Yintoni iMitochondrial Disease? Makhe sithethe ngayo ngokulula.

Ngaba ngamanye amaxesha uziva ngathi awunamandla, uhlala udiniwe, kwaye uhlala ugula? Ngamanye amaxesha, ezi mpawu zingabonakaliyo zinokubangelwa yingxaki kwenye yezona ndawo zincinci zomzimba wethu. Namhlanje, siza kuthetha ngemeko enzima kancinci, kodwa ebaluleke kakhulu ukuyazi. Leyo yiMitochondrial Diseases.

Okokuqala, masibone, yintoni i-mitochondria?

Ngamafutshane, i-mitochondria "ziindawo zamandla" ezincinci ngaphakathi kwiseli nganye emzimbeni wethu. Njengokuba sinesixhobo sombane sokunika amandla emakhaya ethu, iiseli zethu zisebenzisa ezi mitochondria ukuvelisa amandla eziwadingayo ukuze zisebenze. Zisebenzisa ukutya esikutyayo kunye neoksijini esiyiphefumlayo, ezi fektri zincinci zivelisa malunga ne-90% yamandla afunekayo emizimbeni yethu. Ngoko khawucinge ngeengxaki ezinokuvela ukuba ezi zixhobo zombane bezingasebenzi kakuhle.

Xa ezi zityalo zombane zingasebenzi kakuhle, iiseli azifumani amandla eziwadingayo. Emva koko amalungu aqulethe ezo seli angasebenzi kakuhle. Oku kunokuchaphazela naliphi na ilungu lomzimba wethu.

• Ingqondo
• Inkqubo yemithambo-luvo
• Izihlunu
• Izintso
• Intliziyo
• Isibindi
• Amehlo
• Iindlebe
• I-Pancreas

Oku kunokuchaphazela nantoni na.

Ziziphi iintlobo eziphambili zezifo ze-mitochondrial?

Kukho iintlobo ezininzi zesi sifo, kodwa ezinye zezona zixhaphakileyo zezi:

• I-MELAS syndrome (i-Mitochondrial encephalopathy, i-lactic acidosis kunye neziqephu ezifana ne-stroke)
• I-Leber hereditary optic neuropathy (LHON)
• Isifo sikaLeigh
• Isifo sikaKearns-Sayre (KSS)
• Isifo se-Myoclonic epilepsy kunye nesifo se-ragged-red fiber (MERRF)

Oku kusenokuvakala kuyinkimbinkimbi kancinci, kodwa khumbula ukuba ezi ziimeko ezibangela iimpawu ezahlukeneyo kwaye zibangelwa lutshintsho kumsebenzi we-mitochondrial.

Zingaba yintoni iimpawu zezi zifo?

Le yeyona nxalenye inzima kakhulu yesi sifo. Kuba iimpawu zinokwahluka kakhulu kumntu nomntu, kuxhomekeke kuhlobo lweeseli ezichaphazelekileyo kunye nokuba zikuphi emzimbeni. Abanye abantu banokuba neempawu ezibuthathaka kakhulu , ngelixa abanye banokuba neempawu eziqatha kakhulu. Iimpawu zinokwahluka kwanakwintsapho enye.

Le theyibhile ingezantsi ibonisa ezinye zeempawu eziqhelekileyo ezibonakala kwezi zifo.

Ezi mpawu zinokuqala ekuzalweni okanye zivele nakweyiphi na iminyaka ebomini. Ugqirha uhlala ekrokrela oku xa iimpawu zivela ngaxeshanye kwiinkqubo ezininzi zamalungu angadibananga.

Kutheni olu hlobo lwesifo lusenzeka?

Isizathu esiphambili soku ziziphene zemfuza .

Ngamafutshane, i-mitochondria engaphakathi kwiiseli zethu ifumana imiyalelo yayo yokwenza amandla kwi-DNA yethu. Ukuba kukho utshintsho okanye utshintsho kule DNA, i-mitochondria ayifumani imiyalelo ngokuchanekileyo. Emva koko ayinakukwazi ukwenza amandla ngokufanelekileyo. Oku kungonakalisa iiseli okanye kubangele ukuba zife ngaphambi kwexesha.

Umntu uyifumana njani le sifo njengelifa?

Ezi zizifo zemfuza, oko kuthetha ukuba zinokudluliselwa ebantwaneni zisuka kubazali. Ngamanye amaxesha, nokuba akukho mntu unesifo kusapho, umntu unokuba nesifo ngenxa yotshintsho olungaqhelekanga lwemfuza.

Ngaba ezinye izifo zingayiphazamisa indlela esebenza ngayo i-mitochondrial?

Ewe. Kubizwa ngokuba kukungasebenzi kakuhle kwe-mitochondrial yesibini. Oko kuthetha ukuba awunaso isifo se-mitochondrial esibangelwa lufuzo, kodwa kukho esinye isifo esibangela ukuba i-mitochondria yakho ingasebenzi kakuhle. Umzekelo:

• Isifo sika-Alzheimer
• Ukungakwazi kwemisipha
• Uhlobo loku-1 lweswekile
• I-Multiple sclerosis (MS)
• Ezinye iintlobo zomhlaza

I-Mitochondria inokuchaphazeleka zizifo ezifana nezi:

Indlela yokuxilonga esi sifo?

Ukuchonga esi sifo kunokuba nzima kancinci kuba iimpawu zahlukile. Akunakubonwa ngovavanyo olunye kuphela. Ugqirha wakho unokwenza uthotho lweemvavanyo.

• Uphononongo olupheleleyo lwembali yakho neyentsapho yakho yezonyango .
• Ukwenza uvavanyo olupheleleyo lomzimba .
• Uvavanyo olunxulumene nenkqubo yemithambo-luvo .
• Uvavanyo lwegazi nomchamo . Ngamanye amaxesha kunokwenziwa umbhobho womqolo.
• Uvavanyo lwe-DNA .
• Ngokuxhomekeke kwiimpawu, iimvavanyo ezifana ne-MRI scan, i-EKG okanye i-Echocardiogram yentliziyo, uvavanyo lwamehlo, uvavanyo lokuva, kunye novavanyo lwe-EEG lokujonga umsebenzi wobuchopho zinokwenziwa.
• Ngamanye amaxesha kusenokufuneka ukuba uthathe iqhekeza elincinci lesikhumba okanye lemisipha (i-biopsy) uze ulihlolisise phantsi kwe-microscope.

Kungoko ke, kubaluleke kakhulu ukubonana nogqirha okanye isibhedlele esigxile kwezi ntlobo zezifo ukuze kufunyanwe isifo.

Zithini iindlela zonyango?

Ngelishwa, akukho nyango lwesifo se-mitochondrial okwangoku. Nangona kunjalo, kukho iindlela ezahlukeneyo zonyango ezifumanekayo ukunceda ukulawula iimpawu kunye nokuthintela iingxaki ezisongela ubomi .

• Amayeza anciphisa iimpawu:Umzekelo, amayeza okulwa nesifo sokuwa.
• Iivithamini kunye nezongezo: Izinto ezifana ne-riboflavin, i-coenzyme Q10, kunye ne-carnitine zinokuba luncedo kwabanye abantu.
• Utshintsho kwindlela otya ngayo kunye nokuzilolonga: Ugqirha wakho uza kucebisa oku ngokusekelwe kwimeko yakho.
• Unyango lomzimba, unyango lomsebenzi, okanye unyango lonyango lokuthetha .
• Ukunxiba izixhobo zokuncedisa ezifana nezixhobo zokuva .

Oko kusebenza komnye umntu kusenokungasebenzi komnye, ngoko ke kungcono ukuthetha nogqirha wakho uze nesicwangciso sonyango esifanelekileyo kuwe.

Ngaba esi sifo singathintelwa ukuba singabi mandundu?

Nangona kungekho ndlela yokuthintela esi sifo ukuba singabikho, ungaziphepha ezinye izinto eziya kuyenza mandundu le mpawu.

• Kuphephe ukuvezwa kubushushu obugqithisileyo okanye kubushushu obugqithisileyo .
• Musa ukutsiba ukutya.
• Lala kamnandi ebusuku.
• Zigcine kude noxinzelelo kangangoko unako.

Ugqirha wakho unokukucebisa ukuba wonge amandla kunokuba uchithe onke amandla omzimba wakho ngaxeshanye.

Ndifanele ndimbone nini ugqirha?

Ukuba uneempawu zesifo se-mitochondrial kwaye unengxaki yokwenza imisebenzi yakho yemihla ngemihla, qiniseka ukuba ubona ugqirha.

Ukuba ufumana isifo sokuxhuzula okanye ubunzima obukhulu bokuphefumla, yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) esibhedlele ngoko nangoko.

Ukwazi ukuba wena okanye umntu omthandayo unale meko kunokuba nzima. Kodwa khumbula, usapho lwakho, abahlobo, kunye neqela lezonyango, kuquka oogqirha, bakhona ukukunceda uphile ngempumelelo nezi mpawu.