Chii chinoitika kune firita yako yeitsvo? Ngatidzidzei nezveGlomerular Disease!

Wakambonzwa seuri kubuda weti ine furo here? Kana kuti unonzwa kuzvimba kumeso nemaziso paunomuka mangwanani? Izvi zvinogona kunge zvichikonzerwa nedambudziko renzira diki yekusefa iri muitsvo dzedu, inonzi glomeruli. Nhasi tichataura nezvechirwere ichi chinonzi Glomerular Disease.

Chii chinonzi Glomerular Disease?

Zvichitaurwa zviri nyore, chirwere cheGlomerular chirwere chinokonzerwa nemamiriro ezvinhu anokanganisa glomeruli, network yetsinga diki dzeropa dziri muitsvo dzedu, idzo dziri 'sefa' dzeitsvo. Maglomeruli aya ndiwo anosefa tsvina kubva muropa redu uye anobvisa mvura yakawandisa. Saka, kana maglomeruli aya akakuvara uye asingashande zvakanaka, tinoadaidza kuti Glomerular Disease.

Zvirwere zvakawanda nemamiriro ezvinhu zvinogona kukuvadza ma glomeruli aya. Kune mazwi maviri makuru anoshandiswa kutsanangura kukuvara uku:

• Glomerulonephritis: Uku kuzvimba kana kuzvimba kweglomeruli.
• Glomerulosclerosis: Uku ndiko kukora kwemavanga kana kuti kukora kweglomeruli.

Chirwere cheGlomerular chinogona kukuvadza itsvo dzako, uye dzimwe nguva, chinogona kutokonzera kutadza kushanda kweitsvo . Saka zvakakosha kuziva izvi.

Ma glomeruli aya ari muitsvo dzedu anoita sei?

Funga nezvazvo nenzira iyi: itsvo dzedu dzakaita semasefa maviri makuru ari mumiviri yedu. Nhengo mbiri idzi dzakaita sebhinzi dziri kumativi ese emusana wedu, pasi pembabvu dzedu.

Ropa rinopinda muitsvo dzedu kuburikidza netsinga. Kana rapinda muitsvo, tsinga idzi dzinopatsanuka uye ropa rinoyerera richipinda munetwork yetsinga diki dzeropa, dzakaita semesh dzinonzi glomeruli. Glomerulus yega yega (izwi rimwe chete) yakabatana nemugero mudiki unounganidza mvura, unonzi tubule . Tinodana iyi glomerulus imwe chete netubule unit kuti nephron . Zvinonzi kune ma nephrons akadaro angangoita miriyoni muitsvo imwe chete. Ungafungidzira here sisitimu yakapfava kudaro!

Kushanda zvakanaka kweglomeruli kunoita kuti masero eropa nemapuroteni zvirambe zviri muropa. Nekuti ndizvo zvinodiwa nemuviri wedu. Panguva imwe chete, glomeruli inosefa marara nemvura yakawedzerwa yotumira mvura iyoyo kutubule. Ndiyo inozogadzirwa seweti. Ipapo weti inopfuura nemumachubhu makuru anonzi ureters youngana mudundira.

Chii chinoitika pakushanda kweitsvo kana chirwere cheglomerular chikatanga?

Ngationei zvinoitika kana chirwere ichi cheGlomerular Disease chikatanga. Chirwere ichi chinokuvadza Glomeruli. Zvadaro hadzichagoni kushanda zvakanaka.

Chinofanirwa kuitika ndechekuti mapuroteni nemasero matsvuku eropa zvinochengetwa muropa. Zvisinei, zvimwe zvezvinhu izvi zvinotanga kubuda muweti kubva muglomeruli yakakuvara. Rimwe remabasa epuroteni muropa, senge albumin , nderekudhonza mvura yakawedzerwa kubva mumuviri kuenda muropa uye kubatsira kuti iseferwe neitsvo uye ibudiswe seweti. Saka, kana huwandu hweprotein muropa hukadzikira, mvura iyi yakawedzerwa inotanga kuungana mumuviri. Ndosaka nzvimbo dzakadai sechiso, maoko, makumbo, dumbu, nemakumbo zvichizvimba.

Uyewo, ma glomeruli akakuvara haakwanise kusefa tsvina zvakanaka. Zvadaro tsvina iyoyo inotanga kuungana muropa. Izvi hazvina kunaka kumuviri zvachose.

Ndezvipi zvikonzero zvechirwere cheGlomerular?

Pane zvikonzero zvakawanda zvinogona kukonzera chirwere cheGlomerular Disease. Ngationei kuti ndezvipi:

• Utachiona, mushonga kana kemikari inokuvadza itsvo dzako, kana kunyange mishonga yatinotora inogona kukanganisa itsvo.
• Zvirwere zvinobata muviri wese, kusanganisira zviya zvinobata itsvo. Semuenzaniso , chirwere cheshuga kana lupus .
• Zvirwere zvinokonzera kuzvimba kana mavanga e nephron kana glomerulus.
• Dzimwe nguva, zvingasakwanisika kuwana chikonzero. Pane dzimwe nguva dzakadaro.

Ndezvipi zviratidzo zveGlomerular Disease?

Zvakanaka, ngationei kuti zviratidzo zvechirwere ichi ndezvipi. Kana uine chimwe chezviratidzo izvi kana kupfuura, unofanira kunetseka nazvo:

• Weti ine furo: Izvi zvinoreva kuti mune mapuroteni muweti yako. Tinoidaidza kuti proteinuria .
• Weti yepingi kana yebrown yakapfava: Izvi zvinoreva kuti mune ropa muweti. Izvi zvinonzi hematuria .
• Kuzvimba kumeso/maziso (kunyanya mangwanani), maoko, tsoka, kana zvitsitsinho (kunyanya pakupera kwezuva). Kuzvimba uku kunonzi kuzvimba .
• Kukwira kweropa (BP).

Kana uine zviratidzo zvakadai, zvakanaka kuti uone chiremba uye utsvage mazano.

Vanachiremba vanoongorora sei chirwere ichi nemazvo?

Paunoenda kuna chiremba, vanotanga vakubvunza nezvezviratidzo zvako uye vanokuongorora zvakanaka. Zvadaro vanogona kuita mimwe miedzo, yakaita se:

• Kuongororwa kweweti:Izvi zvinotarisa huwandu hweprotein muweti, kana paine masero matsvuku eropa, uye kuti huwandu hwemasero machena eropa hwakaita sei (izvi zvinogona kubatsira kuona kana paine hutachiona kana kuzvimba).
• Kuongororwa kweropa: Izvi zvinoongorora huwandu hweprotein hwakaderera muropa, huwandu hwecreatinine (hunopa pfungwa yekushanda kweitsvo), uye huwandu hweurea nitrogen (chinhu chinoraswa). Zvinoverengawo Glomerular Filtration Rate (GFR) , inova chiyero chekuti itsvo dzako dziri kuchenesa tsvina zvakanaka sei.

Kana bvunzo idzi dzemurabhoritari dzikaratidza kuti itsvo dzako dzakakuvara, chiremba wako anogona kuraira dzimwe bvunzo:

• Kumwe kuongororwa kweropa: Kutarisa hutachiona kana zvirwere zvemuviri zvinorwisa muviri .
• Miedzo yekufungidzira: Muedzo wakaita se ultrasound unogona kutarisa kana paine kusarongeka kwechimiro kana saizi yeitsvo.
• Kuongororwa kweitsvo: Izvi zvinosanganisira kutora chidimbu chidiki chenyama kubva muitsvo uchishandisa tsono wochitarisa uchishandisa maikorosikopu. Izvi zvichabatsira kuona kuti chii chaizvo chiri kunetsa.

Matambudziko akasiyana-siyana uye marapirwo anokonzera chirwere cheGlomerular

Zvirwere zvakawanda zvinogona kukonzera chirwere cheGlomerular. Chinangwa chikuru chekurapa ndechekuwana chikonzero chacho uye kuchirapa, kana zvichibvira. Izvi zvinogona kudzivirira kukuvara kwakanyanya kuitsvo. Ngatitarisei zvimwe zvezvirwere zvikuru zvinokonzera chirwere cheGlomerular, pamwe chete nemienzaniso nemishonga.

Zvirwere zveAutoimmune

Izvi zvirwere umo masoja emuviri wako anorwisa muviri wako. Zvirwere izvi zvinogona kukanganisa muviri wese, kana kuti zvinogona kukanganisa nhengo dzemuviri chete. Heano mamwe ezvirwere zve autoimmune zvinokanganisa itsvo:

• Systemic Lupus Erythematosus (SLE) (inozivikanwawo se lupus): Chirwere ichi che autoimmune chinogona kukanganisa nhengo dzakawanda dzemuviri. Kana chikakanganisa itsvo, chinokonzera chirwere chinonzi lupus nephritis . Uku kuzvimba kweglomeruli. Kuzvimba uku kunokonzera mavanga uye itsvo dzinomira kushanda nemazvo. Kurapa kunosanganisira mishonga inodzvinyirira immune system yakaita seMycophenolate Mofetil kana Cyclophosphamide , pamwe chete ne corticosteroid inonzi Prednisolone .
• Chirwere cheGoodpasture:Chirwere ichi chinorwisa itsvo nemapapu. Muitsvo, chinokonzera glomerulonephritis, kunova kuzvimba kweglomeruli. Izvi zvinogona kukonzera kukuvara kweitsvo zvachose. Kurapa kunosanganisira mishonga inodzvinyirira immune uye plasmapheresis (inobvisa ma antibodies ari kurwisa muviri wako) .
• IgA Nephropathy: Muchirwere ichi che autoimmune, antibody inonzi Immunoglobulin A (IgA) inobva muimmune system yako inozviisa mu glomeruli. Madhizimusi aya anokonzera kuzvimba. Kurapa kunosanganisira mishonga yakaita seAngiotensin-Converting Enzyme Inhibitors (ACE inhibitors) kana Angiotensin Receptor Blockers (ARBs) .

Nhaka yeNephritis

• Alport Syndrome: Ichi chirwere chinogara nhaka. Chinogona kukonzera kurasikirwa nekunzwa kana kuona pamwe chete nechirwere cheglomerular chisingaperi. Chinobata varume nevakadzi. Varume vanowanzova nechirwere cheitsvo chisingaperi. Chinogona kuonekwa vari mumakore avo ekuma20. Pazera remakore makumi mana, itsvo dzinogona kunge dzisisina kushanda zvakanaka zvachose. Mishonga yekudzora BP ndiyo mushonga.

Chirwere cheGlomerular chine chekuita nehutachiona

Dzimwe nguva, chirwere cheglomerular chinogona kukura nekukurumidza mushure mekutapukirwa kune imwe nzvimbo mumuviri.

• Glomerulonephritis Inorwadza Mushure meKutapurirana (PIGN): Chirwere ichi cheglomerular chinoitika mushure mehutachiona hwehuro (Strep throat) kana hutachiona hweganda hunonzi Impetigo (izvi hazviwanzoitiki). Masoja emuviri anogadzira ma antibodies akawanda kupfuura zvinodiwa kurwisa hutachiona. Ma antibodies aya anoenda oisa mu glomeruli ovakuvadza. Kazhinji, hapana kurapwa kwakakosha kunodiwa. Zvisinei, mune zvisingawanzoitiki, dialysis yeitsvo kana kuisirwa itsvo zvinogona kudiwa.
• Bacterial Endocarditis: Uku kutapukira kwemukati memwoyo. Vaongorori havasati vava nechokwadi chekuti maronda ari muitsvo anokonzerwa nemaitiro emuviri wekudzivirira chirwere ichi kana kuti nedzimwe nzira dzekurapa. Mishonga inorwisa mabhakitiriya inopiwa senzira yekurapa.
• Mavhairasi: Hepatitis B , Hepatitis C uyeChirwere cheglomerular chinogonawo kukonzerwa nehutachiona hwakadai seHuman Immunodeficiency Virus (HIV). Mishonga chaiyo inowanikwa kune chirwere chimwe nechimwe.

Zvirwere zveSclerotic - Zvirwere zvinokonzera mavanga

• Glomerulosclerosis: Iyi ndiyo mavanga e glomeruli. Lupus nechirwere cheshuga mienzaniso miviri yezvirwere zvinogona kukonzera glomerulosclerosis.
• Nephropathy inokonzerwa nechirwere cheshuga: Ichi ndicho chikonzero chikuru chechirwere cheglomerular uye kutadza kushanda kweitsvo zvachose muUnited States. Nephropathy inokonzerwa nechirwere cheshuga inokonzera mavanga muitsvo uye inowedzera huwandu hweglucose. Glucose inowedzera kuyerera kweropa kuenda kuitsvo, zvichiita kuti glomeruli isashande zvakanaka uye iwedzere BP. Mishonga inowanzo shandiswa inosanganisira mishonga yeBP (kunyanya angiotensin-converting enzyme inhibitors (ACE inhibitors) kana angiotensin receptor blockers (ARBs) ), kurovedza muviri, uye kudya zvine hutano.
• Focal Segmental Glomerulosclerosis (FSGS): Chirwere ichi chinoratidzwa nekukuvadzwa (kazhinji) mune chimwe chikamu cheglomerulus. FSGS inogona kukonzerwa nechirwere chemuviri kana kuti nechikonzero chisingazivikanwi. Kurapa kwacho kwakanangana nekuderedza BP nemazinga echolesterol .

Zvimwe Zvirwere zveGlomerular

• Nephropathy yeMembranous: Chirwere ichi chinonziwo Membranous Glomerulopathy . Ndicho chikonzero chechipiri chinowanzo kukonzera nephropathy muvanhu vakuru muUnited States, mushure me nephropathy ine chekuita neshuga. Chinobatanidzwa nemamwe maantigen/antibodies . Chirwere ichi chinorwisa membrane layer ye glomeruli. Vamwe vanhu vanopora vasina kurapwa. Mishonga yakaita se angiotensin-converting enzyme inhibitors (ACE inhibitors) , angiotensin receptor blockers (ARBs) , kana calcineurin inhibitors dzimwe nguva inoedzwa.
• Chirwere Chekuchinja Kushoma (MCD): Urwu rudzi rwe nephropathy. Muizvi, kana zvikaongororwa mu biopsy yeitsvo, hapana shanduko inowanikwa muchimiro che glomeruli kana nyama dzakapoteredza. Mafuta (zvinhu zvine mafuta)Panogona kunge paine chirwere chekudonha kwemvura mumuviri, asi hapana kukuvara kweitsvo. MCD inogona kuitika chero pazera ripi zvaro, asi inonyanya kuitika kuvana vadiki. Kurapa kunosanganisira kudya kusina munyu wakawanda uye ACE inhibitors kana ARBs . MaSteroid anowanzo gadzirisa dambudziko racho.

Chirwere cheglomerular chinogona kukonzera kutadza kushanda kweitsvo here?

Ehe, kana itsvo dzako dzisingakwanisi kubvisa tsvina muropa rako, dzinoungana mumuviri wako. Kuungana uku kunogona kukuvadza itsvo dzako uye kuita kuti dzimire kushanda. Kurasikirwa nekushanda uku kunogona kuitika kamwe kamwe (kakuruma) kana zvishoma nezvishoma uye nguva dzose (nguva refu). Zvichienderana nerudzi rwechirwere cheglomerular, kushanda kweitsvo kunogona kurasika mumazuva mashoma kana mavhiki, kana kuti zvinogona kutora makumi emakore kuti zvinyangarike zvishoma nezvishoma.

• Kukundikana kweItsvo Zvakakomba (ARF): Uku kurasikirwa nekushanda kweitsvo kamwe kamwe. ARF inogona kuisa hupenyu panjodzi, uye dialysis inogona kudiwa senzira yekukurumidzira yekudzorera kushanda kweitsvo. Kune vamwe vanhu, kushanda kweitsvo kunodzoka mushure mekunge chikonzero chekutadza kushanda kweitsvo charapwa. Hapana kukuvara zvachose. Zvisinei, vamwe vanhu vanopora kubva kuARF vanogona kuzova nechirwere cheitsvo chisingaperi (CKD) .
• Chirwere cheItsvo Chisingaperi (CKD): Uku kurasikirwa kwekushanda kweitsvo zvishoma nezvishoma. Ungasava nezviratidzo kwemakore. Zvimwe zvezvirwere zvinokonzera CKD zvinogona kudzorwa, asi CKD haigone kurapwa. Kana itsvo dzakuvara, hadzigone kugadziriswa. CKD inogona kukonzera kutadza kushanda kweitsvo zvachose.
• Kukundikana kweItsvo Kwose: Kunonziwo End-Stage Renal Disease (ESRD) . Izvi zvinoreva kuti itsvo dzako dzarasikirwa nekushanda zvachose. Kana itsvo dzako dzakundikana zvachose, uchada dialysis - kungave hemodialysis kana peritoneal dialysis - kana kuisirwa itsvo kuti urarame.

Chii chandinofanira kutarisira kana ndine chirwere cheGlomerular Disease?

Kuongororwa kwechirwere nekukurumidza uye kurapwa nekukurumidza ndizvo zvakanakisa kuti uwane mhedzisiro yakanaka. Chinangwa chekurapa ndechekudzivirira kukuvara kweitsvo kana kudzora kufambira mberi kwayo. Yeuka, kuongororwa kweitsvo nekukurumidza kunogona kubatsira. Kana kukuvara kwacho kwakanyanya uye itsvo dzikatadza kushanda, sarudzo chete ndeye dialysis kana kuisirwa itsvo.

Chirwere cheGlomerular chinogona kudzivirirwa here?

Pane shanduko dzakawanda dzaunogona kuita mumararamiro ako kuti uderedze njodzi yako yekubatwa nezvirwere zvinokanganisa itsvo dzako uye urambe uine hutano hwakanaka. Izvi zvinosanganisira:

• Ramba uine huremu hwakanaka.
• Deredza kudyiwa kwemunyu; usawedzera munyu wakawanda pakudya.
• Chengetedza BP yako ichidzikama. Chinangwa chako ndechekusvika 120/80 mmHg.
• Kana uine chirwere cheshuga, dzora huwandu hweshuga muropa rako.
• Inwa mishonga yese yawakanyorerwa nachiremba wako sezvawakanyorerwa, uye tevedzera zvinangwa zvese zvekutarisira zvawakakurukura naye.
• Rega kusvuta.

Hazvisi zvese zvinokonzera chirwere cheglomerular zvinogona kudzivirirwa. Zvisinei, kana wangotanga kuona zviratidzo zvechirwere cheglomerular, enda kuna chiremba. Zvakakosha kuwana zvikonzero zvinorapika uye kutanga kurapwa nekukurumidza. Kurapa kunogona kubatsira kudzora kukuvara kweitsvo dzako uye kudzivirira kuti zvisanyanya kuipa.

Chii chinonzi Nephrosis kana Nephrotic Syndrome?

Nephrosis, inozivikanwawo se nephrotic syndrome, muunganidzwa wezviratidzo. Mapuroteni akawanda muropa anoburitswa muweti. Izvi zvinokonzera kuti mvura iungane mumuviri. Zviratidzo ndeizvi:

• Kuzvimba (edema), kunyanya kutenderedza maziso, makumbo nemaoko.
• Kukwira kweropa.
• Mazinga echolesterol akakwira.
• Kuderera kwehuwandu hwemapuroteni muropa.
• Kuwedzera kwemapuroteni muweti.

Chinangwa chekurapa ndechekurapa chikonzero chacho, kana zvichibvira. Kurapa kunosanganisira:

• Mishonga inodzivirira enzyme inochinja ropa inonzi Angiotensin (ACE inhibitors) kana kuti angiotensin receptor blockers (ARBs) inopiwa kudzora BP uye kudzivirira mapuroteni kupinda muweti.
• Deredza munyu mukudya kwako.
• Mishonga inodhaka (diuretics) inopiwa kuderedza kuchengetwa kwemvura mumuviri.
• Corticosteroids kana mimwe mishonga inodzvinyirira masoja emuviri inopihwa.
• Mishonga inopiwa kuderedza cholesterol.
• Kana uine chirwere che autoimmune, plasmapheresis inoitirwa kubvisa ma antibodies ari kurwisa muviri wako.

Kana chikonzero chikuru che nephrosis chiri chirwere cheitsvo, hachigone kurapwa. Nekuti glomeruli iri muitsvo haishande zvakanaka, tsvina nemvura zvinoungana muropa. Itsvo dzinotadza kushanda. Kana chirwere chikawedzera, kurapwa kungave dialysis kana kuti kuisirwa itsvo.

Ndinofanira kuona chiremba rini?

Kana uine zviratidzo zveGlomerular Disease, kana kuti ukaona shanduko muhutano hwako, iva nechokwadi chekuona chiremba. Usaregeredza kunyange chinhu chidiki-diki, nekuti kana ukangozviziva nekukurumidza, zvinova nyore kurapa.

Zvirwere zvakasiyana-siyana zvinogona kukanganisa glomeruli iri muitsvo dzako. Zvakakosha kuziva nezvemuviri wako kuitira kuti ugone kuona chiremba nekukurumidza kana ukaona shanduko.

Zvinhu zvakakosha zvekurangarira kubva muchinyorwa chino (Mharidzo Yekuenda Kumba)

Zvakanaka, saka ikozvino wava kunzwisisa zvakanaka zvatanga tichitaura nezvazvo, Glomerular Disease. Heano mamwe mashoko akakosha ekurangarira:

• Chirwere cheglomerular chirwere chinokonzerwa nekukuvara kwemasefa eitsvo (glomeruli).
• Ziva zviratidzo zvakaita seweti iri kubuda furo, ropa muweti, kuzvimba, uye BP. Kana ukaona izvi, enda kuna chiremba nekukasika.
• Kana uine zvirwere zvakaita sechirwere cheshuga neBP, zvakakosha kuti uzvidzore zvakanaka kuti udzivirire itsvo dzako.
• Kana chirwere ichi chikaonekwa nekukurumidza, kurapwa kunogona kudzora kukuvara kweitsvo. Saka usaregeredza zviratidzo chero zvipi zvazvo.
• Kuramba uine mararamiro ane hutano (kudya zvakanaka, kurovedza muviri, uye kusaputa fodya) kunobatsira kudzivirira zvirwere zverudzi urwu.

Itsvo dzako ndidzo nhengo mbiri dzinonyanya kukosha mumuviri wako. Dzitarisire. Kana uine matambudziko, usatya kutaura nachiremba, zvakanaka here?

` Chirwere cheitsvo, Chirwere cheGlomerular, Chirwere cheGlomerular, Kusefa kweitsvo, Glomeruli, Mapuroteni muweti, Ropa muweti, Kuzvimba kwemuviri, Kukwira kweropa, Kukundikana kweitsvo, Nephrosis