Ugqirha wakho usenokuba ukuxelele ukuba uqale ukuthatha iyeza elibizwa ngokuba yi-'Ibrutinib'. Kuqhelekile ukuba uzive usoyika kwaye udidekile xa usiva igama leyeza elinje. Kodwa ungakhathazeki, yinto abantu abaninzi abayifumanayo. Kweli nqaku, siza kuthetha ngokuba liyintoni eli yeza, yintoni eliyenzayo emzimbeni wakho, kunye nento ekufuneka uyilumkele xa ulisebenzisa, ngendlela onokuyiqonda ngokulula.
Kalula nje, yintoni i-Ibrutinib?
Eli liyeza elikhethekileyo elinikwa ukunyanga iintlobo ezithile zomhlaza. Ngokukodwa, lisetyenziselwa ikakhulu iimeko zomhlaza ezifana ne-leukemia kunye ne-lymphoma.
Cinga nje, iiseli zomhlaza luhlobo lweseli ezahlukana ngokukhawuleza kwaye zikhule ngaphandle kolawulo. Zineproteni ekhethekileyo ezinceda ukuba zikhule ngolo hlobo. Eli yeza elithi `Ibrutinib` lithintela umsebenzi waloo proteni. Emva koko amandla eeseli zomhlaza okukhula nokusasazeka ayancitshiswa okanye ayekiswe.
Ukongeza, eli yeza ngamanye amaxesha lisetyenziselwa ukunyanga ingxaki ebizwa ngokuba yi-"chronic graft versus host disease" eyenzeka emva kwento efana nokufakelwa umongo wethambo.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ngaphambi kokuba uqale eli yeza, ugqirha wakho kufuneka abe nomfanekiso opheleleyo wempilo yakho. Ngoko ke, ukuba unenye yezi meko zidweliswe ngezantsi, qiniseka ukuba uxelela ugqirha wakho ngayo.
| Ngaba unazo ezi meko? | Inkcazo |
|---|---|
| Izifo zokopha | Nokuba inxeba elincinci lithatha ixesha elide ukuyeka ukopha okanye ukuba kukho imivumbo kuphela. |
| Isifo seswekile | Ukuba unyangwa isifo seswekile. |
| Utyando | Ukuba usandul’ utyando okanye ucwangciselwe utyando kwixesha elizayo. |
| Isifo sentliziyo | Naluphi na uhlobo lwesifo sentliziyo, ukungasebenzi kakuhle kwentliziyo, ukuphazamiseka kwesingqisho sentliziyo. |
| Uxinzelelo lwegazi oluphezulu okanye i-cholesterol | Ukuba une-high blood pressure okanye i-cholesterol ephezulu. |
| Izifo zesibindi | Naluphi na uhlobo lwesifo sesibindi. |
| Ukuthatha amayeza okunciphisa igazi | Ukuba uthatha amayeza anjenge-`Warfarin` okanye i-`Aspirin` ukuthintela ukuqhekeka kwegazi. |
| Ukukhulelwa okanye ukuncancisa | Ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa. |
| Ezinye izinto ezibangela ukuba umntu angabi naso i-aleji | Ukuba une-aleji kwi-'Ibrutinib' okanye nakweyiphi na enye iyeza okanye ukutya. |
Ndingayisebenzisa njani kanye kanye le yeza?
- Sela eli yeza (ipilisi okanye ikhaphu) neglasi epheleleyo yamanzi.
- Zama ukuyithatha ngexesha elifanayo yonke imihla. Ngale ndlela, awuyi kuyilibala kwaye iyeza liya kusebenza ngcono.
- Oku kubaluleke kakhulu: Musa ukulisika, ukulityumza, okanye ukulihlafuna iyeza. Ginya ithebhulethi/ikhaphu yonke. Ukwenza njalo kunokuchaphazela indlela elisebenza ngayo iyeza.
- Ukuba ufumana iziphumo ebezingalindelekanga, ugqirha wakho unokutshintsha umthamo wamayeza akho okanye akuxelele ukuba uyeke ukuwasebenzisa okwethutyana. Ungaze uyeke ukuthatha amayeza akho okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
Kubaluleke kakhulu: Musa ukusela ijusi yegrapefruit okanye utye iiorenji zaseSeville ngelixa usebenzisa eli yeza. Ezi zinokuphazamisa ukusebenza kakuhle kweli yeza.
Ungenza ntoni ukuba uthatha amayeza amaninzi kakhulu?
Ukuba ukrokrela ukuba uthathe ngaphezu komlinganiselo omiselweyo wale mayeza, musa ukuchitha ixesha kwaye ngoko nangoko yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele esikufutshane. Okanye utsalele umnxeba iZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo ukuze ufumane ingcebiso.
Kuthekani ukuba ndiphoswa lidosi leyeza?
Ukuba ulibele ukuthatha idosi, yithathe kwangoko xa ukhumbula. Nangona kunjalo, ukuba sele kusondele ixesha lokuthatha idosi yakho elandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo.
Ungaze uthathe amayeza amabini ngaxeshanye ukuze ubuyisele umthamo ongawusebenzisanga.
Ezinye izinto ezinokusebenzisana nale mithi
Amanye amayeza owasebenzisayo anokusebenzisana ne-Ibrutinib. Ngoko ke, kubaluleke kakhulu ukwazisa ugqirha wakho ngawo onke amayeza owasebenzisayo.
| Udidi lwezonyango/lokutya | Eminye imizekelo |
|---|---|
| Amanye amayeza okubulala iintsholongwane | `i-clarithromycin`, `i-erythromycin`, `i-rifampin` |
| Amanye amayeza okubulala iintsholongwane anikwa i-HIV okanye i-Hepatitis | Buza ugqirha. |
| Amayeza osulelo lwefungus | `ketoconazole`, `itraconazole`, `voriconazole` |
| Amayeza okuxhuzula/ ukuxhuzula | `carbamazepine`, `phenobarbital`, `phenytoin` |
| Amanye amayeza omhlaza | `apalutamide`, `enzalutamide`, `methotrexate` |
| Iimveliso zezityalo | I-St. John's Wort |
Olu luhlu aluphelelanga. Kubalulekile ukuxelela ugqirha wakho malunga nayo yonke imithi, iivithamini, kunye namayeza esintu owasebenzisayo ukuze ukhuseleke.
Izinto ekufuneka uzilumkele ngakumbi xa usebenzisa amayeza
- Ukuhlolwa rhoqo ngugqirha: Ugqirha wakho uya kukucela rhoqo ukuba wenze uvavanyo lwegazi. Kufuneka bajonge ukuba amayeza ayasebenza na kwaye kukho naziphi na iziphumo ebezingalindelekanga. Ngoko ke musa ukulibaleka olu vavanyo.
- Umngcipheko wokopha: Eli yeza linokukwenza ube nemivumbo lula okanye libangele ukopha okungakumbi nokuba kukusikeka okuncinci. Xelela ugqirha wakho ngoko nangoko ukuba ubona ukopha okungaqhelekanga (umz., igazi elisendle sakho, igazi ekuhlanzeni kwakho, okanye amabala amancinci abomvu/amfusa kulusu lwakho ).
- Umngcipheko wokosuleleka: Eli yeza lisenokunciphisa kancinci amasosha omzimba wakho. Ke ngoko, umngcipheko wokufumana usulelo uphezulu. Ukuba ufumana iimpawu ezinje ngomkhuhlane, iintlungu zomzimba, kunye nomphimbo obuhlungu, musa ukuzinyanga kwaye utsalele umnxeba ugqirha wakho. Nciphisa ukutyelela kwakho kwiindawo apho abantu bagula khona.
- Ukukhulelwa nokuncancisa: Oku kubaluleke kakhulu. Kuphephe ukukhulelwa ngelixa usela eli yeza kwaye inyanga emva kokuyeka iyeza. Eli yeza linokulimaza kakhulu usana olungekazalwa. Kwakhona, kuphephe ukuncancisa ngelixa usela eli yeza kwaye iveki emva kokuyeka iyeza.
Lumka ngokukodwa impilo yamazinyo akho.
Ukuba uza kutyandwa okanye wenze umsebenzi wamazinyo, xelela ugqirha ukuba usela eli yeza. Akucetyiswa ukuba wenze utyando olukhulu lwamazinyo ngelixa usebenzisa eli yeza. Kungoko ke, kungcono ukubona ugqirha wamazinyo ukuze asombulule naziphi na iingxaki zamazinyo ngaphambi kokuba uqale eli yeza.
Zithini iziphumo ebezingalindelekanga ezinokubakho?
Njengayo nayiphi na iyeza, i-Ibrutinib inokubangela iziphumo ebezingalindelekanga. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Ezinye ziyingozi kwaye kufuneka zixelwe ngoko nangoko. Ezinye ziqhelekile kwaye ziyanyamalala emva kweentsuku ezimbalwa.
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha wakho ngoko nangoko | |
|---|---|
| Imiphumela | Iimpawu ezibonisa |
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi. |
| Ukopha okungaqhelekanga | Indle emnyama okanye enegazi, ukuhlanza okufana nekofu egayiweyo, umchamo omdaka/obomvu. |
| Ukumelwa yintliziyo | Ubunzima bokuphefumla, ukudumba kwamaqatha neenyawo, ukunyuka kobunzima ngequbuliso, ukudinwa kakhulu. |
| Utshintsho kwisantya sentliziyo | Ukubetha kwentliziyo, isiyezi, iintlungu zesifuba. |
| Umonakalo wesibindi | Intlungu kwicala eliphezulu lasekunene lesisu, ukungabi namdla wokutya, ukutyheli kwamehlo/ulusu, umchamo omnyama. |
| Isifo seTumor Lysis (TLS) | Imeko ebangelwa kukwahlukana ngokukhawuleza kweeseli zomhlaza. Ukugabha, urhudo, ukuxhuzula kwemisipha, utshintsho kwisantya sentliziyo. |
| Izinto eziqhele ukungabi yingozi, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
|---|---|
| Imiphumela | Inkcazo |
| Intlungu yethambo, amalungu, okanye imisipha | Iintlungu zomzimba, iintlungu zamalungu. |
| Urhudo | Ukuqunjelwa. |
| Isicaphucaphu | Ukuziva ngathi uhlanza. |
| Izilonda zomlomo | Intlungu, ububomvu, okanye izilonda emlonyeni okanye emqaleni. |
Ukuba ubona nantoni na engaqhelekanga engekho kolu luhlu, ungoyiki ukuthetha nogqirha wakho ngayo.
Umyalezo Wokuya Ekhaya
- I-Ibrutinib lunyango olujoliswe kulo oluthintela ukukhula kweeseli zomhlaza ezifana ne-leukemia kunye ne-lymphoma.
- Ngaphambi kokuba uqale amayeza, xelela ugqirha wakho ngazo zonke ezinye izifo onazo kunye nawo onke amayeza owasebenzisayo.
- Sela idosi emiselweyo kanye njengoko ugqirha ekuxelela, ngexesha elimiselweyo. Musa ukuphula, ukutyumza, okanye ukuhlafuna iyeza.
- Musa ukusebenzisa ijusi yegrapefruit kunye neeorenji zaseSeville ngokupheleleyo xa usebenzisa eli yeza.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga eziyingozi ezifana nokopha okungaqhelekanga, umkhuhlane, okanye ubunzima bokuphefumla, funa ingcebiso kagqirha ngokukhawuleza.
- Ngokuqinisekileyo kufuneka ukuphephe ukukhulelwa nokuncancisa xa usebenzisa eli yeza kwaye ixesha elithile elimiselweyo.
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