Ukuba wena okanye umntu omaziyo ufunyaniswe enomhlaza webele, mhlawumbi ukhe weva igama elithi 'unyango lweehomoni'. Ukuva eli gama ngamanye amaxesha kunokukwenza woyike kwaye ube nomdla. Lithetha ukuthini ngokwenene? Ingaba liyingozi? Lisebenza njani? Masithethe ngako konke oku ngendlela elula neyobuhlobo namhlanje.
Yintoni le nyango yehomoni?
Ngamafutshane, unyango lwehomoni lunyango olusebenzayo kakhulu kwiintlobo ezithile zomhlaza webele. Nangona kunjalo, alunikwa kuzo zonke iintlobo zomhlaza webele. Lubaluleke kakhulu kwiintlobo zomhlaza ezine -hormone receptor-positive (HR+) .
Cinga ngayo, kukho iintlobo ezimbini zeehomoni eziveliswa ngokwendalo emizimbeni yethu ezibizwa ngokuba yi-Estrogen kunye neProgesterone. Ezinye iiseli zomhlaza webele zifana nesityalo esincinci. Njengokuba isityalo sifuna amanzi, ezi seli zomhlaza zifuna ezi homoni zimbini ukuze zikhule kwaye zisasazeke. Lo mhlaza siwubiza ngokuba yi-HR+. Xa sithetha nje, izigulane ezimbini kwezintathu ezinomhlaza webele zinolu hlobo lomhlaza.
Usenokuba ukhe wazibona izinto ezinje kwingxelo yakho yomhlaza:
- I-Estrogen receptor positive (ER+)
- I-Progesterone receptor positive (PR+)
Umhlaza unokuba ne-positive kwenye okanye zombini ezi zinto. I-ER+ lolona hlobo luqhelekileyo.
Ngoko ke into eyenziwa lolu nyango lweehomoni ilula kakhulu. Isebenza ngeendlela ezimbini eziphambili:
1. Ithintela iihomoni (i-estrogen kunye ne-progesterone) ezidingwa ziiseli zomhlaza. Kufana nokuvala umbhobho wamanzi obonelela ngesityalo.
2. Yehlisa amanqanaba e-estrogen emzimbeni. Oku kunciphisa iiseli zomhlaza "isondlo" ezisidingayo ukuze zikhule kwaye kuzithintele ekukhuleni.
Okubalulekileyo kukuba, unyango lweehomoni zomhlaza webele lwahlukile ngokupheleleyo kunyango lweehomoni kwiimpawu zokuya exesheni, olusebenza ngokunyusa amanqanaba eehomoni. Unyango lomhlaza lwenza okwahlukileyo koko.
Kutheni kunikwe olu nyango lwehomoni?
Iingcali zomhlaza zicebisa olu nyango kwiimeko ezahlukeneyo.
- Ukunciphisa umngcipheko womhlaza: Olu nyango lunikwa abantu abasengozini enkulu yokuba nomhlaza wamabele, umzekelo, abo bane-genetic mutations efana ne-'BRCA1' kunye ne-'BRCA2', ukuthintela ukuphuhliswa komhlaza.
- Kwimeko ye-DCIS: Lawula ukukhula komhlaza wamabele okwinqanaba lokuqala obizwa ngokuba yi-`Ductal Carcinoma In Situ (DCIS).`
- Ngaphambi kotyando (Unyango lweNeoadjuvant):Olu nyango lunikwa ngaphambi kotyando ukuze kuncitshiswe ithumba kwaye kube lula ukwenza utyando.
- Unyango oluNcedisayo: Olu lolona hlobo luqhelekileyo lonyango. Lunikwa emva kotyando ukususa umhlaza, ukuthintela umhlaza ukuba ungabuyi okanye ukuthintela umhlaza ukuba ungaphumi kwelinye ibele.
- Xa umhlaza usasazekile (Metastatic Breast Cancer): Ukuba umhlaza usasazeke kwezinye iindawo zomzimba, olu nyango lusetyenziselwa ukulawula ukukhula kwezo seli.
Ziziphi iintlobo eziphambili zonyango lwehomoni?
Kukho iintlobo ezahlukeneyo zonyango lweehomoni. Ugqirha wakho uya kugqiba ukuba loluphi unyango olukulungeleyo ngokusekelwe kwizinto ezifana neminyaka yakho, nokuba ukhe wadlula kwixesha lokuya exesheni, kunye nohlobo lomhlaza. Makhe sijonge iintlobo eziphambili.
| Uhlobo loNyango | Indlela esebenza ngayo kunye nemizekelo |
|---|---|
| Izithinteli zeAromatase | Ezi zinikwa ikakhulu abafazi abasele beyekile ukuya exesheni . Zithintela umzimba ekuveliseni i-estrogen. Imizekelo: iLetrozole, iAnastrozole, iExemestane. |
| Ii-SERM (ii-Selective Estrogen Receptor Modulators) | La mayeza athintela i-hormone ye-estrogen ekunamatheleni kwiiseli zomhlaza. Angasetyenziswa ngabasetyhini abangaphambi kokuya exesheni kunye nabasetyhini abasele beyekile ukuya exesheni . Eli liyeza elisetyenziswa kakhulu yiTamoxifen . |
| Ukucinezelwa komsebenzi we-ovarian | Ezi zinikwa abafazi abangekayi exesheni . Ziyekisa okwethutyana ukuveliswa kwe-estrogen kwii-ovari. Ezi zihlala zinikwa njengeenaliti. Imizekelo: iGoserelin, iLeuprolide. |
| Ii-SERD (ii-Selective Estrogen Receptor Downregulators) | Ezi zifana nee-SERM, kodwa zinamandla ngakumbi ekuvaleni nasekutshabalaliseni ii-receptor ze-estrogen. Umzekelo: I-Fulvestrant. |
Ungalufumana njani olu nyango?
Amaxesha amaninzi, olu nyango lunikwa njengepilisi oyithatha yonke imihla. Amanye amayeza ayafumaneka njengolwelo. Amanye, njengamayeza athintela ukusebenza kwamaqanda, anikwa njengenaliti kwiofisi kagqirha wakho kanye ngenyanga. Ngokuxhomekeke kwimeko yakho, olu nyango lunokufuneka luthathwe ixesha elide, njengeminyaka emi-5 okanye eli-10 .
Ngaba kukho naziphi na iziphumo ebezingalindelekanga kolu nyango?
Njengakwezinye iindlela zonyango, ezinye iziphumo ebezingalindelekanga zinokwenzeka kolu nyango. Nangona kunjalo , ayinguye wonke umntu ozifumanayo, kwaye ayinguye wonke umntu oziva ngendlela efanayo . Abanye abantu basenokungaziva ntlungu. Ezona ziphumo bezingalindelekanga zixhaphakileyo zezi:
- Ukuziva udiniwe kwaye udiniwe.
- Ubushushu obugqithisileyo.
- Intlungu okanye ukuqina kwamalungu kunye nemisipha.
- Ukuncipha komnqweno wesondo.
- Ukutshintshatshintsha kweemvakalelo rhoqo.
- Isicaphucaphu nokuhlanza.
- Ukoma kwesisu.
- Ukutyeba kwakho.
Ukuba ufumana naziphi na kwezi ntlungu, musa ukuba neentloni okanye ukoyika ukuthetha nogqirha wakho . Kukho iindlela kunye namayeza anokunceda ukulawula uninzi lwezi ziphumo ebezingalindelekanga. Ngoko ke musa ukubandezeleka wedwa.
Iingenelo kunye nempumelelo yonyango lwehomoni
Enye yezona nzuzo zinkulu zolu nyango kukuba lujolise kuhlobo oluqhelekileyo lomhlaza webele (ER+). Kwakhona, olu nyango lunokunikwa kunye nezinye iindlela zonyango ezifana ne-chemotherapy kunye nonyango olujoliswe kulo.
Uphando lubonise ngokucacileyo ukuba unyango lwe-hormone lunciphisa kakhulu umngcipheko wokuphinda umhlaza kwaye lwandisa ubomi bezigulane, nto leyo eyenza ukuba lube lolona khetho lonyango luphumelele kakhulu kwaye lubaluleke kakhulu.
Ngaba unyango lwe-chemotherapy okanye lwe-hormone lungcono?
Oku kufana nokubuza, "Yeyiphi engcono, i-screwdriver okanye ihamile?" Zizixhobo ezimbini ezahlukeneyo ezisetyenziselwa iinjongo ezahlukeneyo. I-Chemotherapy lunyango olunamandla olubulala iiseli ezahlulahlula ngokukhawuleza. Unyango lwe-hormone lunyango olujolise kuphela kwiiseli zomhlaza ezixhomekeke kwi-hormone. Ngamanye amaxesha unokufuna zombini, kwaye ngamanye amaxesha unokufuna enye kuphela. Ugqirha wakho uya kugqiba ukuba yeyiphi efanelekileyo kuwe.
Kuthekani ukuba andiyithandi le ndlela yonyango?
Lo ngumbuzo obaluleke kakhulu. Khumbula, iminqweno yakho kunye nezimvo zakho zibaluleke kakhulu xa kufikwa kunyango. Ugqirha wakho uza kukucebisa isicwangciso sonyango esisekelwe kuyo yonke into ukususela kuhlobo lomhlaza onalo, impilo yakho iyonke, indlela ophila ngayo, kunye nezinto ozithandayo.
Ukuba unengxaki yokoyika, ukuthandabuza, okanye into ongayithandiyo ngonyango lweehomoni, ungathandabuzi ukuthetha ngokukhululekileyo nogqirha wakho ngalo mba . Eyona nto ibalulekileyo kukuthetha ngeenzuzo kunye neengxaki zonyango, into omawuyenze ukuba kukho iziphumo ebezingalindelekanga, kunye nokuba kukho ezinye iindlela, kwaye wenze isigqibo esinolwazi esilungele wena.
Umyalezo Wokuya Ekhaya
- Unyango lwehomoni lunyango olusebenza kakhulu kumhlaza webele oxhomekeke kwihomoni (i-estrogen, i-progesterone).
- Oku kuthintela iiseli zomhlaza ekufumaneni iihomoni okanye kunciphisa amanqanaba ehomoni emzimbeni.
- Oku kungasetyenziswa ngaphambi okanye emva kotyando ukunciphisa umngcipheko womhlaza okanye ukulawula umhlaza osele usasazekile.
- Iziphumo ebezingalindelekanga zinokwenzeka, kodwa zinokulawulwa. Kubalulekile ukuthetha nogqirha wakho malunga nokungonwabi.
- Xoxani ngayo nayiphi na imibuzo okanye iinkxalabo eninazo malunga nonyango nogqirha wenu nize nenze isigqibo esifanelekileyo kunye.
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