Usenokuba awukaze ulive eli gama ngaphambili. I-Epithelioid Hemangioendothelioma (EHE) ngumhlaza ongaqhelekanga kakhulu, ofumaneka kubantu abamalunga nesigidi. Eli gama liyinkimbinkimbi kancinci, ngoko ke linokuba loyikeka. Kodwa ungakhathazeki. Kubalulekile ukuqonda esi simo singaqhelekanga ngokulula nangokucacileyo. Ngoko ke namhlanje, masithethe nge-EHE kanye kanye.
Kalula nje, loluphi uhlobo lomhlaza i-EHE?
Khawucinge ukuba imithambo yegazi ( imithambo yegazi , imithambo yegazi, kunye nee-capillaries) emizimbeni yethu ifana nenethiwekhi yeendlela ezinqumla ilizwe. Ingaphakathi lale ndlela ligcwele umaleko omncinci kakhulu weeseli. Ezi seli zibizwa ngokuba ziiseli ze-endothelial kwisayensi yezonyango.
Umhlaza we-endothelial uqala kwiiseli ezijikeleze imithambo yegazi. Ekubeni imithambo yegazi ikwindawo yonke emizimbeni yethu, umhlaza we-EHE unokukhula naphi na emzimbeni. Nangona kunjalo, la mathumba adla ngokuqala esibindini, emiphungeni, okanye emathanjeni . Nangona kunjalo, anokukhula nakwezinye iindawo, ezifana nentloko, intamo, i-thyroid, isisu, ama-ovari, i-prostate, ingqondo, kunye nomqolo.
Ngamanye amaxesha i-EHE ingavela njengeqhuma elinye. Ngamanye amaxesha, ingavela njengeqhuma ezininzi kwilungu elinye okanye kwizitho ezininzi. Rhoqo, xa i-EHE ifunyaniswa, umhlaza sele usasazeke kwizitho ezingaphezu kwelinye.
Ngaba i-EHE luhlobo lwe-sarcoma?
Ewe, kunjalo. I-Sarcoma luhlobo lomhlaza olukhula kwizicubu ezithambileyo zomzimba wethu, njengemithambo yegazi. Ngenxa yokuba umhlaza we-EHE uqala kwiiseli ze-endothelial zemithambo yegazi, uhlelwa njengohlobo lwe-sarcoma.
Ingaba lo mhlaza unobungozi?
Ewe, i-EHE iyingozi , oko kuthetha ukuba yimeko embi okanye enomhlaza. Ngokungafaniyo neethumba ezingenobungozi, ezi seli zomhlaza zinokukhula ngokungalawulekiyo, zisasazeke (zitshintshe i-metastasize) kwezinye iindawo zomzimba, kwaye zonakalise izicubu ezisempilweni.
Kodwa nantsi into ekufuneka uyikhumbule. Umhlaza we-EHE unzima kakhulu. Ezinye iithumba ze-EHE zisasazeka ngokukhawuleza, njengeemhlaza ezihlaselayo kakhulu. Kodwa ezinye zikhula kancinci kakhulu, kwiminyaka emininzi. Okumangalisayo kukuba, kubekho iingxelo zezi thumba zincipha ngaphandle konyango. Ngenxa yale ndlela yokuziphatha eguquguqukayo, kunzima ukuqikelela ubukhali balo mhlaza kunye nendlela oza kusabela ngayo kunyango.
Zithini iimpawu ze-EHE?
Izigulane ezininzi ezine-EHE azibonakali zimpawu ekuqaleni. Yiyo loo nto idla ngokufunyanwa ngengozi ngexesha lovavanyo lwenye imeko. Nangona kunjalo, ukuba iimpawu ziyabonakala, zixhomekeke kwindawo ekuyo iqhuma elinomhlaza.
Ezinye zeempawu eziqhelekileyo ezinokubonwa zezi:
- Iqhuma elinokuviwa phantsi kolusu (oku kusenokuba buhlungu okanye kungabi buhlungu)
- Ukunciphisa umzimba ngaphandle kwesizathu
- Umkhuhlane kunye nokudinwa kakhulu
Makhe sijonge indlela iimpawu ezahluka ngayo ngokuxhomekeke kwindawo yomhlaza.
| Indawo yomhlaza | Iimpawu ezinokwenzeka |
|---|---|
| Isibindi | Intlungu yesisu, ukudumba. |
| Imiphunga | Ubunzima bokuphefumla, ukukhohlela, ukukhohlela igazi, ukuqubha iiklabhu. |
| Amathambo | Intlungu yamathambo, ukwaphuka rhoqo. |
| Umqolo | Ubunzima bokuhamba okanye ukushukuma, iintlungu zomqolo. |
Yintoni ebangela umhlaza we-EHE?
Iimhlaza ezifana ne-EHE zikhula xa iseli ephilileyo iguquka ibe yiseli yomhlaza ize iqale ukwahlukana ngendlela engalawulekiyo.
Xa bezama ukufumanisa ukuba yintoni ebangela oku, abaphandi bafumanise ukuba kubangelwa kukuguquka kwezakhi zofuzo ezithile. Ngamafutshane, ii-chromosomes ezimbini kwiiseli zethu zidibene ngendlela engafanelekanga, nto leyo ebangela ukuba ii-genes ezimbini zidibane. Ezi genes zibizwa ngokuba yi- (WWTR1) (ekwabizwa ngokuba yi- (TAZ) ) kunye ne- (CAMTA1) . Xa ezi genes zimbini zidibane, kubangela ukuba iiseli zomhlaza ze-EHE ziqale ukwakheka.
Ngenxa yoko, ugqirha wakho unokuvavanya olu nxulumano olungaqhelekanga lwe-chromosome xa esenza uxilongo.
Yenziwa njani le nto yokuxilonga?
Njengoko besitshilo ngaphambili, i-EHE idla ngokufunyanwa ngengozi. Oogqirha baqaphela kuphela iqhuma ngexesha lovavanyo lomfanekiso, olufana ne -CT scan okanye i-MRI scan, ngesinye isizathu. Emva koko bakhangela indawo, ubungakanani, kunye nokuba sele lisasazeke na kwezinye iindawo.
Ezi zezona zilingo zisetyenziswa kakhulu ukuxilonga i-EHE.
| Uvavanyo | Kalula nje, kwenzeka ntoni? |
|---|---|
| Iskena se-CT | Ii-X-reyi zisetyenziselwa ukuthatha uthotho lwemifanekiso enqamlezileyo yomzimba wakho. Oku kunokunceda ekuchongeni iithumba ze-EHE esifubeni, esiswini, nakwisinqe. Oku kunceda ukubona ngokucacileyo ukuba yintoni engaphakathi kwamalungu omzimba, emathanjeni, nakwimisipha. |
| Iskeni ye-MRI (i-MRI) | Imagnethi enamandla kunye namaza erediyo asetyenziselwa ukwenza imifanekiso ecacileyo yangaphakathi lomzimba. Oku kuluncedo kakhulu ekujongeni iithumba ze-EHE esibindini nasemathanjeni. Ngamanye amaxesha i-MRI yomzimba wonke, egubungela umzimba wonke ukusuka entloko ukuya ezinzwaneni, inokunceda ekufumaneni iithumba ezisasazeke emathanjeni. |
| I-Core-Needle Biopsy | Olu lolona vavanyo lubalulekileyo lokuqinisekisa ukuba iqhuma liyi-EHE emva kokuskena. Iqhekeza elincinci lesicubu lisuswa kwiqhubu kusetyenziswa inaliti ekhethekileyo engenanto. Ugqirha oyingcali obizwa ngokuba yi-pathologist uhlola eli qhekeza lesicubu phantsi kwemakroskopu ukuze abone ukuba kukho iiseli zomhlaza kwaye zeziphi iintlobo zazo. |
Ukongeza, ukuchonga amaqhuma nokujonga ukuba asasazekile na (i-ultrasound) okanyeUgqirha wakho unokucebisa nezinye iimvavanyo, ezifana ne -PET scan .
Ziziphi iindlela zonyango ze-EHE?
Ngenxa yokuba i-EHE yimeko engaqhelekanga, akukho zikhokelo zonyango ezisemgangathweni okwangoku. Ke ngoko, uza kunyangwa liqela loogqirha abanamava okunyanga ii-sarcomas. Eli qela lingabandakanya ingcali yomhlaza , ingcali ye-radiology , kwaye, kuxhomekeke kwisitho apho umhlaza ukhoyo khona (umzekelo, ithambo), ugqirha wamathambo , okanye ingcali yokufakelwa kwesibindi.
Unyango olufumanayo luxhomekeke kwizinto ezininzi, kuquka ubungakanani beqhuma, indawo elikuyo, ukuba zingaphi iiqhuma ezikhoyo, nokuba umhlaza usasazeke na.
Nazi ezinye iindlela zonyango:
Ukulinda Ngokucothayo
Ukuba awunazo iimpawu kwaye awungomntu ufanelekileyo wotyando, ugqirha wakho unokugqiba ekubeni angakunyangi ekuqaleni aze ajonge imeko yakho ngokusondeleyo. Oku kungenxa yokuba ngamanye amaxesha iziphumo ebezingalindelekanga zonyango zinokuba ngaphezu kweenzuzo. Njengoko besitshilo ngaphambili, ezinye iithumba ze-EHE ziyancipha ngaphandle konyango okanye zikhula kancinci. Nangona kunjalo, ukuba imeko iba mandundu, ugqirha wakho unokucebisa enye indlela yonyango.
Utyando
Unyango oluqhelekileyo lwethumba elinye lutyando. Kule nkqubo, ugqirha ususa ithumba elinomhlaza kunye nenani elincinci lezicubu eziphilileyo ezijikeleze lona ukuqinisekisa ukuba akukho ziseli zomhlaza eziseleyo.
Ukuvaleka kwemithambo yegazi
Oku kuquka ukuvala imithambo yegazi enika igazi kwithumba. Kanye njengokuba isityalo sisifa xa uyeka ukusinkcenkceshela, xa igazi linqanyulwa, ithumba alinakukhuli okanye linciphe. Oku kungenziwa ukunciphisa ithumba ngaphambi kotyando okanye njengonyango oluphambili. I-Transarterial chemoembolization (TACE) kunye ne -radioembolization zezinye zeendlela zonyango ezinjalo.
Unyango olujoliswe kulo
Olu lolona nyango luqhelekileyo kwi-EHE ephucukileyo. Olu nyango lusebenzisa amayeza athintela izondlo kunye neoksijini ezifunekayo ukuze iiseli zomhlaza zikhule.
Unyango lweMisebe
Olu nyango lungasetyenziselwa ukutshabalalisa naziphi na iiseli zomhlaza ezinokuthi zihlale emva kotyando. Unyango lwemitha lunokunikwa njengonyango oluphambili kumntu ongenakukwazi utyando. Kolu nyango, imisebe yemitha enamandla aphezulu isetyenziselwa ukutshabalalisa iiseli zomhlaza.
Unyango ngamakhemikhali
Kwi-EHE (iKhemotherapy)Ayisetyenziswa rhoqo, kodwa ukuba umhlaza ukwinqanaba eliphezulu, ingacetyiswa kunye nezinye iindlela zonyango.
Ukufakelwa Kwamalungu
Ukuba iithumba ezininzi zichaphazele isitho esikhulu (ingakumbi isibindi), ugqirha unokucebisa ukuba kufakwe isitho esitsha.
Uphando nge-EHE lusaqhubeka, kwaye unyango olutsha luyavavanywa kwiimvavanyo zeklinikhi . Ngokuxhomekeke kubukhali bemeko yakho, ugqirha wakho unokucebisa ukuba uthathe inxaxheba kolunye lwala mayeza asekelwe kuphando.
Ungaphila ixesha elingakanani ne-EHE?
Xa usiva oku, usenokuba uzibuza, ‘Ndingaphila ixesha elingakanani ke ngoko?’ Inyaniso kukuba, kunzima ukunika impendulo ethe ngqo kuloo mbuzo. Ngenxa yokuba i-EHE yimeko engaqhelekanga, ulwazi ngayo lusaqokelelwa.
Kwakhona, njengoko besitshilo ngaphambili, lo mhlaza awuziphathi ngendlela efanayo kubo bonke abantu. Kwabanye, umhlaza ungasasazeka ngokukhawuleza nokuba unyangwa. Kwabanye, umhlaza ungaphila iminyaka emininzi ngaphandle kweempawu ezinkulu okanye ukusasazeka kwethumba. Amanye amathumba ayancipha ngaphandle konyango.
Ngoko ke, ulwazi olungcono malunga nemeko yakho nekamva lakho lunokufumaneka kuphela kugqirha wakho onyangayo. Uza kuqwalasela zonke iingxelo zovavanyo lwakho kunye nemeko yakho aze akunike ulwazi oluchanekileyo.
Imibuzo omele uyibuze ugqirha wakho
Kuqhelekile ukuba nemibuzo emininzi xa ufumanisa ngesi sifo singaqhelekanga. Xa usiya kugqirha wakho, ungalibali ukubuza le mibuzo.
| Umbuzo omele uwubuze | Kutheni kubalulekile ukwazi oku? |
|---|---|
| Iphi iqhubu lam elinomhlaza? | Iimpawu kunye nonyango ziyahluka ngokuxhomekeke kwindawo. |
| Ziziphi iimpawu ezinokundinceda ndiqonde ukuba iqhuma liyakhula? | Oku kuya kukunceda ukuba waziswe ngokukhawuleza ukuba kukho naluphi na utshintsho. |
| Zeziphi izinto ezichaphazela ukubikezela kwangaphambili kwesifo sam? | Oku kubalulekile ukuze uqonde imeko yakho ngendlela eyiyo. |
| Zeziphi iindlela zonyango ondicebisa zona? Zithini iziphumo zazo ezingalindelekanga? | Ungenza isigqibo esicacileyo malunga nonyango kwaye ulungele iziphumo ebezingalindelekanga. |
| Ngoobani iingcali ezibandakanyekayo kwiqela lam lonyango? | Yazi iqela elikukhathalelayo. |
| Kuza kufuneka ndize kangaphi ukuze ndilandelelwe? | Funda indlela yokulandelela impilo yakho. |
Kusoloko kubalulekile ukufuna unyango koogqirha obathembayo. Kubaluleke ngakumbi xa kufikwa kwimeko engaqhelekanga efana ne-EHE. Ekubeni kusekho okuninzi esingakwaziyo ngale nto, ukufuna unyango koogqirha abanamava okunyanga ii-sarcomas kunye nomhlaza ontsonkothileyo kunokwenza umahluko omkhulu kuhambo lwakho lokuchacha.
Umyalezo Wokuya Ekhaya
- I-Epithelioid Hemangioendothelioma (EHE) luhlobo lomhlaza olungaqhelekanga kakhulu oluqala kwiiseli ezijikeleze imithambo yegazi.
- Indlela lo mhlaza oziphatha ngayo inokwahluka kakhulu kumntu nomntu. Ezinye zikhula ngokukhawuleza, ngelixa ezinye zikhula kancinci okanye zinciphe ngaphandle konyango.
- Idla ngokuba ayinazimpawu kwaye inokubonwa ngengozi ngexesha lokuhlolwa ngesinye isizathu.
- I-biopsy ibalulekile ukuqinisekisa ukuxilongwa.
- Iindlela zonyango zenzelwe umntu ngamnye ukuze zilungele isigulana ngasinye kwaye zinokubandakanya ukujongwa, utyando, kunye nonyango olujoliswe kulo.
- Ekubeni esi sisifo esingaqhelekanga, kubalulekile ukufuna unyango kwiqela leengcali ezinamava kwi-sarcoma. Buza ugqirha wakho imibuzo uze uqonde kakuhle imeko yakho.
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