Ngaba umntwana wakho omncinci ufumana umkhuhlane, izilonda zomlomo, okanye umphimbo obuhlungu ngeentsuku ezifanayo inyanga nenyanga? Ngaba isifo esinye siyaphela, size sibuye emva kweeveki ezimbini okanye ezintathu? Usenokuba ucinga, "Inkqubo yomzimba yomntwana wam ibuthathaka." Ewe, oko kusenokuba yinyani. Kodwa isizathu sesi sifo esijikelezayo sisenokuba yimeko engaqhelekanga. Namhlanje, sithetha ngesinye sezi meko, i-cyclic neutropenia.
Ngamafutshane, yintoni i-cyclic neutropenia?
Ukuze siqonde oku, kufuneka siqale sazi ngesosha elisegazini lethu. Igama lalo sosha yi -neutrophil . Le neutrophil luhlobo lweseli emhlophe yegazi esikhusela kwizifo ngokulwa neentsholongwane, ingakumbi iibhaktheriya, ezingena emizimbeni yethu. Kufana nomkhosi ngaphakathi emizimbeni yethu.
I-Neutropenia kuxa inani lamajoni e-neutrophil egazini lihla ngaphantsi kwamanqanaba aqhelekileyo. Njengokuba umkhosi uba buthathaka xa amajoni awo embalwa, xa ama-neutrophil embalwa, amajoni ethu omzimba aba buthathaka kwaye siqala ukufumana usulelo ngokulula.
Ngoku makhe sijonge intsingiselo yegama elithi cyclic . I-Cyclic ithetha "i-cyclical." Oku kuthetha ukuba inqanaba le-neutrophil alisoloko liphantsi. Liya linyuka lize lihle ngokweshedyuli eqhelekileyo, kumjikelo. Ukuchaneka, ngesiqhelo rhoqo emva kweeveki ezintathu (malunga neentsuku ezingama-21) , inqanaba le-neutrophil lehla kakhulu iintsuku ezintathu ukuya kwezintlanu. Emva koko libuyela kwisiqhelo, lize liphinde lehle kwiiveki ezintathu ezilandelayo. Lo mjikelo wenzeka ngendlela eqikelelweyo.
Ngamafutshane, i-cyclic neutropenia yimeko apho inani leeseli ze-neutrophil, ezikhusela imizimba yethu kwizifo, lincipha ngokwemijikelo yemihla ngemihla ebekiweyo, nto leyo enyusa umngcipheko wosulelo.
Le meko ayiqhelekanga kakhulu. Abaphandi bathi ngumntu omnye kuphela kwisigidi sabantu kwihlabathi liphela onesi sifo.
Zithini iimpawu zesi sifo?
Eyona nto ikhethekileyo ngesi sifo kukuba iimpawu zibonakala ngokuhambelana nomjikelo wokwehla kwamanqanaba e-neutrophil. Oko kukuthi, ezi mpawu zibonakala kwiintsuku ezintathu ukuya kwezine emva kokwehla kwamanqanaba e-neutrophil, kwaye xa amanqanaba e-neutrophil ebuyela kwisiqhelo, iimpawu ziyanyamalala.
| Uphawu | Inkcazo |
|---|---|
| Umkhuhlane kunye nokudinwa | Xa ii-neutrophils ziphantsi, uphawu lokuqala losulelo emzimbeni lunokuba ngumkhuhlane. Kunye noku, umzimba unokuziva ungenabomi. |
| Izilonda zomlomo kunye nomphimbo obuhlungu | Olu luphawu oluqhelekileyo. Lunokubangela izilonda ezibuhlungu emlonyeni nasezintsinini. Lunokubangela nomphimbo obuhlungu. |
| Isifo se-Periodontal | Ukopha rhoqo kunye nokudumba kweentsini kunokwenzeka. |
| Usulelo oluphindaphindayo | Izifo zomchamo (umkhuhlane, ukukhwehlela), izifo zokugaya ukutya (iintlungu zesisu), kunye nezifo zolusu (i-cellulitis) zinokwenzeka rhoqo. |
Uhlobo lwezi mpawu lunokutshintsha ubomi bonke. Kubantu abaninzi, ubunzima beempawu buyancipha njengoko befikelela ebudaleni . Izilonda zomlomo neengxaki zamazinyo zixhaphakile kubantu abancinci, ngelixa iintloko ezibuhlungu kunye nosulelo lwe-sinus (sinusitis) zixhaphakile kubantu abadala.
Kutheni oku kusenzeka?
I-cyclic neutropenia ibangelwa kukuguquka kwezakhi zofuzo . Isizathu esiphambili kukutshintsha kwezakhi zofuzo ze- ELANE emzimbeni wethu.
Cinga nge-gene njengeseti yemiyalelo exelela iiseli emzimbeni wethu indlela yokusebenza. I-gene ye-ELANE inemiyalelo yokwenza i-enzyme enceda ii-neutrophils zisebenze ngokufanelekileyo. Xa kukho isiphene okanye utshintsho kule gene, ii-neutrophils azikwazi ukusebenza ngokufanelekileyo.
Le meko inokuthi ifuzwe ngabazali ukuya ebantwaneni, okanye inokuthi ivele ngexesha lokukhulelwa.
Ngenxa yesi siphene semfuza,
- Umzimba usenokungavelisi ii-neutrophils ezaneleyo.
- Ngaphandle koko, ii-neutrophils zinokufa ngokukhawuleza.
- Okanye ii-neutrophils zisenokungasebenzi kakuhle.
Gqirha, uyixilonga njani le nto?
Ezi mpawu zihlala zibonakala kwasekuzalweni, ngoko ke esi sifo sidla ngokufunyaniswa kwasebuntwaneni. Ugqirha uza kuqwalasela izinto ezininzi ukuqinisekisa esi sifo.
- Imbali yesifo sentsapho: Ekubeni esi sisifo esidluliselwa kwilifa, kuyajongwa ukuba kukho na omnye umntu kusapho (abazali, abantakwabo noodadewabo) onesi sifo.
- Uvavanyo lwegazi: Olu lolona lubalulekileyo. Ugqirha wakho uza kujonga amanqanaba akho e-neutrophil egazini lakho kabini ukuya kathathu ngeveki kangangeeveki ezintandathu . Oku kuya kwenziwa ukuze kubonwe ukuba amanqanaba akho e-neutrophil ayancipha ngokujikeleza.
- Ipateni yeempawu: Ugqirha uza kufunda ngononophelo ukuba iimpawu ziphindaphinda kangakanani (malunga neeveki ezi-3). Le pateni yemijikelo inceda ukwahlula oku kwezinye iintlobo ze-neutropenia.
- Uvavanyo lwemfuza: Ngamanye amaxesha uvavanyo lwemfuza lunokucetyiswa ukuqinisekisa ukuba kukho utshintsho kwimfuza ye-ELANE.
Xa efumanisa le meko, ugqirha kufuneka angazibandakanyi ezinye iintlobo ze-neutropenia ezineempawu ezifanayo, ezifana ne-'Severe congenital neutropenia' (eyayisaziwa ngokuba yi-'Kostmann syndrome'), i-'Autoimmune neutropenia', kunye ne-'Idiopathic neutropenia'.
Zithini iindlela zonyango zoku?
Kukho iinjongo ezimbini eziphambili zonyango. Enye kukuphelisa usulelo olukhoyo. Enye kukunyusa amanqanaba e-neutrophil nokuthintela usulelo oluzayo.
| Indlela yonyango | Ukusebenza kakuhle |
|---|---|
| Ii-antibiotics | Ezi zinikwa ukulwa nosulelo lweentsholongwane oluvela ngexesha lee-neutrophils ezisezantsi. |
| Unyango lwe-G-CSF | Olu lolona nyango luphambili nolusebenzayo. I-G-CSF (i-Granulocyte colony-stimulating factor) liyeza elivuselela umongo wethu wethambo ukuba uvelise ii-neutrophils ezingaphezulu (umz. i-filgrastim (i-Neupogen®)). Inikwa njengenaliti kwaye lunyango olukhuselekileyo olunokusetyenziswa ixesha elide. |
| Ukufakelwa kweeseli zesiqu | Le yindlela esetyenziswa kuphela kwabo banesifo esibi kakhulu kwaye abangaphenduliyo kunyango lwe-G-CSF. Kule ndlela, iiseli eziphilileyo ziyatyalwa ukuze zithathe indawo yeeseli ezinesifo. |
Ngaba kukho naziphi na iziphumo ebezingalindelekanga zonyango?
Unyango lwe-G-CSF lunokubangela iziphumo ebezingalindelekanga ezincinci. Nangona kunjalo, oogqirha badla ngokuqala unyango lwesi sifo ngedosi ephantsi, ngoko ke iziphumo ebezingalindelekanga zincinci.
- Intloko ebuhlungu
- Intlungu emathanjeni nasemalungeni
- Isicaphucaphu kunye norhudo
Izinto ezinje zinokwenzeka. Thetha nogqirha wakho ngononophelo malunga nonyango olufumanayo kunye nemiphumo yalo.
Ndifanele ndimfowunele nini ugqirha?
Ukuba wena okanye umntwana wakho une-cyclic neutropenia, kubaluleke kakhulu ukufuna iingcebiso zonyango ngokukhawuleza xa ubona naziphi na iimpawu zosulelo .
Nika ingqalelo ekhethekileyo kwezi zinto zilandelayo:
* Ifiva
* Intlungu kwindawo ethile emzimbeni
* Ukudumba okanye ukuba bomvu kwesikhumba
Ukuba ubona nayiphi na kwezi mpawu, bonana nogqirha wakho ngoko nangoko. Musa ukuthandabuza ukuya kwiSebe leeNgxamiseko (ETU) ukuba kuyimfuneko.
Yintoni esifanele siyenze ukuze sizikhusele kwiintsholongwane?
Ukongeza ekuzikhuseleni kwiintsholongwane, kufuneka uqaphele xa inani lee-neutrophil zakho liphantsi.
- Hlamba izandla zakho kakuhle rhoqo, ingakumbi phambi kokutya nasemva kokusebenzisa indlu yangasese.
- Gcina umlomo wakho usempilweni. Hlamba amazinyo akho yonke imihla kwaye ubone ugqirha wamazinyo rhoqo .
- Fumana zonke iigonyo ezicetyiswayo ngexesha.
- Kuphephe ukuchukumisa ubuso bakho, amehlo, kunye nempumlo yakho ngaphandle kokuhlamba izandla zakho.
- Sela amayeza akho njengoko ugqirha wakho ekuyalele kwaye wenze uvavanyo lwegazi lakho ngexesha.
Nangona le meko ithatha ubomi bonke, unyango oluphumelelayo olufana ne-G-CSF ngoku luye lwavumela abantu abaninzi abane-cyclic neutropenia ukuba baphile ubomi obuqhelekileyo . Okubalulekileyo kukuba, nangona ezinye iintlobo ze-neutropenia zinomngcipheko wokuba nomhlaza, njenge-leukemia, i-cyclic neutropenia ayinawo.
Umyalezo Wokuya Ekhaya
- I-cyclic neutropenia yimeko engaqhelekanga yemfuza apho inani leeseli ze-neutrophil ezilwa nosulelo liyehla ngokujikeleza.
- Iimpawu (umkhuhlane, izilonda zomlomo) zihlala zibonakala kanye kwiiveki ezi-3.
- Ukuze kufunyanwe isifo, uvavanyo lwegazi kufuneka lwenziwe rhoqo kangangeeveki eziliqela ukuqinisekisa ukujikeleza kwamanqanaba e-neutrophil.
- Ngenxa yokuba kukho unyango olusebenza kakuhle njenge-G-CSF, izigulana zinokuphila ubomi obuqhelekileyo.
- Kubaluleke kakhulu ukufuna iingcebiso zonyango ngokukhawuleza xa ubona naziphi na iimpawu zosulelo (umkhuhlane, iintlungu, ukudumba).
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