Ngaba wakha waba nenxeba elincinci, laza loma kwiintsuku ezimbalwa, laza laphiliswa ngokugqibeleleyo ngokungathi akukho nto yenzekileyo? Umele ukuba wenze njalo, akunjalo? Ngelo xesha, sicinga kuphela ukuba inxeba lipholile. Kodwa asicingi ngezinto ezimangalisayo ezenzeka ngaphakathi emizimbeni yethu ukuze sipholise elo nxeba. Namhlanje, siza kuthetha ngenkqubo engaqhelekanga eyenzeka rhoqo ngaphakathi emizimbeni yethu, ebalulekileyo ekusindeni kwethu, kwaye ngamanye amaxesha isenza sihleke. Oku sikubiza ngokuba yi-angiogenesis.
Ngamafutshane, yintoni i-angiogenesis?
Kulula kakhulu. I-Angiogenesis yinkqubo yokusebenzisa imithambo yegazi esele isemizimbeni yethu ukwenza imithambo yegazi emitsha emincinci (ii-capillaries). Oku kuqala ngaphambi kokuba sizalwe, esibelekweni sikamama wethu, kwaye kuqhubeke logama nje siphila.
Ngoku usenokuba uzibuza ukuba le mijelo yegazi mincinci, ebizwa ngokuba yi-capillaries, yenza ntoni. Enyanisweni, le mijelo yegazi mincinci yenza omnye wemisebenzi ebaluleke kakhulu emizimbeni yethu. Isebenza 'njengenkonzo yokuhambisa' ethwala igazi, izondlo, kunye nomoya-mpilo ofunekayo kumalungu ethu nakwizicubu zethu.
Khawucinge ukuba ndaweni ithile emzimbeni wethu, izicubu azifumani ioksijini eyaneleyo. Le meko siyibiza ngokuba yi-hypoxia. Xa kungekho oksijini yaneleyo, iiseli ezikuloo ndawo ziyaphakuzela zize ziqalise ukukhupha imiqondiso yamakhemikhali ethi, "Sincedeni! Akukho oksijini yaneleyo apha!" Kufana nokuthumela umyalezo 'we-SOS'. Kwangoko nje lo myalezo 'we-SOS' ufunyenwe, iiseli ezenza udonga lwangaphakathi lwemithambo yethu yegazi, ezibizwa ngokuba ziiseli ze-endothelial, ziyavuselelwa kwaye ziqale ukwenza imithambo yegazi emitsha. Oku kukuqala kwenkqubo ye-angiogenesis.
Zenzeka njani ezi mithambo yegazi mitsha? Zimbini iindlela eziphambili!
Umzimba wethu usebenzisa iindlela ezimbini eziphambili ukwenza imithambo yegazi emitsha. Makhe sijonge ezi nkcukacha ukuze siqonde umahluko phakathi kwezi zimbini.
| Igama lendlela | Kwenzeka njani oku | Kalula nje... |
|---|---|---|
| Ukuhluma kwe-Angiogenesis | Ihlumela elitsha likhula kwimithambo yegazi ekhoyo. Eli hlumela likhula kancinci kancinci lisiya kwisignali yekhemikhali (umz., ikhemikhali ebizwa ngokuba yi-VEGF) evela kwindawo engenaoksijini. Ekugqibeleni, iba yimithambo yegazi emitsha ngokupheleleyo. | Kufana nesebe elitsha eliphuma esiqwini somthi. Elitsha liphuma kwesidala lize likhule. |
| I-Angiogenesis ye-Intussusceptive | Amahlumela amatsha awahlumi apha. Endaweni yoko, umthambo omnye wegazi uyaqhekeka embindini, ube yimithambo yegazi emibini. Iiseli ze-endothelial zingena ngaphakathi komthambo wegazi kwaye zenze iikholamu, ziwuhlulahlula kubini. | Kufana nokwakha iindlela ezimbini ngokubeka umsele phakathi kwendlela. Okuphela kwawo okhoyo wahlulwe waba zimbini. |
Ngaba oku kuyafana neVasculogenesis?
Hayi. Nangona la magama mabini esenokuvakala efana, kukho umahluko omncinci kodwa obalulekileyo. Omabini abandakanya ukwenziwa kwemithambo yegazi emitsha. Kodwa umahluko ukho kuhlobo lweeseli eziqalisa yona.
- I-Angiogenesis: Kulapho imithambo yegazi emitsha idalwa khona kwimithambo yegazi esele ikho, ekhule ngokupheleleyo.
- I-Vasculogenesis: Kulapho imithambo yegazi emitsha yenziwa khona ngohlobo oluthile lweseli olubizwa ngokuba yi-angioblast. Ezi ziiseli ezingavuthwanga ezingekaphuhli ngokupheleleyo zibe ziiseli ezijikeleze udonga lwemithambo yegazi.
Ngamafutshane, i-angiogenesis ifana nokwakha igumbi elitsha endlwini endala. I-Vasculogenesis ifana nokwakha indlu ukusuka ekuqaleni ngesiseko esitsha kraca kunye nezitena ezintsha.
Ngoko ke, ngaba le angiogenesis yinto entle okanye embi?
Eli likrele elintlangothi-mbini ngokwenene. Nokuba lilungile okanye libi kuxhomekeke ekubeni ngubani otyiswa yimithambo yegazi esandula ukwenziwa.
I-angiogenesis iba ngcono njani?
Emzimbeni ophilileyo, le nkqubo ibalulekile ukuze siphile.
- Amanxeba ayaphola: Xa usika isandla sakho, kwakheka imithambo yegazi emitsha ejikeleze inxeba, isinika ioksijini kunye nezondlo ezifunekayo. Yiyo loo nto amanxeba ephola ngokukhawuleza.
- Ngexesha lokukhulelwa: Usana olusakhulayo esibelekweni sikanina lufumana zonke izondlo kunye neoksijini oluyidingayo nge-placenta. Le placenta ifuna imithambo yegazi emitsha ukuze isebenze kakuhle.
- Ngexesha lokuzilolonga: Xa sizilolonga, izihlunu zethu zifuna ioksijini engaphezulu. Le nkqubo inceda ekuhlangabezaneni naloo mfuno.
- Ngexesha lokuya exesheni kwabasetyhini: Le nkqubo ibalulekile nakwindlela yokwakha kwakhona iindonga zesibeleko.
Ngamaxesha anje, i-angiogenesis ifana neqhawe elisinceda sisindise ubomi bethu kwaye lisigcine sisempilweni.
Icala elimnyama lale nkqubo - indlela yokunceda umhlaza
Le nkqubo ngokwayo inokuba lutshaba lwethu. Oko kukuthi, xa inceda iiseli zomhlaza zikhule.
Sonke siyazi ukuba umhlaza ukho xa iiseli emzimbeni wethu ziqala ukwahlukana ngokungalawulekiyo, ngokungathi ziphambene. Ezi seli zahlulahlulayo zihlangana ukuze zenze iithumba. Njengazo zonke ezinye izicwili emzimbeni wethu, ezi thumba zifuna ukutya, amanzi, kunye nokunikezelwa kwegazi ukuze ziphile, zikhule, kwaye zisasazeke emzimbeni wonke.
Okwenzekayo apha kukrelekrele kakhulu. Iiseli zomhlaza, njengezicubu eziphilileyo, ziqala ukukhupha ezi mpawu zekhemikhali 'ze-SOS' (ezifana ne-VEGF). Ezi mpawu zithi, "Asifumani gazi laneleyo, thumela imithambo yegazi emitsha apha ngokukhawuleza!"
Xa sifumana olu phawu, inkqubo ye-angiogenesis yomzimba wethu iqala kwaye iqalise ukukhulisa imithambo yegazi emitsha ukuya kwithumba. Ngamanye amazwi, umhlaza 'uyayithimba' inkqubo yendalo emzimbeni wethu.
Le mithambo yegazi mitsha inika ithumba unikezelo oluqhubekayo lweoksijini kunye nezondlo. Ngenxa yoko, ithumba likhula ngokukhawuleza nangokukhawuleza. Okuyingozi ngakumbi kukuba iiseli zomhlaza zinokuhamba kule mithambo yegazi mitsha zize ziqale ukusasazeka ziye kwezinye iindawo zomzimba.
Yiyo loo nto sithi inkqubo ebizwa ngokuba yi-angiogenesis inokuba yingozi kumhlaza. Kufana nokondla utshaba lwethu, silondle.
Ayinakuyekiswa le nto? Masithethe ngee-Angiogenesis Inhibitors
Emva kokuba izazinzulu ziqonde indlela ezibonakala ngayo ezi thumba, zaqala ukukhangela isisombululo. Esinye seziphumo zolu phando yayiludidi lwamayeza abizwa ngokuba yi -Angiogenesis Inhibitors .
Eyona nto iphambili eyenziwa ngala mayeza kukuthintela ukuhanjiswa kwegazi kumhlaza. Kufana nokulambisa utshaba oluya kufa.
La mayeza asebenza ngeendlela ezahlukeneyo. Enye indlela ephambili kukuthintela unxibelelwano phakathi kwesignali yekhemikhali 'ye-SOS' yomhlaza kunye nemithambo yegazi eyifumanayo. Kanye njengokuba i-static iphazamisa umnxeba, la mayeza athintela umyalezo womhlaza ekufikeleleni kwimithambo yegazi. Oku kuyayithintela imithambo yegazi emitsha ukuba ingenzeki, kunciphise izondlo ezifunekayo kumhlaza, kwaye kunciphise ukukhula kwawo.
Namhlanje, inani lamayeza okuthintela i-angiogenesis avunyiwe ziiarhente ezifana ne-US Food and Drug Administration (FDA) ukunyanga umhlaza. Aye aba yinxalenye ebaluleke kakhulu kunyango lomhlaza.
Ukuba wena okanye umntu omaziyo unesifo somhlaza kwaye unemibuzo malunga nolu nyango, umntu ofanelekileyo nofanelekileyo ukuthetha naye ngugqirha wakho onyangayo . Kubaluleke kakhulu ukufuna iingcebiso kugqirha oyazi kakuhle imeko yakho, kunokuthembela kwi-intanethi okanye kwezinye iindawo.
I-Angiogenesis yinkqubo eyenzeka ngemicroscope esingenakuyibona ngamehlo ethu, kodwa ngumzekelo omhle wendlela esebenza ngayo imizimba yethu ngendlela emangalisayo. Ukwazi oku malunga nemizimba yethu, izifo, kunye nonyango kunokusinceda senze izigqibo ezingcono malunga nempilo yethu.
Umyalezo Wokuya Ekhaya
- I-Angiogenesis yinkqubo yendalo yokwenza imithambo yegazi emitsha kwimithambo yegazi ekhoyo emzimbeni wethu.
- Le nkqubo ibalulekile ekusebenzeni kakuhle komzimba ngamaxesha afana nokuphiliswa kwamanxeba nokukhulelwa.
- Nangona kunjalo, le nkqubo inokuba yingozi kuba inika iiseli zomhlaza izondlo kunye neoksijini, nto leyo enceda ukuba zikhule kwaye zisasazeke emzimbeni wonke.
- I-Angiogenesis inhibitors ludidi olutsha lwamayeza anyanga umhlaza ngokuthintela ukuhanjiswa kwegazi kwiithumba.
- Ukwazi indlela umzimba wakho osebenza ngayo kunokukunceda uqonde ngcono impilo yakho. Ukuba unenkxalabo malunga nayo nayiphi na imeko yezonyango okanye unyango, thetha nogqirha wakho.
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