Ngaba une-high blood pressure, okanye into esiyaziyo sonke njenge-'pressure'? Okanye ngaba une-fluid retention kunye nemilenze evuvukileyo ngenxa yemeko efana nokuhlaselwa yintliziyo? Ngoko ke ugqirha wakho usenokuba ukunike iyeza elikhethekileyo. Lolo hlobo lwamayeza esiza kuthetha ngalo kweli nqaku namhlanje, ngokulula nangokuzolileyo. Siwabiza la mayeza ngokuba yi-Aldosterone Antagonists.
Ngamafutshane, ziintoni ezi Aldosterone Antagonists?
Kulungile, masiqonde oku ngale ndlela. Sinezitho ezimbini ezincinci emzimbeni wethu ezibizwa ngokuba zii-adrenal glands. Ezi zivelisa i-hormone ebizwa ngokuba yi-aldosterone. Umsebenzi ophambili wale hormone kukulawula uxinzelelo lwegazi ngokugcina ityuwa namanzi emzimbeni xa kuyimfuneko. Oku akuyongxaki kumntu oqhelekileyo.
Kodwa khawucinge nje, ukuba umntu sele enoxinzelelo lwegazi oluphezulu, okanye ukuba uqokelele amanzi ngokungeyomfuneko emzimbeni wakhe ngenxa yesifo sentliziyo, le hormone ye-aldosterone iya kuyenza ibe mandundu imeko.
Kulapho ke udidi lwamayeza olubizwa ngokuba yi -Aldosterone Antagonists lusiza khona ukuze lusincede. La mayeza asebenza ngokuthintela ukusebenza kwe-aldosterone hormone (i-antagonist ithetha ukusebenza ngokuchasene nayo). Yiyo loo nto olu didi lwamayeza lukwabizwa ngokuba yi-'potassium-sparing diuretics'.
Zeziphi iintlobo eziphambili zamayeza kolu didi?
Kukho iintlobo ezahlukeneyo zamayeza e-Aldosterone Antagonist adla ngokunikwa oogqirha. Usenokuba sele uwabonile la magama.
| Igama leyeza | Ulwazi olubalulekileyo |
|---|---|
| I-Spironolactone (i-spironolactone) | Eli lelona yeza lidala nelisetyenziswa kakhulu kolu hlobo. Liza njengepilisi okanye ulwelo. Lidla ngokuthathwa kube kanye ngemini. Ngamanye amaxesha linikwa kunye nenye indlela yokukhupha isisu, i-hydrochlorothiazide. |
| I-Eplerenone (Eplerenone) | Le ikwayipilisi. Imiselwe ukuba ithathwe kanye okanye kabini ngemini. Kucingelwa ukuba ineziphumo ebezingalindelekanga ezimbalwa xa ithelekiswa neSpironolactone. |
| IFinerenone (I-Finarenone) | Eli liyeza elitsha. Lidla ngokucetyiswa kubantu abanesifo sezintso esinganyangekiyo, ingakumbi abo banesifo seswekile sohlobo lwesibini. |
Eli yeza lisebenza njani emzimbeni?
Kulula kakhulu. Xa uthatha iyeza le-Aldosterone Antagonist, liyahamba lize livale ii-receptors ezivumela i-aldosterone hormone ukuba inamathele kwiiseli emzimbeni. Kuza kwenzeka ntoni emva koko?
I-hormone i-aldosterone ayikwazi ukugcina ityuwa namanzi emzimbeni. Ngenxa yoko, izintso zethu ziqala ukukhupha ityuwa namanzi amaninzi ngomchamo. Into ekhethekileyo ngale nto kukuba ngelixa ikhupha ityuwa namanzi anjalo, ikhusela umzimba ekulahlekelweni yiminerali ebalulekileyo ye-potassium.
Ngamafutshane, kunciphisa ubuninzi bamanzi netyuwa eqokeleleka ngokungeyomfuneko emzimbeni, kwaye kunciphisa noxinzelelo lwegazi. Oku kunciphisa nomthwalo entliziyweni.
Zeziphi iimeko eziphambili ezisetyenziselwa ii-Aldosterone Antagonists?
Oogqirha bacebisa olu hlobo lweyeza njengonyango kungekuphela nje lwesifo esinye, kodwa neemeko ezahlukeneyo.
- Ukungasebenzi kakuhle kwentliziyo: Xa intliziyo ibuthathaka, ulwelo luyaqokelelana emzimbeni (i-edema) luze lubangele ukudumba emilenzeni nasemiphungeni. Eli yeza linceda ukususa ulwelo olugqithisileyo kwaye linciphise uxinzelelo entliziyweni.
- Uxinzelelo lwegazi oluphezulu: Eli yeza linceda ekulawuleni uxinzelelo lwegazi oluphezulu olunzima ukululawula ngamanye amayeza.
- Isifo Sezintso Esingapheliyo: Ezi zisetyenziselwa ukunyanga izifo zezintso, ingakumbi ezo ziza nesifo seswekile.
- I-Hyperaldosteronism: Le yimeko apho umzimba uvelisa i-aldosterone eninzi kakhulu. Eli yeza libalulekile ukunyanga oku.
- Ukudumba okubangelwa sisifo sesibindi: Oku kukwanikwa ukulawula ukugcinwa kolwelo ngenxa yesifo sesibindi.
- Inqanaba eliphantsi le-potassium egazini: Eli yeza linikwa nale meko kuba linceda ukugcina inqanaba le-potassium emzimbeni.
- I-Acne: Abanye oogqirha besikhumba bacebisa i-Spironolactone kwi-acne kuba ilawula umsebenzi weehomoni ezithile.
Iingenelo kunye nemiphumo emibi enokubakho yala mayeza
Njengayo nayiphi na imithi, ezi zinokuba neengenelo kunye nezinye iziphumo ebezingalindelekanga.
Iingenelo eziphambili
- Yandisa ubomi bezigulane ezinesifo sentliziyo.
- Banamandla angakumbi okuzilolonga nokwenza imisebenzi yemihla ngemihla.
- Kunciphisa isidingo sokulaliswa esibhedlele.
- Inciphisa kakhulu umngcipheko wokufa ngequbuliso okunxulumene nesifo sentliziyo.
Iziphumo ebezingalindelekanga ezinokubakho
Xa usebenzisa eli yeza, ungachama rhoqo kunesiqhelo kuba liyi-diuretic. Oku kuqhelekile. Ukongeza, ezinye izinto zinokwenzeka.
- Ukukhwehlela
- Isiyezi (vertigo)
- Intloko ebuhlungu (intloko ebuhlungu)
- Urhudo
- Amanqanaba aphezulu e-potassium egazini: Le yeyona nto iphambili ekufuneka uyixhalabele. Le ngozi iphezulu kakhulu kubantu abanesifo sezintso. Ngoko ke, ugqirha uya kujonga rhoqo amanqanaba e-potassium ngokwenza uvavanyo lwegazi.
Iziphumo ebezingalindelekanga ezithile kwiSpironolactone
Ngenxa yokuba iyeza iSpironolactone lisebenzisana ngandlela thile nezinye iihomoni emzimbeni (androgen kunye neprogesterone), abanye abantu banokufumana oku kulandelayo:
- Ukwandiswa kwamabele (iGynecomastia) kumadoda nakubafazi.
- Ukungasebenzi kakuhle ngokwesondo kumadoda (Iingxaki zokuqina komzimba).
- Ukopha kwamalungu esini emva kokuya exesheni.
Ngenxa yezi zizathu, abanye abantu banokufuna ukutshintshela kwi-Eplerenone. Kodwa khumbula, ngugqirha wakho kuphela onokugqiba ukuba loluphi unyango olukufaneleyo .
Uthetha nini nogqirha wakho
Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ngelixa usebenzisa eli yeza, ungaze uyeke ukulithatha wedwa. Thetha nogqirha wakho ngoko nangoko. Usenokukwazi ukulungisa umthamo okanye akutshintshele kwelinye iyeza.
Kwakhona, ukuba iimpawu zakho aziphucuki emva kokusebenzisa iyeza kangangeeveki ezimbalwa, yazisa ugqirha wakho ngaloo nto.
Kwakhona, ukuba usebenzisa eli yeza, qiniseka ukuba ubuza ugqirha wakho ngaphambi kokuba usele ijusi yegrapefruit okanye usebenzise ezinye iindlela zetyuwa, njengoko ezinye zazo zinokuba ne-potassium.
Umyalezo Wokuya Ekhaya
- Ii-Aldosterone Antagonists ziluhlobo olubalulekileyo lwamayeza anyanga izifo ezifana noxinzelelo lwegazi oluphezulu, isifo sentliziyo, kunye nesifo sezintso.
- Oku kususa ityuwa namanzi agqithisileyo emzimbeni kwaye kugcina amanqanaba e-potassium afunekayo emzimbeni.
- Sela amayeza owanikwe wona kanye njengoko ugqirha wakho ekuxelela, ngexesha elifanelekileyo, ngedosi efanelekileyo. Ungaze uthathe iidosi ezimbini ngaxeshanye ukuze ubuyisele idosi oyiphosileyo.
- Ukuba ufumana naluphi na usizi okanye iziphumo ebezingalindelekanga ezivela kumayeza, musa ukwenza naziphi na izigqibo ngokwakho kwaye udibane nogqirha wakho ngoko nangoko.
- Kubaluleke kakhulu ukuba kwenziwe uvavanyo lwegazi rhoqo, ingakumbi ukujonga amanqanaba e-potassium.
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