Ungave wakanzwa kuti pari zvino kune nzira dzekurapa dzakanyanya kunaka, dzakanangana nezvirwere zvakakomba zvakaita sekenza nearthritis. Saka, nhasi tichataura nezvekuwanikwa kunoshamisa kwemishonga kunobata nzvimbo yakakosha pakati penzira dzekurapa dzakadaro. Ndiwo "Monoclonal Antibodies". Kunyangwe zita racho ringaita serakaoma, mashandiro aro anogona kunzwisiswa zviri nyore.
Zvichitaurwa zviri nyore, maMonoclonal Antibodies aya chii?
Kuti tinzwisise izvi, tinofanira kutanga tadzidza nezve " antibodies " dziri mumiviri yedu. Masoja ekudzivirira chirwere masoja akakosha muimmune system yedu. Kana chimwe chinhu chisiri chemunyika (chatinoti maantigen ) chakaita sehutachiona hunokonzera chirwere kana sero rekenza chikapinda mumiviri yedu, ma antibodies aya anobuda oziva muvengi, omubata, otanga kumuparadza.
Fungidzirai kudai taigona kugadzira varwi vane hunyanzvi ava mumiviri yedu, pamwe chete nevamwe zviuru, murabhoritari? Ndizvo zvakaita ma antibodies e monoclonal . Aya ma antibodies ekugadzira akagadzirwa murabhoritari.
"Mono" zvinoreva "chimwe." "Clonal" zvinoreva "clone." Kureva kuti, aya zviuru zvemakopi chaiwo eantibody imwe chete. Kopi yega yega yakafanana. Yakagadzirirwa kunanga nekurwisa antigen imwechete. Kana ukatarisa bhodhoro remushonga raunopihwa nachiremba wako, zita remushonga uyu rinopera nemabhii ekuti "-mab" (semuenzaniso Trastuzumab, Adalimumab).
Ndeupi musiyano uripo pakati peMonoclonal nePolyclonal Antibodies?
Musiyano uyu uriwo mumazita. "Mono" zvinoreva rimwe chete, uye "poly" zvinoreva akawanda. Fungidzira kuti une rudzi rumwe chete rwemuvengi. Mauto ekudzivirira chirwere eMonoclonal anoshanda sekutumira commando akadzidziswa zvakakwana anogona kurwisa muvengi iyeye chete.
Kune rumwe rutivi, maPolyclonal Antibodies akafanana neuto remasoja ane hunyanzvi hwakasiyana, anokwanisa kurwisa marudzi akasiyana evavengi. Aya akafanana nema antibodies anogadzira miviri yedu, anoumbwa nemasero akasiyana eantibody, uye anogona kurwisa marudzi anopfuura rimwe evavengi (antigen).
| Hunhu | MaAntibodies eMonoclonal | MaAntibodies ePolyclonal |
|---|---|---|
| Kugadzirwa | Makoroni anobva musero rimwe chete reantibody | Kubva kumasero akasiyana-siyana e-antibody |
| Chinangwa | Antigen imwe chete chaiyo | Inogona kurwisa vavengi vakasiyana-siyana (maantigen) |
| Kushandiswa | Kurapwa kwakanangana uye kuongororwa kwakanangana | Kune mhinduro dzakajairika dzemuviri wekuzvidzivirira uye kumwe kuongorora chirwere |
Ndezvipi zvirwere zvinorapwa nenzira iyi yekurapa?
Ma antibodies eMonoclonal chishandiso chinoshamisa chinogona kushandiswa kurapa zvirwere zvakasiyana-siyana, kubva pakushandisa bvunzo dzepamuviri dzaunoshandisa kumba kusvika kumhando dzegomarara dzakakomba.
Heano mamwe emamiriro ezvinhu anonyanya kushandiswa pakurapa uku.
| Rudzi rwezvirwere | Mienzaniso |
|---|---|
| Kenza | Kenza yemazamu, kenza yemuura, kenza yemapapu, leukemia |
| Matambudziko ekuzvimba uye ekudzivirira muviri | Rheumatoid Arthritis, chirwere cheCrohn, Psoriasis, Kurwara |
| Utachiona | Zvirwere zvemavhairasi zvakaita seCOVID-19, RSV virus |
| Mamwe mamiriro ezvinhu | Osteoporosis, migraines, cholesterol yakakwira, zvimwe zvirwere zvemaziso, uye kudzivirira kuramba kuiswa nhengo |
Kurapwa uku kunopiwa sei?
Kazhinji, mishonga iyi ye monoclonal antibody inopihwa semvura mutsinga (intravenous - IV infusion) . Sekunge kupa saline. Izvi zvinowanzoitwa muyuniti yakakosha (infusion centre) yechipatara kana kiriniki.
Kana ukapihwa mushonga uyu kekutanga, vashandi vekurapa vachakuchenjerera zvikuru. Nekuti dzimwe nguva mushonga uyu unogona kukonzera allergy yakanyanya, unogona kukumbirwa kuti nhengo yemhuri iuye newe kekutanga.
Mamwe ma antibodies e monoclonal anowanikwawo sejekiseni repasi peganda . Muzviitiko zvakadaro, mukoti achakudzidzisa maitiro ekuzvipa jekiseni.
Chimwe chezvakanakira zvikuru zvekurapa uku ndechekuti kunogona kungonanga masero ane chirwere chete, zvichideredza kukuvara kwemasero ane hutano. Izvi zvakafanana nekuona muvengi mumwe chete ari munzvimbo yakazara vanhu womubata pasina kukonzera matambudziko kune vamwe.
Ndezvipi zvakanakira uye njodzi dzacho?
Sezvinongoita chero kurapwa kupi zvako, kune dzimwe njodzi dzinobatanidzwa. Asi musazvidya mwoyo, chiremba wenyu achakuudzai nezve zvese izvi uye achatora matanho ekudzivirira anodiwa.
- Kubatwa neInfusion Reactions: Uyu ndiwo mhedzisiro inonyanya kuitika. Zvinoreva kuitika kwemushonga mumuviri kana kuti nguva pfupi mushure mekunge wapiwa. Zviratidzo zvinogona kusanganisira mapundu eganda, fivha, kutonhora, kunetseka kufema, kudikitira, uye kuchinja kweBP. Izvi zvinogona kudzorwa nekuderedza mwero weinfusion panguva dzakadai.
- Kurwara kwakanyanya: Izvi hazviwanzoitiki, asi zvinogona kuisa hupenyu panjodzi. Semuenzaniso , anaphylaxis idambudziko rinowanzoitika kamwe kamwe.
- Cytokine Release Syndrome (CRS): Inozivikanwawo se 'cytokine storm', apa ndipo apo masoja emuviri anotanga kukurudzirwa zvakanyanya uye otanga kukuvadza nhengo dzemuviri.
- Dzimwe njodzi: Dzimwe njodzi dzinoenderana nechirwere chiri kurapwa. Semuenzaniso, kutadza kushanda kweitsvo kunogona kuitika nekuda kweTumor Lysis Syndrome, iyo inogona kuitika panguva yekurapwa kwegomarara.
Chero zvazvingava, chinhu chakakosha kurangarira ndechekuti kurapwa uku kunoitwa pasi pekutarisirwa kwakasimba kwechiremba. Saka, kana paine zviratidzo zvisingawanzoitika, vashandi vekurapa vanofanira kuziviswa nekukasika.
Chii chinoitika mushure mekurapwa?
Nguva inotora kuti mushonga upinde mumuviri wako (nguva yekuupinza) inosiyana. Inogona kutora inenge awa imwe chete, wobva wachengetwa pasi pekutariswa kweimwe awa.
Mushure mekurapwa, kana usina kuneta kana kusagadzikana, unokwanisa kuenda kubasa sezvawagara uchiita. Zvisinei, zvese izvi zvinofanira kusarudzwa nekutaura nachiremba wako, uyo anoziva mamiriro ako uye hutano hwako zvakanyanya.
Kana wakanyorerwa mushonga we monoclonal antibody, ikodzero yako kubvunza chiremba wako chero mibvunzo, zvinokunetsa, kana kusava nechokwadi kwaungave uinako nezvazvo.
Mharidzo Yekuenda Nayo Kumba
- Ma antibodies eMonoclonal ma antibodies ekugadzira akagadzirwa murabhoritari. Anobatsira masoja edu ekudzivirira muviri.
- Nekuti izvi zvinonangwa, zvinogona kuva nemigumisiro mishoma pane mishonga yechinyakare.
- Izvi zvinoshandiswa kurapa zvirwere zvakasiyana-siyana, zvinosanganisira kenza, arthritis, migraines, uye COVID-19.
- Mushonga uyu unowanzopihwa semushonga wemunyu mutsinga. Kusangana nemarwadzo (kusangana nemarwadzo) kunowanzoitika panguva iyi, asi kana ukaona zviratidzo zvakakomba, taura nachiremba wako kana dhipatimendi rekukurumidzira (ETU) nekukasika.
- Gara uchitaura nachiremba wako kuti uone kana kurapwa uku kwakakunakira uye kuti uwane rumwe ruzivo.
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