Ungave wakamboona mumwe munhu mumhuri mako, pamwe baba vako kana sekuru vako, vachitora mushonga wechirwere chemwoyo, BP, kana kusashanda zvakanaka kwenhengo dzemuviri. Saizvozvowo, vanachiremba vanopa mishonga yakasiyana-siyana yezvirwere zveganda, zvirwere zvekufema zvakaita seasthma, nezvimwewo. Waizviziva here kuti kune mhando yakakosha yemishonga inoshandiswa kurapa akawanda ezvirwere izvi? Mhando iyoyo yemishonga, inonzi Phosphodiesterase Inhibitors, ndiyo yatichataura nezvayo muchinyorwa chino nhasi, zviri nyore uye zvine hunhu.
Zvichitaurwa zviri nyore, chii chinonzi Phosphodiesterase Inhibitors?
Izvi zvinganzwika sezita rakaoma kunzwisisa, asi zviri nyore chaizvo. Iyi imhando yemishonga inobatsira kuzorodza nekuwedzera tsinga dzeropa mumiviri yedu, zvichiita kuti dzifambe zvakanaka. Kana kuyerera kweropa kwavandudzika, BP inodzorwawo. Ndokusaka mishonga iyi ichishandiswa kurapa zvirwere zvakasiyana-siyana, kubva paganda, majoini, mwoyo, nemapapu kusvika pakusashanda zvakanaka pabonde.
Mushonga uyu unoshanda sei mumuviri?
Miviri yedu ine rudzi rweenzyme inonzi Phosphodiesterases (PDEs) . Zvichitaurwa zviri nyore, maenzyme akafanana nemadiki anobatsira kukurumidzisa mashandiro emakemikari mumiviri yedu. Kune mhando dzakasiyana dzemaenzyme aya ePDE. Anoverengwa uye akaparadzaniswa. Chinhu chakakosha ndechekuti mhando yega yega yePDE enzyme inowanikwa munzvimbo dzakati wandei mumuviri.
| Rudzi rwe enzyme yePDE | Inowanzowanikwa uye inoshanda |
|---|---|
| PDE-3 | Izvi zvinonyanya kuwanikwa mumoyo mako nemutsinga dzeropa . Zvinobatsirawo mukugwamba kweropa. |
| PDE-4 | Izvi zvinowanikwa mumapapu . Zvinoita kuti tsandanyama dziri munzira dzekufema dziome uye dziome. |
| PDE-5 | Izvi zvinowanikwa mumapapu nemunhengo yemurume. |
MaPhosphodiesterase Inhibitors (PDE Inhibitors) anoshanda nekuvharira mashandiro emaenzymes ePDE ataurwa pamusoro apa. Zvakafanana nekuvhara gonhi. Mamwe maPDE Inhibitors anongoda rudzi rumwe chete rweenzyme (runosarudzwa), nepo mamwe achigona kukanganisa maenzymes ePDE kazhinji (asingasarudze).
Ndezvipi zvirwere zvikuru zvinorapwa nemushonga uyu?
Mishonga iyi inotenderwa kurapa zvirwere zvakasiyana-siyana zvinopfuura gumi nemaviri. Ngatitarisei zvimwe zvezvikamu zvikuru.
Zvirwere zvemwoyo neropa
- Kukundikana kwemoyo kwakabviswa muripo: Kana moyo ukatanga kushaya simba uye usingakwanise kupomba ropa mumuviri sezvinodiwa.
- Pulmonary hypertension: Kumanikidzwa kwakanyanya mutsinga dzeropa mumapapu.
- Kuderera kweropa rinoenda kumakumbo (Peripheral artery disease - PAD): Kusakwana kweropa, kunyanya kumakumbo.
- Kudzivirira kuumbwa kweropa mushure mekuvhiyiwa: Kuumbwa kweropa mushure mekuvhiyiwa kunogona kutungamira kuzvirwere zvine njodzi zvakaita sestroke, kurwara nemoyo, uye pulmonary embolism. Dzivirirai.
- Thrombocythemia: Kugadzirwa kwemaplatelet akawanda, ayo anobatsira kuumba ropa.
Zvirwere zvinozvimba zveganda nemapfundo
- Eczema (Atopic dermatitis): Kuzvimba, kutsvuka kweganda.
- Psoriasis: Kuzvimba kweganda kunokonzerwa nekushanda zvakanyanya kwemuviri.
- Psoriatic arthritis: Kuzvimba kwemajoini kunoitika ne psoriasis.
Zvirwere zvine chekuita nenhengo dzekubereka dzevarume
- Benign prostatic hyperplasia: Kuzvimba kweprostate gland nekuda kwezvikonzero zvisiri zvegomarara.
- Kusashanda zvakanaka kwenhengo dzesikarudzi: Kuomerwa nekuwana nhengo dzesikarudzi.
Zvirwere zvemudumbu
- Chirwere chemapapu chinogara kwenguva refu (COPD): Boka rezvirwere zvinokonzera kutadza kufema zvakanaka.
- Kusakwanisa kufema zvakanaka kwevana vacheche vasati vasvika nguva , kunyanya avo vanoberekwa vasati vasvika mavhiki manomwe.
Ndezvipi zvakanakira mushonga uyu?
Pane zvakanakira zvakawanda pakushandisa mishonga iyi.
- Mhando dzakanakira: Izvi zvinouya muchimiro chemapiritsi ekunwa, mafuta ekuzora, uye jekiseni remutsinga. Mimwe mishonga inofanira kutorwa zuva nezuva, asi mimwe inogona kutorwa chete kana ichidikanwa.
- Kurapa kwakanangana:Sezvatakambokurukura, sezvo kurapwa kuchigona kungoitirwa rudzi rwakati rwePDE enzyme, migumisiro isingadiwe inogona kuderedzwa zvakanyanya.
- Zvakanakira zvakawanda zvemushonga mumwe chete: Dzimwe nguva zvirwere zviviri zvinoitika pamwe chete zvinogona kurapwa nemushonga mumwe chete. Semuenzaniso, munhu ane prostate yakakura uye ane dambudziko rekusvuta anogona kupihwa mushonga wePDE-5 inhibitor tadalafil . Saizvozvowo, mushonga weApremilast unoshandiswa kurapa psoriasis nepsoriatic arthritis.
Ngatiziveiwo nezvemigumisiro nenjodzi.
Kufanana nemishonga yese, izvi zvinogona kukonzera migumisiro yakaipa. Migumisiro iyi inonyanya kuenderana nerudzi rwePDE inhibitor yauri kutora.
Zvakakosha: Kana ukatora mushonga wePDE-5 inhibitor (semuenzaniso Sildenafil, Tadalafil) wobva watanga kurwadziwa pachipfuva mukati memaawa makumi maviri nemana, wobva watora piritsi re nitroglycerin risingashandiswi, enda kuchipatara nekukurumidza. Kusanganiswa kwemishonga iyi miviri kunogona kukonzera kuderera kweropa zvine njodzi.
Heano mimwe migumisiro inogona kuitika ine chekuita nemapoka makuru emishonga.
| Rudzi rwemishonga | Migumisiro midiki uye ine mwero | Migumisiro yakaipa/ine njodzi |
|---|---|---|
| PDE-3 Inhibitors (Yakapihwa kumoyo) | Musoro, kushaya simba, kuzvimba, dumbu rinogumbura (kuda kurutsa, kurutsa), manyoka. | Kusashanda zvakanaka kwemoyo (arrhythmia), kurwadziwa pachipfuva, kubuda ropa kusingawanzoitiki, kuderera kwemaplatelet eropa. |
| PDE-4 Inhibitors (Yakapihwa kune zvirwere zvekufema/zveganda) | Kudzikira kwehuremu, kuda kurutsa, manyoka, musoro, kushaya hope, kuzvimba kwaishandiswa kirimu. | Kuwedzera kwekuora mwoyo, kufunga nezvekuzviuraya, hypersensitivity reactions (kuvaviwa kwakanyanya, kuzvimba). |
| Zvidziviriro zvePDE-5 (Yakapihwa nekuda kwekushaya simba pabonde) | Musoro, kusviba, dumbu rinogumbuka, mhino yakavharika, kurwadziwa kwetsandanyama, dzungu. | Kuzvimba kwenhengo yemurume (Priapism): Kumira kwenhengo yemurume kunorwadza kunotora maawa anopfuura mana pasina kukurudzirwa pabonde. Enda kuETU nekukasika. Kuchinja kwekuona, kudzikira kwekunzwa kana kurasikirwa nekunzwa. |
| Zvidziviriri zvePDE Zvisingasarudze (semuenzaniso Caffeine, Theophylline) | Kusagadzikana, kushaya hope, kudedera, kurwadziwa mudumbu, musoro. | Kurova kwemoyo nekukurumidza, kurova kwemoyo kusina kurongeka, pfari. |
Ndirini pausingafaniri kutora mushonga uyu?
Mushonga uyu unogona kuva nengozi kune vamwe vanhu. Kana uine chimwe chezvirwere zvinotevera, unofanira kutaura nachiremba wako usati watora mushonga uyu.
- Kune chero chinhu chinodzivirira PDE: Kana wakambova neallergy yakanyanya (hypersensitivity) kune chero mushonga kana chimwe chinhu.
- Cilostazol (PDE-3): Izvi hazvikurudzirwi kana uine chirwere chemwoyo.
- PDE-5 inhibitors: Unofanira kudzivisa kutora mishonga iyi kana uine chirwere chemwoyo chakakomba, wakambova nechirwere chemwoyo kana sitiroko munguva pfupi yapfuura, kana kuti une angina isingagadzike.
- Kana uri kutora nitrates , kutora PDE-5 inhibitors kunogona kukonzera kuti BP yako iderere zvakanyanya.
- Mamwe maPDE inhibitors (semuenzaniso Cilostazol) haana kukodzera kana uine chirwere chekubuda ropa.
Shandisa panguva yekuzvitakura
Kana uine pamuviri kana kuti uchironga kubata pamuviri, zvingave zvakanaka kusatora mamwe marudzi emishonga inodzivirira PDE. Bvunza chiremba wako nezvenyaya iyi.
Unofanira kuona chiremba nekukasika rini?
Zvakanaka kuudza chiremba wako kana ukaona zviratidzo zvisingawanzoitika paunenge uchishandisa mushonga uyu. Zvisinei, kana chimwe chezvinotevera chikaitika, enda kuchipatara nekukurumidza.
- Zviratidzo zvechirwere chemwoyo:Zvinhu zvakaita sekurwadziwa pachipfuva, kuoma kwekufema, kudikitira, dzungu, kuda kurutsa.
- Kusasimba: Kumira kwenhengo yemurume kunorwadza kunotora maawa anopfuura mana pasina kukurudzirwa pabonde. Ichi chirwere chinoda kurapwa nekukasika.
- Kurasikirwa/kudzikira kwekuona kana kunzwa kamwe kamwe: Izvi zvinofanirwa kurapwa zvisati zvakuvara zvachose.
Mishonga iyi inokosha zvikuru, inoponesa hupenyu uye inovandudza hupenyu. Asi inofanira kutorwa chete kana yakurudzirwa nachiremba uye muchiyero chakatarwa.
Mharidzo Yekuenda Nayo Kumba
- Mishonga inodzivirira phosphodiesterase iboka remishonga ine simba inorapa zvirwere zvakasiyana-siyana, zvinosanganisira chirwere chemwoyo, kusagadzikana pabonde, zvirwere zveganda, uye zvirwere zvekufema.
- Nguva dzose tora mishonga iyi kana wakurudzirwa nachiremba chete . Dzivisa kubvunza shamwari kana kukumbira mishonga ku pharmacy woishandisa wega.
- Udza chiremba wako nezve mimwe mishonga yauri kutora uye zvimwe zvirwere zvaunazvo.
- Kana ukasangana nemigumisiro yakaipa yakadai sekurwadziwa pachipfuva, kupererwa nepfungwa kwenguva inodarika maawa mana, kana kuona kamwe kamwe kana kurasikirwa nekunzwa, enda kuchipatara kuEmergency Department (ETU) nekukasika.
- Usambofa wakagovana mushonga wako nemumwe munhu. Mushonga wakakodzera mumwe munhu unogona kuva nengozi kune mumwe munhu.
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