Pamwe hapana chinoshungurudza kupfuura kuona amai vedu vakwegura, baba, ambuya, kana sekuru vachikanganwa zvese zvishoma nezvishoma. Kutanga kubva pakukanganwa zvinhu zvidiki kusvika pakusayeuka kuti tiri vanaani kana kuti vana vedu ndivanaani, chirwere cheAlzheimer chirwere chinoita kuti tose tisava neanobatsira semhuri. Saka, ko kana chiedza chezuva chikaonekwa pakati pegore rakasviba kudaro? Ko kana paine nhau nezvemushonga mutsva unogona kunonoka kufambira mberi kwechirwere cheAlzheimer? Nhasi tichataura nezvetsvakurudzo itsva yakaunza tariro yakadaro.
Chii chinonzi Donanemab? Inoshanda sei?
Zvichitaurwa zviri nyore, Donanemab mushonga mutsva uri kugadzirwa kurapa chirwere cheAlzheimer. Unogadzirwa nekambani yemishonga inonzi Eli Lilly.
Zvino, chikonzero chikuru chechirwere cheAlzheimer chinofungidzirwa kuti kuunganidzwa kwepuroteni inokuvadza inonzi amyloid plaques muuropi. Kufanana nengura inoumba mumapombi edu emvura, mapuroteni aya anoungana pakati pemasero etsinga muuropi uye anovhiringidza mashandiro awo. Nekufamba kwenguva, izvi ndizvo zvinokonzera zviratidzo zvakaita sekurasikirwa nendangariro uye kunetseka kufunga.
Mushonga weDonanemab unonyanya kunanga ma deposits aya anonzi amyloid plaques. Kana mushonga uyu ukapihwa mumuviri, unoenda kuuropi, woona maprotein deposits aya asingadiwe, wotanga kuabvisa. Izvi zvinoshanda semushonga wekudzivirira muviri . Hwaro hwesainzi hweizvi ndechekuti nekuchenesa uropi nenzira iyi, zvinogona kunonotsa kufambira mberi kwechirwere.
Mhedzisiro yetsvagurudzo iyi yakabudirira zvekuti Eli Lilly ari kugadzirira kunyorera kuUS Food and Drug Administration (FDA) kuti abvumidze mushonga uyu kuti ushandiswe neveruzhinji.
Mhedzisiro inoshamisa yakaratidzwa neongororo
Uku hakusi kungoita tsvakiridzo chete. Uku kuyedzwa kwakaitwa nemaitiro asina kurongeka, kusingaonekwe kaviri, uye kunodzorwa ne placebo . Kureva kuti, varwere vakakamurwa kuita mapoka maviri, uye boka rimwe rinopihwa mushonga chaiwo, uye rimwe boka rinopihwa mushonga wenhema usina chinhu chinoshanda (placebo). Asi murwere kana timu iri kurapa havazivi kuti ndiani ari kuwana mushonga uyu. Nzira iyi inotibvumira kuyera kushanda kwechokwadi kwemushonga pasina rusaruro.
Saka ngatitarisei mimwe yemigumisiro kubva muongororo iyi. Izvi zvinoratidza kuti izvi zvinogona kuita mutsauko wakakura sei muhupenyu hwevarwere vane chirwere cheAlzheimer.
| Kuwanikwa kwekiyi | Tsananguro yemhedzisiro |
|---|---|
| Zviratidzo hazvisi kuipa zvakanyanya | 47% yeavo vakatora donanemab havana kuratidza kuwedzera kwezviratidzo mushure megore, zvichienzaniswa ne29 % chete yeavo vakatora placebo. |
| Kuderedza chirwere | Zvichienzaniswa nevaya vakatora mushonga we placebo, avo vakatora Donanemab vakaderera ne35% muhuwandu hwezvirwere hunowedzera. |
| Kukwanisa kuita mabasa ezuva nezuva | Kugona kuita mabasa ezuva nezuva akadai sekupfeka nekugadzika tii wega kwaderera ne40 % . Izvi zvinozorodza murwere nemhuri. |
| Njodzi yekufambira mberi kusvika padanho rinotevera rechirwere | Avo vakatora Donanemab vaiva ne39% yekudzikira kwenjodzi yekuenderera mberi kusvika padanho rinotevera, rakanyanya kuoma rechirwere ichi. |
| Mazinga e-amyloid europi | Kunyangwe mukati memwedzi mitanhatu chete yekutanga kurapwa, huwandu hwema plaque e amyloid muuropi hwevarwere hwakaderera zvakanyanya. |
Chidzidzo ichi chaisanganisira varwere vari muchikamu chekutanga chechirwere. Vakaiswawo muzvikamu zvichienderana nemazinga avo etau, rimwe puroteni rinoyera kuoma kwechirwere. Zvinoshamisa kuti kunyange varwere vane chirwere chakanyanya kukura uye huwandu hwakanyanya hwetau vakaona kubatsirwa kwakati kubva pamushonga uyu.
Tinozivawo nezvemigumisiro yakaipa.
Sezvinongoita mishonga yese, kune mimwe migumisiro inoshumwa. Patinotaura nezvetariro, tinofanira kuva vakatendeseka nezvenjodzi idzi.
Mhedzisiro huru inoonekwa nemushonga uyu chirwere chinonzi ARIA (Amyloid-Related Imaging Abnormalities) . Zvichitaurwa zviri nyore, uku kuzvimba kwenguva pfupi kana kubuda ropa muuropi. Zvinofungidzirwa kuti zvine chekuita nekubvisa amyloid.
- 24% yeavo vakatora DonanemabKuzvimba kwehuropi kwakaitika, asi vanhu 6% chete ndivo vakaratidza zviratidzo.
- Kubuda ropa kudiki kwakaitika muvanhu vanosvika 31% (izvi zvakaitikawo mu14% yeavo vakatora placebo).
Chinhu chakanakisa ndechekuti mazhinji ematambudziko aya eARIA haana kunyanya kuipa kana kuti ari pakati nepakati uye anogona kurapwa kana kugadziriswa nekurapwa kwakakodzera.
Zvisinei, hatifaniri kukanganwawo chokwadi ichi. Zvinosuwisa kuti vanhu vatatu vakafa nekuda kwechirwere ichi cheARIA vakashumwawo panguva yekudzidza uku. Izvi zvinotiratidza kuti kutarisirwa kwechiremba kwakakosha sei pakushandisa mushonga une simba kudaro.
Nyanzvi dzinoti chii nezveizvi?
Vanachiremba vetsinga pasi rose vari kufara nemhedzisiro iyi. Vamwe vari kuti, "Iye zvino tapinda munguva yekurapwa kwechirwere cheAlzheimer."
"Mushure memakore akawanda ekutsvaga kusina kubudirira, tava kuwana mhinduro dzinogara dzichiratidza kuti kubvisa amyloid kunogona kuchinja mafambiro echirwere," imwe nyanzvi yakadaro.
Chimwe chinhu chakasiyana nemushonga uyu inzira yaunopihwa nayo. Tsvagiridzo yakaratidza kuti kana puroteni inokuvadza yeamyloid muuropi yaderedzwa kusvika padanho rakati, mushonga uyu unogona kumira . Kurapwa kwamiswa mu52% yevarwere mukati megore uye mu72% mukati memwedzi gumi nemisere. Izvi zvakafanana "nekukonzera kuregererwa" kwechirwere uye kuchiona pasina kurapwa. Izvi zvinogona kuva mukana mukuru kune varwere pamwe nemutengo wekurapwa.
Asi dzimwe nyanzvi dzichiri kungwarira zvishoma. Dzinoti, "Mhedzisiro iyi inoita zvakanaka kwazvo, asi tinofanira kuona data rakazara. Pane migumisiro yakaipa, uye tinofanira kuziva zvakawanda nezvekuti inokanganisa sei varwere."
Mharidzo Yekuenda Nayo Kumba
- Donanemab haisi mushonga wechirwere cheAlzheimer, asi mushonga unononotsa zvakanyanya kufambira mberi kwechirwere, uye unopa tariro huru yeramangwana.
- Izvi zvinoshanda nekubvisa ma plaque ane njodzi anowanikwa muuropi.
- Izvi zvinobatsira varwere, kunyanya pakutanga kwechirwere, kuchengetedza ndangariro dzavo uye kugona kwavo kuita mabasa ezuva nezuva kwenguva yakareba.
- Kuzvimba kwehuropi uye kubuda ropa kudiki (ARIA)Pane njodzi yemigumisiro yakaipa, saka kana ukasarudza kurapwa uku, kunofanira kuitwa uchitarisirwa nachiremba zvakanyanya.
- Mushonga uyu uchiri muchikamu chekutsvagisa. Zvinotora nguva usati watanga kushandiswa muSri Lanka. Saka, kana mumwe munhu mumhuri yako ari kuratidza zviratidzo zveAlzheimer's, chinhu chakanakisa chekuita ndechekuona chiremba ane hunyanzvi nekukurumidza uye kutsvaga mazano.
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