Kuqhelekile ukuba noloyiko xa ugqirha wakho ekuxelela wena okanye umntwana wakho ukuba unengxaki yezintso, aze kwangaxeshanye, akuxelele igama elide nelinzima njenge-'Complement 3 Glomerulopathy'. Oku kubizwa ngokuba yi-'C3G' ngamafutshane. Esi sisifo sezintso esingaqhelekanga. Nangona esi sifo sichaphazela kakhulu abantwana kunye nabantu abadala abancinci, sinokukhula nakweyiphi na iminyaka. Ke namhlanje, masithethe ngesi sifo esibizwa ngokuba yi-C3G, ngokungathi sithetha nomhlobo, ngendlela elula kakhulu.
Yintoni le C3G?
Ngamafutshane, i-C3G sisifo sezintso esibangelwa "yinkqubo yokuncedisana", eyinxalenye yenkqubo yomzimba wethu yokuzikhusela, engasebenzi kakuhle. Le nkqubo yokuncedisana ifana namapolisa alwa neentsholongwane kunye neebhaktheriya ezingena emzimbeni wethu. Nangona kunjalo, kumntu one-C3G, ukusebenza kwale nkqubo kuyaphazamiseka, kwaye iqala ukonakalisa izintso zakhe.
Kukho iintlobo ezimbini eziphambili zesifo se-C3G:
1. Isifo seDense Deposit (DDD)
2. I-C3 Glomerulonephritis (C3 Glomerulonephritis - C3GN)
Zombini ezi ntlobo zinokubangelwa zizizathu zemfuza (mhlawumbi zelifa) okanye ezinye iingxaki zempilo ezenzeka ngexesha lobomi.
Yintoni ebangela oku? Kwenzeka ntoni kwizintso?
Cinga ngezintso zethu njengezihluzi zeti. Ezi zihluzi zibizwa ngokuba yi-glomeruli . Ezi zihluzi zegazi lethu, zicoce, kwaye zikhuphe inkunkuma engafunekiyo ngomchamo.
Kwisifo se-C3G, ukungasebenzi kakuhle okukhankanyiweyo kwinkqubo yokongeza kutshabalalisa ezi zihluzo zithambileyo ezibizwa ngokuba yi-glomeruli. Xa lo monakalo usenzeka, iimbobo ezikwisihluzo ziyanda, kwaye iiproteni, kunye neeseli zegazi ezibomvu nezimhlophe, ezifanele ukuba zisegazini, ziqala ukuvuza kumchamo. Ekuhambeni kwexesha, lo monakalo unokwanda kwaye ukhokelele ekungasebenzini kwezintso. Ezinye izifundo zibonisa ukuba i-DDD ichaphazela abantu abancinci kune-C3GN.
Zithini iimpawu zesifo se-C3G?
Ayingabo bonke abantu abane-C3G abaya kuba neempawu ezifanayo. Nangona kunjalo, kubalulekile ukuqaphela oku. Makhe sijonge iimpawu eziphambili.
| Uphawu | Ingcaciso elula |
|---|---|
| Iiproteni kumchamo (iProteinuria) | Iprotheyini egqithisileyo kumchamo. Umchamo unokuba negwebu, ube namafu, okanye ube mnyama. Xa le meko inzima (i-nephrotic syndrome), ezinye iimpawu ezifana nokudumba nazo zinokubakho. |
| Igazi kumchamo (iHematuria) | Ukonakala kwezihluzo zezintso kubangela ukuba iiseli ezibomvu zegazi ziqokeleleke kumchamo. Umchamo unokuba bomvu, upinki, okanye ube mdaka. |
| Ukudumba | Ngenxa yokuba izintso zingasebenzi kakuhle, ulwelo luyaqokelelana emzimbeni, nto leyo ebangela ukudumba emilenzeni, ezandleni, emaqatheni, nakwamehlo. |
| Igazi elonyukayo | Uxinzelelo oluphezulu kwimithambo yegazi ngenxa yolwelo olungasuswanga kakuhle kwizintso. |
| Ukudinwa kunye nokulala | Ngenxa yokuba izintso azihluzi kakuhle inkunkuma, ziyaqokelelana egazini. Oku kunokuchaphazela ingqondo kwaye kubangele ukudinwa, ukozela, kunye nobunzima bokugxila. Isifo sezintso sinokubangela i-anemia, nto leyo enokunyusa ukudinwa. |
| Iintsholongwane eziQhelekileyo | Inkqubo yokuncedisa ebuthathaka inciphisa amandla omzimba okulwa neentsholongwane, nto leyo enokubangela usulelo oluqhelekileyo. |
| Iingxaki Zamehlo | Ukuphazamiseka kokubona kunokwenzeka ngenxa yeproteni kunye namafutha agciniweyo (drusen) kwi-retina. |
| Ukufakwa kwamafutha eluswini ngokungacwangciswanga (i-Acquired partial lipodystrophy) | Ukutshatyalaliswa kweeseli zamafutha yinkqubo yokuncedisa kunokubangela ukuba ezinye iindawo zomzimba zibe ncinci, ngelixa ezinye iindawo zinokuba nkulu kwaye zibe namafutha amaninzi agciniweyo. |
Ukongeza, iimpawu ezinje ngesicaphucaphu, ukuhlanza, ukuphelelwa ngumdla wokutya, ukungalali, ulusu olomileyo nolurhawuzelelwayo, incasa yesinyithi emlonyeni, kunye nokuxhuzula kwemisipha ebusuku kunokwenzeka xa izintso zingasebenzi kakuhle .
Uyifumana njani le nto, Gqirha?
Eyona ndlela ikuphela kwayo yokufumanisa ngokuqinisekileyo isifo se-C3G kukwenza i-biopsy yezintso . Oku kuquka ukuthatha iqhekeza elincinci lesicubu sezintso phantsi kwe-anesthetic ekhaphukhaphu kwaye ulihlolisise phantsi kwe-microscope. Le yeyona ndlela ikuphela kwayo yokufumanisa ubungakanani bomonakalo kwizintso.
Ukongeza, ugqirha wakho unokucebisa uvavanyo lwegazi nomchamo kwaye mhlawumbi uvavanyo lwemfuza.
Ndingayibuza ntoni ugqirha?
Ngexesha elinje, usenokuba nemibuzo emininzi engqondweni yakho. Xoxa ngezi zinto ngokucacileyo nogqirha wakho. Umzekelo:
- Ndiyifumene njani i-C3G?
- Loluphi uhlobo lwe-C3G endinalo? (i-DDD okanye i-C3GN?)
- Zeziphi iindlela ezilungileyo zokulawula impilo yam ngesi sifo?
- Ziziphi iindlela zonyango endinazo?
- Yintoni endinokuyilindela kwixesha elizayo ngesi sifo?
Zithini iindlela zonyango zoku?
Inyaniso kukuba, akukho nyango lunye olunokunyanga ngokupheleleyo isifo se-C3G okwangoku. Nangona kunjalo, kukho iindlela ezahlukeneyo zonyango ezinokulawula esi sifo, zinciphise iimpawu, kwaye zinciphise umonakalo kwizintso.
- Lawula uxinzelelo lwegazi kunye nokukhupha iiproteni: Amayeza oxinzelelo lwegazi (i-Angiotensin-converting enzyme (ACE) inhibitors kunye ne-Angiotensin II type-1 receptor blockers (ARBs)) anokunciphisa ukuphuma kweeproteni emchameni kwaye anciphise ukuqhubela phambili kwesifo.
- Ulawulo lweKholesteroli: Ukuba unekholesteroli ephezulu (i-hyperlipidemia), uphando lubonise ukuba amayeza okunciphisa ikholesteroli anokunceda ukulawula ukonakala kwesifo se-C3G.
- Amayeza okuthintela amasosha omzimba: Indibaniselwano yamayeza acinezela inkqubo yomzimba yokuzikhusela, anjenge-glucocorticoids kunye ne-mycophenolate mofetil (MMF), inokuthintela ukubuyela umva kwezinye izigulana.
- Unyango lwanamhlanje: Amayeza alwa nokongeza amayeza afana ne-`eculizumab` anokulawula ukusebenza kwenkqubo yokongeza amayeza aze anciphise ukuqhubela phambili kwesi sifo. Ukongeza, iyeza elitsha elibizwa ngokuba yi-`iptacopan` lisafundwa ngoku. Libonakalise iziphumo ezithembisayo kakhulu, ngoko ke livunyiwe ukuba likhawulezise uphando ngalo.
Ndingazinyamekela njani?
Njengamayeza, indlela ozinyamekela ngayo ibaluleke kakhulu ekulawuleni esi sifo.
- Ukutya okunempilo: Yitya iziqhamo ezininzi, imifuno, iimbotyi, kunye neenkozo ezipheleleyo. Nciphisa amafutha agcweleyo, ityuwa, kunye neswekile. Ugqirha wakho angakuxelela ukuba unciphise ukutya kwakho i-potassium, i-sodium (ityuwa), okanye i-phosphate. Ungaze wenze naluphi na utshintsho olukhulu kwindlela otya ngayo ngaphandle kokubonisana nogqirha wakho kuqala.
- Nyamekela impilo yakho: Nokuba uzive uphilile, thatha amayeza akho njengoko ugqirha wakho ekuyalele. Xelela ugqirha wakho ngamanye amayeza, iivithamini, okanye izongezo ozithathayo.
- Ukuzilolonga: Ukuzilolonga kunokukunceda ulale ngcono, wongeze amandla akho, kwaye unciphise umngcipheko wesifo sentliziyo. Thetha nogqirha wakho malunga nesicwangciso sokuzilolonga esifanelekileyo kuwe.
- Kuphephe ukutshaya: Oku kulungile kakhulu kwimpilo yakho iyonke.
- Nciphisa utywala: Thetha nogqirha wakho malunga nokusetyenziswa kotywala kwaye ucele iingcebiso.
Yintoni esinokuyilindela kwixesha elizayo?
Wakuba ufunyenwe unesifo se-C3G, iqela lakho lezonyango liza kukunceda ufumane isicwangciso sonyango esifanelekileyo.
Kwezinye iimeko, esi sifo sinokuba nzima kakhulu. Malunga nama-50% abantu abane-C3G banesifo sezintso esikwinqanaba lokugqibela (ESRD) kwiminyaka eli-10 emva kokufunyaniswa kwesi sifo. Kule nqanaba, amandla ezintso okususa inkunkuma ayaphela ngokupheleleyo. I-Dialysis okanye ukufakelwa kwezintso kunokufuneka.
Kodwa kubalulekile ukukhumbula ukuba nasemva kokufakelwa izintso, kukho ithuba elikhulu lokuba isifo se-C3G siphinde sivele kwizintso ezintsha. Ngoko ke thetha nogqirha wakho ixesha elide malunga nokhetho olulungele wena.
Iqela lakho lezonyango linokuquka ingcali yezifo zengqondo, ingcali ye-hematologist, kunye nengcali yezifo zengqondo. Kubalulekile ukugcina ubudlelwane obuhle nabo.
Umyalezo Wokuya Ekhaya
- I-C3G sisifo sezintso esingaqhelekanga kodwa esibi kakhulu esibangelwa sisiphene kwinkqubo yokuncedisa, eyinxalenye yenkqubo yomzimba yokuzikhusela.
- Iimpawu eziphambili zingabandakanya iproteni okanye igazi kumchamo, ukudumba, uxinzelelo lwegazi oluphezulu, kunye nokudinwa.
- Esi sifo sichongwa ngokuqinisekileyo ngokuhlolwa kweentso.
- Nangona kungekho ndlela ithile yokunyanga oku, esi sifo sinokulawulwa kwaye izintso zinokukhuseleka ngokulawula uxinzelelo lwegazi, amayeza alawula amasosha omzimba, kunye nendlela yokuphila enempilo.
- Kubaluleke kakhulu ukuhlala unxibelelana rhoqo neqela lakho lezonyango kwaye ulandele imiyalelo yabo ngokuchanekileyo.
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