Ingaba isingqisho sentliziyo yakho asihambelani? Masifunde ngeDofetilide!

Ngaba ugqirha ukuxelele ukuba kukho ingxaki ngesingqisho sentliziyo yakho, oko kukuthi, isantya sentliziyo yakho? Umele ukuba uzive usoyika kancinci, akunjalo? I-Dofetilide luhlobo lonyango olunikwayo ngamaxesha anjalo. Ngoko ke, namhlanje siza kuthetha ngale mayeza abizwa ngokuba yi-Dofetilide, ngokungathi sixelela umhlobo.

Yintoni iDofetilide?

Ngamafutshane, iDofetilide liyeza elilwa nokubetha kwentliziyo . Oku kuthetha ukuba inceda ekulungiseni isingqisho sentliziyo yakho. Idla ngokuza ngendlela yecapsule. Idla ngokuthathwa kanye okanye kabini ngemini. Usenokuba uyibonile phantsi kwegama lebrendi elithi Tikosyn®.

Kodwa kukho into enye ekufuneka uyikhumbule. Umlinganiselo wale mayeza, oko kukuthi, umlinganiselo onikwa wona ukuba usele, unokwahluka kumntu nomntu . Ukuba umhlobo wakho usela le mayeza, awuyi kunikwa umlinganiselo ofanayo nalowo anikwa wona. Ugqirha uza kuvavanya imeko yakho aze akunike umlinganiselo ofanelekileyo (ofana ne-`125 mcg, 250 mcg` okanye `500 mcg`). `(mcg)` imele ii-micrograms.

Kuxa kutheni apho iDofetilide isetyenziswa khona?

Eli yeza lisetyenziswa kakhulu ukunyanga iingxaki ezithile zesingqisho sentliziyo nokuthintela ukuba zingaphindi zivele.

Ukuphazamiseka kwesingqisho sentliziyo

• I-Atrial Fibrillation (Afib): Kulapho amagumbi aphezulu entliziyo yakho (abizwa ngokuba yi-atria) ebetha ngokukhawuleza nangokungaqhelekanga, endaweni yokuba abethe ngendlela enesingqisho. Cinga ngayo njengedrama ekufanele idlalwe ngendlela ethile, kodwa ibetha ngendlela engafanelekanga ize iphambane. Oku kubizwa ngokuba yi-"Afib".
• I-Atrial Flutter: Le yenye indlela engaqhelekanga yokubetha kwentliziyo eyenzeka kumagumbi aphezulu entliziyo. Ifana kancinci ne-"Afib", kodwa kukho umahluko omncinci.

Kubalulekile: Kuzo zombini ezi meko, ukusebenza kwentliziyo kuyaphazamiseka, ngoko ke igazi lisenokungampompi kakuhle. Oku kunokukhokelela kwiingxaki ezahlukeneyo. Ngoko ke, eli yeza lisebenza ngokulungisa loo ngxaki kwaye lenze intliziyo isebenze kakuhle kwakhona.

Ukusetyenziswa "okungafakwanga kwileyibhile"

Ngamanye amaxesha oogqirha banika iDofetilide kwezinye izifo zentliziyo ngaphandle kokusetyenziswa kwayo kwasekuqaleni. Oku kubizwa ngokuba kukusetyenziswa "okungekho kwileyibhile". Oko kukuthi, oogqirha bayazi ukuba eli yeza linokunceda kwezo meko, kodwa ekuqaleni lalingekavunywa kwezo meko.

Ezinye iingxaki ezifanayo zesingqisho sentliziyo zezi:

• I-Ventricular Tachycardia: Kule nto, amagumbi asezantsi entliziyo abetha ngokukhawuleza kakhulu.
• I-Supraventricular Tachycardias: Le ikwayintliziyo ekhawulezayo eyenzeka kumagumbi aphezulu entliziyo. Kukho ezinye iintlobo ngaphandle kwe-`(Afib)` kunye ne-`(Atrial Flutter).`
• Isifo sikaWolff-Parkinson-White: Esi sisifo apho intliziyo ibetha ngokukhawuleza ngenxa yendlela yombane eyongezelelweyo entliziyweni.

Ungayiqala njani iDofetilide?

Oku kukhethekile kancinci. Xa uqala ukuthatha iDofetilide, kuya kufuneka uhlale esibhedlele malunga neentsuku ezintathu ukuya kwezine . Oku kusenokuvakala kungaqhelekanga, akunjalo? Isizathu kukuba oogqirha bafuna ukujonga indlela eli chiza elichaphazela ngayo isigqi sentliziyo yakho kunye nokuba uhlangabezana naziphi na iingxaki ezintsha. Baza kusebenzisa eli xesha ukufumana idosi efanelekileyo kuwe. Ngelixa usesibhedlele, banokutshintsha ubungakanani bamayeza owanikwayo. Ungakhathazeki, konke oku kungenxa yokhuseleko lwakho.

Ungayithatha njani iDofetilide ekhaya?

Emva kokuba ufikile ekhaya uvela esibhedlele, ilebhile yemithi oyinikwayo iya kuchaza ngokucacileyo ukuba umele uyithathe kangakanani kwaye umele uyithathe kangaphi ngemini.

Kubaluleke kakhulu ukukhumbula la manqaku:

• Sela amayeza kanye njengoko ugqirha ekuxelela. Musa ukwandisa okanye ukunciphisa umthamo.
• Sela amayeza ngexesha elifanayo yonke imihla. Ukuba kusekuseni, thatha kusasa, ukuba kubusuku, thatha ebusuku. Musa ukutshintsha ixesha.
• Nokuba uzive ungcono, ungayeki ukuthatha amayeza. Qhubeka uwathatha logama nje ugqirha wakho ekuxelele ukuba wenjenjalo.
• Ungathatha eli yeza nokuba utya okanye ungenalo.
• Musa ukulibazisa amayeza akho.
• Thatha kuphela ubungakanani obuchazwe ngugqirha.

Ukuba unemibuzo malunga namayeza akho okanye indlela yokufumana i-refill, ungoyiki ukubuza ugqirha wakho okanye ingcali yezemithi. Ukuba kukho into ongayiqondiyo, bacele bakuchazele.

Ndimele ndimxelele ntoni ugqirha wam ngaphambi kokuba ndithathe iDofetilide?

Ngaphambi kokuba ubhale eli yeza kuwe, kubalulekile ukuxelela ugqirha wakho oku kulandelayo:

• Ngaba wakha waba ne-allergy kwi-dofetilide? Ukuba kunjalo, nceda uchaze okwenzekileyo.
• Dwelisa onke amayeza owasebenzisayo ngoku (umyalelo kagqirha, othengiswa ngaphandle kwephepha likagqirha (OTC), iivithamini, kunye nezongezo zezityalo). Musa ukuqala nawaphi na amayeza amatsha okanye izongezo ngaphandle kokubonisana nogqirha wakho kuqala.
• Sixelele ukuba unesifo sentliziyo, ingakumbi isifo sentliziyo esibizwa ngokuba yi -`Long QT Syndrome` , okanye ukuba unesifo sezintso okanye sesibindi, okanye ukuba unamaqondo aphantsi e-potassium okanye i-magnesium egazini lakho.
• Qiniseka ukuba uyasixelela ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa .

Ngawaphi amayeza angafanele asetyenziswe ngeDofetilide?

Ukuba usebenzisa la mayeza, ukuthatha iDofetilide kunokuba yingozi kakhulu.Ngoko ke, ukuba usebenzisa amayeza anje, ngokuqinisekileyo kufuneka uxelele ugqirha wakho. Emva koko akayi kukunika iDofetilide.

• I-Cimetidine (umz. iTagamet®)
• I-Cisapride
• IDolutegravir (umzekelo, iTivicay®)
• IVerapamil (`Verapamil` - umz. `Calan®`)
• I-Ketoconazole
• I-Itraconazole (umz. iSporanox®)
• I-Trimethoprim (`iTrimethoprim` - umz. i-`iProloprim®`)
• I-Trimethoprim ene-sulfamethoxazole (umz., iBactrim®, iSeptra®)
• I-Hydrochlorothiazide (`Hydrochlorothiazide` - umz. `Microzide®`)
• I-Ziprasidone
• Ii-antidepressants ze-Tricyclic ezifana ne-amitriptyline
• I-Promethazine
• I-Prochlorperazine (umz., i-Compro®)
• I-Quinidine
• IDisopyramide (umz., iNorpace®)
• I-Sotalol (`Sotalol` - umz. `Betapace®`)

Amanye amayeza anokusebenzisana neDofetilide

Kukho amanye amayeza anokusebenzisana neDofetilide. Oku kuthetha ukuba ukuba uwasebenzisa kunye la mayeza, anokutshintsha indlela esebenza ngayo iDofetilide okanye anyuse iziphumo zayo ezingalindelekanga. Ngoko ke, ukuba usebenzisa naliphi na kula mayeza adweliswe ngezantsi, thetha nogqirha wakho ngaphambi kokuba uqale iDofetilide.

• I-Amiodarone (`Amiodarone` - umz. `Cordarone®`)
• I-Digoxin (`Digoxin` - umz. `Lanoxin®`)
• I-Metformin (`Metformin` - umz. `Glucophage®`)
• I-Megestrol
• I-Diltiazem (umz. iCardizem®)
• I-Zafirlukast
• I-Quinine
• I-Fluconazole
• I-Erythromycin (`Erythromycin` - umz. `PCE®`)
• IClarithromycin
• Ii-antibiotics ze-Fluoroquinolone ezifana neNorfloxacin kunye neMoxifloxacin
• Ii-SSRI (i-Selective Serotonin Reuptake Inhibitors) ezifana neFluoxetine, iSertraline, iParoxetine (umz. iPaxil®)
• I-Diuretics (amayeza asusa amanzi emzimbeni) afana neFurosemide, iTriamterene, kunye neAmiloride
• Ii-protease inhibitors (amayeza ezifo ezifana ne-HIV) ezifana ne-Indinavir

Ukwazi nje: Njengamanye amayeza, ukusela ijusi yegrapefruit (isiqhamo esifana negrapefruit) kunokunyusa izinga leyeza i-dofetilide emzimbeni wakho. Oku kunokuba yingozi. Ngoko ke, buza ugqirha wakho ukuba kulungile na ukusela ijusi yegrapefruit ngelixa usebenzisa eli yeza.

Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?

Ukuba oku kuyenzeka, thatha idosi oyiphosileyo ngokukhawuleza xa ukhumbula . Nangona kunjalo, ukuba sele kusondele ixesha ledosi yakho elandelayo xa ukhumbula, yeka idosi oyiphosileyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe idosi ephindwe kabini. Ukuba awuqinisekanga ukuba wenze ntoni, thetha nogqirha wakho okanye nosokhemesti.

Zithini iingenelo zeDofetilide?

I-Dofetilide inokunceda ukulawula ezinye zeengxaki zokubetha kwentliziyo ezingaqhelekanga entliziyweni yakho, nto leyo enokwenza ubomi bakho bube lula kancinci. Nangona kunjalo, kubalulekile ukukhumbula ukuba ayinyangi ngokupheleleyo isifo.

Zithini iziphumo ebezingalindelekanga zeDofetilide?

Njengayo nayiphi na iyeza, iDofetilide inokubangela ezinye iziphumo ebezingalindelekanga. Asinguye wonke umntu ozifumanayo, kodwa kulungile ukuzazi.

Iziphumo ebezingalindelekanga ezincinci ezinokubakho:

• Iintlungu zesifuba
• Intloko ebuhlungu (intloko ebuhlungu)
• Isiyezi (vertigo)
• Isicaphucaphu (ukuziva ngathi uhlanza)
• Urhudo (intlungu yesisu)
• Intlungu yesisu

Into ekufuneka uyilumkele kakhulu:

I-Dofetilide inikwa ukulungisa ukubetha kwentliziyo okungahambelaniyo, kodwa kukho umngcipheko wolunye uhlobo lokubetha kwentliziyo okungahambelaniyo ngale mithi. Ngokukodwa, ukubetha kwentliziyo okukhawulezayo kwigumbi elisezantsi lentliziyo (`ventricular tachycardia`) ebizwa ngokuba yi``Torsades de Pointes`` kunokwenzeka.

Le yeyona sizathu sokuba kufuneka ulaliswe esibhedlele kwaye uqalise ukusebenzisa amayeza! Oogqirha bafuna ukukubeka esweni ngokusondeleyo olu kubetha kwentliziyo kuyingozi kwaye kungaqhelekanga.

Ndiza kuziva bhetele nini emva kokuqalisa amayeza?

I-Dofetilide ithatha malunga neeyure ezimbini ukuya kwezintathu ukuqala ukusebenza. Nangona kunjalo, nokuba uzive ungcono, ungayeki ukuthatha amayeza de ugqirha wakho akuxelele ukuba wenjenjalo. Qhubeka uwathatha.

Ndingayinyamekela njani impilo yam ngelixa ndisebenzisa iDofetilide?

Kukho izinto ezimbalwa ekufuneka uzenze ngelixa usebenzisa eli yeza.

• Qiniseka ukuba uya kuzo zonke iintlanganiso zakho nogqirha wakho, kuquka novavanyo lwelabhoratri. Kulapho unokubona khona indlela amayeza akuchaphazela ngayo.
• Mhlawumbi kuya kufuneka wenze uvavanyo lwe-electrocardiogram (EKG) malunga neenyanga ezintandathu . Oku kuya kujonga izinga kunye nesingqisho sentliziyo yakho.
• Basenokuyalela uvavanyo lwegazi ukuze babone ukuba umthamo wamayeza kufuneka utshintshwe na.
• Soloko ufunda incwadana yolwazi eza namayeza akho, ingakumbi ukuba kukho utshintsho olwenziwe kutshanje kumayeza akho okanye imeko yakho yempilo. Buza ikhemisti yakho ukuba unemibuzo.

Ezinye izinto onokuzenza:

• Ukuba utyando, utyando lwamazinyo, okanye unyango olungxamisekileyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha iDofetilide.
• Kusenokufuneka unxibe ikhadi lokuzazisa elichaza ukuba usebenzisa iDofetilide.
• Ungaze uyeke ukuthatha eli yeza ngaphandle kokubuza ugqirha wakho.
• Landela iingcebiso zikagqirha wakho malunga nokutya neziselo, ingakumbi iziselo ezinxilisayo.
• Soloko ugcina amayeza aneleyo kuwe. Ngaphambi kokuba uye ekhefini okanye ohambweni, jonga ukuba amayeza akho ayaphela na. Kungenjalo, usenokungakwazi ukuwafumana xa kukho imeko engxamisekileyo.

Ufanele uye nini kugqirha?

Ukuba ufumana naziphi na kwezi mpawu, fowunela ugqirha wakho ngoko nangoko okanye uye kwigumbi likaxakeka:

• Ukubetha kwentliziyo ngokukhawuleza okanye ngokungangqalanga.
• Uziva ngathi intliziyo yakho ibetha ngokukhawuleza, uziva ngathi ukubetha kwentliziyo yakho kuyabetha ngamandla.
• Iintlungu zesifuba.
• Ukuba nesiyezi okanye ukuziva unentloko ekhaphukhaphu (`intloko ekhaphukhaphu`).
• Ubunzima bokuphefumla.
• Urhudo oluqatha.
• Ukuhlanza okubangelwa kukungabi namdla wokutya.
• Ukubila okungaqhelekanga.
• Ukwanda kokunxanelwa amanzi.
• Ukuqhambuka kwesikhumba.

Nokuba iziphumo ebezingalindelekanga ezingezizo ezinzulu kangako, thetha nogqirha wakho ukuba ziyakukhathaza:

• Intloko ebuhlungu.
• Ukungalali.
• Naziphi na ezinye iziphumo ebezingalindelekanga ezikukhathazayo.

Ndingayithenga phi iDofetilide?

I-Dofetilide ayifumaneki kuzo zonke iikhemesti. Ngoko ke, fowunela ikhemesti ekufutshane nawe ukuze ubone ukuba banayo na. Ukuba unengxaki yokufumana iyeza, thetha nogqirha wakho.

Ungayigcina njani iDofetilide?

• Gcina iDofetilide kwisitya esivalwe kakuhle, kubushushu begumbi, kwindawo eyomileyo .
• Musa ukuyibeka elangeni ngqo okanye kwiindawo ezishushu.
• Musa ukugcina eli yeza kwiindawo ezinomswakama ophezulu, njengakwigumbi lokuhlambela. Ukufuma kunokutshabalalisa iimpawu zeli yeza.
• Gcina le mithi kude nabantwana, kodwa zonke ezinye iziyobisi mazigcinwe kude.
• Ungaze wabelane ngamayeza akho nomnye umntu.
• Ungaze usebenzise amayeza aphelelwe lixesha. Amanye amaphakheji amayeza anomhla wokuphelelwa kwawo obhalwe kuwo. Okanye, ukuba awuqinisekanga ukuba amayeza angakanani, fowunela ikhemesti yakho ubuze.

Okokugqibela, izinto ekufuneka uzikhumbule

Kunokuba buhlungu kakhulu ukwazi ukuba unengxaki yesingqisho sentliziyo. Nangona kunjalo, ukuba ugqirha wakho ukunike iDofetilide, inokukunceda. Eyona nto ibalulekileyo kukulandela imiyalelo kagqirha kunye nemiyalelo ekwiphakheji yamayeza ngokuchanekileyo. Ukuba uneminye imibuzo okanye iinkxalabo malunga nale yeza, ungathandabuzi ukubuza ugqirha wakho okanye ikhemisti. Baya kukwazi ukukunceda.

I- Dofetilide, Ukubetha kwentliziyo, i-Arrhythmia, i-Atrial fibrillation, i-Atrial flutter, i-Tikosyn, isifo sentliziyo