Isisombululo esitsha seentlungu zomqolo ezibangelwa yi-Ankylosing Spondylitis (AS): Yonke into malunga ne-JAK Inhibitors

Ngaba uqala usuku lwakho ngomqolo oqinileyo kunye nentlungu kwangoko nje ukuvuka kusasa? Ngaba le ntlungu iyancipha xa uhamba kancinci, wenze into eluncedo, kwaye iyanda kwakhona xa uhleli? Ezi zinokuba ziimpawu eziqhelekileyo zesifo esibizwa ngokuba yi-Ankylosing Spondylitis (AS). Le yimeko ecaphukisayo kakhulu ephazamisa ubomi bemihla ngemihla. Njengonyango loku, oogqirha baqala ngokukunika ii-painkillers (NSAIDs). Ukuba ezi azilawuli isifo, banokukuthumela kwiinaliti ezibizwa ngokuba yi-biologics. Nangona kunjalo, abanye abantu abafumani kuphumla kwezi ndlela zonyango, okanye iziphumo zazo ezingalindelekanga kunzima ukuzinyamezela. Ngaba ufumana into efanayo? Ukuba kunjalo, ungakhathazeki. Ngokuhambela phambili kwesayensi yezonyango, olunye unyango olutsha noluphumeleleyo ngoku luye lwavela. Loo nto yi -Janus Kinase (JAK) inhibitors . Makhe sithethe ngale nto namhlanje.

Zithini iiJAK Inhibitors?

Ii-JAK inhibitors ziluhlobo olutsha lwamayeza okunyanga i-ankylosing spondylitis. Njenge-biologics, zikwiqela lamayeza abizwa ngokuba yi-disease-modifying antirheumatic drugs (DMARDs). "Disease-modifying" ithetha ukuba la mayeza awanciphisi nje iintlungu. Akwalawula umonakalo kumqolo nakwamanye amalungu, nto leyo enciphisa ukuqhubela phambili kwesifo.

Kodwa ezi azisetyenziswa kuphela kwi-Ankylosing Spondylitis. Olu hlobo lwamayeza lukwavunyiwe nakwezinye izifo ezininzi ezizikhuselayo emzimbeni. Oko kukuthi, izifo apho inkqubo yomzimba yokuzikhusela ihlasela iiseli zayo.

• Irheumatoid arthritis
• Ikhosi yePolyarticular yesifo samathambo solutsha idiopathic (JIA)
• Isifo samathambo se-Psoriatic
• I-ulcerative colitis

Eyona nto ikhethekileyo kukuba ungazithatha ezi pilisi endaweni yokuba ufumane inaliti efana ne-biologics. Ngoko ke oku kuyanceda kakhulu kwabo bayoyikayo inaliti.

Ziziphi iintlobo ezisetyenziselwa i-Ankylosing Spondylitis?

Okwangoku, iintlobo ezimbini ze-JAK inhibitors zivunyiwe kunyango lwe-Ankylosing Spondylitis.

• I-Tofacitinib (igama lophawu: Xeljanz, Xeljanz-XR)
• I-Upadacitinib (igama lophawu: Rinvoq)

Ezi zihlala zinikwa izigulana ezingakhange zilawulwe ziimpawu zazo ngeyeza elinye okanye ngaphezulu lebhayoloji elibizwa ngokuba yi-TNF inhibitors, okanye ezingakwaziyo ukunyamezela iziphumo ebezingalindelekanga zaloo mayeza. Ke ngoko, ugqirha wakho uza kujonga ngononophelo imbali yakho epheleleyo yezonyango ngaphambi kokuba akunike eli yeza.

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Lisebenza njani eli yeza?

Ukuze siqonde oku, masithathe umzekelo omncinci. Khawucinge ukuba inkqubo yomzimba wethu yokuzikhusela ngumkhosi omkhulu. Kwisifo esifana ne-Ankylosing Spondylitis, lo mkhosi ufumana umyalezo ongafanelekanga uze uqalise ukuhlasela amalungu elizwe lawo (emizimba yethu). Olu hlaselo lubangela intlungu kunye nokudumba (ukudumba).

Kukho "abathunywa" abathile abathumela le miyalezo ingalunganga. Babizwa ngokuba zii-enzymes ze-JAK . Ezi enzymes zezo zixelela iiseli zomzimba ukuba "ziye kuhlasela," iikhemikhali ezibizwa ngokuba zii-cytokines.

Oko kwenziwa ngamayeza abizwa ngokuba zi-JAK inhibitors kukuthintela ezo zithunywa (ii-enzymes ze-JAK). Oku kuyayekisa ukuhamba kwaloo miyalezo ingalunganga kwaye kunciphisa amandla omzimba okuhlasela amalungu.

Amayeza e-biologic asebenza ngendlela eyahlukileyo kancinci. Amayeza e-biologic ajolise kwaye athintele i-cytokine ethile, efana ne-TNF okanye i-IL-17. Ii-JAK inhibitors zithintela ukuveliswa kwee-cytokines ezininzi ngaxeshanye. Ngamafutshane, zithintela ingxaki kwasekuqaleni.

Ngaba kukho naziphi na iziphumo ebezingalindelekanga?

Njengakweminye imithi, kukho ithuba lokuba nemiphumo emibi. Kodwa kubantu abaninzi, ikhuselekile. Ugqirha wakho uza kukujonga kakuhle ngaphambi kokuba uqale ukuyisebenzisa le mithi kwaye ngelixa uyithatha.

Okungakumbi malunga nemiphumo emibi kakhulu

Ngenxa yokuba la mayeza ecinezela inkqubo yomzimba yokuzikhusela, amandla omzimba okulwa neentsholongwane ezifana neebhaktheriya kunye neentsholongwane ayancipha kancinci. Oku kwandisa umngcipheko wosulelo.

Uvavanyo lweSifo sePhepha (TB): Ngaphambi kokuba uqale eli yeza, ugqirha wakho ngokuqinisekileyo uza kukuvavanya isifo sePhepha. Abanye abantu banokuba neentsholongwane zeTB ezifihlakeleyo emizimbeni yabo. Xa usebenzisa i-JAK inhibitor, le ntsholongwane ingasebenziyo inokuba namandla. Ke ngoko, ugqirha wakho uza kukujonga oku ngexesha lonyango.

Kubalulekile: Ngelixa usebenzisa eli yeza, kufuneka uphephe ukufumana imijovo ephilayo. Imizekelo ibandakanya imasisi, i-mumps, i-rubella (MMR), kunye ne-rotavirus. Ezi mijovo zinokukwenza ugule kuba inkqubo yakho yokuzikhusela yomzimba iba buthathaka ngelo xesha. Qiniseka ukuba uthetha nogqirha wakho ngaphambi kokuba ufumane naluphi na ugonyo.

Yintoni endimele ndiyilindele xa ndiqala amayeza?

Abanye abantu baqala ukuziva bekhululekile kwiimpawu zabo kwiiveki nje ezimbini emva kokuqalisa eli yeza. Nangona kunjalo, kungathatha ukuya kuthi ga kwiinyanga ezi-6 ukuba abanye abantu bazive bekhululekile ngokupheleleyo. Oku kuyahluka kumntu nomntu.

Ukuba awuziva bhetele emva kokuthatha amayeza kangangeenyanga ezimbalwa, ungoyiki, thetha nogqirha wakho ngaloo nto uze ufumane ingcebiso malunga nento omawuyenze ngokulandelayo.