Umhlaza webele yinto eyoyikisa abafazi abaninzi. Ingakumbi emva kokuya exesheni, oko kukuthi, emva kokuba ukuya exesheni kwenyanga kuyekile, abantu abaninzi bacinga ngale ngozi. Ngoko ke, namhlanje sithetha ngeyeza elinceda abafazi abasengozini yolu hlobo lomhlaza ukunciphisa loo ngozi. Eli yeza libizwa ngokuba yi-Evista. Isithako esisebenzayo kulo yi-raloxifene. Lisetyenziselwa ukunciphisa umngcipheko womhlaza webele , kunye nokunciphisa umngcipheko wokuqhekeka okubangelwa yi-osteoporosis, isifo sokuncitshiswa kwamathambo esenzeka emva kokuya exesheni.
Yintoni kanye kanye umhlaza webele ohlaselayo?
Masiqale sikuqonde oku ngokulula. Kukho iintlobo ezimbini eziphambili zomhlaza webele. Enye yi-non-invasive cancer. Kule nto, iiseli zomhlaza zingaphakathi kwimibhobho yobisi okanye kwiigland ezivelisa ubisi (ii-lobules) zebele, kwaye azidluli kuloo mida.
Nangona kunjalo, umhlaza webele ohlaselayo yimeko enzulu ngakumbi. Okwenzekayo apha kukuba iiseli zomhlaza ziphuma kwimibhobho yobisi kunye namadlala zize zisasazeke kwizicubu zebele eziphilileyo ezijikelezileyo. Ukusuka apho, zinokusasazeka ziye nakwezinye iindawo zomzimba, ezifana nesibindi, imiphunga, kunye nengqondo. Le yeyona meko iyingozi kakhulu. Yiyo loo nto kubaluleke kakhulu ukuyibona nokunyanga loo mhlaza kwangethuba.
I-Evista iwunciphisa njani umngcipheko womhlaza?
Eli yeza i-Evista likwiqela lamayeza abizwa ngokuba yi-``SERM (Selective Estrogen Receptor Modulator)''. Ngamafutshane, la mayeza asebenza njengehomoni i- estrogen kwezinye iindawo zomzimba kwaye asebenza ngokuchasene nehomoni i-estrogen kwezinye.
Njengoko usenokuba uyazi, i-estrogen inceda ezinye iintlobo zomhlaza webele zikhule. Kanye njengokuba isityalo sifuna amanzi ukuze sikhule. I-Evista isebenza ngokuncamathisela kwii-receptors ze-estrogen kwizicubu zebele, ivala indawo yokuba i-hormone ye-estrogen yokwenyani inamathele apho. Oku kuthetha ukuba iyayithintela iiseli zomhlaza ekufumaneni umyalezo we-estrogen ekufuneka zikhule.
Kodwa kubalulekile ukukhumbula oku: I-Evista ayilonyango lomntu osele enomhlaza webele. Ayinikwa ukuthintela umhlaza ukuba ungabuyi kumntu osele enomhlaza. Isetyenziselwa kuphela ukunciphisa umngcipheko womhlaza kubafazi abafunyaniswe benawo emva kokuya exesheni.
Ngaba kukho naziphi na iziphumo ebezingalindelekanga ze-Evista?
Ewe. Njengayo nayiphi na imithi, i-Evista inokuba nemiphumo emibi. Eminye incinci, kodwa kukwakho nemiphumo emibi ekufuneka uyazi. Ngoko ke, kufuneka uxoxe ngezinto ezilungileyo nezingalunganga nogqirha wakho ngaphambi kokuba uthathe isigqibo sokuthatha eli yeza.
| Uhlobo lwesiphumo esibi | Inkcazo |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ezifuna ingqalelo ekhawulezileyo | |
| Amahlwili egazi | Umngcipheko wokuqhekeka kwegazi kwimithambo yemilenze (iDeep Vein Thrombosis) kunye nemiphunga (iPulmonary Embolism) unokwanda. |
| Istroke | Abafazi, ingakumbi abo basengozini yesifo sentliziyo, banokuba sengozini yokwanda kancinci kwesifo sohlangothi. |
| Iziphumo ebezingalindelekanga eziqhelekileyo, ezingabalulekanga kangako | |
| Ukungonwabi ngokwasemzimbeni | Ukuqaqamba kwemilenze, iintlungu zamalungu, ukudumba kwamalungu. |
| Ezinye iingxaki | Iimpawu ezinje ngomkhuhlane, ukushisa okukhulu, ukubila, ukungalali, kunye nokoma kwelungu lobufazi. |
Ngubani ke ofanelekileyo ukuthatha eli yeza?
Lo ngumbuzo obaluleke kakhulu. I-Evista ayisiyoyeza elifanele bonke abantu. Ugqirha wakho uza kuxoxa nawe ngembali yakho yempilo .Kwaye izinto ezinobungozi zizo ezigqiba ukuba oku kufanelekile na okanye akunjalo. Ngokubanzi, abantu abanokungenelwa kakhulu kweli yeza ngaba:
- Abafazi abangaphezu kweminyaka engama-60 ubudala: Kuba umngcipheko wokuba nomhlaza webele uyanda njengoko iminyaka ikhula.
- Abantu abakhe baba nomhlaza webele kwiintsapho zabo: ingakumbi isalamane esisondeleyo njengomama okanye udade wabo.
- Abantu abanesifo sofuzo: Ukuba uvavanyo luqinisekisile ukuba baneziguquguquko zemfuza ezifana ne-BRCA1 kunye ne-BRCA2.
- Abo bakha bavavanywa amabele ngaphambili kwaye bafunyaniswa benemeko enokuba negalelo kumhlaza, efana ne-`lobular carcinoma in situ (LCIS).`
- Abantu abanezinye izinto ezinokuba yingozi: Umzekelo, ukuguga ngexesha lokuzalwa kokuqala, ukuyeka ukuya exesheni kade, njl.
Emva kokuqwalasela konke oku, ugqirha wakho uza kuvavanya ngokuchanekileyo umngcipheko wakho.
Ngubani ongafanele athathe i-Evista?
I-Evista inokwenza umonakalo omkhulu kunokuba ibe luncedo kubasetyhini abaneengxaki ezithile zempilo. Ke ngoko, akuvumelekanga ukusebenzisa eli yeza ukuba ulilungu lala maqela alandelayo:
- Abafazi abakhulelweyo okanye abanethemba lokukhulelwa.
- Abafazi abanesifo sokugabha igazi emilenzeni, emiphungeni, okanye emehlweni okwangoku okanye ngaphambili.
- Abafazi abangaphambi kokuya exesheni, oko kuthetha ukuba basaya exesheni ngenyanga.
- Abantu abasebenzisa iyeza lokunciphisa i-cholesterol njengeCholestyramine.
- Abo basebenzisa ezinye iindlela zonyango lweehomoni ze-estrogen (i-estrogen eyongezelelweyo).
Yintoni umahluko phakathi kwe-Evista ne-Tamoxifen?
Usenokuba ukhe weva ngeyeza elibizwa ngokuba yiTamoxifen. Likwaliyeza elikwiklasi yeSERM. Izifundo zifumanise ukuba omabini la mayeza asebenza ngokulinganayo ekunciphiseni umngcipheko womhlaza webele.
Nangona kunjalo, kukho umahluko obalulekileyo. Kuye kwaxelwa ukuba iTamoxifen inxulunyaniswa nomngcipheko ophezulu womhlaza wesibeleko kune-Evista. Kukwabonakalisiwe ukuba i-Evista ayithinteli umhlaza ongengowokungenwa njenge-ductal carcinoma in situ (DCIS), ngelixa iTamoxifen isenza njalo.
Iingozi zokuqhekeka kwegazi kunye nesifo sohlangothi ziqhelekile kuzo zombini ezi ziyobisi. Ezinye izifundo zithi umngcipheko uphantsi kancinci nge-Evista kuneTamoxifen, ngelixa ezinye izifundo zithi akukho mahluko ubalulekileyo.
Ngoko ke ekugqibeleni, isigqibo sokuba leliphi kula mayeza mabini elilungele wena, okanye ukuba kuyimfuneko na ukuthatha amayeza anjalo, sisigqibo ekufuneka siqwalaselwe ngononophelo emva kokuxoxa ngazo zonke izinto ezilungileyo nezingalunganga nogqirha wakho.
Umyalezo Wokuya Ekhaya
- I-Evista (i-raloxifene) liyeza elinikwa abafazi abasengozini enkulu yokuba nomhlaza wamabele emva kokuya exesheni ukunciphisa loo mngcipheko . Ayilonyango lomhlaza.
- Kukho umngcipheko weziphumo ebezingalindelekanga ezinje ngokuqhekeka kwegazi kunye nokukhubazeka xa usebenzisa eli yeza.
- Isigqibo sokuthatha eli yeza okanye ukungalisebenzisi sesomntu siqu ekufuneka senziwe emva kokuxoxa ngononophelo nogqirha wakho malunga nezinto ezikubangela umngcipheko kunye nemeko yakho yempilo.
- Kwanasemva kokuthatha i-Evista, abanye abafazi basenokufumana umhlaza webele, ngoko ke kubalulekile ukuqhubeka nokuzihlola rhoqo amabele kunye nokuhlolwa kwe-mammogram.
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