Nabani na angakoyika kakhulu ukuba ubona igazi kwindle yakhe, ingakumbi kumntwana omncinci. Okanye ukhathazekile ngezinto ezifana neentlungu zesisu ezingapheliyo, ukudumba, kunye nokuziva udiniwe? Ezi ngamanye amaxesha zinokuba ziimpawu zesifo semfuza esiza kuthetha ngaso esibizwa ngokuba yiJuvenile Polyposis Syndrome (JPS). Musa ukoyika nangona igama livakala linzima kancinci. Nangona esi sisifo singaqhelekanga, kubalulekile ukuba usiqaphele. Masithethe ngaso ngendlela elula onokuyiqonda.
Ngamafutshane, yintoni iJuvenile Polyposis Syndrome (JPS)?
Ngamafutshane, i-JPS yimeko yemfuza ebangela ukukhula okuncinci okubizwa ngokuba zii-polyps ukuba kwakheke eludongeni lwenkqubo yethu yokugaya ukutya (indlela yesisu (i-GI) . Ezi zifana nembewu encinci exhonywe kwisiqu esincinci.
Ezi polyps zinokukhula naphi na kwinkqubo yokugaya ukutya, kodwa zifumaneka kakhulu kwi:
- Ikholoni
- Ingxolo
Ukongeza, ngamanye amaxesha zinokukhula esiswini nasemathunjini amancinci. Umntu one-JPS unokuba nee-polyps ezininzi, ngamanye amaxesha ezingaphezulu kwekhulu.
Xa sisithi "abaselula," ngaba oku kuthetha ukuba esi sisifo esichaphazela abantwana abancinci kuphela?
Lo ngumbuzo abantu abaninzi abawucingayo. Xa sisiva igama elithi "ubutsha," sicinga ngabantwana abancinci kunye nabantu abadala abancinci. Nangona kunjalo, eli gama alisetyenziswa apha ukubhekisa kubudala besigulana. Eli gama linikwa ngokusekelwe kwindlela ezi polyps ezibonakala ngayo phantsi kwe-microscope (uhlobo lweeseli zazo).
Nangona kunjalo, eyona nto ibalulekileyo kukuba iimpawu ze-JPS zihlala ziqala ukubonakala ngaphambi kweminyaka engama-20 , oko kukuthi, ngexesha lobuntwana okanye lokufikisa. Ngoko ke, umntu unokucinga ukuba eli gama lifanelekile ngandlela ithile.
Ngaba kukho iintlobo eziphambili zeJPS?
Ewe, i-JPS inokwahlulwa ibe ziintlobo ezintathu eziphambili. Uhlobo ngalunye lwahlukile kancinci kolunye. Masibone ukuba zeziphi.
| Uhlobo lweJPS | Inkcazo |
|---|---|
| Ulutsha olunepolyposis yobuntwana (JPI) | Olu lolona hlobo lunzima nolunzima kwiintlobo zeJPS.Uhlobo. Oku kuchaphazela iintsana ezincinci kunye nabantwana abancinci. |
| Iipolyposis zolutsha eziqhelekileyo | Olu lolona hlobo luqhelekileyo lwe-JPS. Kolu hlobo, ii-polyps zinokukhula naphi na kwinkqubo yokugaya ukutya (isisu, amathumbu amancinci, amathumbu amakhulu). |
| I-polyposis coli yabantwana abancinci | Kolu hlobo, iipolyps zenzeka kuphela kwikholoni . |
Ingaba esi sifo sizuzwe njengelifa?
Ewe, i-JPS sisifo esidluliselwa kwilifa. Sidluliselwa ngendlela elawulayo ye-autosomal . Ngoku usenokuba uyazibuza ukuba le autosomal dominant ithetha ukuthini.
Ngamafutshane, oku kuthetha ukuba nokuba umntwana uzuze i-gene ebangela esi sifo kumzali omnye kuphela , nokuba ngumama okanye ngutata, kwanele ukuba umntwana abe nale meko.
Malunga nama -75% ezigulane ze-JPS ziyizuza njengelifa kubazali bazo ngale ndlela. Kodwa malunga nama -25% eemeko, ibangelwa lutshintsho olutsha lwemfuza olungazange lubekho kusapho ngaphambili. Oku kuthetha ukuba umntu angayihlakulela nokuba akukho mntu kusapho onalo.
Zithini iimpawu ze-JPS?
Uphawu oluphambili lwe-JPS zii-polyps esithethe ngazo ngaphambili. Ezi zikhula ngaphakathi emzimbeni, ngoko ke asinakuzibona ngaphandle. Nangona kunjalo, kunqabile kakhulu, ezinye ii-polyps zinokubonakala ngaphandle kwe-rectum.
Ixesha elininzi, iimpawu ziyavela xa iipolyps zikhula ngobukhulu okanye ngenani. Ziipolyps esimele sizixhalabele.
| Iimpawu ezibangelwa ziipolyps |
|---|
| 🩸 Igazi elikwindle okanye ukopha emqolo: Olu lolona phawu luqhelekileyo nolokuqala. |
| 😩 Ukuziva ubuthathaka kwaye udiniwe (i-anemia): Le meko inokwenzeka ngenxa yokuncipha komthamo wegazi emzimbeni ngenxa yokopha okuqhubekayo. |
| 😖 Intlungu okanye iintlungu zesisu: Iipolyps zinokuphazamisa ukusebenza kwamathumbu kwaye zibangele ukuqaqamba. |
| 🚽 Urhudo okanye Ukuqhinwa: Indlela yokuhambisa amathumbu ingatshintsha. |
| 📉 Ukuqhubeka nokunciphisa umzimba: Ukuba unciphisa umzimba ngaphandle kwesizathu, kufuneka uxhalabe. |
Ezinye iimpawu abanye abantwana abanokuba nazo xa bezalwa
Malunga ne-15% yezigulana ze-JPS zinokuba nezinye iziphene zomzimba ezikhoyo xa zizalwa ukongeza kwi-polyps. Ezi ziquka:
- Intlama eqhekekileyo
- Ukuba neminwe eyongezelelweyo ezandleni nasezinyaweni (nge-Polydactyly)
- Ukuphazamiseka kophuhliso lwengqondo, intliziyo, amalungu esini, okanye inkqubo yomchamo
- Ukujija kwamathumbu (iMalrotation)
- Utshintsho kwimithambo yegazi eluswini (iTelangiectasia)
Ngaba kukho unxibelelwano phakathi kweJPS kunye nomngcipheko womhlaza?
Oku kubaluleke kakhulu kwaye yinto ekufuneka siyiqwalasele. Iipolyps ezibangelwa yi-JPS ekuqaleni zikhula njengeethumba ezingezizo umhlaza (ezingenobungozi) . Oko kuthetha ukuba azizo umhlaza.
Nangona kunjalo, abantu abane-JPS banomngcipheko ophezulu wokufumana umhlaza wenkqubo yokugaya ukutya kunabanye. Le yeyona nkalo iyingozi kakhulu yesi sifo. Umngcipheko unokuba phezulu ukuya kuthi ga kwi-30% - 50%.
Umhlaza onobungozi obukhulu:
- Umhlaza weColoral
- Umhlaza wesisu
- Umhlaza wePancreatic
- Umhlaza wamathumbu amancinci
Oku akuthethi ukuba wonke umntu one-JPS uza kuba nomhlaza. Nangona kunjalo, ekubeni umngcipheko uphezulu, kubalulekile ukufumanisa isifo ngexesha elifanelekileyo, ukususa ii-polyps, kunye nokuhlolwa rhoqo njengoko kucetyisiwe ngugqirha wakho. Emva koko, lo mngcipheko unokulawulwa kakhulu.
Kutheni i-JPS isenzeka? Sithini isizathu sesayensi?
I-JPS ibangelwa kukuguquka kwenye yezakhi zofuzo ezimbini emzimbeni wethu, i-BMPR1A kunye ne -SMAD4 .
Cinga ngezi jini zimbini "njengabaphathi" ababini abalawula umsebenzi weeseli zethu. Umsebenzi wabo ophambili kukuxelela iiseli, "Kulungile, yahlulahlula ngoku" kunye "Kulungile, yeka ukwahlulahlula ngoku." Le yindlela ezilawula ngayo ukukhula kweeseli.
Okwenzekayo kwi-JPS kukuba xa ezi jini ziguquguquka, loo "mphathi" akasebenzi kakuhle. Emva koko iiseli ziyaphuma ekulawuleni. Ziyahlukana ngokukhawuleza, ziqokelelene phezu kwenye, kwaye zenze ezo polyps sizikhankanyileyo.
Ifunyaniswa njani i-JPS?
Ukuba uneempawu ze-JPS, ugqirha wakho uza kuqala akuhlole aze akubuze ngeempawu zakho nokuba kukho nabani na kusapho lwakho okhe waba neemeko ezifanayo. Ukuze kufunyaniswe ukuba une-JPS, kufuneka ubuncinane ube nenye yezi zilandelayo:
* Ukuba neepolyps ezintlanu nangaphezulu kumathumbu amakhulu kunye/okanye i-rectum yakho.
* Ubukho bee-polyps kwezinye iindawo zenkqubo yokugaya ukutya.
* Ukuba nembali yosapho ene-JPS, kunye nokuba khona kwee-polyps.
Zeziphi iimvavanyo ezenziwayo koku?
Ugqirha uza kucebisa iimvavanyo ezininzi ukuqinisekisa ukuxilongwa:
- I-Colonoscopy okanye i-Endoscopy: Oku kuquka ukufaka ityhubhu encinci, eguquguqukayo enekhamera kunye nokukhanya nge-anus ukuze kuhlolwe ingaphakathi lamathumbu amakhulu. Oku kunokunceda ekuqinisekiseni ukuba kukho ii-polyps, ziphi, kwaye zingaphi. Ukuze kuhlolwe isisu, ityhubhu ifakwe ngomlomo (Upper GI Endoscopy).
- Uvavanyo lwegazi oluvela kwimfuza: Kuthathwa isampulu yegazi ize ivavanywe ukuze kujongwe utshintsho lwemfuza olubangela i-JPS.
Ziziphi iindlela zonyango ze-JPS?
Iinjongo eziphambili zonyango lwe-JPS kukususa ii-polyps, ukulawula iimpawu, kunye nokunciphisa umngcipheko womhlaza. Ugqirha wakho uya kumisela unyango olungcono kuwe ngokusekwe kwiminyaka yakho, impilo, inani lee-polyps, kunye nendawo ezikuyo.
Kukho iindlela ezininzi zonyango:
- Ukususa iipolyps ngexesha le-colonoscopy: Ukuba kukho iipolyps ezimbalwa kuphela, zinokunqunyulwa kwaye zisuswe kusetyenziswa izixhobo ezikhethekileyo ezidluliselwa kwityhubhu.
- Ukususwa kweepolyps ngotyando: Ukuba iipolyps zinkulu kakhulu okanye zikwindawo engenakususwa ngexesha le-colonoscopy, utyando lunokufuneka.
- Ukususwa kwecandelo lekholoni okanye lesisu ngotyando: Ukuba kukho inani elikhulu lee-polyps kwindawo enye, oogqirha banokugqiba ekubeni basuse lonke elo candelo lekholoni.
Uphila njani ubomi bakho emva kokuba ufunyenwe unesifo?
Akukho nyango lwe-JPS. Ngoko ke, xa sele ifunyenwe, eyona nto ibalulekileyo kukufunda ukuphila nayo nokulawula esi sifo. Eyona ndlela ilungileyo yokwenza oku kukuhlolwa rhoqo kwezonyango.
Ndifanele ndihlolwe kangaphi?
- Uvavanyo lokuqala kufuneka lwenziwe xa iimpawu ziqala ukubonakala okanye ngaphambi kokuba umntu abe neminyaka eli-15 ubudala .
- Ukuba akukho ngxaki ngexesha lovavanyo lokuqala (akukho polyps), kwanele ukuba ihlolwe rhoqo emva kweminyaka emi-3 .
- Ukuba ukhe waba nee-polyps ezininzi waza wazisusa okanye watyandwa, kufuneka uhlolwe rhoqo ngonyaka . Ukuba akukho polyps zifunyenweyo kwakhona, ungatshintshela ekuhlolweni rhoqo emva kweminyaka emi-3, njengoko ugqirha wakho ekucebisa.
Emva konyango, kufuneka unike umzimba wakho ixesha lokuba uphile. Ngokuqhelekileyo kuthatha malunga neeveki ezimbini ukuba iimpawu ziphele kwaye uqale ukuziva ungcono.
Nanini na xa ufuna ukubona ugqirha.
Ukuba uneempawu ze-JPS, ingakumbi igazi elisesitulweni sakho , musa ukuzityeshela. Bona ugqirha ngokukhawuleza. Kwakhona, ukuba kukho umntu kusapho lwakho onembali yee-polyps okanye i-JPS, qiniseka ukuba uxelele ugqirha wakho. Ngenxa yokuba esi sisifo esidluliselwa kwilifa, olo lwazi lubaluleke kakhulu ekuxilongeni isifo.
Umyalezo Wokuya Ekhaya
- I-JPS yimeko yemfuza ebangela ukuba kubekho ii-polyps kwinkqubo yokugaya ukutya.
- Iimpawu eziphambili kukuphuma kwegazi esitulweni, iintlungu zesisu, kunye nokudinwa. Ukuba ubona into efana nale, bonana nogqirha ngokukhawuleza.
- Igama elithi "ubutsha" libhekisa kuhlobo lwee-polyps, hayi kubudala bomguli. Nangona kunjalo, iimpawu zihlala zibonakala kubantu abancinci.
- I-JPS inyusa umngcipheko wokuba nomhlaza. Ngoko ke, njengoko ugqirha esitsho, kubalulekile ukuba kwenziwe uvavanyo olufana ne-colonoscopy ngexesha elifanelekileyo ukuze ukhusele ubomi bakho.
- Nangona kungekho nyango lupheleleyo loku, ngokususa ii-polyps nokuba phantsi kweliso likagqirha rhoqo, esi sifo sinokulawulwa kakuhle kwaye ubomi obuqhelekileyo bunokukhokelwa.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho