Masifunde ngamayeza esifo seswekile iCanagliflozin kunye neMetformin.

Ngaba unesifo seswekile, okanye isifo seswekile sohlobo lwesibini? Okanye ngaba kukho umntu omaziyo onale meko? Ugqirha wakho usenokuba ukunike umxube wamayeza amabini, iCanagliflozin kunye neMetformin, ingakumbi ipilisi ekhutshwa ixesha elide . Igama lophawu lwale nto lisenokuba yi-Invokamet XR. Ngoko ke, masithethe kancinci ngale chiza namhlanje, akunjalo?

Kwenzeka ntoni ngokwenene ngale mithi?

Ngamafutshane, eli yeza lisetyenziselwa ukulawula amanqanaba eswekile egazini lakho (iglucose egazini) . Xa une-`Type 2 Diabetes`, kukho utshintsho oluthile kwindlela umzimba wethu olawula ngayo iswekile. Eli yeza lisebenza ngokunciphisa elo nqanaba leswekile kwaye likuncede uhlale usempilweni. Kule nto, i-`Canagliflozin` inceda umzimba ukuba ukhuphe iswekile egqithisileyo ngomchamo, ngelixa i-`Metformin` inciphisa ukuveliswa kweswekile sisibindi kwaye yonyusa uvakalelo lweeseli zomzimba kwi-insulin. Kodwa khumbula, eli yeza lodwa alanelanga. Ukutya okunempilo kunye nokuzilolonga nako kubaluleke kakhulu koku.

Zeziphi izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza?

Oku kubaluleke kakhulu. Ukuba unenye yezi meko zilandelayo, ngokuqinisekileyo kufuneka uxelele ugqirha wakho ngaphambi kokuba uqale eli yeza. Kuba, kulapho kuphela apho ugqirha anokuthi agqibe khona ukuba eli yeza lifanelekile kuwe okanye akunjalo, okanye ukuba umthamo kufuneka utshintshwe na. Cinga nje, ukuba awumxeleli ugqirha ezi nkcukacha, unokujongana neengxaki ezingeyomfuneko.

• Ukuba une-'Anemia'
• Ukuba unesifo semithambo yegazi
• Ukuba uphelelwe ngamanzi emzimbeni ngenxa yokunqongophala kwamanzi
• Ukuba sele ukhe waba ne-`Diabetic ketoacidosis (DKA)` (ukwanda kwe-asidi egazini ngenxa yesifo seswekile)
• Ukuba utya ukutya okungenatyuwa ingako
• Ukuba utya kancinci ngenxa yokugula, utyando, ukunciphisa ukutya, okanye ezinye izizathu
• Ukuba unezilonda ezinyaweni
• Ukuba uza kutyandwa kwixesha elizayo
• Ukuba unesifo sentliziyo
• Ukuba une-cholesterol ephezulu (`i-cholesterol ephezulu`)
• Ukuba inqanaba le-potassium egazini liphezulu (`Amanqanaba aphezulu e-potassium egazini`)
• Ukuba ukhe wasuswa umlenze okanye inxalenye ngaphambili (`Imbali yokunqunyulwa kwelungu`)
• Ukuba unembali ye-pancreatitis okanye ezinye iingxaki nge-pancreas yakho
• Ukuba unembali yosulelo lwe-yeast kwilungu lobudoda okanye lobufazi
• Ukuba usela utywala rhoqo
• Ukuba ufumana usulelo kwisinyi, kwizintso, okanye kwindlela yomchamo
• Ukuba unesifo sezintso (eli yeza alifanelekanga ukuba ukusebenza kwezintso kungaphantsi kwenqanaba elithile)
• Ukuba unesifo sesibindi
• Ukuba uxinzelelo lwakho lwegazi luphantsi (`uxinzelelo lwegazi oluphantsi`)
• Ukuba unomonakalo wemithambo-luvo
• Ukuba ungumntu ophononongwa nge-hemodialysis
• Ukuba une-`Polycystic ovary syndrome (PCOS)` (imeko apho ii-cysts zenzeka khona kwii-ovari)
• Ukuba uneengxaki zokuchama
• Ukuba unosulelo olukhulu okanye ukwenzakala
• Ukuba unesifo seswekile sohlobo 1 (Eli yeza lelabo banesifo seswekile sohlobo 2)
• Ukuba uyindoda engalukanga
• Ukuba uhlanza rhoqo
• Ukuba une-allergy kwiCanagliflozin, iMetformin, amanye amayeza, ukutya, iidayi, okanye izithinteli
• Ukuba ukhulelwe okanye uzama ukukhulelwa
• Ukuba ungumama oncancisayo (`oncancisayo`)

Musa ukothuka lolu luhlu. Ayizizo zonke ezi zinto ezichaphazela wonke umntu. Kodwa ukuba kukho into echaphazela wena, kubalulekile ukuba uxelele ugqirha wakho ukuze ukhuseleke .

Ndingayisebenzisa njani le yeza?

Kulungile, ngoku makhe sibone indlela yokusebenzisa eli yeza.

• Ufanele usele le pilisi neglasi yamanzi .
• Oku kufanele kuthathwe kunye nokutya . Ngokwesiqhelo kunye nesidlo sokuqala esiphambili sosuku. Okanye njengoko kuyalelwe ngugqirha wakho.
• Ginya ithebhulethi yonke . Musa ukuyityumza okanye ukuyihlafuna. Oku kungenxa yokuba yenzelwe ukusebenza ixesha elide. Ukuba uyayiphula, iyeza liza kungena emzimbeni wakho ngoko nangoko, nto leyo ebangela ukwehla ngequbuliso kweswekile egazini okanye ezinye iingxaki.
• Sela amayeza amiselweyo, ngexesha elimiselweyo, kwidosi emiselweyo, njengoko kuyalelwe kwileyibhile kagqirha.
• Musa ukusela ngaphezu kokucetyiswa ngugqirha, okanye usele rhoqo.
• Musa ukuyeka ukuthatha amayeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho. Ukwenza njalo kunokubangela ukuba amanqanaba eswekile egazini lakho anyuke ngequbuliso.

Xa ufumana eli yeza kwikhemesti, uza kunikwa incwadana yolwazi ekhethekileyo (i-'MedGuide') kunye nalo. Qiniseka ukuba ulifunda ngononophelo ngalo lonke ixesha ufumana iyeza lakho okanye ufumana 'ukugcwalisa kwakhona'. Liqulethe ulwazi oluninzi olubalulekileyo kuwe.

Ngaba eli yeza linokunikwa abantwana?

Kuya kufuneka uthethe neqela lakho lezempilo malunga nokunika abantwana eli yeza. Eli liyeza elihlala linikwa abantu abadala. Ukuba liyimfuneko kubantwana, lifuna izizathu ezikhethekileyo kunye nolawulo.

Kuthekani ukuba usela kakhulu? (`Umthamo ogqithisileyo`)

Ukuba ucinga ukuba usele kakhulu eli yeza, yiya kwicandelo lezonyango ezingxamisekileyo lesibhedlele elikufutshane ngoko nangoko, okanye utsalele umnxeba kwiziko lokulawula ityhefu (umz. iZiko loLwazi lwePoisons leSizwe - 0112 686 143) . Musa ukuchitha ixesha.

Kubalulekile: Eli yeza limiselwe wena wedwa. Musa ukwabelana ngamayeza akho nabanye, nokuba bakwimeko efanayo neyakho. Kuba iyeza elisebenzela omnye umntu lisenokungasebenzi komnye.

Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?

Owu, ngamanye amaxesha uyaphoswa yidosi. Ukuba oko kuyenzeka, yithathe ngokukhawuleza xa ukhumbula . Nangona kunjalo, ukuba sele kusondele ixesha ledosi yakho elandelayo (umz., kwiiyure ezimbalwa), yeka idosi ephosiweyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe idosi ephindwe kabini. Ukwenza njalo kunokubangela ukuba iswekile yakho yegazi yehle kakhulu.

Ngawaphi amanye amayeza anokusebenza kunye nale mithi?

Le yingongoma ebaluleke kakhulu. Ngelixa usela eli yeza le-'Canagliflozin; Metformin', akucetyiswa ukuba usele amanye amayeza. Kwakhona, linokunxibelelana namanye amayeza. Ke ngoko, kufuneka uxelele ugqirha wakho ngawo onke amayeza owasebenzisayo (achazwe ngugqirha, lawo uwathengayo kwikhemesti, amayeza esintu, iivithamini, kwanezongezo zokutya). Kwakhona, xelela ugqirha wakho ukuba utshaya icuba, usela utywala, okanye usela amanye amayeza.

Amayeza angafanele asetyenziswe kunye nale yeza:

• Iindidi ezithile zamayeza 'angafaniyo', anikwa ngemithambo ngaphambi kovavanyo oluthile olufana ne-X-ray, i-CT scans, kunye ne-MRIs, zinokuchaphazela izintso kwaye, xa zidityaniswe ne-'Metformin', zandisa umngcipheko wesimo esiyingozi esibizwa ngokuba yi-'Lactic Acidosis'.
• `Dofetilide` (eli liyeza elinikwa isingqisho sentliziyo esingahambelaniyo).

Amanye amayeza anokusebenzisana nalo mayeza:

(Olu luhlu lusenokungaphelelanga, ngoko ke kubalulekile ukuxelela ugqirha wakho yonke into oyithathayo)

• `I-Acetazolamide`
• Utywala - Bunyusa umngcipheko we-lactic acidosis kwaye bunokubangela iswekile ephantsi egazini.
• Amanye amayeza e-antiviral e-HIV okanye i-Hepatitis
• Amanye amayeza oxinzelelo lwegazi, isifo sentliziyo, kunye neengxaki zesingqisho sentliziyo (umz., ii-beta-blockers, ezinokufihla iimpawu zeswekile ephantsi yegazi)
• `I-Cimetidine`
• `I-Dichlorphenamide`
• I-Digoxin (iyeza lentliziyo) - Amanqanaba e-Digoxin anokutshintsha xa ethathwa neCanagliflozin.
• I-Diuretics (amayeza abangela ukwanda kokuchama) - Yandisa umngcipheko wokuphelelwa ngamanzi emzimbeni kunye noxinzelelo lwegazi oluphantsi.
• Iihomoni ze-estrogen okanye ze-progestin
• `I-Glycopyrrolate`
• `Isoniazid` (iyeza lesifo sephepha)
• `I-Lamotrigine`
• `Ilithiyum`
• `I-Memantine`
• `I-Methazolamide`
• 'I-Metoclopramide'
• `I-Midodrine`
• `INiacin`
• `I-Phenobarbital`
• IiPhenothiazines (umz. i-chlorpromazine, i-prochlorperazine, i-thioridazine)
• `Phenytoin`
• `I-Ranolazine`
• I-Rifampin (iyeza elisetyenziselwa ukunyanga isifo sephepha okanye ezinye izifo) - Inganciphisa ukusebenza kweCanagliflozin.
• `I-Ritonavir`
• Amayeza e-steroid (umz. i-prednisone okanye i-cortisone) - anokunyusa amanqanaba eswekile egazini.
• Amayeza okukhuthaza ukuphazamiseka kwengqondo, ukwehla kobunzima, okanye ukuhlala uphaphile
• Amayeza e-thyroid
• 'I-Topiramate'
• `I-Trospium`
• `Vandetanib`
• `I-Zonisamide`

Khawucinge nje, zininzi izinto ezinokutshintsha impembelelo yale yeza. Yiyo loo nto kubaluleke kakhulu ukwazisa ugqirha wakho ngayo yonke imithi oyithathayo .

Zeziphi izinto ekufuneka uzilumkele xa usebenzisa eli yeza?

Xa usebenzisa eli yeza, kufuneka ulumke ngakumbi ngempilo yakho.

• Bona ugqirha wakho rhoqo ('ukuhlolwa rhoqo') ukuze ujonge imeko yakho . Fumana uvavanyo olufana nokusebenza kwezintso kunye namanqanaba evithamini B12 njengoko ugqirha wakho ecebisa.
• Ngenxa yokuba eli yeza line-'Metformin', ngamanye amaxesha i-asidi yegazi inokuba phezulu ngendlela eyingozi ('Lactic Acidosis') . Nangona oku kunqabile kakhulu, kunokuba yingozi kakhulu ukuba kuyenzeka. Ukuba ufumana iimpawu ezifana nokucaphuka, ukuhlanza, iintlungu zesisu, ukudinwa okungaqhelekanga, ubunzima bokuphefumla, ukuphefumla ngokukhawuleza, ukuziva ubanda, okanye isiyezi, yeka ukuthatha eli yeza ngoko nangoko kwaye ubize ugqirha wakho okanye uye esibhedlele . Ukuba kunokwenzeka, jonga nomchamo wakho ukuba kukho ii-ketones nge-'ketone dipstick'.
• I-Canagliflozin inokubangela imeko ebizwa ngokuba yi-Diabetic Ketoacidosis (DKA) . Le yimeko apho amanqanaba eswekile egazini enganyuki kakhulu. Iimpawu ziquka ukoma kakhulu, ukuchama rhoqo, umlomo owomileyo, ukudinwa, ivumba lomphefumlo elifana neziqhamo, ukuphefumla kancinci, iintlungu zesisu, isicaphucaphu, kunye nokuhlanza. Ukuba ufumana naziphi na kwezi mpawu, xelela ugqirha wakho ngoko nangoko.
• Ugqirha wakho uhlala eyalela uvavanyo olubizwa ngokuba yi-`HbA1C (A1C)` ukuze abone ukuba iswekile yakho yegazi ilawulwa kakuhle kangakanani na . Olu luvavanyo lwegazi olulula. Lungabonisa ukuba iswekile yakho yegazi ilawulwa kakuhle kangakanani na kwixesha leenyanga ezi-2-3. Olu vavanyo ludla ngokwenziwa rhoqo emva kweenyanga ezi-3-6.
• Funda indlela yokuvavanya amanqanaba eswekile egazini lakho ekhaya . Kwakhona, qaphela iimpawu zeswekile ephantsi egazini (hypoglycemia) kunye neswekile ephezulu egazini (hyperglycemia) kunye nendlela yokuzilawula .
• Soloko ugcina umthombo weswekile okhawulezayo (umz., iityhubhu zeswekile, iipilisi zeswekile, isiselo esinoshukela, ijusi yeziqhamo) kuwe ukuba ufumana iimpawu zeswekile ephantsi egazini (ukubila, ukungcangcazela, indlala enkulu, ukubetha kwentliziyo ngokukhawuleza, isiyezi, ukudideka). Nangona kunjalo, ukuba uphelelwa zingqondo okanye unesifo sokuxhuzula , xelela amalungu osapho lwakho ukuba asenokukrwitshwa ukuba azama ukukunika ukutya okanye isiselo. Ukuba oku kuyenzeka , kufuneka ufune unyango ngokukhawuleza .
• Eli yeza lisenokunciphisa amanqanaba akho e-folic acid kunye ne-vitamin B12, ingakumbi xa usebenzisa i-metformin. Ngoko ke, qiniseka ukuba utya iivithamini ezaneleyo ngelixa usebenzisa eli yeza. Ugqirha wakho unokukunika isongezelelo seevithamini ukuba kuyimfuneko.
• Kuphephe ukuphelelwa ngamanzi emzimbeni . Sela amanzi amaninzi, ingakumbi xa kushushu, xa uzilolonga, okanye ukuba unesisu esibuhlungu.
• Lumka kakhulu iinyawo zakho . Jonga iinyawo zakho yonke imihla, kuba kukho umngcipheko omncinci wokosuleleka okanye ukunqunyulwa kwemilenze engezantsi ngelixa usebenzisa eli yeza (ingakumbi iCanagliflozin). Ngoko ke ukuba unezilonda, imifantu, ukubomvu, okanye ukudumba ezinyaweni zakho, xelela ugqirha wakho ngokukhawuleza.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengalo naliphi na iyeza, eli linokubangela iziphumo ebezingalindelekanga. Kodwa ayinguye wonke umntu ozifumanayo. Ezinye ziyingozi kwaye kufuneka uxelele ugqirha wakho ngoko nangoko. Ezinye zihlala zingekho mbi kakhulu, kodwa ukuba ziyaqhubeka, kulungile ukuxelela ugqirha wakho .

Iziphumo ebezingalindelekanga ekufuneka uxelele ugqirha wakho ngazo ngoko nangoko

• Iimpendulo ze-allergy : ukurhawuzelela kwesikhumba, ukurhawuzelela, amaqhuqhuva (amaqhuqhuva abomvu eluswini), ukudumba kobuso, imilebe, ulwimi, okanye umqala (kunokubangela ubunzima bokuphefumla).
• Ukuphelelwa ngamanzi emzimbeni : Ukomelana nokoma, umlomo owomileyo, isiyezi, intloko ebuhlungu, umchamo otyheli okanye omdaka omnyama, kunye nokuncipha kokuphuma komchamo.
• I-ketoacidosis yesifo seswekile (DKA) : Ukoma okanye ukuchama okwandayo, umlomo owomileyo, ukudinwa kakhulu, ivumba lomphefumlo elifana neziqhamo, ukuphefumla okufutshane, iintlungu zesisu, isicaphucaphu, kunye nokuhlanza.
• Usulelo lwe-genital yeast : (kwilungu lobufazi kubafazi, kwilungu lobudoda kumadoda) ukubomvu, ukudumba, iintlungu okanye ukurhawuzelela, ivumba elibi, kunye nokukhupha okumhlophe okujiyileyo okanye okugobileyo.
• Ukwanda kwe-lactic acid egazini (`Lactic Acidosis`) : Iintlungu okanye ukuqaqamba kwemisipha, iintlungu zesisu, ubunzima bokuphefumla, ukuphefumla ngokukhawuleza, ukungakhululeki ngokubanzi kunye nokudinwa, isiyezi, ukubanda.
• Usulelo olujikeleze amalungu esini okanye kwindawo ekhokelela kwi-anus (`i-Fournier's gangrene`) : ukubomvu, ukudumba, ukuqina, okanye intlungu, ngamanye amaxesha kunye nomkhuhlane. Le yimeko embi kakhulu, esongela ubomi, ngoko ke xelela ugqirha wakho ngokukhawuleza ukuba ubona nayiphi na kwezi mpawu.
• Inqanaba eliphantsi levithamini B12 : Intlungu, ukuba ndindisholo, okanye ukuphelelwa zimvakalelo emalungeni, ubuthathaka bemisipha, isiyezi, ubunzima bokugxila, ukudideka, ulwimi olubuhlungu, umbala wolusu.
• Intlungu entsha okanye ukuqina emlenzeni okanye ezinyaweni, ukutshintsha kombala wolusu, izilonda okanye izilonda, okanye usulelo.Ezi zizinto ekufuneka ziqwalaselwe ngokukhawuleza.
• Usulelo lomchamo (UTI) : Ukutsha xa uchama, ukuchama rhoqo, umchamo onegazi okanye amafu, iintlungu emqolo ongezantsi okanye emqolo, umkhuhlane.
• Ukuqhekeka kwamathambo : Ezinye izifundo zibonise ukuba umngcipheko wokuqhekeka kwamathambo uyanda kancinci kubantu abasebenzisa iCanagliflozin. Ngoko ke lumka xa uwa.

Iziphumo ebezingalindelekanga ezihlala zingadingi ngcebiso kagqirha, kodwa ukuba ziyaqhubeka, kufuneka uxelele ugqirha wakho.

• Urhudo
• Igesi
• Intloko ebuhlungu
• Isicaphucaphu
• Intlungu Yesisu
• Ukuhlanza
• Ukwanda kokuchama rhoqo
• Ukoma okugqithisileyo

Olu luhlu lusenokungabandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona nantoni na engaqhelekanga, thetha nogqirha wakho. Ungaxela iziphumo ebezingalindelekanga kwi-FDA (Food and Drug Administration) ku-1-800-FDA-1088.

Ufanele uwagcine njani amayeza akho?

Kubaluleke kakhulu ukugcina amayeza akho ngokufanelekileyo.

• Gcina kude nabantwana kunye nezilwanyana zasekhaya.
• Gcina kubushushu begumbi (phakathi kwe-15 kunye ne-30 degrees Celsius, phakathi kwe-59 kunye ne-86 degrees Fahrenheit). Khusela kumswakama ogqithisileyo kunye nelanga elithe ngqo. Musa ukugcina kwiindawo ezinomswakama ophezulu, njengegumbi lokuhlambela.
• Musa ukusebenzisa amayeza aphelelwe lixesha. Walahle.

Uzilahla njani amayeza angasetyenziswanga naphelelwe lixesha?

• Ukuba kunokwenzeka, nikela ngale mithi kwinkqubo yokubuyisela amayeza. Ungafumana ulwazi ngeendawo ezinjalo kwikhemesti yakho okanye kwigunya lezempilo lasekuhlaleni.
• Ukuba akunjalo, jonga ilebheli ekwibhotile/ipakethi yamayeza ukuze ubone ukuba afanele alahlwe kwinkunkuma okanye ahlanjwe kwindlu yangasese. Ukuba awuqinisekanga, buza ugqirha wakho okanye ikhemisti.
• Ukuba ungayilahla enkunkuma (okuqhele ukwenzeka), khupha iyeza kwisitya, ulixube nento engayi kutyiwa mntu, efana nekofu esetyenzisiweyo, umhlaba, okanye inkunkuma yekati, uze ulifake kwibhegi okanye kwisitya esivalekayo uze ulilahle enkunkuma. Oku kwenzelwa ukuthintela omnye umntu ekufumaneni iyeza nokulisebenzisa.

Umyalezo Wokuya Ekhaya

Kulungile, sithethe kakhulu ngamayeza esifo seswekile i-'Canagliflozin' kunye ne-'Metformin'. Ngamafutshane:

• Eli liyeza elibalulekileyo lesifo seswekile sohlobo lwesibini elilawula iswekile egazini .
• Iziphumo ezilungileyo zifumaneka xa oku kudityaniswe nokutya kunye nokuzilolonga.
• Qiniseka ukuba uxelela ugqirha wakho ngezinye izifo onazo kunye nezinye amayeza owasebenzisayo.
• Kanye njengoko ugqirha etshilo,Thatha idosi emiselweyo, ngexesha elimiselweyo, kunye nokutya . Ginya ithebhulethi yonke.
• Qaphela iimpawu zeswekile ephantsi egazini (hypoglycemia) kwaye ugcine iswekile ikufutshane xa uyidinga.
• Ukuba ufumana naziphi na iimpawu ezingaqhelekanga (ingakumbi iimpawu ezinokubakho ze-'DKA' okanye 'Lactic Acidosis', usulelo lwangasese (umngcipheko we-'Fournier's gangrene'), izilonda zemilenze, iimpawu zokuphelelwa ngamanzi emzimbeni), xelela ugqirha wakho ngoko nangoko.
• Hlala unxibelelana nogqirha wakho kwaye uthethe ngemeko yakho. Musa ukoyika ukubuza imibuzo.

Khumbula, eli yeza liluncedo kuphela ekulawuleni isifo sakho seswekile. Impilo yakho ixhomekeke ngokupheleleyo kwindlela ophila ngayo, ukutya, kunye nokulandela imiyalelo kagqirha wakho. Eli yeza alinyangi isifo seswekile, linceda kuphela ekusilawuleni.

Ukuba uneminye imibuzo, ungaze ungathandabuzi ukubuza ugqirha wakho, ikhemisti, okanye omnye umboneleli wezempilo. Bakho ukuze bakuncede.

I- Canagliflozin, i-Metformin, i-Invokamet XR, iSifo seswekile sohlobo lwesibini, isifo seswekile, iswekile egazini, amayeza esifo seswekile, iziphumo ebezingalindelekanga