Ngaba wena okanye umntu omaziyo wakha wadumba ngequbuliso kwiindawo zomzimba wakho, ingakumbi ubuso bakho, imilebe, ulwimi, okanye amalungu omzimba, ngaphandle kwentlungu? Ngamanye amaxesha oku kudumba kunokukhokelela ekuphefumleni nzima. Le meko siyibiza ngokuba yi-Angioedema. Namhlanje sithetha ngesitofu esikhethekileyo esinikwa ukuthintela ukuhlaselwa kokudumba okwenzeka kule meko. Sibizwa ngokuba yi-C1 Inhibitor, isitofu sabantu.
Ngamafutshane, yintoni le nto yokugonyela i-C1 Inhibitor?
I-C1 Inhibitor yiproteni eveliswa ngokwendalo kuyo yonke imizimba yethu. Ilawula ezinye zeenkqubo zenkqubo yethu yokuzikhusela. Nangona kunjalo, kwabanye abantu, ngenxa yezizathu zemfuza (oku kubizwa ngokuba yiHereditary Angioedema) okanye ezinye izizathu, le protein ye-C1 Inhibitor ayiveliswanga emzimbeni ngobuninzi obaneleyo. Kulapho ke kuvela khona ukudumba ngequbuliso njengoko bekutshiwo ngaphambili.
Ngoko ke, into eyenziwa lolu gonyo kukunika umzimba iproteni ye-C1 Inhibitor engekhoyo. Olu gonyo lubizwa ngokuba 'luLuntu' kuba lucocwa kwinxalenye yeplasma yegazi lomntu kwaye lwenziwa emva kwenkqubo ekhethekileyo. Eli yeza lingafumaneka kwimarike phantsi kwamagama eempawu ezifana neCinryze okanye iHAEGARDA.
Okubaluleke kakhulu, eli yeza lisetyenziselwa ukuthintela ukuhlaselwa yi-angioedema.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uthathe eli yeza
Ngaphambi kokuba akunike eli yeza, ugqirha wakho kufuneka ayazi imbali yakho yonke yempilo. Qiniseka ukuba umxelele ukuba unayo nayiphi na kwezi meko zilandelayo:
- Iingxaki zokunqanda igazi: Ukuba ukhe waba nengxaki yokunqanda igazi ngaphambili, njengokunqanda igazi emthanjeni osemlenzeni (DVT - Deep Vein Thrombosis) okanye isifo sohlangothi.
- Ii-Allergy: Ukuba une-allergy kwi-C1 Inhibitor vaccine okanye naliphi na elinye iyeza, ukutya, okanye izithinteli.
- Ukukhulelwa: Ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa.
Ngokusekelwe kolu lwazi, ugqirha wakho uya kugqiba ukuba eli yeza lifanelekile na kuwe kwaye angalinika njani.
Indlela yokusebenzisa eli yeza?
Eli yeza linikwa ikakhulu ngeendlela ezimbini.
1. Ukufakwa kwe-infusion emthanjeni: Indlela yokunika isisombululo, esifana ne-saline, emthanjeni.
2. Inaliti phantsi kwesikhumba: Inaliti encinci enikwa phantsi kwesikhumba.
Eli yeza lidla ngokunikwa ngugqirha wezempilo esibhedlele okanye ekliniki. Nangona kunjalo, kwezinye iimeko, unokufuna ukulisela ekhaya eli yeza. Kwimeko enjalo, uya kunikwa uqeqesho olufanelekileyo malunga nendlela yokulungiselela iyeza kunye nendlela yokulifaka ngokuchanekileyo . Kubaluleke kakhulu ukulisela eli yeza ngexesha elifanelekileyo nangedosi efanelekileyo, njengoko ugqirha wakho ekuxelela.
Ukuba uyisebenzisa ekhaya, cinga ngale nto.
Ukuba usebenzisa iinaliti kunye neesirinji ekhaya, musa ukuzilahla emgqomeni emva kokuzisebenzisa. Sebenzisa isitya esibukhali. Ukuba awunaso, buza ugqirha wakho ngendlela yokusifumana. Oku kubalulekile kukhuseleko lwakho, losapho lwakho, kunye nokusingqongileyo.
Iziphumo ebezingalindelekanga ezinokubakho zale yeza
Njengalo naliphi na iyeza, eli linokuba nemiphumo emibi. Kodwa ayinguye wonke umntu oyifumanayo. Masiwahlule la miphumo ibe ngamacandelo amabini.
| Iziphumo ebezingalindelekanga ze-C1 Inhibitor vaccine | |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha wakho okanye kwi-ETU ngoko nangoko | |
| Ukwaliwa kakhulu | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi, ubunzima bokuphefumla. |
| Iimpawu zokuqhekeka kwegazi | Intlungu, ukudumba kunye nokufudumala emlenzeni (DVT), ubunzima bokuphefumla, iintlungu zesifuba. |
| Iimpawu zeStroke | Ukuba ndindisholo okanye ubuthathaka ebusweni, engalweni, okanye emlenzeni, ukudideka, ubunzima bokuthetha okanye bokuqonda, ubunzima bokuhamba, isiyezi, ukulahlekelwa kukulinganisela. |
| Ezinye iimpawu ezinzulu | Intloko ebuhlungu kakhulu, utshintsho lombono. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Intloko ebuhlungu | Esi sisiphumo esiqhelekileyo esingalindelekanga. |
Ukuba ufumana naziphi na ezinye iimpawu ezingaqhelekanga ezingakhankanywanga kolu luhlu, nceda wazise ugqirha wakho ngazo.
Ezinye izinto ezimbalwa ekufuneka uziqwalasele
- I-Overdose: Ukuba ucinga ukuba usele amayeza amaninzi, fowunela iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko, okanye uye kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
- Ukuba uphoswe yidosi: Ukuba uphoswe yidosi, yithathe ngokukhawuleza njengoko ukhumbula. Nangona kunjalo, ukuba sele kusondele ixesha lomthamo wakho olandelayo, yeka umthamo ophoswe yidosi uze uthathe umthamo wakho olandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngexesha elinye.
- Yenziwe ngegazi lomntu: Njengoko bekutshiwo ngaphambili, eli yeza lenziwe ngegazi lomntu. Ke ngoko, kukho umngcipheko omncinci kakhulu, kodwa awukho nowokubakho, wokudlulisela usulelo. Nangona kunjalo, eli yeza lenziwa emva kweenkqubo ezingqongqo kakhulu zokucoca nokuvavanya. Okwangoku, akukho sulelo luxeliweyo. Thetha nogqirha wakho malunga nayo nayiphi na imibuzo onokuba nayo malunga noku.
- Musa ukwabelana ngeyeza nabanye abantu: Eli yeza limiselwe wena wedwa. Ungaze wabelane ngalo nabanye abantu.
Kubaluleke kakhulu ukwazisa ugqirha wakho ukuba iimpawu zakho aziphucuki, okanye ukuba ziya zisiba mandundu.
Umyalezo Wokuya Ekhaya
- I-C1 Inhibitor sisitofu esikhethekileyo esinikwa ukuthintela ukudumba ngequbuliso okubangelwa yi-Angioedema.
- Ngaphambi kokuba usebenzise eli yeza, xelela ugqirha wakho ngalo lonke ulwazi lwakho lwezempilo, ingakumbi iingxaki zokujiya kwegazi kunye ne-allergies.
- Xa usebenzisa iyeza, qaphela iziphumo ebezingalindelekanga ezinzulu (ingakumbi iimpawu zokuqhekeka kwegazi okanye isifo sohlangothi). Ukuba ufumana nayiphi na kwezi, funa ingcebiso kagqirha ngokukhawuleza.
- Thetha ngokukhululekileyo nogqirha wakho malunga nemibuzo okanye iinkxalabo onazo malunga nale mithi. Musa ukoyika.
- Ukuba usebenzisa iisirinji ekhaya, qiniseka ukuba uzilahla ngokufanelekileyo nangokukhuselekileyo.
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Zisetyenziselwa ntoni iipilisi zeDifenoxin kunye neAtropine / Motofen?
Eli asiloyeza onokulithenga kwikhemesti! Eli lichiza elinamandla kakhulu elikwiqela lamayeza (i-opioid antidiarrheal) elinikwa ngoogqirha ukuze bayeke ngoko nangoko urhudo olunzima okanye ukuhlanza okunganyamezelekiyo nokuqhubekayo nokufana nolwelo!
💬 Xa kukho urhudo olunzima, le pilisi (iMotofen) ingaluphelisa njani urhudo ngoko nangoko?
Xa uphuma isisu, amathumbu ahamba ngokukhawuleza aze atyhale isitulo siphume. I-Opioid drug (Difenoxin) kweli yeza ikhubaza izihlunu zamathumbu nge-100% kwaye inciphise isantya (Yehlisa ukuhamba kwe-GI). Emva koko, xa isitulo sisemathunjini, sifunxa amanzi kakuhle kwaye urhudo luyeke ngoko nangoko. I-Atropine (Anticholinergic) ikwanceda ukomisa ukuhamba kwamathe/ulwelo emathunjini.
💬 Kutheni kukho i-atropine encinci kule pilisi yokuthintela urhudo? Zithini iingozi zayo?
I-'Difenoxin' equlethwe apha sisiyobisi esifana ne-Opioid! Ngoko ke, ukuba usela kakhulu kwesi, unganxila kakhulu/unxile kakhulu. Ukuthintela oko, i-'Atropine' yongezwa njengesohlwayo kwabo basela ezi pilisi ngasese! Ukuba usela iipilisi ezininzi, le Atropine ibangela umlomo owomileyo kakhulu, ukubetha kwentliziyo ngokukhawuleza, kunye nokugcinwa komchamo (ubuthi be-Anticholinergic). Kwakhona, ukuba inikwa abantwana, banokuyeka ukuphefumla (ukudandatheka kokuphefumla) baze bafe!
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