 65 ekuberekwa
• Vanhu vane mamwe matambudziko ehutano hwepfungwa kana kuremara kwekukura

Vanhu ava vanogona kunge vachinetseka kuziva nyota yavo, kana kuti vangasakwanisa kuita chimwe chinhu nezvazvo.

Sei izvi zvisinganzi 'Diabetes Insipidus' pari zvino?

Muna 2022, masangano akati wandei ekurapa akasarudza kuchinja zita rekuti 'Diabetes Insipidus' kuita 'Arginine Vasopressin Deficiency' uye 'Arginine Vasopressin Resistance'. Chikonzero chikuru cheizvi kwaive kuvhiringidzika kwakakonzerwa neshoko rekuti 'diabetes' uye migumisiro yakaipa pahutano yayakakonzera.

Vanhu vazhinji pavanongoti "chirwere cheshuga", vanenge vachireva chirwere cheshuga . Chinokonzerwa nehuwandu hweshuga muropa. Chine zviratidzo zvakaita senyota yenguva dzose uye kuita weti. Zvisinei, chinowanzoitika kupfuura zvirwere zvinonzi `AVP-D` uye `AVP-R` (zvaimbonzi `Diabetes Insipidus`). Uyewo, kurapwa kwechirwere cheshuga kwakasiyana zvachose nekurapa `AVP-D` uye `AVP-R`.

Izwi rekuti "diabetes" rinobva pashoko rechiGiriki rekuti "diabetesine," rinoreva "kupfuura nepakati." Zita iroro rinoshandiswa nekuti, semuchirwere cheshuga, mvura inopinda nepakati pemuviri nekukurumidza, izvo zvinoitika muzvirwere izvi zve arginine vasopressin.

Pakupedzisira, ndinofanira kukuudzai... (Mharidzo Yekuenda Nayo Kumba)

Kana uine `AVP-D` (kushomeka kwearginine vasopressin) kana `AVP-R` (kuramba kurwisa arginine vasopressin), unganzwa sekunge unopedza hupenyu hwako hwakawanda uri muchimbuzi, usingakwanise kugutsa nyota yako zvisinei nekuti unonwa mvura yakawanda sei. Asi mashoko akanaka ndeekuti mamiriro aya anogona kudzorwa.

Chiremba wako achagadzira hurongwa hwekurapa hunokushandira, uye achakuudzawo kuti unofanira kunwa mvura yakawanda sei pazuva kuti ugare wakachena. Usatya. Tsvaga rutsigiro nenhungamiro kubva kuna chiremba wako. Yeuka, ichi hachisi "chirwere cheshuga." Ndosaka zvichikosha kuti uongororwe uye kurapwa kwakakodzera. Hausi wega, ramba uchiziva, uye ramba wakasimba.

Matambudziko eArginine Vasopressin, Chirwere cheshuga Insipidus, AVP, ADH, Nyota Yakawandisa, Kugara Uchinwa Weti, Kushaya Mvura Mumuviri, Polydipsia, Nocturia, Desmopressin, Itsvo, Mahormone