Ngaba uyazi ngokwenene ngale hormone "imbi" ebizwa ngokuba yi-Adiponectin?

Sonke sivile ngeentlobo ezahlukeneyo zeehomoni emizimbeni yethu. Sithetha ngezinye zazo rhoqo, kwaye noogqirha bathetha ngazo. Kodwa ngaba ukhe weva ngehomoni ebizwa ngokuba yi-Adiponectin ? Mhlawumbi awukaze weva. Kodwa idlala indima ebaluleke kakhulu emizimbeni yethu, ngakumbi kwizinto ezifana nobunzima bethu kunye namanqanaba eswekile egazini. Ngoko ke, namhlanje, masithethe nge-Adiponectin ngendlela elula nethe ngqo.

Yintoni iAdiponectin? Kulula kakhulu!

Ngamafutshane, i-adiponectin yi-hormone yeproteni eveliswa kakhulu ziiseli zamafutha, okanye izicubu zamafutha, emizimbeni yethu. Ikwabizwa ngokuba yi-adipokine , kuba iveliswa ngokunxulunyaniswa namafutha. Nangona kunjalo, ayiveliswa kuphela ziiseli zamafutha, kodwa nakwezinye iindawo zomzimba wethu.

Lo mfo ogama linguAdiponectin wafunyanwa ngeminyaka yoo-1990. Oko kuthetha ukuba izazinzulu zisafunda lukhulu ngayo. Mhlawumbi kukho ezinye izinto ezenziwa yile hormone esingazaziyo okwangoku. Ngokwendlela esifumanise ngayo, inceda kakhulu ekunyuseni uvakalelo lwemizimba yethu kwi-insulin kwaye inciphise ukudumba emzimbeni .

Zithini iingenelo zeAdiponectin emizimbeni yethu?

Lo mhlobo ubizwa ngokuba yiAdiponectin ubandakanyeka kwiinkqubo ezininzi ezibalulekileyo emzimbeni wethu. Makhe sijonge ezimbini kwezona zibalulekileyo.

1. Indlela yokwazisa umzimba wethu nge-insulin

Uyazi ukuba yintoni i-insulin? Ngamafutshane, i-insulin ifana nesitshixo esivula ucango ukuze iswekile (i-glucose) ingene kwiiseli zomzimba wethu. Ukuba novelwano kwi-insulin kuthetha ukuba esi sitshixo sinokuvula ucango ngokufanelekileyo. Emva koko umzimba unokusebenzisa iswekile ngokulula kwaye ugcine amanqanaba eswekile egazini ekwinqanaba elifanelekileyo.

Ngoko ke, nantsi indlela i-Adiponectin enceda ngayo:

• Izihlunu zakho zamathambo kunye nesibindi zinceda umzimba wakho ukuba usabele kwi-insulin ngokufanelekileyo.
• Iyandisa ukukhululwa kwe-insulin kwi-pancreas.
• Iyayithintela indawo yokugcina iswekile engeyomfuneko ebizwa ngokuba yi-glycogen esibindini.
• Inceda ekuqhekezeni amafutha acids kwaye idale amandla.

Cinga nje, iiseli zomzimba wakho zifana nezindlu. I-insulin yiyo ethwala ukutya okubizwa ngokuba yiswekile ukuya kwezo zindlu. I-Adiponectin inceda ekungeniseni oku kutya ngomnyango. Emva koko indlu ifumana ukutya, akunjalo?

2. Indlela yokunciphisa ukudumba emzimbeni

Ukudumba kuxa inkqubo yethu yomzimba ithumela iiseli ukulwa nento efana neebhaktheriya okanye ukuphilisa inxeba. Ngamanye amaxesha oku kuyimfuneko. Kodwa ukudumba okungapheliyoOko kuthetha ukuba akulunganga ukuba umzimba uhlale une-inflammation encinci ngaphakathi. Khawucinge ukuba uhlala unomlilo omncinci ngaphakathi emzimbeni wakho... Yiloo nto ibizwa ngokuba yi-inflammation engapheliyo.

I-Adiponectin inceda ekunciphiseni ukudumba kwezi ndawo zilandelayo:

• IiMacrophages (uhlobo lweseli emhlophe yegazi egquma kwaye ibulale izinto ezifana neebhaktheriya kunye neentsholongwane)
• Izicubu ze-Endothelial (ezi ziiseli ezenza ulwelwesi oluncinci olujikeleza ngaphakathi kwentliziyo kunye nemithambo yegazi)
• Iiseli zemisipha
• Iiseli ze-Epithelial (ezi ziiseli ezigubungela yonke indawo ngaphakathi nangaphandle komzimba)

Ngokunciphisa ukudumba ngale ndlela, i-Adiponectin ikhusela la malungu:

• Inkqubo yemithambo yegazi
• Intliziyo
• Imiphunga
• Ikholoni

Iphi iAdiponectin eveliswa emizimbeni yethu?

I-Adiponectin yenziwa kwaye ikhutshwa kakhulu ziiseli ezibizwa ngokuba zii-adipocytes, ezigcina amandla kwizicubu zethu ezimhlophe ze-adipose . Izicubu ezimhlophe ze-adipose lolona hlobo luphambili lwamafutha emizimbeni yethu. Ifumaneka kwi:

• Amafutha angaphantsi kwesikhumba - oko kukuthi, umaleko wamafutha esiwuvayo xa siwuchukumisa.
• Amafutha angaphakathi esiswini - La ngamafutha angaphakathi esiswini anokuba yingozi kancinci.
• Umongo wamathambo (amafutha ommongo)

I-Adiponectin inokwenziwa nazizinye iintlobo zeeseli:

• Iiseli zemisipha yamathambo
• Iiseli zemisipha yentliziyo
• Iiseli ze-Endothelial

Alawulwa njani amanqanaba e-adiponectin?

Njengoko benditshilo ngaphambili, i-adiponectin yinto entsha efunyenweyo. Ngoko ke izazinzulu zisaphanda ngayo. Okwangoku, kuye kwafunyanwa iihomoni ezininzi ezinceda ekulawuleni amanqanaba e-adiponectin.

Nangona i-hormone i-insulin ibonakala ngathi ibandakanyeka koku, ayingabo bonke abantu abavumelanayo ngendlela eyenzeka ngayo.

I-insulin-like growth factor (IGF-1) kunye ne-growth hormone (GH) zilawula ukukhutshwa kwe-adiponectin kwizicubu zamafutha. I-Leptin (enye i-hormone eveliswa ziiseli zamafutha) nayo inokuba negalelo.

Ungayijonga njani amanqanaba e-Adiponectin?

Ungajonga amanqanaba akho e-Adiponectin ngovavanyo lwegazi .

Oogqirha ngamanye amaxesha badidanisa isifo seswekile sohlobo lwesibini kunye nesifo se-metabolic syndrome.Uvavanyo lwegazi lwe-adiponectin lungasetyenziselwa ukunceda ekuchongeni izifo ezifana nezi:

Afanele abe njani amanqanaba aqhelekileyo e-adiponectin?

Amanqanaba aqhelekileyo e-adiponectin ayahluka ngokuxhomekeke kwisini sakho kunye ne -Body Mass Index (BMI) , obubunzima bakho ngobude bakho.

Uluhlu oluqhelekileyo lwe-Adiponectin kumadoda lulandelayo:

• Ukuba i-BMI ingaphantsi kwama-25: 5 ukuya kuma-37 ee-micrograms/millilitha (5 ukuya kuma-37 ug/mL)
• Ukuba i-BMI iphakathi kwama-25 nama-30: 5 ukuya kuma-28 ug/mL
• Ukuba i-BMI ingaphezu kwama-30: 2 ukuya ku-20 ug/mL

Uluhlu oluqhelekileyo lwe-Adiponectin kubasetyhini lulandelayo:

• Ukuba i-BMI ingaphantsi kwama-25: 5 ukuya kuma-37 ug/mL
• Ukuba i-BMI iphakathi kwama-25 nama-30: 4 ukuya kuma-20 ug/mL
• Ukuba i-BMI ingaphezulu kwama-30: 4 ukuya kuma-22 ug/mL

Into ebalulekileyo kukuba la manani anokwahluka kancinci kumntu nomntu nakwilabhoratri. Ngoko ke, jonga uluhlu oluqhelekileyo kwingxelo yakho yelabhoratri. Ukuba unemibuzo malunga neziphumo zakho, qiniseka ukuba ubuza ugqirha wakho okanye umongikazi.

Zeziphi izifo ezinokuvela xa amanqanaba e-adiponectin engaqhelekanga?

Kukho iimeko ezininzi zempilo ezinxulunyaniswa namanqanaba angaqhelekanga e-adiponectin. Ezi ziquka:

• Ukutyeba kakhulu kunye nokutyeba okungaphantsi komzimba
• Ukuxhathisa i-insulin
• I-atherosclerosis
• I-Lipodystrophy

Uninzi lwezi meko lunxulunyaniswa namanqanaba aphantsi e-adiponectin .

I-Adiponectin kunye nokutyeba kakhulu

Abantu abatyebe kakhulu banezinga eliphantsi le-adiponectin. Kwelinye icala, abantu ababhityileyo kakhulu, nokuba kungenxa yeemeko ezifana ne -anorexia nervosa okanye ukungondleki kakuhle, banezinga eliphezulu le-adiponectin.

Ngamafutshane, njengoko amafutha omzimba womntu esanda, amanqanaba akhe e-adiponectin ayancipha. Ngokufanayo, njengoko amafutha omzimba ehla, amanqanaba akhe e-adiponectin ayanda. Xa umntu otyebileyo ehla, amanqanaba akhe e-adiponectin ayanda.

I-Adiponectin kunye nokuxhathisa i-insulin

Ngenxa yokuba i-adiponectin inceda ekwandiseni uvakalelo lwe-insulin, abantu abanokuxhathisa i-insulin badla ngokuba namanqanaba aphantsi e-adiponectin. Ukuxhathisa i-insulin kuxa iiseli zomzimba wakho zingaphenduli kakuhle kwi-insulin, nto leyo ebangela ukuba umzimba wakho ukhuphe i-insulin eninzi kakhulu (hyperinsulinemia).

Ngenxa yokuxhathisa i-insulinI-prediabetes, isifo seswekile sohlobo lwesibini , kunye nesifo seswekile sokukhulelwa sinokuvela. Oku kudla ngokunxulunyaniswa nokutyeba kakhulu. Nangona kunjalo, abantu abangatyebanga kakhulu nabo banokuba nokuxhathisa i-insulin. Okumangalisayo kukuba, abantu abaxhathisa i-insulin ngaphandle kokutyeba kakhulu banamanqanaba aphantsi e-adiponectin. Oku kubonisa ukuba kukho into ebangela i-genetic ebandakanyekayo ekuxhathiseni i-insulin kunye ne-adiponectin.

I-Adiponectin kunye ne-Atherosclerosis

I-atherosclerosis yimeko apho i-plaque iqokelelana ngaphakathi kwemithambo yakho, iyivale. Kufana nomhlwa oqokelelana ngaphakathi kumbhobho wamanzi.

I-Adiponectin ineempawu zokulwa nokuvuvukala, ezikhusela intliziyo kunye nemithambo yegazi. Ngoko ke, xa amanqanaba e-adiponectin ephantsi, umngcipheko wokufumana izifo zentliziyo ezifana ne-atherosclerosis kunye nokuhlaselwa yintliziyo unokwanda.

I-Adiponectin kunye ne-Lipodystrophy

I-lipodystrophy sisifo esingaqhelekanga kakhulu esibangela ukulahleka kwamafutha kwezinye iindawo zomzimba kunye nokuqokelelana kwamafutha amaninzi kwezinye.

I-lipodystrophy inokubakho ukususela ekuzalweni, okanye inokuvela kamva ebomini. Amanqanaba e-Adiponectin aphantsi kwi-lipodystrophy yokuzalwa kunye ne-HIV enxulumene ne-lipodystrophy. Oku kusenokuba kungenxa yokuba i-adiponectin ibandakanyeka kwindlela egcinwa ngayo amafutha emzimbeni.

Ngaba kukho unyango lwamanqanaba angaqhelekanga e-adiponectin?

Enyanisweni, kukho unyango lwendalo olunokunceda ukuphucula amanqanaba e-adiponectin. Oku kuquka ukuzilolonga rhoqo kunye nokunciphisa umzimba ngendlela enempilo. Nangona kunjalo, kufuneka uhlale uthetha nogqirha wakho ngaphambi kokuba wenze naluphi na utshintsho olukhulu kwindlela otya ngayo okanye kwindlela yakho yokuzilolonga.

Amayeza esifo seswekile afana ne -metformin kunye ne -thiazolidinediones afunyenwe enyusa amanqanaba e-adiponectin.

Oososayensi ngoku baphanda ngamayeza asebenza ngendlela efanayo neAdiponectin ukunyanga izifo ezingapheliyo zokudumba. Oko kungaba ziindaba ezimnandi kuthi kungekudala!

Yintoni umahluko phakathi kwe-Adiponectin ne-Leptin?

I-Leptin kunye ne-Adiponectin zombini zii-hormone ezenziwe kwaye zikhutshwa yizicubu zakho zamafutha, uhlobo lwee-adipokines. I-Leptin isebenza ngokunyusa imetabolism kunye nokunciphisa inkanuko yokutya.

Njenge-adiponectin, amanqanaba angaqhelekanga e-leptin nawo anxulunyaniswa nokutyeba kakhulu - kodwa ngendlela eyahlukileyo. Amanqanaba e-Leptin ayanda njengoko amafutha omzimba esanda. Nangona kunjalo, amanqanaba e-adiponectin ayancipha njengoko amafutha omzimba esanda. Kulula ukukhumbula, akunjalo?

Okokugqibela, eyona nto ibalulekileyo

Mhlawumbi ngoku uyaqonda ukuba i-adiponectin ibaluleke kangakanani emizimbeni yethu. Ekubeni iyinto entsha, izazinzulu zisafunda okungakumbi ngayo.

Ukuba unengxaki ye-metabolic efana nokutyeba kakhulu okanye isifo seswekile sohlobo lwesibini, kusenokwenzeka ukuba ukhe weva ugqirha wakho ethetha nge-adiponectin. Ukuba ukhe waba nombuzo malunga nelizwi elithethwa ngugqirha wakho, ungoyiki ukubuza. Balapha ukukunceda.

Akukho nto ibalulekileyo xa kufikwa kumanqanaba akho e-adiponectin. Imikhwa emihle yempilo, ukutya okunesondlo, kunye nendlela yokuphila esebenzayo zihlala ziyindlela ezilungileyo zokugcina la manqanaba eehomoni elawulwa. Ngoko ke, khathalela umzimba wakho, kuba impilo yeyona nto ibalulekileyo!

I- Adiponectin, i-Adiponectin, iHormone, i-Insulin, isifo seswekile, ukutyeba kakhulu, ukudumba, iMetabolism, iiSeli zamafutha