Ingaba iiplatelet zakho ziphezulu? Masithethe ngeThrombocytosis!

Ngaba nawe ukhe wafunyaniswa ukuba une-platelet ephezulu egazini lakho? Okanye ngaba kukho umntu omaziyo onayo le meko? Kuqhelekile ukuba uzive unexhala xa usiva into efana nale. Kodwa ungakhathazeki, namhlanje siza kuthetha ngale meko ebizwa ngokuba yiThrombocytosis ngendlela elula onokuyiqonda.

Yintoni i-thrombocytosis? Ngamafutshane...

Ngamafutshane, i-thrombocytosis iyenzeka xa unee-platelet ezininzi egazini lakho. Ngoku usenokuba ubuza, “Zithini ii-platelet?” Lo ngumbuzo obaluleke kakhulu!

Iiplatelets luhlobo lweeseli ezincinci ezifumaneka egazini lethu. Umsebenzi wazo ophambili kukuyeka ukopha xa kukho ukopha, njengaxa kukho inxeba. Zisebenza njengedama elincinci.

Kodwa kuya kwenzeka ntoni ukuba inani lee-platelet liyanda kakhulu? Igazi lakho linokuba likhulu kwaye linamathele. Kwezinye iimeko ezinzima, ezi platelet zigqithisileyo zinokubangela ukuba kubekho amahlwili egazi ayingozi ngaphakathi kwemithambo yegazi. Oku kunokunyusa umngcipheko weemeko ezifana nestroke okanye ukuhlaselwa yintliziyo .

Nangona kunjalo, ayizizo zonke iimeko zeThrombocytosis eziyingozi ngokulinganayo. Ubunzima bemeko, nokuba uyalufuna unyango okanye awuludingi, kuxhomekeke kwisizathu.

Kukho iintlobo ezimbini eziphambili ze-thrombocytosis:

Ewe, oogqirha bachonge iintlobo ezimbini eziphambili zale meko. Makhe sithethe ngayo kancinci.

1. I-Essential Thrombocythemia (ET) okanye i-Primary Thrombocytosis

Esi sisifo segazi esingaqhelekanga. Sivela xa umongo wakho wethambo – ifektri yeeseli zegazi ngaphakathi emathanjeni akho – ivelisa iiplatelets ezininzi kakhulu. Cinga ngako, uninzi lweeseli zegazi emizimbeni yethu zenziwe kulo mongo wethambo. Umntu one-essential thrombocythemia unemveliso ephezulu kakhulu yeeplatelets ngenxa yesiphene kule nkqubo yokuveliswa kweeseli zegazi.

Le meko, ebizwa ngokuba yi -ET (Essential Thrombocythemia) , ithathwa njengesona sifo sixhaphakileyo kudidi lwegazi esibizwa ngokuba yiMyeloproliferative Neoplasm (MPN) .

2. I-Reactive Thrombocytosis okanye i-Secondary Thrombocytosis

Olu lolona hlobo luqhelekileyo lwe-Thrombocytosis. Oku kwenzeka xa umzimba wakho usenza iiplatelets ezininzi ngenxa yesinye isimo, usulelo, ukwenzakala, utyando, okanye ukususwa kwepleen. Ngamafutshane, umzimba wakho usabela kwenye into kwaye wonyusa amanqanaba eplatelets. Oku kwenzeka xa umzimba wakho usenza ezinye iiplatelets.I-reactive thrombocytosis idla ngokuba yeyokwexeshana, nto leyo ethetha ukuba xa unobangela ulungisiwe, inani leeplatelet libuyela kwisiqhelo.

Ngubani ofumana i-thrombocytosis?

Le meko idla ngokufunyaniswa kubantu abaneminyaka engaphezu kwama-60 ubudala. Kwakhona, kuxelwe ukuba uhlobo olubizwa ngokuba yi -Essential Thrombocythemia (ET) lufunyaniswa kwabasetyhini ngokuphindwe kabini kunakumadoda.

Zithini izizathu ze-thrombocytosis?

Izizathu zeentlobo ezimbini esizixubushe ngaphambili nazo zahlukile.

Izizathu ze-Essential Thrombocythemia (ET)

I-Essential Thrombocythemia (ET) yimeko yemfuza efunyenweyo. Ayisiyonto ozalwa nayo. Ibangelwa lutshintsho, okanye utshintsho, kwiijini ezithile ezibandakanyekayo ekuvelisweni kweeplatelets. Oku kubangela ukuba umongo wakho wethambo uvelise iiplatelets ezininzi kakhulu.

Abantu abangaphezu kwesiqingatha abane -Essential Thrombocythemia (ET) banotshintsho kwi- JAK2 gene. Utshintsho kwi -CALR okanye kwi-MPL genes nalo luqhelekile.

Izazinzulu azikakwazi ukucacisa ukuba yintoni kanye kanye ebangela olu tshintsho lwezakhi zofuzo, kodwa uphando ngalo luyaqhubeka.

Izizathu ze-Thrombocytosis esebenzayo

Olu hlobo lwenzeka kuba umzimba wakho uvelisa iiplatelets ezininzi ngenxa yeemeko ezahlukeneyo. Okanye, ngamanye amaxesha, kusenokwenzeka ukuba iiplatelets ezindala ziyaqokelelana endaweni yokuba zitshatyalaliswe ngesantya esiqhelekileyo.

Nazi ezinye zezinto ezinokubangela i-Reactive Thrombocytosis :

• I-anemia , ingakumbi i-anemia yokungabikho kwesinyithi .
• Ezinye iingxaki zegazi.
• Ezinye iintlobo zomhlaza .
• Iintsholongwane, ezifana ne -pneumonia .
• Iimeko zokudumba – iimeko ezibangela ukudumba emzimbeni, njenge-rheumatoid arthritis.
• Ukwenzakala .
• Ukungasebenzi kakuhle kwezintso .
• Amanye amayeza.
• Utyando, ingakumbi utyando lwesisu.
• Ukususwa kwepleen .
• Ukunyanga ukungabikho kwe -vitamin B12 .

Olu luhlu luquka izizathu ezimbalwa eziqhelekileyo. Kunokubakho ezinye izizathu ezininzi ze- Reactive Thrombocytosis .

Zithini iimpawu ze-thrombocytosis?

Rhoqo, abantu abaneeplatelet ezininzi abanazo iimpawu, ubuncinane kungekhona kwizigaba zokuqala. Ukuba une -Reactive Thrombocytosis , unokufumana iimpawu zesifo esibangele oku.

Nangona kunjalo, xa kuvela iimpawu, zihlala zinxulumene nokopha okungaqhelekanga kunye nokujiya kwegazi emzimbeni wakho. Ungabona iimpawu ezifana nezi:

• Intloko ebuhlungu .
• Ityumkile lula.
• Ukuziva ubuthathaka, unesizungu, okanye unentloko ebuhlungu.
• Ukopha okuphuma empumlweni, emlonyeni, nasezintsinini.
• Ukopha esiswini okanye emathunjini.

Abanye abantu abane -Essential Thrombocythemia (ET) banokuba nesifo esibizwa ngokuba yi -Erythromelalgia . Oku kubangela iintlungu, ukudumba, kunye nokubomvu ezandleni nasezinyaweni. Basenokuba nokuziva bengenazimvakalelo kwaye berhawuzelelwa ezandleni nasezinyaweni.

Kwiimeko ezinzima kakhulu, i-thrombocytosis inokukhokelela ekuqhekekeni kwegazi okungaqhelekanga esiswini (umz., i-Budd-Chari syndrome ) kwaye yonyuse umngcipheko we- stroke okanye ukuhlaselwa yintliziyo .

Ifunyanwa njani i-thrombocytosis?

Ngenxa yokuba i-thrombocytosis ayisoloko ibangela iimpawu, uphawu lokuqala onalo kukuba uvavanyo lwegazi oluqhelekileyo (umz., i-Complete Blood Count – CBC ) lubonisa ukubala iiplatelet okwandileyo.

I-Thrombocytosis ichazwa ngokuba neeplatelets ezingaphezu kwama-450,000 kwi-microliter nganye yegazi. Ukuba inani leeplatelets zakho liphezulu, ugqirha wakho usenokuyalela olunye uvavanyo lwegazi kwiiveki ezimbalwa ukuze abone ukuba inqanaba lihlala liphezulu na. Ukunyuka kube kanye kwinani leeplatelets uze ubuyele esiqhelweni akusoloko kuyingxaki. Nangona kunjalo, amanqanaba aphezulu angapheliyo anokubonisa imeko yezonyango engabonakaliyo.

Kwimeko ye -reactive thrombocytosis , ukuchonga imeko esisiseko eyibangeleyo (umz., i-anemia yokungabikho kwesinyithi , umhlaza, usulelo) kunokunceda oogqirha ukuba bayixilonge baze bayilawule. Nangona kunjalo, ukuba ugqirha akakwazi ukufumana unobangela wesibini onjalo, baya kwenza olunye uvavanyo ukuze babone ukuba unayo na i-Essential Thrombocythemia (ET) .

Olu vavanyo lungabandakanya:

• I-smear yegazi engaphandle:Oku kujonga ukuba iiplatelets egazini lakho azibonakali zingaqhelekanga na.
• Uvavanyo lwe-DNA/ufuzo: Oku kunokufumanisa utshintsho lwemfuza olufana ne -JAK2 , oluhlala lunxulunyaniswa ne -ET (Essential Thrombocythemia) .
• I-Bone Marrow Biopsy: Oku kujonga ukuba kukho iiseli ezingaqhelekanga kwi-bone marrow yakho.

Inyangwa njani i-thrombocytosis?

Ukuba awunazo iimpawu, ungadinga uhlolo oluqhelekileyo kuphela.

I-reactive thrombocytosis (i-secondary thrombocytosis) ayisoloko ifuna unyango. Ngokwesiqhelo, amanqanaba eeplatelet abuyela kwisiqhelo xa imeko ebangele ukuba inani eliphezulu leeplatelet (njengokwenzakala, usulelo, okanye impendulo yotyando) iphelile. Nangona kunjalo, ukuba uneempawu, ugqirha wakho uya kunyanga unobangela oyintloko.

Ukuba une- Essential Thrombocythemia (ET) kwaye uneempawu, ugqirha wakho unokucebisa unyango oluninzi, olufana nolu:

• Ukusela i-aspirin enedosi ephantsi imihla ngemihla: Ungayisela i-aspirin yonke imihla ukuthintela ukuqhekeka kwegazi. Le dosi iphantsi ayisoloko ibangela ukudumba kwesisu okanye ukopha. Nangona kunjalo, musa ukuyisela i-aspirin rhoqo ngaphandle kokuthetha nogqirha wakho.
• Ukusela amayeza anciphisa amanqanaba eeplatelet: Amayeza afana neHydroxyurea (amagama eebrendi: Droxia®, Hydrea®, Siklos®, Mylocel®) kunye neAnagrelide (igama lebrendi: Agrilyn®) anciphisa ukuveliswa kweeplatelet kumongo wethambo. I-Interferon alfa (igama lebrendi: Multiferon®) ithintela iiplatelet ezingaqhelekanga ukuba zingahlukani kwaye ziphindaphindeke.
• Ukuba nenkqubo yokususa iiplatelets zakho: Ukuba amanqanaba eplatelets zakho aphezulu kangangokuba usengozini yokufumana amahlwili egazi asongela ubomi, ugqirha wakho unokucebisa inkqubo ebizwa ngokuba yiplatelepheresis . Oku kubandakanya ukusebenzisa umatshini ukucoca iiplatelets ezigqithisileyo egazini lakho. Nangona kunjalo, kwiimeko ezininzi ze-thrombocytosis , iplatelepheresis ayiyomfuneko.

Kubalulekile: Musa ukuqala okanye ukuyeka naluphi na olu nyango ngaphandle kwengcebiso kagqirha. Yonke into mayixoxwe nogqirha wakho kwaye yenziwe phantsi kwesikhokelo sakhe.

Ngaba i-thrombocytosis inganyangeka ngokupheleleyo?

I-Essential Thrombocythemia (ET)Okwangoku akukho nyango lwe-thrombocytopenia. Nangona kunjalo, ugqirha wakho unokukunceda ulawule le meko ukuze anciphise umngcipheko wokuqhekeka kwegazi. Kwimeko ye- reactive thrombocytosis (ebangelwa zizizathu zesibini), amanqanaba eeplatelet adla ngokubuyela kwisiqhelo xa unobangela oyintloko unyangiwe.

Ngaba i-thrombocytosis ingathintelwa?

Iimeko ezininzi ezibangela i-thrombocytosis azinakuthintelwa, kuquka i-Essential Thrombocythemia (ET) .

Ngaba i-thrombocytosis iyingozi ebomini?

Amanqanaba aphezulu eeplatelet akasongeli ubomi, kodwa iingxaki ezinokubakho - ezinje ngokuqhekeka kwegazi okanye ukopha kakhulu - zinokuba yingozi.

Uninzi lwezizathu ze-thrombocytosis zezokwexeshana, kwaye azifane zikhokelele ekuqhekekeni kwegazi okukhulu. Kwi- Essential Thrombocythemia (ET) , umngcipheko uphezulu kancinci. Nangona kunjalo, ugqirha wakho uza kukujonga ngokusondeleyo, akunike amayeza afunekayo, aze enze iinkqubo ezifunekayo ukuthintela ukuqhekeka kwegazi okuyingozi. Ngoko ke ungakhathazeki.

Injani imbono yomntu one-thrombocytosis?

I-reactive thrombocytosis idla ngokuphela xa ingxaki esisiseko inyangwa. Nangona inani leeplatelet zakho lisenokuphakama ixesha elifutshane (kwaye mhlawumbi ixesha elide emva kokuba i-spleen yakho isusiwe), i-secondary thrombocytosis ayibangeli ukuqhekeka kwegazi okungaqhelekanga.

I-Essential Thrombocythemia (ET) , okanye i-primary thrombocytosis, inokubangela ukopha okukhulu okanye iingxaki zokujiya kwegazi. Ukusela amayeza ukugcina amanqanaba akho eeplatelet esemgangathweni kunokunceda ekuthinteleni oku. Nangona kunjalo, emva kweminyaka emininzi yokuba nesi sifo, i-bone marrow fibrosis (amanxeba e-bone marrow) inokwenzeka. Inani elincinci labantu abane -Essential Thrombocythemia (ET) nabo banokuba ne -leukemia .

Ndifanele ndimbone nini ugqirha wam?

Landela imiyalelo kagqirha wakho ngqo malunga nokuba kufuneka uye kangaphi kuvavanyo lwezonyango kunye nokuba kufuneka wenze uvavanyo lwegazi na ukujonga inani leeplatelet zakho.

Ndingaya nini kwiSebe leeNgxamiseko (i-ETU) ?

Ukuba ufumana iimpawu zestroke okanye isifo sentliziyo, fowunela ku-1990 ngoko nangoko okanye uye kwigumbi likaxakeka lesibhedlele esikufutshane. Qaphela ezi mpawu.

Ndingayibuza yiphi imibuzo ugqirha wam?

Ungabuza ugqirha wakho imibuzo efana nale:

• Ngaba kufuneka ndikhathazeke ngamanqanaba am aphezulu eeplatelet?
• Ngaba kuya kufuneka ndiphinde ndivavanywe ukuze ndijonge amanqanaba eeplatelet zam kwakhona?
• Zeziphi iimvavanyo ekufuneka ndizenze ukuze ndifumanise unobangela weThrombocytosis yam?
• Loluphi unyango olucebisayo?
• Zeziphi iinguqu endinokuzitshintsha kwindlela endiphila ngayo ukuze ndikwazi ukulawula le meko?

Ukuba iziphumo zovavanyo lwakho lwegazi zibonisa ukuba iiplatelet zakho ziphezulu, ungoyiki. Iiplatelet zakho zinokuba phezulu ngezizathu ezahlukeneyo. Uninzi lwezi zizathu aludingi nyango. Kodwa ukuba amanqanaba akho ahlala ephezulu kwaye uneempawu, ugqirha wakho uya kuzama ukufumana unobangela. Ukubeka esweni ngononophelo kunye namayeza kudla ngokuthintela iingxaki ezinkulu ezinxulumene ne-thrombocytosis.

Okokugqibela, izinto ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

Kaloku, sithethe kakhulu nge-Thrombocytosis namhlanje, akunjalo? Ndiyathemba ukuba uyiqonda kakuhle le nto.

Eyona nto ibalulekileyo kukuba ungoyiki ukuba ufumanisa ukuba amanqanaba eeplatelet zakho aphezulu. Ayizizo zonke iimeko zeThrombocytosis eziyingozi.

• I-Reactive Thrombocytosis lolona hlobo luqhelekileyo, kwaye idla ngokubangelwa yenye imbangela yexeshana. Oku kuya kuba ngcono xa loo ngxaki inyangiwe.
• I-Essential Thrombocythemia (ET) luhlobo olungaqhelekanga olunokufuna unyango lwexesha elide.
• Qiniseka ukuba uvavanywa kwaye unyangwa ngendlela efanelekileyo njengoko ugqirha wakho ekuyalele.
• Musa ukuyityeshela nayiphi na impawu. Funa uncedo lwezonyango ngokukhawuleza, ingakumbi ukuba unesifo sokopha esingaqhelekanga, ukukrweleka, intloko ebuhlungu kakhulu, iintlungu zesifuba, okanye ubunzima bokuphefumla.
• Thetha ngokukhululekileyo nogqirha wakho. Buza nayiphi na imibuzo okanye iinkxalabo onazo.

Khumbula, awuwedwa. Ngoncedo nolwalathiso olufanelekileyo lwezonyango, ungayilawula kakuhle le meko kwaye uphile ubomi obusempilweni.