Unonzwa kurwadziwa here nekushandisa mushonga wekutindivadza? Ngatidzidzei nezve (Pseudocholinesterase Deficiency)?

Wakambotya here nezve anesthesia yaunopiwa pakuvhiyiwa? Zvakajairika kuti vamwe vanhu vanzwe saizvozvo. Asi fungidzira zvaizoitika dai mimwe yemishonga yeanesthesia yaunopiwa isina kunyatsokodzera muviri wako. Nhasi tichataura nezvechimwe chirwere chisingawanzoitiki, asi chakakosha zvikuru chaunofanira kuziva. Idambudziko rinonzi `(Pseudocholinesterase Deficiency)`.

Chii chinonzi `(Pseudocholinesterase Deficiency)`? Ngatizvinzwisise zviri nyore, handiti?

Zvakanaka, zita iri rinonzwika rakareba, handiti? Ngatizvichengetedze zviri nyore. `(Pseudocholinesterase)` ienzyme yakakosha `(Enzyme)` mumuviri wedu. Rimwe remabasa makuru e`(Enzyme)` iyi nderekuputsa (ndiko kuti, `(metabolize)`) mumuviri mimwe yemishonga inopiwa kuti inyaradze tsandanyama , kunyanya kana tava neanorexia (tinodaidza kuti `(Choline esters)`). Fungidzira, panguva yekuvhiyiwa, tsandanyama dzako dzinofanira kuoma kwenguva yakati. Iyi ndiyo mishonga inopihwa izvozvo.

Zvino, kana uri mumamiriro ezvinhu anonzi `(Pseudocholinesterase Deficiency)`, chinoitika ndechekuti `(Enzyme)` iyi inonzi `(Pseudocholinesterase)` mumuviri wako haigadzirwe zvakakwana , kana kuti haisi kushanda zvakanaka . Chii chinoitika ipapo? Mishonga inopiwa yekuzorodza tsandanyama (`(Succinylcholine)` uye `(Mivacurium)` mienzaniso miviri yeizvi) haibviswi mumuviri nekukurumidza. Inogara mumuviri kwenguva yakareba.

Nekuda kweizvozvo, tsandanyama dzako dzinogona kuramba dzakaoma kwenguva yakareba mushure mekunzwa kurwadziwa, uye ungatove nematambudziko ekufema. Izvi zvinoreva kuti ungasakwanisa kufamba kana kufema wega kusvika mushonga wacho wapera.

Dambudziko iri rakajairika zvakadii?

Kutaura zvazviri, chirwere ichi chinonzi `(Pseudocholinesterase Deficiency)` hachiwanzoitika . Paavhareji, munhu mumwe chete pavanhu 3,200 kana 5,000 muvanhu ava ndiye anosangana nechirwere ichi. Kureva kuti, vanhu vashoma kwazvo.

Zviratidzo zvacho ndezvipi? Unozviziva sei izvi?

Vanhu vazhinji vane chirwere ichi havachizivi kusvika vagamuchira rudzi rwemushonga unonyaradza marwadzo wandambotaura, unonzi ``Choline esters.'' Ndipo panotanga kuoneka zviratidzo zvikuru:

• Tsandanyama dzakanyatsosununguka (kureva kuti, dzisina hupenyu) kwenguva yakareba kupfuura zvaitarisirwa.
• Kunyangwe tsandanyama dzinokubatsira kufema dzinopedzisira dzisingachashandi kwenguva pfupi .

Zvinogona kutora maawa mashoma kuti zviratidzo izvi zviderere. Nguva iyi inosiyana kubva pamunhu kusvika pamunhu. Munguva iyi, timu yako yezvekurapa ichakuchengetedza pasi peanesthesia uye ichakubatsira kufema ne "ventilator", muchina wekufema wekugadzira, kusvika wakwanisa kufema wega.

Ndezvipi zvinokonzera izvi? Izvi zvinoitika sei?

Dambudziko iri (Pseudocholinesterase Deficiency) rinogona kugarwa nhaka (kureva kuti, kugara nhaka), kana kuti rinogona kukura gare gare muhupenyu..

Zvikonzero zvakagarwa nhaka

Vanhu vanozvarwa vaine chirwere ichi vane shanduko, kana kuti mutation, mu gene inonzi `(BCHE)`. Iri gene `(BCHE)` ndiro rinoudza muviri wedu kuti ugadzire enzyme `(Pseudocholinesterase)`. Saka, kana paine shanduko mu gene iri, muviri wako unogona kubudisa enzyme iyi shoma, kana kuti ungasaigadzira zvachose.

Zvikonzero zvinokura muhupenyu (Zvakawanikwa)

Dzimwe nguva, chirwere ichi (Pseudocholinesterase Deficiency) chinogona kuitika muhupenyu hwese. Chinogona kukonzerwa nezvirwere zvakasiyana-siyana uye mimwe mishonga.

Zvimwe zvirwere zvinogona kukonzera chirwere ichi:

• Kushaya chikafu chinovaka muviri
• Kukuvara kwakanyanya kwekutsva
• Chirwere cheitsvo
• Chirwere chechiropa
• Hypothyroidism (thyroid isingashande zvakanaka)
• Kenza
• Pamuviri

Mimwe mishonga inogona kuwedzera njodzi yechirwere ichi inosanganisira:

• MAO inhibitors (semuenzaniso Phenelzine (Nardil®))
• Mapiritsi ekudzivirira pamuviri (Mishonga yekudzivirira pamuviri inonwiwa)
• Madonhwe emaziso eEchothiophate
• Metoclopramide
• Cyclophosphamide
• Pyridostigmine

Vanachiremba vanoongorora sei izvi?

Kana uchinetseka kudzora tsandanyama dzako kana kufema mushure mekunzwa kuneta, chiremba wako anogona kufungidzira kushomeka kwepseudocholinesterase. Kuti vasimbise izvi, vanogona kuita bvunzo yeropa kuti vaone huwandu hweenzyme yako yepseudocholinesterase.

Kana mumwe munhu mumhuri yako aine chirwere ichi, chiremba anogona kuita bvunzo dzemajini kuti aone kana iwewo uine chirwere ichi. Izvi zvinosanganisira kutora ropa woongorora kana uine (BCHE) gene mutation.

Kana chiremba wako achifungidzira kuti une chirwere ichi, achashandisa mamwe marudzi emishonga inozorodza tsandanyama isingashandisi enzyme inonzi ``Pseudocholinesterase''.

Kurapwa kwacho chii?

Kana ukaona zviratidzo zve `(Pseudocholinesterase Deficiency)` mushure mekunge wapihwa anesthesia, ungangoda rubatsiro rwechiremba nekukurumidza. Chikwata chekurapa chichakutarisa zvakanyanya kusvika wapora. Kana zvichidikanwa, vachakuchengetedza pasi peanesthesia uye vanoshandisa muchina we ``mechanical ventilation`` kuti ukubatsire kufema kusvika wagona kufema wega.

Chii chaunofanira kutarisira kana uine chirwere ichi?

Kana ukaonekwa uine `(Pseudocholinesterase Deficiency)`, chinhu chakanakisa chaungaita kuzivisa vanachiremba vako nezvazvo - kunyanya vanachiremba vachange vachikuona kuti uvhiyiwe .

Uyewo, unofanira kuudza mhuri yako nezveizvi zvakare., saka vanogonawo kuongororwa kuti vaone kana vaine `(BCHE)` gene mutation. Kana zvakadaro, vanofanirawo kuzivisa vanachiremba vavo vasati vavhiyiwa.

Zvakanakawo kupfeka chitupa chekurapa kuitira kuti vanachiremba vazive kana uchida kuvhiyiwa nekukurumidza.

Izvi zvinogona kudzivirirwa here?

Kushaikwa kwePseudocholinesterase chirwere chekuzvarwa nacho chisingadzivisike. Zvisinei, kana mumwe munhu mumhuri yako aine chirwere ichi, unogona kuongororwa kuti une BCHE gene mutation here usati waitwa anesthesia. Izvi zvinogona kubatsira kudzivirira matambudziko panguva yekuvhiyiwa.

Kana uine genetic mutation, chiremba wako angangosiya kushandisa Choline esters osarudza imwe anesthetic. Rocuronium ndiyo anesthetic inonyanya kushandiswa kune vanhu vane Pseudocholinesterase Deficiency.

Unogona kuderedza njodzi yako yekuve neAcquired Pseudocholinesterase Deficiency gare gare muhupenyu hwako nekurapa zvirwere zviri pasi pako, zvakaita sekushaya chikafu chakakwana kana chirwere cheitsvo chisingaperi (CKD). Zvakare, kana uri kutora mishonga inoderedza kugadzirwa kwePseudocholinesterase enzyme, ungangoda kutaura nachiremba wako nezvekuchinja mishonga yako.

Ndezvipi zvinopesana nemishonga, kureva kuti, mishonga ipi isingakodzeri kushandiswa nevanhu vane chirwere ichi?

Kana wakamboonekwa uine `(Pseudocholinesterase Deficiency)`, unofanira kudzivisa mhando dzinotevera dzemishonga inonyaradza marwadzo :

• Succinylcholine `(Succinylcholine)`
• Mivacurium
• Procaine
• Chloroprocaine
• Benzocaine
• Tetracaine

Mibvunzo yekubvunza chiremba wako

Kana uine chirwere chinonzi ``Pseudocholinesterase Deficiency'', kungave wakazvarwa nacho kana kuti wakazochiwana gare gare, ungangoda kubvunza chiremba wako mimwe mibvunzo yakaita seyi:

• Ndezvipi zvinhu zvinondirambidza chaizvo, kureva kuti, ndeapi mishonga yandinofanira kudzivisa?
• Dambudziko iri ndiro randakaberekwa naro here kana kuti rinokonzerwa nechimwe chirwere?
• Zvakanaka here kuti mhuri yangu iongororwe majini?

Kuenda kuvhiyiwa kunogona kunetsa zvishoma. Vazhinji vedu tinonyanya kutarisa pakuvhiyiwa zvekuti hatitombofungi nezvekuti zvinogona kukonzera kusagadzikana kana munhu akabatwa nechirwere cheanesthesia. Hapana mushonga wePseudocholinesterase Deficiency. Zvisinei, kuziva kana uine chirwere ichi kunogona kukubatsira kudzivirira kushaya simba kwetsandanyama kwenguva pfupi uye matambudziko ekufema anogona kuitika mushure mekuvhiyiwa. Kana uine Pseudocholinesterase Deficiency, udza nhengo dzemhuri yako nezvazvo. Vanogonawo kuongororwa jini uye kudzivirira matambudziko asina basa angamuka panguva yerwendo rwavo rwehutano.

Pakupedzisira, zvinhu zvekurangarira

Saka, `(Pseudocholinesterase Deficiency)` izita rinotyisa zvishoma, asi zvakakosha kuti uzvizive. Kunyanya kana uchizovhiyiwa, kana kuti mumwe munhu mumhuri mako akasangana nechimwe chinhu chakadai , zvakanaka kutaura navanachiremba vako nezvazvo. Yeuka, kuziva kazhinji ndiyo nhoo yakanakisisa inogona kutiponesa kubva kumatambudziko asina basa!

Anesthesia , pseudocholinesterase, kushomeka kwema enzyme, matambudziko ekuvhiyiwa, mamiriro ejini, kusashanda zvakanaka kwetsandanyama, mishonga inonyaradza marwadzo