Yintoni iGastrin? Ngaba iyayichaphazela ingxaki yesisu sakho?

Ngaba wakha wazibuza ukuba zingaphi izinto ezenzekayo emizimbeni yethu, ingakumbi emva kokutya? Sineqela leekhemikhali ezincinci emizimbeni yethu ezinceda konke oku kwenzeke. Sizibiza ezi hormones. Namhlanje siza kuthetha ngehomoni enye ekhethekileyo. Yiyo leyo i-gastrin. Le gastrin ibaluleke kakhulu ekusebenzeni kwenkqubo yethu yokugaya ukutya.

Yintoni kanye kanye eyenziwa yiGastrin?

Kulungile, masibone ukuba lo mhlobo ubizwa ngokuba yiGastrin wenza ntoni emizimbeni yethu. Inemisebenzi emininzi ephambili.

• Ukuveliswa kwe-asidi yesisu: Eyona nto ibalulekileyo kukuxelela isisu sakho ukuba sikhuphe i-asidi yesisu. Le asidi yesisu yinto esiyibiza ngokuba yi-hydrochloric acid. Ngaphandle koku, kunzima kakhulu ukugaya ukutya.
• Ukusebenza kwemisipha yesisu: I-Gastrin ikwanceda imisipha esesiswini sakho ukuba isebenze kakuhle, oko kuthetha ukuba ibangela ukuhamba kwesisu, okunceda ukuxuba nokuqhekeza ukutya.
• Hlaziya Udonga Lwesisu: Ulwelo oluthambileyo lwesisu sethu, i-mucosa, kufuneka luhlaziywe rhoqo. I-Gastrin nayo iyanceda koku.
• Ukukhuthaza inyongo kunye nepancreas: I-Gastrin, kunye nenye ihomoni ebizwa ngokuba yi-cholecystokinin, inceda inyongo kunye nepancreas yakho ukuba zinciphe kwaye zikhuphe iijusi zokugaya ukutya.

Yintoni umahluko phakathi kweGastrin kunye neGastric acid?

Ngaba oku kuvakala ngathi kuyadida? Ngamafutshane, kunje. I-Gastrin yi -hormone . Ifana neleta. Le leta ixelela isisu, "Kulungile, ngoku khupha i-asidi yesisu." Emva koko le asidi yesisu ivuselela i-enzyme yokugaya i-pepsin. Xa zidibene, ezi zimbini zenza ijusi yesisu esiswini sethu. Uyaqonda?

Iveliswa phi i-gastrin?

I-Gastrin iveliswa ikakhulu ngamalungu omzimba akwinkqubo yethu yokugaya ukutya. Le hormone ivela kuhlobo oluthile lweseli olubizwa ngokuba zii-G-cells. Unobumba u-"G" umele "i-gastrin."

Uninzi lwe-gastrin luvela esiswini sakho , ingakumbi inxalenye esezantsi yesisu sakho (siyibiza ngokuba yi-antrum). Ezi G-cells zifumaneka kwiindlala zesisu eludongeni lwesisu sakho. Ukongeza, enye i-gastrin iveliswa yi-duodenum, inxalenye yokuqala yamathumbu akho amancinci, kunye ne-pancreas.

Ziziphi izinto ezichaphazela ukukhululwa kwe-gastrin?

Kuyamangalisa indlela i-gastrin ekhutshwa ngayo xa ucinga ngokutya! Uyazi njani loo nto? Ingqondo yethu kunye nenkqubo yokugaya ukutya zihlala ziqhagamshelwe ngenethiwekhi ekhethekileyo yemithambo-luvo ebizwa ngokuba yi-vagal nerves. Ulwazi luhamba lubuya lubuye ngale mithambo-luvo.

Ngoko ke, xa ucinga ngokutya, imithambo-luvo yesitho sangasese somntu esebuchotsheni bakho ithumela umyalezo esiswini, isithi, "Kulungile, ukutya kuyeza, khupha i-gastrin uze ulungiselele ukugaywa." Emva koko, xa uqala ukutya, imithambo-luvo esesiswini sakho iyaqaphela ukuba ukutya kungene kwaye ikhuphe i-gastrin engaphezulu.

Ezinye izinto ezikhuthaza ukukhululwa kwe-gastrin:

• Ukwanda kwe-pH yesisu (oko kukuthi, xa i-acidity iyancipha).
• Iindonga zesisu ziyatsalwa xa ukutya kungena.
• Ukutya okuthile, ingakumbi okuneproteni, kungena esiswini.

I-Gastrin ibangela ukukhululwa kwe-asidi yesisu, evuselela i-pepsin. Xa zidibene, ezi zinto ziyaphula kwaye zigaye iiproteni esiswini. I-Gastrin ikwavuselela intshukumo yemisipha esiswini.

Ungayimisa njani i-gastrin?

Njengoko ukutya kuphuma esiswini sakho kuze kungene kwinxalenye yokuqala yamathumbu amancinci, i-duodenum, inqanaba elilandelayo lokugaya liqala. Kulapho ke ukukhululwa kwe-gastrin kuqala ukwehla. Njengoko ukutya kuphuma amanqanaba e-asidi esiswini kunye nesisu ayanda, i-gastrin iyancipha.

Xa ukutya kungena kwi-duodenum, i-gallbladder yakho kunye ne-pancreas zikhupha iijusi zazo zokugaya ukutya. Emva koko, inkqubo yethu yokugaya ukutya ikhupha enye i-hormone ebizwa ngokuba yi-somatostatin. Le somatostatin ivala ezinye ii-hormone (ezifana ne-gastrin). Kufana nokucima iswitshi.

Ungayijonga njani inqanaba le-gastrin?

Kukho uvavanyo lwegazi olukhethekileyo lokujonga amanqanaba e-gastrin yakho. Silubiza ngokuba luvavanyo lwe-gastrin. Umboneleli wezempilo, njengogqirha okanye umongikazi, uthatha isampuli encinci yegazi emthanjeni osengalweni yakho aze ayithumele kwilebhu ukuze ivavanywe.

Kutheni inqanaba lesisu sam libalulekile?

Oogqirha bajonga amanqanaba e-gastrin yakho ukuze babone ukuba aphezulu kakhulu na . Amanqanaba aphantsi e-gastrin anqabile, kodwa amanqanaba aphezulu e-gastrin anokubonisa izifo ezithile zesisu kunye neemeko ezithile.

Kuthetha ukuthini ukuba namanqanaba aphezulu e-gastrin (i-Hypergastrinemia)?

Xa amanqanaba e-gastrin ephezulu, siyibiza ngokuba yi-hypergastrinemia. Ngamanye amaxesha, i-hypergastrinemia ingathetha ukuba une-tumor evelisa i-gastrin emzimbeni wakho, ebizwa ngokuba yi-gastrinomas. Ezi zinokwenzeka kwi-pancreas okanye kwi-duodenum yakho.

Ngamanye amaxesha, i-hypergastrinemia ingathetha ukuba kukho into esiswini sakho ethintela ukuba singavelisi i-asidi yesisu. Xa i-asidi yesisu incipha, i-gastrin engaphezulu iyakhutshwa. Kwakhona, iimpawu eziyekisa ukuveliswa kwe-gastrin ziyaphazamiseka.

Kuthekani ukuba amanqanaba e-gastrin ayanda?

Ukuba amanqanaba akho e-gastrin aphezulu, ubungakanani be-asidi yesisu esiswini sakho nakwi-duodenum bunokuba phezulu kakhulu. I-asidi eninzi inokonakalisa ulwelo olukhuselayo lwesisu sakho kunye ne-duodenum, nto leyo ebangela izilonda, ezaziwa ngokuba sisifo sesilonda se-peptic.

Kwakhona, ukuba ne-asidi eninzi esiswini kunokubangela imeko ebizwa ngokuba yi-GERD (Gastroesophageal Reflux Disease), imeko ehlala ixesha elide apho i-asidi ingena emqaleni. Ukuba unesifo sesilonda se-peptic okanye i-GERD kwaye ayiphucuki ngamayeza, ugqirha wakho unokujonga amanqanaba akho esisu.

Ziziphi iimeko zonyango ezinokunxulunyaniswa namanqanaba aphezulu e-gastrin?

Ukuba une-gastrinomas, amanqanaba e-gastrin kunye ne-gastric acid anokuba phezulu. I-Gastrinomas luhlobo lwe-pancreatic neuroendocrine tumor (PET) ekhupha i-gastrin. Isenokuba ngumhlaza okanye ingabi ngumhlaza.

Iimeko ezibangela i-gastrinomas:

• Isifo sikaZollinger-Ellison.
• Uhlobo 1 lwe-neoplasia ye-endocrine ehlukahlukeneyo (MEN1).

Iimeko apho i-gastrin kunye ne-asidi yesisu ziphakanyisiwe ngaphandle kwe-gastrinomas:

• Ukungasebenzi kakuhle kwezintso okungapheliyo.
• Ukuvaleka kwesisu (GOO).

Ukuba imveliso ye-asidi yesisu sakho iphantsi, usenokuba namanqanaba aphezulu e-gastrin kodwa amanqanaba aphantsi e-asidi yesisu. Oku kusenokuba kungenxa ye-atrophic gastritis, imeko apho iiseli ezivelisa i-asidi yesisu zitshatyalaliswa khona.

Izizathu eziphambili ze-atrophic gastritis:

• Usulelo lwe-H. pylori.
• Izifo ezichaphazela umzimba ngokwawo (umz. i-atrophic gastritis).

Ezinye izizathu zokuncipha kwemveliso ye-asidi esiswini:

• Amayeza okuthintela i-asidi, anjenge-H2 blockers okanye i-proton pump inhibitors (PPIs).
• Ukususwa kweVagotomy (ukususwa ngotyando okanye ukunqunyulwa komthambo wevagal).

Ndingenza ntoni ukuba ndineempawu ze-gastrin ephezulu?

Ukuba uneempawu zesisu, ingakumbi ukuba zivela rhoqo okanye sele zikhona ixesha elide, kubalulekile ukubona ugqirha. Nazi ezinye iimpawu ezinokunxulunyaniswa nokunyuka kwesisu:

• Intlungu yesisu okanye ukuqaqamba kwesisu.
• Intlungu yesifuba engapheliyo kunye nokungagaywa kakuhle kokutya.
• Ukurhawuzelelwa yi-asidi okanye ukutya okunamathelayo emqaleni.
• Umphimbo obuhlungu ongapheliyo kunye nokurhawuzelela.
• Urhudo oluqhubekayo.
• Iingxaki zokugaya ukutya.

Ezi mpawu zinokubonisa ukuba unezinga eliphezulu le-asidi esiswini, okanye ukuba une-gastritis engapheliyo, isifo sesilonda se-peptic, okanye i-GERD. Oku kusenokunxulumana okanye kungabi njalo ne-gastrin. Nangona kunjalo, kubalulekile ukuxilonga nokunyanga ezi meko ngokuchanekileyo.

Khumbula, ukuba uneempawu ezinje, ungazami ukuzixilonga ngokukhangela ulwazi kwi-intanethi. Kungcono ukubona ugqirha uze ufumane ingcebiso.

Umyalezo Wokuya Ekhaya

Kulungile, makhe sijonge izinto ezilula ekufuneka sizikhumbule nge-gastrin esithethe ngayo.

• I-Gastrin yi -hormone ebalulekileyo kwinkqubo yethu yokugaya ukutya .
• Umsebenzi wayo ophambili kukuxelela isisu ukuba sikhuphe i-asidi yesisu .
• Ukuba i-asidi yesisu sakho iphezulu kakhulu okanye iphantsi kakhulu , isenokuba inxulumene ne-gastrin.
• Ukuba uneempawu zesisu, okanye iimeko ezingaphucukiyo ngonyango, ugqirha unokuvavanya amanqanaba akho e-gastrin.
• Amanqanaba aphezulu e-gastrin ngamanye amaxesha angaba luphawu lwengxaki yempilo, ngoko ke kubalulekile ukufuna iingcebiso zonyango ukuba uneempawu.

Ngoko ke, iGastrin yinto encinci kodwa enamandla esebenza buthule emizimbeni yethu. Ukukwazi oku kuya kuba yinto ebalulekileyo kakhulu kwimpilo yakho. Ukuba uneminye imibuzo, ungathandabuzi ukubuza ugqirha wakho.

Isisu , iihomoni, ukugaya ukutya, i-asidi yesisu, isilonda se-peptic, i-GERD, i-hypergastrinemia