Chii chinonzi POEMS Syndrome? Unodawo kuziva nezveizvi here?

Wakambonzwa nezvePOEMS Syndrome here? Ichi chirwere chisingawanzonzwikwa. Zvisinei, zvakakosha kuziva zvishoma nezvacho nekuti chinogona kukanganisa masisitimu mazhinji mumuviri wedu panguva imwe chete. Zvichitaurwa zviri nyore, chirwere chakaoma chine chekuita neropa redu. Nhasi, tichataura nezve POEMS Syndrome chii, zviratidzo zvayo ndezvipi, inoonekwa sei, uye kana paine kurapwa.

Chii chinonzi POEMS Syndrome?

Zvakanaka, ngationei kuti POEMS Syndrome chii. Ichi chirwere cheropa chisingawanzoitiki. Tine rudzi rwemasero eropa anonzi plasma cells mumuviri wedu. Kana POEMS syndrome ikaitika, masero aya eplasma anopatsanuka uye anowanda zvisingawanzoitiki, zvisingadzoreki. Masero aya eplasma asina kujairika anoburitsa protein yakakosha muropa redu. Inonzi monoclonal protein, kana kuti M-protein muchidimbu. Zvino unogona kufungidzira, handiti? Kana masero aya eplasma asina kujairika, M-protein, akawedzera zvakanyanya muropa, zvinogona kukuvadza tsinga dzedu nenhengo dzemukati.

Zita rekuti POEMS rinobva pamavara ekutanga ezviratidzo zvishanu zvikuru zvechirwere ichi:

• P - Polyneuropathy: Izvi zvinoreva kukuvara kwetsinga mumuviri wese. MuNHEYO, kukuvara uku kunogona kukonzera marwadzo kana mamwe manzwiro asina kunaka (akadai sekukwenya, kupisa, nezvimwewo) mumakumbo ako, maoko, pasi, nemaoko.
• O - Organomegaly: Izvi zvinoreva kuti nhengo dzemukati dzinokura zvisingawanzoitiki. Munhu ane POEMS anogona kunge aine nhengo dzakakura dzakadai sechiropa, chirwatata, uye lymph nodes.
• E - Endocrinopathy: Muchidimbu, iri idambudziko remahormone. MuPOEMS, huwandu hwemahormone anoburitswa nema endocrine glands edu hunogona kunge husina kujairika. Mamwe mahormone anogona kuburitswa akawandisa kana kuti muhuwandu hudiki.
• M - Monoclonal protein (M-protein): Iyi ndiyo protein inokosha inoungana muropa muPOEMS. Kana sero rimwe chete replasma rikaita makopi akawanda (clones) aro, rimwe nerimwe remasero iwayo rinowedzera iyi M-protein muropa. Pakupedzisira, huwandu hweM-protein muropa hunowedzera zvakanyanya.
• S - Kuchinja kweganda: Vanhu vane ZVINHU ZVINOKOSHA vanogona kusangana nekuchinja kwakasiyana-siyana kweganda, sekusviba kweganda uye kukora kweganda.

POEMS syndrome inozivikanwawo se osteosclerotic myeloma , Crow-Fukase syndrome , PEP syndrome , uye Takatsuki syndrome .

Ndiani anonyanya kukonzera chirwere chePOEMS?

Chirwere chePOEMS chirwere chisingawanzoitiki. Chinongobata vanhu vashoma pasi rose. Chinonyanya kuonekwa muvanhu vane makore ari pakati pe50 ne60. Chinogona kubata vanhurume nevanhukadzi, asi chinoita sechinowanzoitika muvarume.

Ndezvipi zviratidzo zvePOEMS syndrome?

Sezvatakambotaura, mavara ari muzita rekuti POEMS anoratidza zvimwe zvezviratidzo zvikuru. Kureva kuti, Polyneuropathy, Organomegaly, Endocrinopathy, M-protein elevation, uye shanduko dzeganda ndizvo zviratidzo zvikuru. Anenge munhu wese ane POEMS ane polyneuropathy uye M-protein elevation. Zvimwe zviratidzo zvinogona kusiyana kubva pamunhu nemunhu.

Zviratidzo zvinokonzerwa ne polyneuropathy

Zviratidzo zvinokonzerwa nekukuvara kwetsinga uku ndizvo zvinonyanya kuwanikwa muNHEMBO. Kazhinji, kurwadziwa kunonyanya kunzwika mumakumbo netsoka. Asi dzimwe nguva kunogona kukanganisa maoko nemaoko. Heino manzwiro aungaita kana uine chirwere ichi:

• Kushaya simba
• Kurira
• Kushaya simba
• Kunzwa kwekubaya /kunzwa kwepini netsono
• Kunzwa kupisa

Organomegaly - kuwedzera kwenhengo dzemukati

Maitiro ekutora mifananidzo anoitwa navanachiremba anogona kuona kana nhengo idzi dzakakura:

• Chiropa (Chiropa - `(Hepatomegaly)`)
• Danda (Spleen)
• Manodhi eLymph (Manodhi eLymph - `(Lymphadenopathy)`)

Endocrinopathy - matambudziko ehomoni

Dambudziko guru remahormone rinouya nePOEMS kudzikira kwehuwandu hwemahormone epabonde. Mahormone aya epabonde anonzi ``Testosterone``` muvarume uye ``Estrogen``` muvakadzi. Pamusoro pezvo, unogona kuona zviratidzo zvakaita se:

• Matambudziko ekudzora huwandu hweshuga muropa (semuenzaniso chirwere cheshuga)
• Matambudziko e thyroid (semuenzaniso Hypothyroidism)
• Chirwere cheAddison (Kusakwana kweAdrenal - `(Chirwere cheAddison)`)

Varume vanogona kusangana nedambudziko rekushaya mbereko uye kukura kwemazamu (Gynecomastia).

Kuvakadzi , kuenda kumwedzi kunogona kumira (`(Amenorrhea)`), mazamu anogona kukura. Munguva yekuzvitakura, hormone `(Prolactin)`, iyo inobatsira mukugadzirwa kwemukaka, inogona kugadzirwa zvakanyanya. Saka, zvinokwanisika kuti mukaka ubude mumazamu kunyangwe usina pamuviri.

Kuwedzera kweM-Protein

Chinhu chikuru chePOEMS huwandu hwakakwira hweM-protein muropa. Kuwanda kweM-protein uku kunogona kukonzera kuumbwa kwebundu muropa. Zvakare, nekuda kwehuwandu hwakawanda hweM-protein, yakoMapfupa anogona kuomarara uye kuomarara (osteosclerosis) .

Kuchinja kweganda

Kuchinja kwakasiyana-siyana kweganda kunogona kuitika, kwakadai se:

• Ganda rakasviba
• Ganda gobvu
• Nzara chena
• Kuwedzera kukura kwebvudzi pachiso nemakumbo
• Kukura kwetsinga dzeropa dzinoita semacherry madiki paganda rechipfuva

Zvimwe zviratidzo

Pamusoro peizvi, zvimwe zviratidzo zvinogona kuonekwa:

• Kuzvimba kwemaoko netsoka
• Kuderedza uremu pasina chikonzero
• Kurwadziwa mumapfupa nemajoini
• Kutadza kuona zvakanaka
• Kuoma kufema
• Kuneta
• Kupindwa nechando

Vamwe vanhu vane chirwere chePOEMS vanogonawo kunge vaine chirwere chinonzi Castleman Disease (CD), chinokanganisa ma lymph nodes. Kana uine zviratidzo zveCastleman Disease, chiremba wako anogonawo kufungidzira kuti POEMS.

Chii chinokonzera chirwere chePOEMS?

Kana uine POEMS, unosangana nezviratidzo zvakasiyana-siyana uye mhedzisiro inokonzerwa nechirwere chemasero eplasma emonoclonal . Zvichitaurwa zviri nyore, sero replasma risingawanzoitiki rinozvigadzira zvakawandisa. Kana masero aya akawanda, anogona kukonzera kukuvara kukuru kumatishu. Masero aya anowedzera M-protein muropa, zvichiita kuti huwandu hweM-protein muropa huwedzere. Masero aya akawandisa uye M-protein ndiwo anokuvadza masisitimu akasiyana-siyana mumuviri.

Zvisinei, masayendisiti haasati aziva kuti sei masero aya eplasma achitanga kukura zvisina kujairika pakutanga.

Vaongorori vakaona kuti puroteni inonzi Vascular Endothelial Growth Factor (VEGF) inogona kunge iriyo. Vanhu vazhinji vane POEMS syndrome vane huwandu hwakawanda hweVEGF muropa ravo. Tsvagiridzo pamusoro pehukama huripo pakati peVEGF nePOEMS syndrome ichiri kuenderera mberi.

Chirwere chePOEMS chinoonekwa sei? (Kuongororwa)

Chiremba wako achatanga nekukubvunza nezvenhoroondo yako yezvekurapa uye zviratidzo zvauri kuratidza pari zvino. Zvadaro, vachakuongororwa kuti vaone kana paine zviratidzo zvePOEMS syndrome.

Pamusoro pezvo, chiremba anogonawo kuita bvunzo dzakasiyana siyana, dzakadai se:

• Kuongororwa kweropa neweti: Kuongororwa uku kunogona kubatsira kuona kana paine huwandu hwakakwira hweM-protein kana VEGF muropa rako kana weti. Kunogonawo kutarisa huwandu hwemasero eropa husina kujairika kana masero eropa asingatarisike zvakanaka. Izvi zvinogona kuva zviratidzo zvePOEMS.
• Kuongororwa kwemifananidzo: Kuongororwa kwakadai seX-rays neCT scans kunogona kuratidza kana mapfupa ako akakora kana kuti akaomarara. Kuchinja uku kunogona kuitika kana huwandu hweM-protein hwakwira.
• Kuongororwa kwemapfupa emubofu: Izvi zvinogona kuona kana uine masero eplasma asingatarisike zvakanaka mumapfupa ako emubofu, kana kuti huwandu hwemasero eplasma hwakanyanya.
• Electromyogram (EMG): EMG ibvunzo inoyera mashandiro etsinga. Inogona kubatsira chiremba wako kuona polyneuropathy.

Zvichienderana nezviratidzo zvako, chiremba wako anogonawo kuita mimwe miedzo, yakadai seyekufema, echocardiograms, kana bvunzo dze endocrine.

Kana wakamboonekwa uine chirwere chinonzi Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) , chiremba wako anogonawo kukuyedza kuti aone kana uine POEMS syndrome.

Chirwere chePOEMS chinorapwa kana kurapwa sei?

Hapana mushonga wePOEMS syndrome. Zvisinei, kurapwa kunogona kubatsira kudzora nekubata zviratidzo. Sarudzo dzekurapa dzinosanganisira:

• Kurapa nemwaranzi: Izvi zvinosanganisira kutungamira mwero wemwaranzi wakakwira pamasero eplasma asina kujairika kuti uaparadze.
• Kurapa neKemotherapy: Mishonga yekurwisa kenza, inozivikanwawo se "Chemotherapy," inoshandiswa kuuraya kana kuderedza kukura kwemasero eplasma asina kujairika. Kurapa neKemotherapy yePOEMS kwakafanana nekurapa multiple myeloma. Kurapa uku kunoshanda zvikuru uye kazhinji hakukonzeri migumisiro yakaipa.
• Kuisirwa kwemasero emuviri (Autologous stem cell transplant): Maitiro aya anotsiva masero ako eplasma asina kujairika nemasero emuviri ane hutano. Masero emuviri ndiwo masero anokura kuita masero akakura semasero eplasma. Mukuisirwa uku, chiremba wako anotanga abvisa mamwe masero emuviri ane hutano mumuviri wako. Zvadaro, vanoshandisa chemotherapy kana radiation therapy kuparadza masero eplasma asina kujairika. Mushure mekurapwa, masero emuviri akabviswa anodzoserwa mumuviri wako. Anozokura kuita masero eplasma ane hutano.
• Kurapa muviri: Kana uchinetseka nekufamba nekuda kwe polyneuropathy, kurapwa uku kunogona kubatsira.

Pamusoro pezvo, chiremba anogona kunyora mishonga yakaita semasteroid ekuderedza zviratidzo uye mapiritsi emvura ekuderedza kuzvimba.

Ndezvipi zvinetso zvinobatanidzwa nePOEMS syndrome?

Nechirwere chePOEMS, kukuvara kwetsinga uye kushaya simba kunogona kuwedzera nekufamba kwenguva. Zvinogonawo kuita kuti zviome kufamba-famba. Kana mvura yakawanda ikawanda pedyo nemapapu kana mukati mechipfuva, zvinogona kukonzera kurwadziwa kwechipfuva uye kuoma kufema.

Asi yeuka,Kurapa kunobudirira kunogona kumisa kana kuderedza kukuvara kwetsinga. Kunogonawo kubatsira kuderedza zvimwe zviratidzo. Kunyangwe kukuvara kwetsinga kunogona kupora zvishoma nezvishoma nekufamba kwenguva.

Pane zvinhu zvinokonzera njodzi yePOEMS syndrome here?

Parizvino hapana zvinhu zvakawanikwa zvinogona kukonzera POEMS syndrome.

Ko chirwere chePOEMS chinogona kudzivirirwa here?

Zvinosuwisa kuti chirwere chePOEMS hachidziviriki.

Chii chinonzi fungidziro yevanhu vane POEMS syndrome?

Hutano hwako hunoenderana nezvinhu zvakawanda, zvinosanganisira kuti ndeapi nhengo dzemuviri wako dzinobatwa nechirwere ichi, kuti chirwere ichi chinokurumidza kuonekwa sei uye kuti chinotanga kurapwa sei, uye kuti unoita sei kana warapwa.

Zvakakosha kuti munhu arapwe chirwere chePOEMS. Chirwere chePOEMS chinogona kuisa upenyu panjodzi kana chikasarapwa. Kune rumwe rutivi, kurapwa kunobudirira kunoparadza masero eplasma asina kujairika kunogona kukubatsira kuti urarame kwenguva yakareba. Pamusoro pezvo, kurapwa kunogona kuderedza zviratidzo uye kuvandudza hupenyu hwako.

Avhareji yehuwandu hwevanhu vazhinji vane POEMS inorarama makore angangoita gumi nemana. Izvi zvinoreva kuti hafu yevanhu vanorarama makore asingasviki gumi nemana, nepo imwe hafu ichirarama kwenguva yakareba. Nguva yako yekurarama inoenderana neruzivo rwako rwechirwere uye kurapwa.

Bvunza chiremba wako nezveramangwana rako semunhu anorarama nePOEMS syndrome.

Unofanira kuona chiremba rini nezve POEMS syndrome?

Kana ukaona zviratidzo zvine chekuita nePOEMS syndrome, kunyanya kushaya simba kwemaoko nemakumbo , enda kuna chiremba nekukasika.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu nezve POEMS syndrome?

Unogona kubvunza mibvunzo yakaita seiyi:

• Dambudziko rangu rakakomba zvakadii?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Chii chandinofanira kuita kuti ndideredze kana kudzora migumisiro yakaipa?
• Ndedzipi nzira dzekubatsira dziripo kwandiri?
• Ndinofanira kuona chiremba ane ruzivo nezvezvirwere zvemasero eropa kuti anditungamirire pakurapwa kwangu here?

Ndingadzokera rini kumabasa angu enguva dzose kana ndine chirwere chePOEMS?

Chirwere chePOEMS chinogona kukanganisa kugona kwako kuita mabasa ako ezuva nezuva. Chiremba wako achakutsanangurira kuti chirwere ichi chichakanganisa sei hupenyu hwako hwezuva nezuva.

Ko POEMS syndrome chirwere che autoimmune here?

Nhetembo chirwere cheparaneoplastic.Hachisi chirwere che autoimmune. Paraneoplastic syndrome muunganidzwa wezviratidzo zvinokonzerwa nechirwere chiripo. MuPOEMS, dambudziko guru nderekuti masero eplasma asina kujairika anogadzira M-protein yakawandisa muropa (chirwere chemasero eplasma emonoclonal). Zviratidzo zvePOEMS zvinokonzerwa nemasero eplasma asina kujairika uye M-protein inokuvadza tishu dzemuviri.

Ko chirwere chePOEMS chakafanana here nechirwere chemultiple myeloma?

Multiple myeloma igomarara rinokanganisa masero eplasma. POEMS syndrome muunganidzwa wezviratidzo zvinokonzerwa nemasero eplasma asina kujairika uye kuwedzera kweM-protein. Mwero wekurarama kwePOEMS syndrome uri nani pane hupenyu hwe multiple myeloma.

Zvisinei, kurapwa nechemotherapy yePOEMS nemultiple myeloma kunowanzo fanana. Zvimwe zvezviratidzo zvinogona kunge zvakafananawo.

POEMS syndrome chirwere chakaoma kunzwisisa. Zvinogona kutora chiremba wako nguva kuti aone kuti zviratidzo zvako zvinokonzerwa nePOEMS syndrome kwete nechimwe chirwere. Kana wangoonekwa kuti une chirwere ichi, shanda pamwe chete nechikwata chako chekurapa kuti uone kuti ndeapi marapirwo achakubatsira zvikuru kubva pazviratidzo zvako. Bvunza chiremba wako nezvemasangano kana mapoka ekutsigira anobatsira vanhu nemhuri dziri kubata nechirwere ichi sePOEMS syndrome.

Mharidzo Yekuenda Nayo Kumba

Zvakanaka, saka tataura zvakawanda nezvePOEMS Syndrome nhasi. Chinhu chakakosha kunzwisisa kuti ichi chirwere chisingawanzoitiki, asi chakakomba . Chinogona kukanganisa masisitimu mazhinji mumuviri wedu.

• Zita rekuti POEMS rinobva pamabhii ekutanga emazita eChirungu ezviratidzo zvishanu zvikuru (kusagadzikana kwetsinga, kukura kwenhengo dzemukati, matambudziko emahormone, kuwedzera kweM-protein, uye kuchinja kweganda).
• Chikonzero chikuru cheizvi masero eplasma asina kujairika uye M-protein yaanogadzira.
• Kunyange hazvo pasina mushonga wakakwana, kune mishonga inoshanda yekudzora zviratidzo uye kuvandudza hupenyu.
• Zvakakosha zvikuru kuongorora chirwere ichi uye kutanga kurapwa nekukurumidza .

Kana uine chimwe chezviratidzo izvi, ndapota tsvaga rubatsiro rwechiremba. Usavhunduke, neruzivo rwakakodzera uye rutsigiro rwechiremba, unogona kugadzirisa mamiriro ezvinhu aya.

` POEMS syndrome, zvirwere zveropa, kukuvara kwetsinga, matambudziko emahormone, M-protein, shanduko dzeganda, plasma cells