Masifunde ngesitofu sokugonya iFosdenopterin (iyeza lokunqongophala kweMolybdenum Cofactor)

Ukuzisa usana olusandul’ ukuzalwa ekhaya luyolo kusapho. Kodwa ngamanye amaxesha, ezinye iintsana zinokuzalwa zineemeko zemfuza ezingaqhelekanga. Kuqhelekile ukuba sizive sisoyika kwaye sixhalabile xa sisiva ngezi zinto. Kodwa namhlanje, ngenxa yokuba isayensi yezonyango ihambele phambili kakhulu, ngoku kukho izisombululo zezifo ezininzi ebezingenalo unyango ngaphambili. Namhlanje, siza kuthetha ngamayeza akhethekileyo anikwayo kwimeko engaqhelekanga kangaka. Elo ligonyo leFosdenopterin.

Yintoni le Fosdenopterin? Yintoni eyenzayo?

Ngamafutshane, iFosdenopterin (igama lophawu: Nulibry) liyeza elisetyenziselwa ukunyanga imeko engaqhelekanga kakhulu yemfuza ebizwa ngokuba yiMolybdenum cofactor deficiency (MoCD) . Kulungile, ngoku masibone ukuba yintoni iMoCD. Khawuthelekelele ukuba umzimba wethu ufana nomzi-mveliso omkhulu. Ukuze lo mzi-mveliso wenze yonke into ngokufanelekileyo, udinga abasebenzi abancinci abahlukeneyo ababizwa ngokuba ziienzymes. Ukuze lo mzi-mveliso usebenze ngokufanelekileyo, udinga elinye icandelo elincinci eliwuncedayo. Siwubiza ngokuba yicofactor. I-Molybdenum cofactor ngomnye wabancedisi ababalulekileyo. Umntu oneMoCD unesiphako semfuza emzimbeni wakhe esimthintela ekwenzeni lo mzi-mveliso weMolybdenum. Emva koko, ngenxa yalo mncedisi, ezinye iienzymes azisebenzi. Ngenxa yoko, iityhefu eziyingozi emzimbeni ziqala ukuqokelelana emzimbeni. Ezi tyhefu, ingakumbi ezo zibangela umonakalo obulalayo engqondweni, zezo zenzekayo kwiMoCD. Kulapho iyeza elibizwa ngokuba yiFosdenopterin lingena khona. Okwenziwa leli yeza kukubonelela ngeMolybdenum cofactor engenakuveliswa ngumzimba ngaphandle. Kufana nokuzisa umsebenzi olahlekileyo kumzi-mveliso. Emva koko ezo enzymes zingasebenziyo ziqala ukusebenza kwakhona, ukuqokelelana kweetyhefu kuyayeka, kwaye umonakalo engqondweni uyancitshiswa.

Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uthathe amayeza

Ngaphambi kokuba unike wena okanye umntwana wakho eli yeza, kubaluleke kakhulu ukuxoxa ngolwazi oluthile nogqirha wakho. Kuba impumelelo kunye nokhuseleko lonyango luxhomekeke kolo lwazi. Nazi ezinye izinto ekufuneka uzikhankanye:

• Ii-Allergies : Sixelele ukuba unayo nayiphi na i-allergies kwi-Fosdenopterin okanye naliphi na elinye iyeza, ukutya, iidayi, okanye izithinteli.
• Ukukhulelwa : Ukuba ukhulelwe, uzama ukukhulelwa, okanye ukrokrela ukuba ukhulelwe, ngokuqinisekileyo kufuneka uxelele ugqirha wakho.
• Ukuba ungumama oncancisayo: Ukuba ungumama oncancisayo, yazisa ugqirha ngale nto.

Ukuba usixelela olu lwazi ngokunyaniseka kwaye ungalufihli, kuya kunceda kakhulu iqela lezonyango ukuba likunike unyango olufanelekileyo nolukhuselekileyo.

Ulisebenzisa njani eli yeza?

I-Fosdenopterin yinaliti efakwa emthanjeni. Idla ngokunikezelwa liqela lezonyango esibhedlele okanye ekliniki. Nangona kunjalo, kwezinye iimeko, inokunikwa ngaphandle kwesibhedlele, ekhaya. Ukuba oku kuyenzeka, akukho nto unokukhathazeka ngayo. Iqela lezonyango liya kukuqeqesha ngokupheleleyo malunga nendlela yokulungiselela nokunika eli yeza ngokuchanekileyo.

• Landela imiyalelo ngokuchanekileyo: Kubaluleke kakhulu ukusela amayeza kanye njengoko ugqirha wakho ekuxelela, ngexesha elifanelekileyo, yonke imihla. Qhubeka uwasela de iqela lakho lezonyango likuxelele ukuba uyeke.
• Iinaliti neesirinji ezisetyenzisiweyo: Eli linqaku elibaluleke kakhulu. Ungaze ulahle iinaliti neesirinji ezisetyenzisiweyo emgqomeni wenkunkuma. Kukho isitya esikhethekileyo sazo (isitya esibukhali). Ukuba awunaso, ungacela ugqirha wakho okanye iqela lezonyango ukuba likunike sona. Oku kuya kukukhusela wena, usapho lwakho, kunye nokusingqongileyo.
• Imiyalelo Yokusetyenziswa: Funda imiyalelo yokusebenzisa ehambisana nale yeza ngononophelo. Ukuba unemibuzo malunga nomxholo walo, cela ingcaciso kwiqela lakho lezonyango.

Yintoni omawuyenze ukuba uphoswe yidosi?

Oku kuyahluka kancinci kuxhomekeke ekubeni iyeza lifumaneka phi.

• Ukuba usela amayeza akho esibhedlele okanye ekliniki: Ukuba awukwazi ukuya kwintlanganiso yakho ecwangcisiweyo, fowunela iqela lakho lezonyango ngokukhawuleza. Kubaluleke kakhulu ukuba ungaphoswa yintlanganiso yakho ecwangcisiweyo.
• Ukuba usela amayeza akho ekhaya: Ukuba uphoswe yidosi, yisele ngokukhawuleza xa ukhumbula. Kodwa xa usela idosi yakho elandelayo, linda ubuncinane iiyure ezi-6 ngaphambi kokuba uthathe idosi ephoswe yiyo. Ungaze uthathe idosi ephindwe kabini okanye idosi eyongezelelweyo. Ukuba awuqinisekanga, thetha neqela lakho lezempilo ukuze ufumane iingcebiso.

Yintoni omawuyenze ukuba ugqithisile?

Ukuba ucinga ukuba uthathe amayeza amaninzi kakhulu, fowunela iZiko loLwazi lweeTyhefu zeSizwe kwiSibhedlele sikaZwelonke eColombo ngoko nangoko, okanye uye kwiSebe leNgxamiseko (i-ETU) lesibhedlele esikufutshane.

Izinto ekufuneka uzilumkele xa usebenzisa iyeza

• Amanye amayeza: Akulindelekanga ukuba la mayeza asebenzisane namanye amayeza. Nangona kunjalo, kukhuselekile ukuxelela ugqirha wakho ngawo onke amanye amayeza owasebenzisayo (kuquka iivithamini , amayeza ezityalo, kunye nezongezo). Kwakhona, xelela ugqirha wakho ukuba utshaya okanye usela utywala .
• Zikhusele elangeni: Oku kubaluleke kakhulu. Ulusu lwakho lunokuba novelwano kakhulu elangeni ngelixa usela eli yeza. Ngoko ke, kuphephe ukuphuma elangeni kangangoko unako. Ukuba kufuneka uphume, nxiba impahla egquma ulusu lwakho kakuhle kwaye usebenzise i-sunscreen elungileyo. Musa ukusebenzisa izibane zelanga okanye iibhedi zokutshisa ilanga.
• Ukuhlolwa rhoqo: Qiniseka ukuba uya kugqirha wakho. Kufuneka ujonge rhoqo ukuba unyango lwakho luhamba njani. Ukuba iimpawu zakho aziphucuki okanye zibonakala zisiba mandundu, yazisa iqela lakho lezonyango.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengayo nayiphi na iyeza, iFosdenopterin inokubangela ezinye iziphumo ebezingalindelekanga. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Ezinye zezi ziyingozi, ngelixa ezinye ziqhelekile. Eyona nto ibalulekileyo kukuziqaphela. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana naziphi na iimpawu ezingaqhelekanga, thetha nogqirha wakho ukuze akunike iingcebiso zonyango.

Ungayigcina njani iyeza?

Kubaluleke kakhulu ukugcina eli yeza ngokufanelekileyo. Ukuba ligcinwe ngendlela engafanelekanga, eli yeza lisenokuphelelwa ngamandla alo.

• Gcina kude nabantwana: Gcina kude nabantwana nezilwanyana zasekhaya.
• Iibhotile ezingavulwanga: Ezi kufuneka zigcinwe efrijini kubushushu obuphakathi kwe -25 kunye ne -10 degrees Celsius . Gcina kwibhokisi yokuqala ide isetyenziswe. Khusela ekukhanyeni. Susa kwibhokisi malunga nemizuzu engama-30 ngaphambi kokusetyenziswa.
• Emva kokuxuba: Emva kokuxuba iyeza, lingagcinwa kubushushu begumbi okanye efrijini kubushushu obuphakathi kwe-2 kunye ne-8 degrees Celsius . Nangona kunjalo, kufuneka lisetyenziswe kwiiyure ezi-4 emva kokuxuba .
• Amayeza aphelelwe lixesha: Lahla amayeza aphelelwe lixesha.

Cela icebiso kwiqela lakho lezonyango malunga nendlela yokulahla ngokukhuselekileyo amayeza angasetyenziswanga naphelelwe lixesha. I-Fosdenopterin, i-Nulibry, i-Molybdenum cofactor deficiency, i-MoCD, izifo zemfuza, izifo zabantwana, isitofu sokugonya, iziphumo ebezingalindelekanga, amayeza, iSri Lanka