Mwana wenyu anowanzova nefivha pasina chikonzero here? Ngatidzidzei nezveSAIDs idzi (Systemic Autoinflammatory Diseases)!

Mwana wako mudiki dzimwe nguva anongonzwa fivha asina dzihwa kana chimwe chirwere here? Fivha inouya, yopera mumazuva mashoma, yozodzokazve mushure memazuva mashoma here? Vamwe vabereki vanosangana nezviitiko zvakadaro. Saka nhasi tichataura nezvechikonzero chefivha chinowanzoitika uye chakaoma kuwana. Izvi zvinonzi SAIDs (Systemic Autoinflammatory Diseases) . Kare, izvi zvainzi `(Periodic Fever Syndromes)` kana `(Recurrent Fever Syndromes)`.

Chii chinonzi SAIDs idzi? Ngatizvinzwisise zviri nyore!

Zvichitaurwa zviri nyore, SAIDs iboka rezvirwere zvinokonzerwa nekusashanda zvakanaka kana dambudziko rehurongwa hwemuviri wedu . Muchiitiko ichi, pasina hutachiona hwekunze (senge hutachiona kana mabhakitiriya), muviri wedu unongogadzira kuzvimba. Zvinoita sekunge dziviriro yemuviri wedu iri kukwira zvakanyanya.

Funga nezvazvo, tine boka remasoja mukati memiviri yedu (ndiko kuti immune system). Basa ravo nderekurwisa utachiona hunokonzera zvirwere pahunopinda. Asi mumuviri wemunhu ane SAIDs, masoja aya dzimwe nguva anongonetseka uye anokonzera matambudziko mumuviri.

Zvino ungangove uchishamisika kana izvi zvakaita sekuti `(zvirwere zve autoimmune)` (ndiko kuti, zvirwere zve autoimmune). Semuenzaniso, `(rheumatoid arthritis)` kana `(lupus)` zvakafanana. Kwete, izvi zviviri zvakasiyana zvishoma. Muzvirwere zve autoimmune, chinoitika ndechekuti immune system yemuviri wedu inorwisa masero ayo ane hutano zvisirizvo. Asi muSAIDs, dambudziko riri pa immune system yatinozvarwa nayo.

MaSAID haawanzoitiki kupfuura zvirwere zve autoimmune. Mazhinji acho anogarwa nhaka , zvichireva kuti anokonzerwa nekuchinja kwemajini kana kuti shanduko yemajini.

MaSAID anowanzo tanga achiri mudiki kana achiri mudiki . Asi handizvo zvinoitika nguva dzose. Mwana wako anogona kunge aine fivha nezvimwe zviratidzo. Mwana wako anogona kunge asina zviratidzo zvachose pakati pekurwiswa. Hapana mushonga weSAIDs. Zvisinei, kune mishonga inogona kubatsira kudzora zviratidzo muzviitiko zvakawanda.

Ndeapi marudzi makuru eSAIDs?

Vatsvagurudzi vaona mhando dzeSAIDs dzinosvika makumi matanhatu, uye dzimwe dziri kuwanikwa. Ngatitarisei dzimwe dzemhando dzakajairika.

• Fevha yeMediterranean yemhuri (FMF): Iyi ndiyo inonyanya kurwara nefivha inogarwa nhaka, inodzokororwa. Inogona kukonzera kuzvimba kunorwadza mudumbu, chipfuva, uye majoini emwana .
• Fivha yenguva nenguva, aphthous-stomatitis, pharyngitis, adenitis (PFAPA): Izvi zvinowanzotanga muvana vadiki vasati vasvitsa makore mana. Dambudziko iri rinogona kupera roga mushure memakore gumi.
• Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): Izvi zvinogona kuitika muhudiki, kuyaruka, uye dzimwe nguva kunyange muhukuru.
• Kushaikwa kweMevalonate kinase (MKD): Kare kwainzi hyper-IgD syndrome, izvi zvinowanzotanga muvana vari pasi pegore rimwe chete.
• Zvirwere zve autoimmune zvinosanganiswa neNLRP3: Izvi zvaimbonzi cryopyrin-associated periodic syndromes (CAPS). Kune mamwe marudzi matatu mukati meizvi.
• Chirwere cheAdult-onset Still's (AOSD): Ichi chirwere chesystemic juvenile idiopathic arthritis (JIA) chinoitika kuvanhu vakuru.
• Chirwere chegranulomatous chinokonzerwa neNOD-2 (Blau syndrome): Izvi zvinowanzotanga mwana asati asvitsa makore mana. Zvinonyanya kukanganisa ganda, maziso, uye majoini .

Ndezvipi zviratidzo zveSAIDs? Tinozviziva sei ?

Zviratidzo zveSAID zvinowanzotanga muhudiki. Chiratidzo chinonyanya kuzivikanwa uye chinoonekwa ifivha yenguva nenguva kana kuti nguva nenguva . Vanhu vanowanzo ramba vasina zviratidzo pakati pekurwiswa. Zvisinei, panogona kunge paine zvimwe zviratidzo zvakanangana nerudzi rumwe nerumwe rweSAID.

Ngatitarisei zviratidzo chaizvo zvemarudzi akasiyana-siyana eSAID ataurwa pamusoro apa:

• FMF: Izvi zvinogona kukonzera kurwadziwa kwakanyanya mudumbu remwana, chipfuva, uye majoini, pamwe chete nekuzvimba . Dzimwe nguva, mapundu anogona kutanga pamakumbo epasi kana muzviziso. Fungidzira, mwana anongoerekana aita kurwadziwa nemudumbu nefivha. Vabereki pavanonetseka voenda naye kuchipatara, vanogona kufunga kuti iappendicitis. Asi zvinozopera uye zvinodzoka mushure memazuva mashoma.
• PFAPA: Izvi zvinogona kukonzera zviratidzo zvakaita sekurwadziwa pahuro, maronda mumuromo, uye kuzvimba kwema lymph nodes mumutsipa .
• MISUNGO: Izvi zvinogona kukonzera kutonhora, kurwadziwa kwetsandanyama muchipfuva nemaoko , uye mapundu matsvuku anorwadza anotanga pamaoko nemakumbo opararira mumuviri wese.
• MKD: Mune izvi zvakareUnganzwa kusanzwa zvakanaka nechando, musoro, kurwadziwa nemudumbu, kushaya chido chekudya, uye zviratidzo zvakaita sefuruu.
• Zvirwere zveNLRP3: Izvi zvinogona kukonzera zviratidzo zvakaita semapundu eganda, musoro, kusagadzikana, kurwadziwa kwemajoini, uye maziso matsvuku (conjunctivitis) .
• AOSD: Ichi chirwere chinowanzo kukonzera mapundu paganda, kurwadziwa kwemajoini, uye kurwadziwa kwetsandanyama . Vamwe vanhu vanogonawo kunzwa kurwadziwa pahuro, kurwadziwa mudumbu, kuneta zvakanyanya, uye kurwadziwa kwemuviri.
• Blau syndrome: Izvi zvinogona kukonzera maronda paganda remwana wako, maoko, tsoka, kana muviri . Zvinogonawo kukonzera kurwadziwa kwemajoini nekurwadziwa kwemaziso .

Sei maSAID aya achiitika? Ndezvipi zvinokonzera?

Mazhinji eSAIDs zvirwere zvemajini . Kureva kuti, chirwere chega chega chinokonzerwa nekusiyana (variant) mune rimwe jini.

Ngatitarisei majini anokanganisa mhando dzakawanda dzeSAID:

• FMF: Izvi zvinokonzerwa nejini rinonzi `(MEFV gene)`. Jini iri rinorayira maitiro ekugadzira puroteni inonzi `(pyrin)`.
• PFAPA: Chikonzero chaicho cheizvi hachisati chawanikwa .
• MISUNGO: Izvi zvinokonzerwa nejini rinonzi `(TNFRSF1A gene)`. Izvi ndizvo zvinopa mirairo yekugadzira puroteni inonzi `(tumor necrosis factor receptor - TNFR)`.
• MKD: Chikonzero cheizvi ijini rinonzi `(MVK gene)`. Izvi zvinorayira kugadzirwa kwepuroteni inonzi `(mevalonic kinase)`.
• Zvirwere zveNLRP3: Izvi zvinokonzerwa nejini rinonzi `(NLRP3 gene)`. Izvi zvinopa mirairo yekugadzira puroteni inonzi `(cryopyrin)`.
• AOSD: Chikonzero chaicho cheizvi hachisati chawanikwa .
• Blau syndrome: Izvi zvinokonzerwa nejini rinonzi `(NOD2 gene)`. Izvi zvinorayira kugadzirwa kwepuroteni inonzi `(NOD2)`.

MaSAID aya anogona kukonzera mamwe matambudziko here?

Ehe, izvi zvinogona kukonzera matambudziko kana zvikasarapwa nemazvo . Kana kuzvimba kukaramba kuripo mumuviri, zvinogona kutungamira kuchirwere chinonzi ``amyloidosis.`` Kureva kuti, rudzi rweprotein runochengetwa muitsvo dzedu. Izvi zvinogona kukonzera kukuvara kusingaperi kweitsvo . Ndosaka zvichikosha kuongorora chirwere ichi nekukurumidza uye kurapwa.

Chiremba anoongorora sei chirwere ichi cheSAIDs?

Kutaura zvazviri, kuongorora zvirwere izvi zvinozvimba muviri kunogona kuoma zvishoma , sezvo zviratidzo zvazvo zvichigona kufanana nezvimwe zvirwere zvakakomba zvakaita se lupus kana kenza senge lymphoma. Saka, zvakakosha kuona chiremba ane hunyanzvi hwezvirwere zvinozvimba, chiremba wemapfupa, kuti aongorore uye agadzirise mamiriro emwana wako nemazvo.

Chiremba wemapfupa emwana wenyu achashandisa zvinhu zvakati wandei kuongorora SAIDs. Achakubvunzai nezvezviratidzo zvemwana wenyu uye kana paine mumwe munhu mumhuri menyu ane zvirwere izvi (nhoroondo yemhuri). Chiremba anogona kufungidzira kuti mwana wenyu anogona kunge aine chirwere chefivha chinogara kwenguva refu kana:

• Kana mwana achigara achirwara nefivha .
• Kana paine munhu mumhuri ane nhoroondo yefivha yakadai kakawanda .
• Kana mwana ari weboka revanhu vanowanzobatwa nefivha dzakadai nguva nenguva .

Ndedzipi bvunzo dziri kuitwa pakuita izvi?

Kuti vasimbise chirwere ichi, chiremba wemapfupa emwana wenyu anogona kukurudzira bvunzo dzinoverengeka. Izvi zvinogona kusanganisira:

• Miedzo yekurabhoritari: Miedzo yakaita se "C-reactive protein (CRP)`` uye `complete blood count (CBC)`` inogona kushandiswa kutarisa kuzvimba mumuviri. Miedzo iyi inoratidza kuti yakamira zvakanaka panguva ye "kurwiswa" kwefivha uye inodzokera kune yakajairika kana "kurwiswa" kwapera.
• Kuongororwa kweweti: Kuongororwa kweprotein yeweti kunogona kuitwa kuti paonekwe kana mapuroteni akawandisa ari muweti. MuMKD, kuongororwa kweweti kunotarisa organic acids (acids ine atomu imwe chete yekabhoni) kunogona kuratidza huwandu hwakakwira hwemevalonic acid.
• Kuongororwa kwemajini: Izvi zvinogona kutarisa magene akasiyana. Zvisinei, vamwe vana vane SAIDs vanogona kunge vasina magene akasiyana akawanikwa, izvo zvinogona kukonzera mhedzisiro yebvunzo isina kunaka.

Ndeapi marapirwo eSAID idzi?

Kurapwa kweSAIDs kunosiyana zvichienderana nerudzi uye kuoma kwechirwere . Hapana mushonga wezvirwere izvi. Zvisinei , zviratidzo zvemwana wako zvinowanzo gadziriswa nemishonga . Kana mwana wako achingobatwa nechirwere kashoma pagore, unogona kumupa mishonga inoderedza marwadzo yakadai semishonga isingarwisi hutachiona (NSAIDs) kuti ibatsire kuderedza zviratidzo zvake. Zvisinei, kana chirwere chacho chakanyanya kuoma, chiremba wako anogona kukupa mamwe marapirwo.

Heano mamwe acho:

• FMF: Mushonga unonzi `(colchicine)` unogona kushandiswa kudzora izvi. Izvi zvinoderedza kuzvimba. Kana mwana asingakwanise kutora colchicine, mushonga we`(biologic)` unonzi `(canakinumab)` unogona kuyedzwa.
• PFAPA: MaSteroid (anowanzoitwa prednisone) anogona kupihwa kupfupisa nguva yekurwiswa kwePFAPA. Mune vamwe vana, cimetidine, mushonga unoshandiswa kurapa maronda emudumbu, unogona kubatsirawo kudzora zviratidzo.
• MISUNGO: Mushonga unonzi ``canakinumab'' unowanzo shanda pakuita izvi. Zvakare, zviratidzo zvinogona kuderedzwa nemishonga inorwisa kuzvimba inonyorerwa nachiremba, yakadai se``glucocorticoids''.
• MKD:Canakinumab mushonga unoshandawo weMKD. Kupa NSAIDs kana steroid panguva yekurwiswa kunogonawo kubatsira.
• Zvirwere zveNLRP3: Mishonga inogadzirisa muviri yakaita secanakinumab, rilonacept, uye anakinra inoshandiswa zvinobudirira pakuita izvi.
• AOSD: Mhando dzakasiyana dzemishonga inoderedza kuzvimba dzinoshandiswa paAOSD. Mienzaniso inosanganisira masteroid, mishonga inogadzirisa zvirwere (DMARDs), uye biologics.
• Blau syndrome: Zvichienderana nezviratidzo zvemwana wako, anogona kuedza mishonga inodzvinyirira immune, tumor necrosis factor (TNF) inhibitors, uye/kana mishonga yemaziso inotorwa nemaziso.

Zvirwere zveSAID izvi zvichagara zviripo here kana kuti zvichapera?

Zvimwe zvirwere zvinozvimba muviri ndezvehupenyu hwese . Zvimwe zvinogona kugara kwemakore mashoma uye zvinopera nekukura. Zvimwe zvirwere ndezvehupenyu hwese, asi nekufamba kwenguva, kuwanda uye kuoma kwezvirwere zvinogona kudzikira. Chiremba wemwana wako anogona kukupa ruzivo rwakananga nezvechirwere chemwana wako.

Kurera mwana ane chirwere chinozvimba muviri kunogona kuoma. Kana wakambotaura nezveSAID, unogona kushandisa ruzivo rwako pachako kuti utsigire zviri nani kutarisirwa kwemwana wako. Unogonawo kushandisa ruzivo rwako kubatsira mwana wako kuti ajairane nemamiriro ezvinhu aya ehupenyu hwese.

Chinhu chinonyanya kukosha ndechekutsvaga kurapwa kubva kune nyanzvi dzine ruzivo nezveSAIDs. Vanachiremba vakadaro vanogona kubatsira kudzora zviratidzo zvemwana wako uye kumubatsira kuti ave nehudiki hwakanaka.

Mharidzo Yekupedzisira Yekuenda Kumba

Saka, ndinovimba une ruzivo nezveSAID dzatataura nezvadzo nhasi. Yeuka, kana mwana wako aine fivha isingatsananguriki, taura nachiremba nezvazvo . Usazviregeredza, uchifunga kuti zvakajairika.

• SAIDs iboka rezvirwere zvinowanzo kukonzera fivha uye zvinokonzerwa nedambudziko remasoja emuviri.
• Izvi zvinowanzova zvemajini uye zvinotanga pazera diki.
• Kunyange zvazvo pasina mushonga wechigarire weizvi, kune mishonga inogona kudzora zviratidzo.
• Zvakakosha kutsvaga kuongororwa kwakakodzera uye kurapwa kubva kuna chiremba ane hunyanzvi (Rheumatologist).
• Kana kurapwa kukatanga kare, matambudziko akadai seamyloidosis anogona kudzivirirwa uye mwana anogona kurarama hupenyu hwakajairika.

Kana muine mimwe mibvunzo nezvenyaya iyi, musazeza kubvunza chiremba wemhuri yenyu kana chiremba wevana.

SAIDs , Zvirwere zveSystemic Autoinflammatory, Fivha Dzinowanzoitika, Zvirwere zveMajini, Fivha muVana, Immune System, Rheumatologist