"Gqirha, sele kudlule ixesha elide ndiqala ukuthatha amayeza ale cholesterol. Ndilawula ukutya kwam kakuhle. Kodwa inqanaba le cholesterol yam alikanciphi..." Ngaba nawe uziva into efana nale? Okanye kukho umntu kusapho lwakho onayo le ngxaki? Enyanisweni, ukulawula i cholesterol ngumceli mngeni omkhulu kwabanye abantu. Nangona abantu abaninzi befumana iziphumo ezilungileyo kumayeza ohlobo lwe 'statin', abanye abafumani. Ngoko ke, iyeza elitsha elibizwa ngokuba yiLeqvio liziswe ukunceda abantu abanjalo. Makhe sithethe ngale nto ngokweenkcukacha nangokulula namhlanje.
Yintoni le cholesterol iphezulu (iHyperlipidemia)?
Ngamafutshane, i-Hyperlipidemia iyenzeka xa uneentlobo ezininzi zamafutha (esizibiza ngokuba zii-lipids) egazini lakho. Sonke sidinga amafutha athile emizimbeni yethu. Enza imisebenzi emininzi ebalulekileyo. Kodwa kuxa efikelela phezulu kakhulu apho iingxaki ziqala khona. Ukuba la manqanaba amafutha aphezulu ngokuhamba kwexesha, umngcipheko wokufumana izifo ezinzulu ezifana nesifo sentliziyo, istroke, kunye nokuhlaselwa yintliziyo uyanda kakhulu.
Sidla ngokuthetha ngeentlobo ezimbini eziphambili zamafutha.
| Uhlobo lwamafutha | Kalula nje... |
|---|---|
| I-LDL (i-Low-Density Lipoprotein) i-cholesterol | Oku sikubiza ngokuba yi- "cholesterol embi" kuba ifakwa eludongeni lwemithambo yegazi, izivale kancinci kancinci ize ibangele isifo sentliziyo. |
| I-cholesterol ye-HDL (i-High-Density Lipoprotein) | Oku kubizwa ngokuba yi- "good cholesterol" kuba kunceda ekuthwaleni i-cholesterol embi (LDL) iye esibindini kwaye iyisuse emzimbeni. |
Ukongeza, kukho olunye uhlobo lwamafutha olubizwa ngokuba yi-triglycerides. Akulunganga ukuba nawo amaninzi kakhulu.
Zithini izizathu ze-cholesterol ephezulu?
Ixesha elininzi, oku kubangelwa kukudibana kwendlela esiphila ngayo, ukutya esikutyayo, kunye nezifo ezithile.
- Ukutya Neziselo: Inyama ebomvu, iisoseji, ibhekoni, kunye nokutya okunamafutha (irayisi eqhotsiweyo, ikhuthu, iparatha) kunamafutha amaninzi agcweleyo. Ukutya oku kudla ngokunyusa i-cholesterol.
- Indlela yokuphila:Izinto ezinje ngokutshaya, ukusela utywala ngokugqithisileyo, uxinzelelo, kunye nokungazilolongi zinefuthe elikhulu ekwandeni kwe-cholesterol.
- Ezinye iimeko zonyango: Iimeko ezifana nesifo seswekile, iingxaki zesibindi okanye zezintso, i-hypothyroidism, kunye ne-sleep apnea nazo zinokubangela i-cholesterol ephezulu.
Injongo ephambili yonyango kukunciphisa amanqanaba ala mafutha "amabi" egazini. Oku kunokunciphisa umngcipheko weziganeko ezinzulu ezifana nokuhlaselwa yintliziyo kunye nokubetha kwentliziyo.
Isebenza njani iyeza iLeqvio?
Iistatins zezona pilisi ziphambili ze-cholesterol. Nangona kunjalo, abanye abantu abafumani amanqanaba abo e-cholesterol ephantsi njengoko bebengathanda nangona besebenzisa la mayeza kwaye belandela ukutya okunempilo. Abantu abane-genetic disorder ebizwa ngokuba yi-"primary hyperlipidemia" banokufuna amayeza angaphezu kwelinye.
ILeqvio liyeza elitsha elize kunceda aba bantu. Isithako esisebenzayo kuyo yi-Inclisiran. Ikwiqela lamayeza abizwa ngokuba yi-'small interferensing RNA (siRNA)'.
Ngamafutshane, eli yeza lonyusa amandla esibindi okufunxa "i-cholesterol embi" (LDL) egazini. Ngokukodwa, linceda isibindi ukuba siqaphele amasuntswana e-LDL. Emva kokuba isibindi sifunxa la masuntswana e-LDL, siyawasebenzisa okanye siwasuse emzimbeni. Oku kunciphisa kakhulu izinga le-LDL egazini.
Le yindlela eyahlukileyo ngokupheleleyo kunendlela amayeza e-statin asebenza ngayo.
Ngaba kukho umntu onesifo se-cholesterol angayisebenzisa iLeqvio?
Hayi. Eli liyeza alilolwawo wonke umntu. ILeqvio ivunyiwe kubantu abasele betya ukutya okunesondlo kwaye bethatha idosi ephezulu ye-statin, kodwa basenamanqanaba aphezulu e-cholesterol .
Eli yeza lingacetyiswa, ingakumbi kubantu abane-genetic disorder ebizwa ngokuba yi-`Heterozygous Familyal Hypercholesterolemia (HeFH).` Ukuba une-cholesterol ephezulu kwaye amanqanaba akho awehli nangona uthatha ii-statins kwaye ulandela ukutya okunempilo, ugqirha wakho unokuthetha nawe ngeLeqvio. Ngugqirha wakho kuphela onokugqiba ukuba oku kulungile na kuwe.
Ndingayifumana njani le gonyo?
ILeqvio ayilo pilisi, yinaliti . Yinaliti efakwa ngaphantsi kwesikhumba. Awunakuyinika ekhaya. Inikwa yingcali yezempilo (ugqirha okanye umongikazi) esibhedlele okanye ekliniki.
Ishedyuli yokugonywa yile ilandelayo:
1. Ugonyo lokuqala: Uza kunikwa ugonyo olunye kuqala.
2. Ugonyo lwesibini:Ugonyo lwesibini lunikwa emva kweenyanga ezi-3 emva kolokuqala.
3. Emva koko: Emva koko, kufuneka ufumane inaliti enye rhoqo kwiinyanga ezi-6 .
Olu gonyo lunokufakwa ethangeni, esiswini, okanye ngasemva kwengalo engasentla. Kubaluleke kakhulu ukufumana ugonyo lwakho ngexesha kwaye ungaphoswa yiyo nayiphi na idinga.
Yintoni oyaziyo ngempumelelo kaLeqvio?
Izifundo ezintathu eziphambili zenziwe ukuze kubonwe ukuba iLeqvio isebenza kakuhle kwaye ikhuselekile kangakanani. Ezi zifundo zenziwe kwixesha leenyanga ezili-18.
- Izifundo ezibini: Abathathi-nxaxheba baquka abantu abanesifo sentliziyo abangazange bakwazi ukwehlisa amanqanaba abo e-cholesterol nangona besebenzise ii-statins.
- Kolunye uphando, abathathi-nxaxheba yayingabantu abane-cholesterol yemfuza ebizwa ngokuba yi-'HeFH'.
Kwezi zifundo, elinye iqela lanikwa isitofu sokugonya seLeqvio kwaye elinye iqela lanikwa isitofu sokugonya se-placebo esingazange sibe nampembelelo. Iziphumo zazicacile kakhulu.
| Iqela | Utshintsho kumanqanaba e-cholesterol "embi" (LDL) emva kweenyanga ezili-18 |
|---|---|
| Abo bafumene uLeqvio | Ngokomndilili, yehle ngama- 40% - 51% . |
| Abo bafumene i-placebo (amayeza obuxoki) | Ukunyuka okuphakathi yi- 1% - 8% . |
Ezi ziphumo zibonisa ukuba iLeqvio liyeza elinokunciphisa kakhulu amanqanaba e-cholesterol ye-LDL angalawulwa zii-statins. Amanqanaba e-cholesterol adla ngokuqala ukwehla kwiinyanga ezi-3 zokuqala.
Ingaba eli yeza liyanciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nesifo sohlangothi?
Lo ngumbuzo obaluleke kakhulu. Amayeza e-statin abonakalisiwe ukuba anciphisa i-LDL cholesterol kwaye anciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nestroke. Kodwa iLeqvio liyeza elisebenza ngendlela eyahlukileyo.
Izifundo zangoku zibonisa ukuba iLeqvio inokunciphisa kakhulu i-LDL cholesterol. Nangona kunjalo, ezi zifundo zenziwe ixesha elifutshane, malunga neenyanga ezili-18. Ke ngoko, elo xesha alanele ukubona ukuba ngaba iyeza liyawunciphisa na umngcipheko wokuhlaselwa sisifo sentliziyo kunye nestroke.
Nangona kunjalo, ukwehla okukhulu kangaka kwe-cholesterol ye-LDL kubonisa ukuba le ngozi inokuncipha kwixesha elizayo. Izifundo ezininzi zexesha elide ziyaqhubeka ukuqinisekisa oku.
Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Njengayo nayiphi na iyeza, iLeqvio inokubangela iziphumo ebezingalindelekanga ezincinci. Ezona zixhaphakileyo ziimpendulo kwindawo efakwe kuyo inaliti .
- Ububomvu kwindawo yokutofa
- Ukurhawuzelela
- Intlungu
Ngenxa yesi sizathu, ingcali yezempilo enika ugonyo ayizukunika ugonyo kwindawo etshiswe lilanga, enerhashalala, okanye enesifo. Ukuba ukhe wajova ngaphambili kwaye ube neentlungu ezingaphezulu, xelela ugqirha okanye umongikazi. Banokukhetha indawo eyahlukileyo emva koko.
Ngaphandle kwezi, ezinye iziphumo ebezingalindelekanga zinokubakho. Ukuba ufumana naziphi na iimpawu ezingaqhelekanga, thetha nogqirha wakho ngoko nangoko.
Okwangoku akukho nxibelelwano luxeliweyo phakathi kweLeqvio kunye namanye amayeza. Nangona kunjalo, kubalulekile ukuxelela ugqirha wakho ngawo onke amayeza, iivithamini, kunye neemveliso zezityalo ozisebenzisayo.
Umyalezo Wokuya Ekhaya
- ILeqvio yindlela entsha yokugonya yokulawula i-cholesterol.
- Oku kucetyiswa kubantu abanezinga eliphezulu le-cholesterol abangenakulawulwa ngamayeza e-statin kunye nokutya.
- Olu lugonyo olunikwa yingcali yezempilo rhoqo emva kweenyanga ezi-6 (emva kweedosi ezimbini zokuqala).
- Izifundo zibonise ukuba oku kusebenza kakhulu ekunciphiseni amanqanaba e-cholesterol "embi" ye-LDL.
- Ngugqirha wakho kuphela onokugqiba ukuba eli yeza likulungele na, ngoko ke thetha nogqirha wakho ngalo mba.
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