Ukuba wena okanye umntu omthandayo une-Cystic Fibrosis (CF), mhlawumbi uyazi kakuhle imingeni yokuphila nayo. Kodwa iindaba ezimnandi zezokuba ngenxa yokuqhubela phambili kwesayensi yezonyango, ngoku kukho amayeza amatsha anokukunceda ujongane nale meko. Namhlanje, siza kuthetha ngelinye lamayeza anjalo. Libizwa ngokuba yi-Ivacaftor. Usenokuba ulazi ngegama elithi Kalydeco. Makhe sijonge eli yeza ngokukhawuleza.
Kwenzeka ntoni ngokwenene ngale mithi?
Ngamafutshane, i-Ivacaftor liyeza elisetyenziselwa ukunyanga i-Cystic Fibrosis (CF) . Nangona kunjalo, alifanelekanga kubo bonke abaguli abane-CF. Eli yeza lisebenza kuphela kubantu abaneenguqu ezithile kwizakhi zofuzo ezibangela i-CF. Ugqirha wakho uza kwenza uvavanyo olufunekayo ukuze abone ukuba eli yeza lifanelekile na kuwe.
I-Cystic Fibrosis sisifo semfuza esiphazamisa ukusebenza kweproteni emzimbeni wethu. Oku kubangela ukuba iincindi eziqinileyo nezinamathelayo ziqokelele kwizitho ezifana nemiphunga kunye nepancreas, nto leyo ebangela iingxaki ezahlukeneyo. Eli yeza i-Ivacaftor lisebenza ngokubuyisela ukusebenza kweproteni engasebenzi kakuhle kwinqanaba elithile, linciphise iincindi kwaye livumele ukuba zisuswe ngokulula emzimbeni.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ngaphambi kokuba usebenzise eli yeza, kubaluleke kakhulu ukunika ugqirha wakho umfanekiso ocacileyo wempilo yakho iyonke. Qiniseka ukuba ubaxelela ngezi zinto ngokukodwa:
- Isifo sesibindi: Kubalulekile ukuxelela ugqirha wakho ukuba unesifo sesibindi. Oku kungenxa yokuba eli yeza lisetyenziswa kakhulu sisibindi. Ukuba unengxaki yesibindi, ugqirha wakho unokufuna ukulungisa umthamo wakho.
- Isifo sezintso: Ngokufanayo, ukuba unengxaki yezintso, sixelele ngaloo nto.
- Ii-Allergy: Xelela ugqirha wakho ukuba une-allergies kwi-Ivacaftor okanye naliphi na elinye iyeza, ukutya, okanye idayi.
- Ukukhulelwa okanye uceba ukuba nomntwana: Ukuba ukhulelwe okanye uzama ukukhulelwa, xelela ugqirha wakho.
- Ukuba ungumama oncancisayo: Qiniseka ukuba uyayikhankanya le nto ukuba uncancisa.
Kukhuselekile kuwe ukuxelela ugqirha ngaphandle kokufihla olu lwazi. Ngoko ke ungalibali ukumxelela nokuba yinto encinci.
Ndingayisebenzisa njani kanye kanye le yeza?
Ukuze ufumane unyango olungcono kakhulu, kubaluleke kakhulu ukulusebenzisa ngokuchanekileyo.
Indlela yokusela iyeza
Eli yezaNgokuqinisekileyo kufuneka ithathwe kunye nokutya okunamafutha. Umzekelo, ukuba uthatha le pilisi kunye nento efana neqanda, itshizi ethosiweyo, isilayi sesonka esinebhotolo yamandongomane, okanye i-omelet eyenziwe ngebhotolo, iyeza liya kufunxwa ngcono ngumzimba. Musa ukulithatha ungatyanga.
Okubaluleke kakhulu: Musa ukulisebenzisa eli yeza kunye nejusi yegrapefruit nangasiphi na isizathu. Iiorenji zaseSeville nazo azilunganga. Ezi zinokuchaphazela ukusebenza kakuhle kweyeza.
Thatha kuphela idosi emiselweyo, xa unikwe ngugqirha wakho. Kuphephe ukuthatha ngaphezulu. Musa ukuyeka ukuthatha amayeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho.
Ukuba uyinika abantwana
Eli yeza ngamanye amaxesha linikwa abantwana abangaphezu kweminyaka emi-6 ubudala. Nangona kunjalo, thetha nogqirha wabantwana ngalo mba ngononophelo kwaye ulandele imiyalelo yakhe.
Ukuba umthamo weyeza unyusiwe (i-Overdose)
Ukuba ucinga ukuba uthathe amayeza amaninzi kakhulu, yiya kwiYunithi yoNyango oluNgxamisekileyo (ETU) ekufutshane nawe ngoko nangoko . Okanye utsalele umnxeba iZiko loLwazi lweeTyhefu leSizwe kwiSibhedlele sikaZwelonke saseColombo ukuze ufumane ingcebiso.
Ukuba uphoswe yidosi yamayeza
Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba kungaphantsi kweeyure ezi-6 ngaphambi kokuba idosi yakho elandelayo ifike, yitsibe idosi oyiphosileyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe idosi ephindwe kabini.
Amanye amayeza anokusebenzisana ne-Ivacaftor
Kubaluleke kakhulu ukuxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo, kuquka iivithamini kunye neemveliso zezityalo. Amanye amayeza anokusebenzisana ne-Ivacaftor. Jonga le theyibhile.
| Uhlobo lweyeza/into | Inqanaba lenkxalabo |
|---|---|
| Amanye amayeza asetyenziselwa ukuxhuzula (umz. i-carbamazepine, i-phenobarbital, i-phenytoin) | Inciphisa ukusebenza kwe-Ivacaftor. |
| Ijusi yegrapefruit kunye neeorenji zaseSeville | Akunyanzelekanga ukuba kunyuswe uxinzelelo lweziyobisi. |
| I-Rifampin, i-Rifabutin (amayeza esifo sephepha) | Inciphisa kakhulu ukusebenza kwe-Ivacaftor. |
| I-St. John's Wort (imveliso yezityalo) | Inciphisa ukusebenza kwe-Ivacaftor. |
| Ii-Antifungal (umz. i-ketoconazole, i-itraconazole, i-fluconazole) | Amanqanaba e-Ivacaftor anokunyuka. |
| Amanye amayeza okubulala iintsholongwane (umz. i-clarithromycin, i-erythromycin) | Amanqanaba e-Ivacaftor anokunyuka. |
| I-Cyclosporine, iTacrolimus, iDigoxin | I-Ivacaftor inokuchaphazela ukusebenza kakuhle kwala mayeza. |
Olu luhlu aluphelelanga, ngoko ke kungcono ukuxelela ugqirha wakho ngayo yonke into oyithathayo.
Iziphumo ebezingalindelekanga ezinokubakho zokuthatha iyeza
Njengalo naliphi na iyeza, i-Ivacaftor inokubangela iziphumo ebezingalindelekanga kwabanye abantu. Ezinye zezi zimbi kakhulu, ngelixa ezinye zincinci.
| Ukuba ufumana ezi mpawu, xelela ugqirha wakho ngoko nangoko. | |
|---|---|
| Iimpawu ze-aleji | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi. |
| Iziphumo kwisibindi | Umchamo omnyama, indle ekhanyayo, ukutyheli kwamehlo okanye ulusu, iintlungu kwinxalenye ephezulu ngasekunene yesisu, ukungabi namdla wokutya. |
| Utshintsho lombono | Umbono ofipheleyo okanye naluphi na olunye utshintsho. |
| Okunye | Ndiziva ndidiniwe kakhulu, ndiziva ngathi ndinomkhuhlane. |
| Ezi zihlandlo azibalulekanga kangako, kodwa ukuba ziyaqhubeka, xelela ugqirha wakho. | |
| Inkqubo yokugaya ukutya | Ukungagayi kakuhle ukutya, isicaphucaphu, urhudo. |
| Okunye | Intloko ebuhlungu , isiyezi , iintlungu zamalungu. |
Ngelixa usela eli yeza, ugqirha wakho unokufuna ukujonga amehlo akho kunye namanqanaba ee-enzymes zesibindi egazini lakho rhoqo. Oku kuqhelekile.
Ungayigcina njani imithi ikhuselekile?
- Gcina kude nabantwana.
- Gcina kubushushu begumbi (phakathi kwe-15-30 degrees Celsius).
- Lahla amayeza aphelelwe lixesha ngaphandle kokuwasebenzisa.
Eli yeza limiselwe wena wedwa. Musa ukwabelana ngalo nabanye abantu nangasiphi na isizathu.
Umyalezo Wokuya Ekhaya
- Ivacaftor liyeza elikhethekileyo elinikwa ukunyanga iintlobo ezithile ze-cystic fibrosis.
- Eli yeza lifanele lisetyenziswe rhoqo kunye nokutya okunamafutha.Yithathe. Ungaze uyithathe nejusi yeediliya.
- Xelela ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo kunye nazo zonke ezinye izifo zakho.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga, ezinje ngokutyheli kwamehlo, umchamo omnyama, okanye amaqhakuva eluswini, xelela ugqirha wakho ngoko nangoko.
- Eli yeza lelakho kuphela. Musa ukulinika omnye umntu. Ukuba unemibuzo, thetha nogqirha wakho rhoqo.
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