Ingaba i-pituitary gland yakho "ayinanto"? Masifunde nge-Empty Sella Syndrome (ESS)!

Ngaba ngamanye amaxesha usoloko uphathwa ziintloko ezibuhlungu? Okanye ucinga ukuba yinto enxulumene neehomoni? Ukuba ugqirha uthi kufuneka enze i-"(CT)`` scan yentloko yakho okanye i-"(MRI)`` scan, banokufumanisa ukuba indawo apho i-pituitary gland yakho ikhoyo ibonakala "ingenanto." Yiloo nto siyibiza ngokuba yi-Empty Sell. Kodwa ngaba isoloko iyingxaki enkulu? Makhe sithethe ngale nto ngokweenkcukacha.

Yintoni i-Empty Sella Syndrome (ESS)?

Ngamafutshane, i-Empty Sella Syndrome (ESS) yimeko engaqhelekanga kakhulu. Yenzeka xa i-pituitary gland yakho – i-gland encinci kodwa ebaluleke kakhulu ekwisiseko sobuchopho bakho – ithambekile okanye ishwabene endaweni yayo, umngxuma wamathambo obizwa ngokuba yi-sella turcica . Cinga ngale ndlela, i-sella turcica ifana nendlu encinci ekhusela i-pituitary gland. Ngesizathu esithile, le 'ndlu' inokuba nkulu kakhulu, ibangele ukuba i-pituitary gland ivuvuke kwaye ibe ncinci.

Igama elithi 'sella turcica' livela kwisiLatini, elithetha 'isihlalo saseTurkey'. Libizwa njalo kuba lifana nesimo sesihlalo sehashe. Abanye abantu abane-ESS banokufumana iimpawu ezifana nokungalingani kwamahomoni , iintloko ezibuhlungu rhoqo, kunye nokutshintsha kombono .

Ubusazi na ukuba i-pituitary gland yinxalenye ebaluleke kakhulu kwinkqubo yethu ye-endocrine , eyinkqubo evelisa iihomoni. Ivelisa iihomoni ezininzi ezibalulekileyo emizimbeni yethu. Ezi homoni zilawula ezinye iihomoni emizimbeni yethu.

Yintoni umahluko phakathi kwe-Empty Sella kunye ne-Empty Sella Syndrome?

Oku kuyadida kancinci, ngoko ke phulaphula ngononophelo. Nangona amagama athi 'iseli engenanto' kunye 'nesifo seseli esingenanto' ngamanye amaxesha esetyenziswa ngokutshintshana, kukho umahluko omncinci. Ngamafutshane, iseli engenanto sisiphumo se-radiological , ngelixa isifo seseli esingenanto sisimo sempilo.

'Empty Sella' kuxa i-pituitary gland yakho ibonakala ithambile okanye inciphile kwi-scan. Kwimeko enjalo, oogqirha abanakuyibona kakuhle i-pituitary gland kwi-scan. Ke ngoko, indawo apho i-pituitary gland ikhoyo, ebizwa ngokuba yi-sella turcica, ibonakala 'ingenanto'. Kulapho igama elithi 'empty sella' livela khona.

Nangona kunjalo, i-sella turcica ayipheleli. Uninzi lwexesha, izaliswe lulwelo lwe-cerebrospinal (CSF) . Le CSF lulwelo olujikeleza kwaye lukhusela ingqondo yethu kunye nomqolo. Kwimeko 'ye-sella engenanto', olu lwelo lwe-CSF luvuza kwi-sella turcica kwaye lubeka uxinzelelo kwi-pituitary gland. Olu xinzelelo lubangela ukuba i-gland inciphe okanye ithambe.

Ixesha elininzi, oogqirha bafumanisa le 'seli ingenanto' ngengozi. Oko kukuthi, xa besenza iskeni ``(CT)`` okanye ``(MRI)``` yentloko ngesizathu esithile.

Nangona abanye abantu 'beneeseli ezingenanto' kwiiskeni zabo, abanakuba nazimpawu kwaye i-pituitary gland yabo inokusebenza kakuhle.

Nangona kunjalo, ukuba umntu une-'empty sella' kwaye i-pituitary gland yakhe ayisebenzi kakuhle, yiloo nto siyibiza ngokuba yi -Empty Sella Syndrome (ESS) . I -syndrome yingqokelela yeempawu ezinxulumene nayo. Abantu abane-ESS banokuhlangabezana nezinto ezifana nokungalingani kwamahomoni, utshintsho lombono, kunye neentloko ezibuhlungu rhoqo.

Kukho iintlobo ezimbini ze-Empty Sella, akunjalo?

Ewe, xa iskeni sakho sibona 'iseli engenanto', oogqirha bayahlulahlula ibe ziintlobo ezimbini: eyokuqala neyesibini.

• I-Primary Empty Sella (PES): Kulapho oogqirha bengenakukwazi ukufumana unobangela ocacileyo wokuba i-pituitary gland yakho ibe buthathaka. Kwiimeko ezininzi, i-primary empty sella ayibangeli i-empty sella syndrome. Oku kuthetha ukuba ayibangeli zimpawu rhoqo.
• Ukuthengiswa Okungenanto Kwesibini (i-SES): Oku kubangelwa yenye imeko echongiweyo echaphazela ulwakhiwo lwe-pituitary gland yakho okanye i-sella turcica. Ngamafutshane, kubangelwa kukonakala okuvela kwesinye isifo okanye isiganeko. Kwimeko ye-secondary empty sella (i-SES), i-empty sella syndrome inokwenzeka ngakumbi kunakwimeko ye-primary empty sella (i-PES).

Ingaba le Empty Sella Syndrome (ESS) isongela ubomi?

Hayi, i-Empty Sella Syndrome (ESS) ayisosifo esisongela ubomi. Inganyangwa ngamayeza e-hormone kwaye ngamanye amaxesha utyando.

Kwakhona, ukuba nje iskeni yakho yobuchopho ithi 'iseli engenanto' akuthethi ukuba isongela ubomi. Kwiimeko ezininzi 'zeseli engenanto', akukho zimpawu okanye isifo seseli engenanto.

Yintoni indima ye-Pituitary Gland?

I-pituitary gland yi-endocrine gland ebaluleke kakhulu emzimbeni wethu. Ivelisa iihomoni ezininzi ezahlukeneyo. Ikwaxelela amanye amadlala kwinkqubo yethu ye-endocrine ukuba akhuphe iihomoni. Oko kukuthi:

• Iindlala ze-adrenal
• Amaqanda (kwabasetyhini) okanye amasende (kumadoda)
• Indlala yegilo

Iihormone zifana nezithunywa zeekhemikhali. Zihamba ngegazi kwaye zithwala imiyalezo kwizitho zethu zomzimba, kwimisipha nakwezinye izicwili. Ezi miyalezo zixelela umzimba into omawuyenze kunye nexesha omawuyenze ngalo.

I-pituitary gland idibene ne-hypothalamus esebuchotsheni bethu.Iqhagamshelwe yisiqu esenziwe ngemithambo yegazi kunye nemithambo-luvo. Oku kubizwa ngokuba yisiqu se-pituitary. Kungesi siqu apho i-hypothalamus ithetha ne-pituitary gland ize ithi, 'Kulungile, ngoku khupha la ma-hormone.' I-hypothalamus yinxalenye yengqondo yethu elawula izinto ezifana noxinzelelo lwegazi, isantya sentliziyo, ubushushu bomzimba, kunye nokugaya ukutya.

I-pituitary gland ivelisa kakhulu ezi hormone zilandelayo:

• I-Adrenocorticotropic hormone (ACTH): Oku kukhuthaza amadlala e-adrenal ukuba avelise iihomoni (umz. i-cortisol) ezisabela kuxinzelelo.
• I-hormone yokulwa nokudaya (i-ADH okanye i-vasopressin): Ilawula ibhalansi yamanzi emzimbeni.
• I-Follicle-stimulating hormone (FSH): Inceda amaqanda avuthiweyo kubasetyhini kwaye ivelise isidoda kumadoda.
• Ihomoni yokukhula (GH): Inceda imizimba yethu ikhule ukususela ebuntwaneni ukuya ebudaleni, ingakumbi emathanjeni nakwizihlunu.
• I-Luteinizing hormone (LH): Isebenza ne-FSH ukunceda inkqubo yokuzala isebenze. Ibalulekile ekuvuthweni kwamaqanda kwabasetyhini nasekuvelisweni kwe-testosterone kumadoda.
• I-Oxytocin: Inceda isibeleko ukuba sinciphe ngexesha lokubeleka kunye nokunciphisa ubisi ngexesha lokuncancisa.
• I-Prolactin: Ivuselela ukuveliswa kobisi lwebele.
• Ihomoni evuselela i-thyroid (TSH): Ixelela i-thyroid gland entanyeni ukuba yenze iihomoni ze-thyroid. Ezi homoni ze-thyroid zilawula isantya umzimba wethu osebenzisa ngaso amandla (i-metabolism).

Ayizizo zonke ezi hormone eziveliswa rhoqo. Uninzi lwazo lukhutshwa ngokukhawuleza, malunga neyure nganye ukuya kwezintathu.

Ngubani ochaphazeleka kakhulu yi-Empty Sella Syndrome (ESS)?

Nangona esi sisifo esingaqhelekanga, abantwana kunye nabantu abadala banokuba ne-empty sella syndrome (ESS).

Nangona kunjalo, i-primary empty cell (PES) – oko kuthetha ukuba leyo ibonakala kuphela kwiskeni ngaphandle kweempawu – ixhaphake ngokuphindwe kane kubasetyhini kunakumadoda.

I-PES ixhaphake kakhulu kubantu abaphakathi kweminyaka engama-30 ukuya kwengama-40 ubudala. Ngamanye amaxesha inokwenzeka kwangethuba kwabasetyhini kunakwamadoda. Abafazi abakhulelwe ixesha elizeleyo basengozini enkulu yokufumana i-PES.

I-PES ayixhaphakanga kangako ebantwaneni kunakwabantu abadala. Xa isenzeka, idla ngokunxulunyaniswa nezinye iimeko zonyango, ezifana ne-Turner syndrome, isifo seMoyamoya, kunye ne-Prader-Willi syndrome.

Kuqheleke kangakanani oku?

I-Empty Sella Syndrome (ESS) ayiqhelekanga kakhulu. Abanye abaphandi baqikelela ukuba ngaphantsi kwe-1% yabantu abane-'empty sella' baba neempawu (oko kukuthi, baba ne-ESS).

Nangona kunjalo, ukuba ne-sella engenanto ngaphandle kweempawu kuxhaphake kakhulu. Ezinye iingxelo zibonisa ukuba phakathi kwe-8% kunye ne-35% yabemi banokuba ne-sella engenanto. Ezinye iingxelo zibonisa ukuba malunga ne-12% yabantu bane-sella engenanto, ngokusekelwe kwiziphumo zeskeni yobuchopho.

Zithini iimpawu ze-Empty Sella Syndrome (ESS)?

Uphawu oluphambili oluhambelana ne-empty sella syndrome (ESS) ziintloko ezingapheliyo. Nangona kunjalo, abaphandi abakaqiniseki ukuba ezi ntloko zibangelwa yi-ESS okanye ukuba zenzeke ngengozi nje. Oku kungenxa yokuba abantu abaninzi abane-ESS nabo banoxinzelelo lwegazi oluphezulu (uxinzelelo lwegazi), olunokubangela iintloko ezibuhlungu ukuba ziba nzima.

I-ESS idla ngokubangela ukungalingani kwamahomoni ngenxa yomonakalo kwi-pituitary gland. Abantu abane-ESS banokufumana iimpawu ezahlukeneyo ngokuxhomekeke kumonakalo kwi-pituitary gland yabo kunye nokuba zeziphi iihomoni ezichaphazelekileyo. Ukuba une-ESS, unokuba nezinye zezi mpawu zilandelayo:

• Ukuphuma kolwelo olungenabisi oluvela emabeleni (i-galactorrhea) (oku kunokwenzeka nakumadoda)
• Ukungasebenzi kakuhle kwe-erectile ( kumadoda)
• Ukuya exesheni okungacwangciswanga okanye ukungabikho ngokupheleleyo kwenyanga (i-amenorrhea) (kwabasetyhini)
• Ukuncipha okanye ukuphelelwa ngumnqweno wesondo (i-libido ephantsi)
• Ndiziva ndidiniwe ngalo lonke ixesha (Ukudinwa)

Kunqabile kakhulu, abanye abantu abane-ESS banokufumana iimpawu ezifana nezi:

• Uxinzelelo olunyukileyo ngaphakathi kwekhakayi (uxinzelelo olungelulo olungaphakathi kwentloko)
• I-cerebrospinal rhinorrhea (ukuvuza kwe-CSF empumlweni)
• Ukudumba kwediski ye-optic ngaphakathi kweliso (i-papilledema) ngenxa yoxinzelelo oluphezulu kwikhakayi
• Utshintsho lombono, umzekelo, umbono ofipheleyo.

Kwakhona, unokuba 'neseli engenanto' kwi-brain scan, kodwa usenokungabi nazimpawu. Enyanisweni, abantu abaninzi abane 'iiseli ezingenanto' abanazo iimpawu kwaye abasoze babe nazo.

Ngaba i-Empty Sella Syndrome (ESS) ibangela ukutyeba?

Ukuba i-pituitary gland yakho ayivelisi i-hormone evuselela i-thyroid (TSH) eyaneleyo ngenxa ye-empty sella syndrome (ESS), kukho ithuba lokuba uya kutyeba.

I-TSH ivuselela i-thyroid gland, ekwi-front of your entanyeni, phantsi kolusu, ukuze ikhuphe ii-hormone ze-thyroid. Umsebenzi ophambili we-thyroid gland kukuvelisa ii-hormone ze-thyroid, ezilawula isantya oguqula ngaso ukutya okutyayo kube ngamandla, okanye isantya sakho se-metabolic .

Ukuba i-pituitary gland yakho ayivelisi i-TSH eyaneleyo ngenxa ye-ESS, i-thyroid gland yakho isenokungavelisi ii-hormone ze-thyroid ezaneleyo. Oku kunokubangela ukuba imetabolism yakho yehle ngenxa yamanqanaba aphantsi e-thyroid hormone, nto leyo enokubangela ukuba umzimba utyebe.

Yintoni ebangela i-Empty Sella Syndrome (ESS)?

I-Empty Sella Syndrome (ESS) inokubangelwa yi-primary empty sella (PES) okanye yi-secondary empty sella (SES). Nangona kunjalo, i-secondary empty sella (SES) inokubangela i-ESS.

Izizathu zePrimary Empty Sella Syndrome (PES)

I-Primary esophagitis (PES) yenzeka xa enye yee-membrane ezigubungela umphandle wobuchopho bakho (umaleko we-arachnoid), i-sella turcica, ivuvukala ngaphakathi, icinezela i-pituitary gland.

Oogqirha abakakwazi ukufumana unobangela ochanekileyo we-primary empty sella syndrome.

Enye ingcamango kukuba ubuthathaka bokuzalwa kwizicubu ezigquma ingqondo buvumela ulwelo lwe-cerebrospinal (CSF) ukuba lungene kwi-sella turcica, nto leyo ethintela i-pituitary gland. Kwiimeko ezinjalo, i-pituitary gland idla ngokuba nzima ukuyibona kwi-scan, kodwa isebenza ngokuqhelekileyo, ngoko ke i-empty sella syndrome ayiveli.

Izizathu ze-Secondary Erectile Dysfunction (SES)

I-Secondary empty sella (SES) yenzeka xa i-pituitary gland yakho okanye i-sella turcica yonakaliswe sisifo okanye isiganeko esithile. Ke ngoko, zininzi izizathu ezinokubakho ze-SES. Ngokubanzi, izizathu eziphambili zalo monakalo zezi:

• Umhlaza wobuchopho.
• Unyango ngemitha .
• Utyando lobuchopho lwenziwa kwindawo ejikeleze i-pituitary gland.
• Ukwenzakala okukhulu entloko, umzekelo ukwenzakala okubuhlungu engqondweni.

Nazi ezinye izizathu ezithile ezinokuchaphazela ukukhupha kwesibini kwesinyi:

• Iithumba zobuchopho: Ngamanye amaxesha iithumba zobuchopho zinokubangela uxinzelelo oluphezulu olujikeleze ingqondo yakho (uxinzelelo lwangaphakathi kwentloko), olunokucinezela indlala ye-pituitary.
• Idiopathic intracranial hypertension (IIH): IIH kukunyuka koxinzelelo ngaphakathi kwentloko ngenxa yokuqokelelwa kolwelo lwe-cerebrospinal (CSF) olujikeleze ubuchopho bakho. Olu xinzelelo lugqithisileyo lunokucinezela i-pituitary gland.
• Ii-adenoma zepituitary: Ezi zii-tumor ezikhula kwi-pituitary gland. Uninzi lwexesha, azinamhlaza (azinabungozi). Ezi adenomas zinokubangela uxinzelelo kwi-pituitary gland kwaye ziyonakalisa.
• Isifo sikaSheehan: Esi sisifo esinokwenzeka ngamanye amaxesha ukuba kukho ukopha okugqithisileyo, okusongela ubomi ngexesha lokubeleka. Oku kunokubangela ukuba umzimba ungabi naoksijini kwaye konakalise i-pituitary gland.

Ifunyanwa njani i-Empty Sella Syndrome (ESS)?

Uninzi lwexesha, oogqirha bafumana i-sella engenanto ngengozi, xa besenza iskeni yentloko ngesinye isizathu. Kwakhona, abantu abaninzi abane-sella engenanto ababi naso isifo se-sella esingenanto okanye babe nazo naziphi na iimpawu.

Nangona kunjalo, ukuba uneempawu ezinxulumene ne-empty cell syndrome, ezifana neentloko ezibuhlungu rhoqo kunye nokungalingani kwamahomoni, ugqirha wakho uza kukubuza ngembali yakho yezonyango, enze uvavanyo lomzimba, kwaye mhlawumbi uya kuyalela ukuba kwenziwe iskeni yentloko kunye nobuchopho.

Iiskeni ezisetyenziselwa ukuxilonga i-ESS zezi:

• Iskeni ye-CT yobuchopho (i-computed tomography): Iskeni ye-CT yindlela yokuthatha imifanekiso ecacileyo yengqondo yakho kunye ne-pituitary gland usebenzisa i-X-reyi kunye nekhompyutha.
• Iskeni yobuchopho ye-magnetic resonance imaging (MRI): Iskeni ye-MRI isebenzisa amaza erediyo kunye neemagnethi ezinamandla ukwenza imifanekiso ecacileyo yamalungu angaphakathi emzimbeni wakho, njenge-sella turcica yakho.

Ugqirha wakho unokuyalela iimvavanyo ezongezelelweyo, ezifana novavanyo lwegazi, ukujonga amanqanaba eehomoni zakho.

Ngamanye amaxesha, oogqirha banokwenza uvavanyo olufana nolu ukujonga uxinzelelo oluphezulu engqondweni yakho:

• Cela ugqirha wamehlo ukuba ahlole i-retina engaphakathi kweliso lakho.
• Ukubhoboza i-Lumbar (i-spinal tap) – Oku kulinganisa uxinzelelo lolwelo lomqolo.

Ziziphi iindlela zonyango lwe-Empty Sella Syndrome (ESS)?

Nokuba iiskeni zakho zibonisa 'iseli engenanto', ukuba i-pituitary gland yakho isebenza kakuhle, akuyi kufuneka naluphi na unyango. Oku kwenzeka rhoqo.

Nangona kunjalo, ukuba une-Empty Sella Syndrome (ESS) kwaye i-pituitary gland yakho ayisebenzi kakuhle, unyango luxhomekeke kumayeza okulungisa amanqanaba aphantsi e-hormone. Oko kukuthi, amayeza amiselwa ngokusekelwe kwi-hormone ephantsi.

Ukuba i-ESS ibangela ukuba ulwelo lwe-cerebrospinal (CSF) luphume empumlweni yakho (CSF rhinorrhea), unokufuna utyando lokulungisa i-sella turcica yakho.

Ziziphi izinto ezibangela umngcipheko we-Empty Sella Syndrome (ESS)?

Oogqirha abaqinisekanga ukuba yintoni ebangela i-empty sella syndrome kwabanye abantu abane-empty sella. Nangona kunjalo, i-empty sella syndrome inokwenzeka ukuba ivele kwi-secondary empty sella (SES) kune-primary empty sella (PES). Oku kuthetha ukuba ukuba i-empty sella ibangelwa yenye into, efana ne-brain tumor, i-radiation therapy, okanye ukwenzakala entloko, kusenokwenzeka ukuba ube neempawu.

Ithini ingqikelelo yomntu one-Empty Sella Syndrome (ESS)?

Ithemba lomntu one-empty sella syndrome (ESS) lihlala lilungile. Kukho amayeza okunyanga ukungalingani kweehomoni. Ukuba une-hormonal imbalance ngenxa ye-ESS, unokufuna ukuthatha amayeza ubomi bakho bonke.

Ufanele uye nini kugqirha ukuba une-empty cell syndrome?

Ukuba ufunyaniswe une-Empty Sella Syndrome (ESS), kwaye ubonakalisa iimpawu ezintsha okanye ukuba iimpawu zakho ezikhoyo ziya zisiba mandundu, bonana nogqirha wakho ngoko nangoko.

Ukuba usela amayeza okungalingani kwamahomoni ngenxa yesifo sesisu esingenanto, kubaluleke kakhulu ukubona ugqirha wakho rhoqo ukuqinisekisa ukuba amayeza akho asebenza kakuhle.

Ngoko ke, yintoni esifanele siyikhumbule koku?

Kaloku, i-Empty Sella Syndrome (ESS) yimeko engaqhelekanga kakhulu. Nangona kunjalo, kuqhelekile ukufumanisa ukuba unento ebizwa ngokuba yi-'empty cell' kwi-brain scan. Ngoko ke ungoyiki kuba ugqirha ekutshilo. Uninzi lwexesha, abantu abane-'empty cell' abanazo iimpawu kwaye abanayo i-Empty Sella Syndrome.

Ukuba unemibuzo malunga nengxelo yakho yeskeni, ungoyiki ukubuza ugqirha wakho. Bakho ukuze bakuncede. Ukunyamekela impilo yakho yeyona nto ibalulekileyo.

I- Empty Sella Syndrome, i-Pituitary gland, iiHormones, i-Brain scan, iSellae Tursica