Ingaba une-gastrin eninzi esiswini sakho? Masithethe nge-(Hypergastrinemia)!

Ngaba uhlala uziva ungakhululekanga esiswini, uzele, okanye ezinye iingxaki zokugaya ukutya? Ngamanye amaxesha isizathu soku kukuba inqanaba lehomoni ebizwa ngokuba yi-`(Gastrin)` eveliswa emzimbeni wakho liphezulu kunesiqhelo. Namhlanje, siza kuthetha ngale meko ebizwa ngokuba yi-`(Hypergastrinemia)` ngokweenkcukacha nangokulula.

Yintoni `(i-Hypergastrinemia)`? Masiqonde kakuhle!

Ngamafutshane, `(Hypergastrinemia)` ithetha ukuba inqanaba le `(Gastrin)`, ihomoni enceda umzimba wethu ukuba utye ukutya, liphezulu kunokuba kuyimfuneko. Le hormone `(Gastrin)` iveliswa luhlobo oluthile lweseli eludongeni lwesisu kwinxalenye esezantsi yesisu sethu, oko kukuthi, kufutshane namathumbu amancinci. Oku sikubiza ngokuba yi `(iiseli ze-G)`.

Ngoku khangela, le hormone `(Gastrin)` yiyo exelela isisu sethu ukuba, "Kulungile, ngoku khupha i-asidi." Le asidi yesisu, oko kukuthi `(i-asidi yesisu), ibaluleke kakhulu kuthi. Kuba, le asidi yesisu isinceda ekugayeni ukutya esikutyayo kwaye ifunxe izondlo ezikuloo kutya, umzekelo `(ii-amino acid)` kunye neeproteni.

Nangona kunjalo, into enokwenzeka nge-`(Hypergastrinemia)` inzima ngakumbi. Ngamanye amaxesha inokubangela i-asidi eninzi yesisu (`hyperchlorhydria`), kwaye ngamanye amaxesha inokubangela i-asidi encinci yesisu (`hypochlorhydria`). Ngoko ke indlela oku `(Hypergastrinemia)` ekuchaphazela ngayo ixhomekeke kwezinye iimeko zempilo oye wazifumana, utyando olwenzileyo, kunye namayeza owasebenzisayo.

Ngubani onokuba nethuba elikhulu lokufumana le meko?

Enyanisweni, le meko ibizwa ngokuba yi-"Hypergastrinemia" inokwenzeka nakubani na, nokuba uneminyaka okanye isini. Ngoko ke, kulungile ukuba sonke sikuqaphele oku.

Zithini izizathu ze-`(Hypergastrinemia)`?

Kunokubakho izizathu ezininzi ezibangela le meko, kuquka "i-Hypergastrinemia." Ezinye zibangela ukwehla kwemveliso ye-asidi esiswini, ngelixa ezinye zinyusa imveliso ye-asidi esiswini. Makhe sijonge zombini ngokwahlukeneyo.

Izizathu zokuncipha kwe-asidi yesisu

Xa kuthethwa nge-"Hypergastrinemia", ukuveliswa kwe-asidi yesisu okuqhelekileyo kunokuncipha ngenxa yezi zizathu zilandelayo:

• Ii-antacids ze-heartburn okanye i-GERD (Gastroesophageal Reflux Disease): Ukuba usebenzisa olu hlobo lwamayeza rhoqo , oko kungaba yimbangela.
• I-Chronic atrophic gastritis: Oku kuxa udonga lwesisu lusiba buthathaka kancinci kancinci luze luvuvuke ngokuhamba kwexesha.
• Umhlaza we-Coloral: Oku kunokuchaphazeleka nako.
• Usulelo lwe-`(H. pylori)`: `(Helicobacter pylori)` yintsholongwane enokuphila esiswini. Olu sulelo lukwangunobangela we-`(Hypergastrinemia).`
• Ukungasebenzi kakuhle kwezintso: Le meko inokwenzeka xa izintso zingasebenzi kakuhle.
• Ukusetyenziswa kweeProton Pump Inhibitors (PPIs):Ukusetyenziswa ixesha elide kwamayeza e-PPI (afana ne-omeprazole) kwi-gastritis, i-acid reflux, i-indigestion, okanye isifo sesilonda se-peptic nako kuyimbangela ephambili.
• Utyando lweVagotomy: Oku kuquka ukususa inxalenye yemithambo-luvo ye-vagus. Le mithambo-luvo isuka ebuchotsheni iye esiswini kwaye ithwala imiqondiso eya entliziyweni nakwinkqubo yokugaya ukutya. I-Hypergastrinemia inokwenzeka emva kolu tyando.

Izizathu zokwanda kwe-asidi yesisu

Ngoku makhe sijonge ukuba yintoni ebangela ukwanda kwemveliso ye-asidi esiswini (i-Hypergastrinemia):

• I-Antral G-cell hyperplasia (i-pseudo-Zollinger-Ellison syndrome / i-Ps-ZES): Le yimeko engaqhelekanga. Ifana ne-Zollinger-Ellison syndrome, kodwa akukho zithumba zivelisa i-gastrin kwi-pancreas okanye inxalenye yokuqala yamathumbu amancinci (i-duodenum).
• Ukuvaleka kokuphuma kwesisu: Le meko inokwenzeka xa indlela esuka esiswini eya emathunjini amancinci ivaliwe. Cinga ngayo njengombhobho wamanzi ovalekileyo.
• I-neoplasia ye-endocrine enininzi uhlobo-1 (MEN-1): Le meko ibangela ukuba kuvele iithumba ze-neuroendocrine kwi-adrenal glands, kwi-thyroid glands, okanye kwi-parathyroid glands.
• Isifo se-antrum esihlala sihleli: Le meko inokwenzeka ukuba iqhekeza elincinci lenxalenye esezantsi yesisu (i-antrum) lishiywe emva kotyando lokususa iithumba okanye ukunyanga izilonda.
• I-Zollinger-Ellison syndrome (ZES): Le yimeko apho iithumba zivelisa i-gastrin yehomoni ngokugqithisileyo. Le meko (ZES) inokubangela izilonda zesisu.

Zithini iimpawu zesifo `(Hypergastrinemia)`?

Ukuba une-`(Hypergastrinemia)`, unokufumana iimpawu ezifana nezi:

• Intlungu yesisu: Usenokuba neentlungu zesisu rhoqo.
• Urhudo olungapheliyo: Urhudo oluhlala iintsuku eziliqela.
• Iithumba zePancreatic: Ezi zinokuba ziithumba ezinomhlaza okanye ezingenabungozi.
• Izilonda zesisu: Izilonda ezenzeka xa isisu sidumbile.
• I-esophagitis eqatha: Ukudumba okukhulu kunye nentlungu emqaleni.

Oogqirha bayixilonga njani le meko?

Ukuze baxilonge ngokuchanekileyo i-hypergastrinemia, oogqirha kufuneka bamisele ukuba ingakanani na i-asidi eveliswa sisisu sakho. Bakwalinganisa nenqanaba le-gastrin egazini lakho.

• Ngaphambi kolu vavanyo, ugqirha wakho uza kukuxelela ukuba uzile ukutya (ungatyi) ixesha elithile .
• Kwakhona, ukuba ungumsebenzisi we-``(PPI)```,Kuya kufuneka uyeke ukuthatha loo mayeza malunga neveki ngaphambi kovavanyo.
• Emva koko, bathatha isampuli yegazi lakho baze bajonge amanqanaba eGastrin yakho. Ngamanye amaxesha, bangathatha ezi sampuli zegazi izihlandlo ezininzi ngemini, kangangeentsuku ezininzi, ukuze babone ukuba amanqanaba eGastrin yakho ayatshintsha na.

Ukuba ugqirha wakho ukrokrela ukuba une-hypergastrinemia, unokuyalela iimvavanyo ezongezelelweyo ukuze aqinisekise ukuba akukho zimo zimbi, kuquka:

• Uvavanyo lokukhuthaza i-Secretin: Oku kuquka ukunika i-hormone ebizwa ngokuba yi-secretin, eveliswa yinxalenye yokuqala yamathumbu akho amancinci (i-duodenum). Ukuba amanqanaba akho e-gastrin anyuka kakhulu ngequbuliso, oko kungaba luphawu lwe-Zollinger-Ellison syndrome.
• Uvavanyo lwe-pH yesisu: Oku kuhlola amanqanaba e-asidi esiswini sakho. I-pH engaphantsi kwe-2 ikwaluphawu lokuba usenokuba une-Zollinger-Ellison syndrome.

Iphathwa njani i-Hypergastrinemia?

Unyango lwe-hypergastrinemia luxhomekeke kwisizathu.

• Umhlaza wamathumbu amakhulu, ukuvaleka komqala, isifo sezintso, kunye neemeko ezifana ne-`(MEN-1)` kunye ne-`(ZES)`: Xa ezi meko zinyangwa (rhoqo ngotyando), iimpawu ze-`(Hypergastrinemia)` nazo ziyaphela.
• I-Atrophic gastritis (ACG) kunye nosulelo lwe-H. pylori: Ezi meko zinokunyangwa ngamayeza okubulala iintsholongwane.
• Izithinteli zeProton-pump (PPIs): Ukuba uthatha iPPI, i-hypergastrinemia idla ngokuphela kwiintsuku ezintlanu ukuya kwezisixhenxe emva kokuyeka amayeza.
• Isifo se-antrum esigciniweyo: Ukususa izicubu eziseleyo ze-antrum kwinxalenye esezantsi yesisu kunokunciphisa ubungakanani be-asidi engaphezulu yesisu eveliswayo.

Eyona nto ibalulekileyo kukuthetha nogqirha wakho malunga nonyango olufanelekileyo kwimeko yakho.

Ndingawunciphisa na umngcipheko we-`(Hypergastrinemia)`?

Ukuba usebenzisa ii-antacids okanye ii-PPI ixesha elide, kukho umngcipheko wokuba ne-hypergastrinemia. Ngoko ke, kubalulekile ukuthetha nogqirha wakho malunga nendlela yokulawula le ngozi.

Ukuba ndine-`(Hypergastrinemia)`, yintoni endinokuyilindela? Kwenzeka ntoni ukuba ayinyangwa?

Ukuba i-hypergastrinemia ayinyangwa ngokufanelekileyo, amanqanaba e-gastrin emzimbeni ahlala ephezulu. Abaphandi bacinga ukuba oku kunokubangela ukukhula kweeseli zomhlaza. Umzekelo:

• Umhlaza wegazi: njenge-leukemia, i-lymphoma, kunye ne-multiple myeloma.
• Umhlaza wesisu
• Umhlaza wePancreatic

Kwakhona, ixesha elide `(Hypergastrinemia)` inokukhokelela kwiithumba zesisu `(gastric carcinoids)` okanye `gastric adenocarcinoma`. Kukho iintlobo ezimbini `(gastric carcinoids)`:

• Ii-carcinoids zesisu zohlobo lwe-1: Ezi zinxulunyaniswa nesifo se-chronic atrophic gastritis.
• Ixhaphake kakhulu kubafazi.
• Ingabonakala kwiindawo ezahlukeneyo esiswini.
• Amathuba okuba nomhlaza aphantsi.
• Uhlobo lwesibini lwee-carcinoids zesisu: Ezi zinxulunyaniswa neemeko ze-ZES kunye ne-MEN-1.
• Inokwenzeka kumadoda nakubafazi.
• Ingabonakala kwiindawo ezahlukeneyo esiswini.
• Ngamanye amaxesha inokuguquka ibe ngumhlaza (phakathi kwe-7% kunye ne-12%).

Iyintoni imbono yomntu one-`(Hypergastrinemia)`?

Impilo yomntu one-"Hypergastrinemia" kwixesha elizayo ixhomekeke kwizinto ezininzi:

• Unobangela wesifo.
• Imfuza.
• Imbali yempilo.
• Indlela yokuphila.

Nangona kunjalo, ngonyango olufanelekileyo, abantu abane-"Hypergastrinemia" banokuphila ubomi obuqhelekileyo nobusebenzayo.

Ndine `(Hypergastrinemia)`, ndingazinyamekela njani?

Ukuba uthatha ii-antacids okanye ii-PPI ixesha elide, kubalulekile ukuba uhlolwe rhoqo ngugqirha. Nxibelelana nogqirha wakho ukuze akunike ingcebiso.

Ndifanele ndimbone nini ugqirha?

Ukuba ufumana naziphi na kwezi mpawu zintsha, okanye ukuba uziva ngathi iimpawu zakho ezikhoyo ziya zisiba mandundu, qiniseka ukuba ubona ugqirha kwaye ufumane uvavanyo olupheleleyo.

Izinto ekufuneka uzikhumbule ngokufutshane

Kulungile ke, masikhumbule nje into ebesithetha ngayo:

• I-Hypergastrinemia kukwanda kwe-gastrin yehomoni emzimbeni.
• Le hormone (iGastrin) ichaphazela amanqanaba e-asidi esiswini (i-asidi inokwanda okanye inciphe).
• Kunokubakho izizathu ezininzi – izinto ezifana `(PPI)`/ukusetyenziswa rhoqo kwee-antacids, usulelo lwe`(H. pylori)`, isifo se-gastritis, `(Zollinger-Ellison syndrome)`.
• Oogqirha baxilonga oku ngokuvavanya inqanaba le-``Gastrin''.
• Unyango lusekelwe kwisizathu esiyintloko.
• Musa ukuzityeshela iimpawu, kuba zinokukhula zibe ziithumba kunye nomhlaza ukuba azinyangwa! Funa ingcebiso kagqirha ngoko nangoko.

Ndiyathemba ukuba olu lwazi uza kulufumana luluncedo. Hlala usempilweni!

I- Hypergastrinemia, iGastrin, i-Stop Acid, ukugaywa kokutya, i-Zollinger-Ellison syndrome, i-H. pylori, i-PPI, iGastritis, ukudumba kwesisu