Ingaba uvelisa iiseli zegazi ezininzi kakhulu emzimbeni wakho? Masifunde ngezi Myeloproliferative Neoplasms (MPN)!

Ngaba wakha wazibuza ukuba kuya kwenzeka ntoni ukuba umongo wakho wethambo uvelisa iiseli zegazi ezininzi emzimbeni wakho? Yiyo loo nto ifana ne-myeloproliferative neoplasms, okanye i-MPN ngamafutshane. Lo ngumhlaza wegazi ongaqhelekanga, kodwa osongela ubomi onokubulala ukuba awuphathwanga ngokufanelekileyo. Makhe sithethe ngawo ngendlela elula onokuyiqonda.

Yintoni le myeloproliferative neoplasm (MPN)?

Ngamafutshane, ii-myeloproliferative neoplasms (ii-MPN) ziimeko apho umongo wakho wethambo (isicwili esithambileyo esifumaneka ngaphakathi emathanjeni akho) wenza iiseli ezibomvu zegazi ezingaphezulu , iiseli ezimhlophe zegazi, okanye iiplatelets (iiseli ezinceda ukujiya kwegazi lakho). Cinga ngayo njengomzi-mveliso ovelisa iimveliso ezininzi kakhulu. Oku kwenzeka xa kukho into engahambi kakuhle kwinkqubo yokwenza iiseli zegazi.

Ezi meko ze-MPN zihlala zikhula kancinci kakhulu . Ngoko ke abanye abantu basenokungabi nazo iimpawu kangangeminyaka. Yiyo loo nto zikwabizwa ngokuba zii-neoplasms ze-myeloproliferative "ezingapheliyo" okanye zexesha elide. Nangona kunjalo, kwiimeko ezingaqhelekanga, ezi meko ze-MPN zinokukhula zibe yinto enzulu ngakumbi.

Kodwa ungakhathazeki, kukho unyango olufanelekileyo lokulawula iimpawu zale meko nokuthintela ukuba ibe mandundu ngakumbi.

Ziziphi iintlobo ze-MPN ezikhoyo?

Kukho iintlobo ezahlukeneyo ze-MPN. Uhlobo ngalunye luchaphazela uhlobo lweeseli zegazi eziveliswa ngumongo wakho ngokugqithisileyo. Ngamanye amaxesha iiseli ezibomvu zegazi kuphela ezinokuthi ziveliswe, ngelixa ngamanye amaxesha iiseli ezimhlophe zegazi okanye iiplatelets kuphela ezinokuthi ziveliswe. Kwezinye iintlobo ze-MPN, indibaniselwano yezi ntlobo zeeseli inokuthi ziveliswe ngokugqithisileyo. Esinye isizathu kukuba ezi seli zigqithisileyo zinokuziphatha ngendlela eyahlukileyo kwiiseli zegazi eziphilileyo.

Ngubani ochaphazeleka kakhulu yile meko?

Izinto ezimbini eziphambili ezichaphazela ukwenzeka kwe-MPN bubudala bakho kunye nesini sakho .

• Ubudala: Nangona i-MPN inokwenzeka kubantu bayo yonke iminyaka, ixhaphake kakhulu kubantu abaneminyaka engama-50, engama-60, okanye ngaphezulu .
• Isini: Umzekelo, i-polycythemia vera, uhlobo lwe-MPN, ixhaphake kakhulu kumadoda. I-Essential thrombocythemia ixhaphake kakhulu kubafazi. Ezinye iintlobo ze-MPN zinokuchaphazela zombini izini ngokulinganayo.

I-MPN ichaphazela njani umzimba wakho?

Ezi zifo ezinxulumene negazi zenzeka xa umongo wakho wethambo uvelisa uhlobo oluthile lweeseli zegazi ezingaphezu kwezo umzimba wakho uzifunayo. Ngoko ke, impembelelo oku okunayo emzimbeni wakho ixhomekeke ekubeni loluphi uhlobo lweeseli zegazi eziveliswayo ngokugqithisileyo . Umzekelo, olunye uhlobo lwe-MPN lunokunyusa umngcipheko wokuba nesifo sentliziyo okanye isifo sohlangothi. Olunye uhlobo lunokubangela i-anemia.

Ukuze uziqonde ngcono ezi meko zingaqhelekanga, kuyanceda ukuba nokuqonda okuncinci ngendlela ezenziwe ngayo umongo wakho wamathambo kunye neeseli zegazi. Zonke iiseli zethu zegazi ziqala njengeeseli ze-stem kwimongo wakho wamathambo. Lo mongo wethambo sisicwili esithambileyo nesithambileyo ngaphakathi kwamathambo akho. Iiseli ze-stem eziphuhliswa kuwo zinokuba ziiseli ze-myeloid stem okanye iiseli ze-lymphoid stem.

• Iiseli ze-lymphoid stem ziintlobo zeeseli ezimhlophe zegazi ezilwa nosulelo.
• Iiseli ze-Myeloid stem zinokubangela iiseli ezibomvu zegazi (ezithwala ioksijini emzimbeni wonke), ezinye iintlobo zeeseli ezimhlophe zegazi, kunye neeplatelets (ezinceda ekumiseni ukopha xa kusenzeka).

Njengazo zonke ezinye iiseli, ezi seli ze-stem zisebenza ngokwemiyalelo ezinikwe yi-genes. Ngokwesiqhelo, ezi seli ze-stem ziyahlukana kwaye ziphindaphindeke njengoko kufuneka kwi-bone morrow yakho ukuze zenze iiseli ezintsha. Nangona kunjalo, ukuba kukho utshintsho kwezi genes, oko kukuthi, ukuba ii-genes ziyatshintsha, ezo genes zithumela imiyalelo engalunganga kwii-stem cells ukuze ziqhubeke zahlukana kwaye ziphindaphindeke. Ekugqibeleni, ezi seli zegazi ezigqithisileyo ziyaqokelelana kwi-bone morrow okanye kwimithambo yegazi, zithintele ukuhamba kwegazi. Xa oku kuhamba kwegazi kuvaliwe, iingxaki zempilo zinokwenzeka.

Ziziphi iintlobo ze-MPN eziqhelekileyo?

Kukho iintlobo ezintathu eziqhelekileyo ze-MPN: i-polycythemia vera, i-essential thrombocythemia, kunye ne-primary myelofibrosis.

I-Polycythemia Vera

Olu lolona hlobo luqhelekileyo lwe-MPN . Lwenzeka xa umongo wakho wethambo wenza iiseli ezibomvu zegazi ezininzi kakhulu . Oku kubangela ukuba igazi lakho lijiye kwaye linciphe. Abantu abane-polycythemia vera basengozini enkulu yokuba namahlwili egazi. La mahlwili anokubangela ukuhlaselwa yintliziyo kunye nokubetha kwentliziyo. Amaxesha amaninzi, le meko inokukhokelela ekubeni ngumhlaza wegazi onzima obizwa ngokuba yi-acute leukemia.

I-Myelofibrosis

Olu luthathwa njengolona hlobo lunobundlongondlongo lwe-MPN . Kwi-myelofibrosis, umongo wakho wethambo uvelisa ii-stem cells ezingaqhelekanga. Ezi seli ziyavuvukala kwaye zenze izicubu ezibomvu ngaphakathi komongo wethambo. Ekuhambeni kwexesha, umongo uzaliswa yile zicubu ezibomvu. Umongo wethambo awusakwazi ukwenza iiseli ezibomvu zegazi ezaneleyo zokuthwala ioksijini emzimbeni. Oku kunokubangela ukuba ube ne-anemia. Ukwanayo nemveliso ephantsi yeeplatelet. Abanye abantu abane-myelofibrosis banokufumana i-acute myeloid leukemia (AML).

I-Thrombocythemia ebalulekileyo

I-Essential thrombocythemia yimeko apho umongo wakho wethambo wenza iiplatelets ezininzi kakhulu.Ukwenza. Ngokwesiqhelo, xa umthambo wegazi uqhuma, iiplatelets ziyahlangana ukuze zenze ihlwili kwaye ziyeke ukopha. Kodwa kule meko, iiplatelets zenziwa kwi-bone mongo ngaphandle kwesizathu. Ezi platelets zongezelelweyo zinokubangela amahlwili egazi kwaye zonyuse umngcipheko wokuhlaselwa yintliziyo kunye nokubetha kwentliziyo. Njengezinye ii-MPN, iimpawu zikhula kancinci. Uninzi lwabantu lufunyaniswa lunale meko xa uvavanyo lwegazi oluqhelekileyo lubonisa amanqanaba aphezulu eplatelets. Kwabanye abantu, le meko inokuqhubela phambili ibe yi-leukemia.

Ngaba zikho ezinye iintlobo ze-MPN?

Ewe, kukho ezinye iintlobo ezininzi ze-MPN. Ezinye zazo zezi:

• I-Chronic eosinophilic leukemia (CEL): Le yimeko apho kukho ukuveliswa okugqithisileyo kohlobo lweseli emhlophe yegazi ebizwa ngokuba yi-eosinophil. Ihlala ikhula kwi-spleen. Ayifane ikhule ibe yi-acute myeloid leukemia (AML). Oku kukwabizwa ngokuba yi-hypereosinophilic syndrome.
• I-Chronic myelogenous leukemia (CML): Olu luhlobo lweeseli ezimhlophe zegazi ezibizwa ngokuba zii-granulocytes ezivelisa kakhulu. Ezi seli ziyaqokelelana kwaye zenze kube nzima ukuba umongo wethambo wenze ezinye iiseli zegazi ezifunekayo.
• I-Chronic neutrophilic leukemia (CNL): Kule meko, uhlobo lweseli emhlophe yegazi ebizwa ngokuba yi-neutrophils lwenziwa ngokugqithisileyo.
• I-Myeloproliferative neoplasm, engahlelwanga (MPN-U): Olu luhlobo lwe-MPN olungangeni nakwezinye iindidi. Lunokubangela ukuveliswa ngokugqithisileyo kweentlobo ezahlukeneyo zeeseli zegazi, ezifana neeseli ezimhlophe zegazi, iiseli ezibomvu zegazi, okanye iiplatelets.

Zithini iimpawu ze-MPN?

Kwinqanaba lokuqala, usenokungabi nazimpawu . Njengoko imeko iqhubeka, unokubona iimpawu zepleen evuvukileyo (i-spleen). Ipleen ikwicala lakho lasekhohlo phantsi kweembambo zakho. Isenokuvakala igcwele, iqinile, kwaye ingakhululekanga. Nangona oku kudumba kwepleen kuqhelekile kwiintlobo ezininzi ze-MPN, akuqhelekanga kangako kwi-essential thrombocythemia.

Ezinye iimpawu ziyahluka ngokuxhomekeke kuhlobo lwe-MPN .

I-leukemia ye-eosinophilic engapheliyo (CEL)

• Uphawu oluqhelekileyo kukuqhambuka kwesikhumba .
• Usenokuziva udiniwe kwaye unomkhuhlane.
• Ezinye iimpawu zixhomekeke kwiindawo zomzimba wakho ezichaphazeleka ngamanqanaba aphezulu eosinophil.

I-Chronic myelogenous leukemia (CML) kunye ne-chronic neutrophilic leukemia (CNL)

• Intlungu yethambo
• Ukubila ebusuku
• Umkhuhlane kunye nokudinwa
• Ukugruzuka lula
• Ukulahlekelwa ngumdla wokutya kunye nokunciphisa umzimba

I-thrombocythemia ebalulekileyo

• Ukugruzuka lula
• Ukopha empumlweni, emlonyeni, okanye kwiintsini ngaphandle kwesizathu
• Ukopha esiswini okanye emathunjini
• Igazi kumchamo

I-Polycythemia vera

• Intloko ebuhlungu
• Isiyezi
• Ukudinwa
• Umbono ofipheleyo okanye umbono ophindwe kabini

I-myelofibrosis ephambili

• Iimpawu ze-anemia (ukudinwa, ubuthathaka, ukuphefumla kancinci) zinokubonakala.
• Ezinye iimpawu:
• Ulusu olukhanyayo
• Ukubila ebusuku
• Ifiva
• Ulusu olurhawuzelelayo
• Ukutya kakhulu okanye ukuziva uzele ngokukhawuleza emva kokutya (ukuqala kokwanela)
• Ukuhla ukusinda
• Intlungu yethambo

Yintoni ebangela i-MPN?

Zonke iimeko ze-MPN ziingxaki zemfuza ezifunyenweyo . Oku kuthetha ukuba azizuzwa njengelifa kubazali bakho. Zenzeka xa utshintsho okanye utshintsho lwenzeka kwiijini ezilawula ukukhula kweeseli, nto leyo ebangela ukuba iiseli zegazi zikhule ngendlela engafanelekanga.

Abaphandi bezonyango baye bafumanisa oku kulandelayo malunga notshintsho lwemfuza olubangela i-MPN:

• Utshintsho lweJanus kinase (JAK): Iimeko ezifana ne-polycythemia vera, i-primary myelofibrosis, kunye ne-essential thrombocythemia zihlala zibangelwa kukuguqulwa kwejini ebizwa ngokuba yiJanus kinase 2 (JAK2) . Olu tshintsho lunokubangela ukuba iiseli zahlukane ngokungalawulekiyo.
• Utshintsho kwi-gene ye-MPL okanye i-gene ye-CALR: Abantu abane-thrombocythemia ebalulekileyo kunye ne-primary myelofibrosis badla ngokuba notshintsho kwi-gene yabo ye-MPL okanye i-gene ye-CALR.
• Iimpazamo zeChromosome: Abantu abane-chronic myelogenous leukemia (CML) banempazamo ethile kwiichromosomes zabo (ulwakhiwo oluqulethe iijini). Kwi-CML, isiqwenga sechromosome enye sitshintshana nesinye, senza "i-Philadelphia chromosome."

Nangona ezi ziphumo zingachazi kakuhle ukuba yintoni ebangela utshintsho kwimfuza, zinceda oogqirha ukuba baxilonge izifo baze baphuhlise unyango olujolise kolu tshintsho kwimfuza.

Ziziphi izinto ezibangela umngcipheko we-MPN?

Imbali yentsapho yesi sifo (nangona ezi zizifo ezifunyenweyo, ezinye iintsapho zinokubonisa ukuba zinesifo esithile), ubudala, kunye nesini kunokunyusa umngcipheko wokuba ne-MPN.

Abaphandi bafumanise unxibelelwano phakathi kwe-MPN kunye nokuvezwa kwiityhefu ezithile kunye nemitha . Ezinye izifundo zibonisa ukuba abantu abachaphazeleka kumanqanaba aphezulu emitha kunye neetyhefu ezithile, ezifana ne-benzene, basengozini enkulu yokufumana ii-MPN, ezifana ne-polycythemia vera, i-primary myelofibrosis, kunye ne-chronic myelogenous leukemia.

Ifunyaniswa njani i-MPN?

Ugqirha wakho uza kukubuza ngeempawu zakho kunye nembali yempilo yakho. Emva koko, baza kwenza uvavanyo lomzimba ukujonga iimpawu ze-MPN. Baza kuvavanya igazi lakho kunye nomongo wamathambo ukuze bafumane isifo.

• Ubalo lwegazi olupheleleyo (i-CBC):Oku kulinganisa amanqanaba azo zonke iintlobo zeeseli zakho zegazi. Kwi-essential thrombocythemia, amanqanaba eeplatelet ayajongwa. Kwi-polycythemia vera, i-hemoglobin (iproteni efumaneka kwiiseli ezibomvu zegazi), kunye namanqanaba eeseli ezimhlophe zegazi kunye neeplatelet, ayajongwa.
• I-Peripheral blood smear (PBS): Olu vavanyo lunokujonga iimilo ezingaqhelekanga kwiiseli zegazi, nto leyo enokunika izikhokelo malunga nemeko yempilo.
• Uvavanyo lwekhemikhali yegazi: Olu vavanyo lunokulinganisa amanqanaba eekhemikhali ezahlukeneyo (ezifana neeproteni, ii-enzymes, kunye neglucose) egazini lakho. La manani anokunika izikhokelo malunga nendlela amalungu akho asebenza ngayo, nto leyo enokubangela ukurhanelwa kwe-MPN.
• I-Bone Marrow Biopsy: Ugqirha wakho unokwenza i-bone marrow aspiration okanye i-bone marrow biopsy. Oku kuquka ukuthatha isampuli ye-bone marrow yakho aze ayihlole ukuze abone iiseli zegazi. Iingcali zonyango emva koko zihlola iiseli zegazi kunye nezicubu phantsi kwe-microscope ukuze zijonge umahluko phakathi kweeseli eziqhelekileyo nezingaqhelekanga. Ziya kukhangela naziphi na iiseli ze-stem ezingaqhelekanga. Ziya kukhangela notshintsho lwe-chromosome kunye nezinye iingxaki zemfuza ezinokubonisa uhlobo lwe-MPN.
• Uvavanyo lwemfuza: Oogqirha banokuhlalutya iiseli zakho zegazi ukuze babone ukuba kukho naluphi na utshintsho kwiijini oluchaphazela ukuveliswa kweeseli zegazi.

Ngaba i-MPN inganyangeka ngokupheleleyo? Zithini iindlela zonyango?

Unyango olulodwa kuphela olukhoyo ngoku lokunyanga ezi zifo yi-allogeneic stem cell transplantation . Ngelishwa, abantu abaninzi abanakukwazi ukwenza olu tyando lwe-stem cell kuba yinkqubo enzima nenzima emzimbeni.

Ugqirha wakho uza kukunika unyango lokulawula imeko yakho, ukunciphisa inani leeseli zegazi lakho, ukunciphisa iimpawu, kunye nokuthintela iingxaki. Ezinye iindlela zonyango zinokubangela ukuba isifo siphinde siphele. Unyango lwe-MPN luyahluka ngokuxhomekeke kuhlobo:

• I-Chronic eosinophilic leukemia (CEL): Ugqirha wakho angasebenzisa i-chemotherapy, i-corticosteroids, okanye i-immunotherapy ukunciphisa amanqanaba akho e-eosinophil.
• I-Chronic myelogenous leukemia (CML): Unyango olusetyenziswa kakhulu lunyango olujoliswe kulo, oluthintela iiseli ukuba zingaphindaphindani ngokungalawulekiyo. Ezinye iindlela zonyango ziquka i-chemotherapy, i-immunotherapy, i-radiation therapy, kunye nokufakelwa kweeseli ze-stem.
• I-Chronic neutrophilic leukemia (CNL): Unyango lunokubandakanya i-chemotherapy, i-immunotherapy, kunye nokufakelwa kweeseli ze-stem.
• I-thrombocythemia ebalulekileyo:Ukuba awunazo iimpawu, ugqirha wakho unokugqiba ekubeni ayijonge ngokusondeleyo imeko yakho endaweni yokukunika unyango. Ukuba unazo iimpawu, unokufuna unyango oluthintela iiseli ukuba zingaphindaphindani ngokungalawulekiyo. Unokufuna kwakhona ukuthatha amayeza okunciphisa umngcipheko wokuqhekeka kwegazi okanye ukuthintela umongo wakho ekwenzeni iiplatelets ezininzi.
• I-Polycythemia vera: I-Phlebotomy lolona nyango luqhelekileyo lwe-polycythemia vera. Kule nkqubo, ugqirha wakho uya kususa igazi elincinci rhoqo (njengokutofelwa igazi) ukunciphisa umthamo wegazi lakho nokususa iiseli ezibomvu zegazi ezingaphezulu. Ukuba uneempawu, unokunikwa unyango olujoliswe ekuthinteleni iiseli ukuba zingaphindaphindani ngokungalawulekiyo. Usenokunikwa amayeza anciphisa umngcipheko wokuqhekeka kwegazi (njenge-aspirin) okanye amayeza anciphisa inani leeseli ezibomvu zegazi.
• I-myelofibrosis ephambili: Ukuba awunazo iimpawu, ugqirha wakho unokugqiba ekubeni ayijonge ngokusondeleyo imeko yakho. Kukho iindlela ezahlukeneyo okanye amayeza angasetyenziswa ukunyanga i-anemia. Umzekelo, ukuba umongo wakho wethambo awuvelisi iiseli ezibomvu zegazi ezaneleyo, unokufuna utofelo-gazi. Unokufuna kwakhona ukuthatha amayeza akhuthaza umongo wethambo ukuba wenze iiseli zegazi ezingaphezulu. Ezinye iindlela zonyango ziquka unyango olujoliswe kulo, i-chemotherapy, i-immunotherapy, unyango lwemitha, kunye nokufakelwa kweeseli ze-stem.

Umntu one-MPN angaphila ixesha elingakanani?

Oku kuyahluka kakhulu kumntu nomntu . Zininzi izinto ezichaphazela oku, kuquka uhlobo lwe-MPN, ukuba isifo sifunyanwa njani kwangethuba, kunye nendlela osabela ngayo kunyango. Ngokubekwa esweni nonyango olufanelekileyo, abantu abaninzi baphila iminyaka emininzi . Akukho ngxelo inye okanye isiphumo esilindelekileyo kwezi meko. Ngokubanzi, uninzi lwabantu abafunyaniswe bene-MPN basaphila emva kweminyaka emihlanu.

Amazinga okusinda kwiintlobo ezithile ze-MPN ngala alandelayo:

• I-Chronic myelogenous leukemia (CML): Izinga lokusinda elinxulunyaniswa ne-CML linyuke kakhulu ngenxa yempumelelo yeendlela ezintsha zonyango ezijoliswe kuzo. Izinga lokusinda kweminyaka emihlanu kwi-CML yi-90%.
• I-Chronic neutrophilic leukemia (CNL) kunye ne-polycythemia vera: Ngolawulo olufanelekileyo, uninzi lwabantu luphila umyinge weminyaka engama-20 emva kokufunyaniswa kwesi sifo.
• I-Essential thrombocythemia: Abantu abaninzi baphila iminyaka emininzi xa bethatha amayeza athintela iingxaki ezisongela ubomi ezifana nokuqhekeka kwegazi.
• I-myelofibrosis ephambili: Uninzi lwabantu abane-myelofibrosis yokuqala baphila iminyaka emihlanu ukuya kwelishumi emva kokuba bexilongiwe.

Ukuba unale meko, buza ugqirha wakho ngesifo sakho. Ngabo bazi zonke izinto ezichaphazela isifo sakho. Kwaye okona kubaluleke kakhulu, bayakwazi wena, ubudala bakho, kunye nempilo yakho iyonke, kunye nezinto ezinobungozi ezichaphazela isifo sakho.

Ngaba ezi zifo ziyabulala?

Ezi azizozifo ezibulalayo zodwa , kodwa ezinye iintlobo ze-MPN zinokubangela iingxaki ezisongela ubomi ezifana nokuhlaselwa yintliziyo kunye nokubetha kwentliziyo.

Ndingayibuza yiphi imibuzo ugqirha wam?

I-MPN sisifo esintsonkothileyo. Zininzi iindlela zonyango, kwaye ngamanye amaxesha iziphumo ebezingalindelekanga. Kwakhona, kukho iingxaki ezininzi ezinokubakho ngokuxhomekeke kwimeko yakho. Kubalulekile ukwazi ukuba zeziphi iimpawu ekufuneka uzazi. Thetha nogqirha wakho ukuze uqonde isifo sakho kwaye wenze izigqibo malunga nonyango.

Eminye imibuzo onokuyibuza:

• Yintoni injongo yonyango (ukunceda ukuphelisa esi sifo, ukunciphisa iimpawu, ukuthintela iingxaki, njl.njl.)?
• Ziziphi iindlela zonyango endinokukhetha kuzo?
• Zithini iziphumo ebezingalindelekanga zonyango?
• Kuza kufuneka ndinyangwe ixesha elingakanani ngenxa yemeko yam?
• Kuza kufuneka kangaphi ukuba ndenze uvavanyo (umfanekiso okanye umsebenzi wegazi) ukuze ndijonge imeko yam?
• Ziziphi iimpawu eziya kundinceda ndiqonde ukuba imeko yam iya isiba ngcono okanye imbi?
• Ziziphi iimpawu ezindilumkisa ngengxaki?
• Ziziphi iingxaki ezifuna unyango olungxamisekileyo?
• Yintoni elindelekileyo ukuba ndibe nesifo?
• Zeziphi iinguqu zendlela yokuphila ozicebisayo ukulawula imeko yam kunye nemiphumo emibi yonyango?

Ndingazinyamekela njani? (Izinto ezibalulekileyo kuwe)

Ukuphila ne-MPN kunokuba yinto edidayo ngamanye amaxesha. Usenokuba uphilile kwaye ungaziboni iingxaki, kodwa usenokuzibuza ukuba kukho into endinokuyenza ukuthintela iimpawu. Ukuba ufumana unyango, unokufuna uncedo lokulawula iziphumo ebezingalindelekanga zonyango kunye neempawu. Nangona kunjalo, kuya kufuneka uphile nesi sifo iminyaka emininzi ezayo. Nazi ezinye iingcebiso ezinokukunceda:

• Qonda imeko yakho yempilo: Iimpawu ezininzi ze-MPN ziyafana nezezinye iimeko ezingabalulekanga kangako. Ezinye iimpawu zinokuba ziimpawu zeengxaki ezinkulu zempilo. Kunokuba nzima ukubona umahluko, kwaye ungaziva ngathi uphoswa ziimpawu ezibalulekileyo. Cela ugqirha wakho ukuba akuchazele indlela le meko enokukuchaphazela ngayo. Ukwazi into onokuyilindela kunokukunceda uzive uqinisekile ngakumbi ngemeko yakho.
• Lawula uxinzelelo lwakho: Ukuphila nesigulo esihlala ixesha elide kunokuba luxinzelelo. Ukuba ukhathazekile ngemeko yakho, thetha nogqirha wakho ngayo. Banokukuchazela into abanokuyenza ukukunceda ngoku kunye nento abanokuyenza ukukunceda kwixesha elizayo.
• Yitya ukutya okunempilo okunesondlo:Ukutya kakuhle kunokukunceda ulawule imeko yakho. Thetha nengcali yesondlo ukuba ufuna uncedo lokuphuhlisa imikhwa yokutya enempilo.
• Yenza umthambo: Ukuzilolonga yindlela entle yokulawula uxinezeleko.
• Fumana inkxaso: I-MPN sisifo esingaqhelekanga. Amaqela enkxaso anokuba yindlela entle yokunxibelelana nokuthetha nabantu abaziyo ukuba ujamelene nantoni na.

Khumbula, nokuba unesifo esifana nesi, ungaphila ubomi obuhle ngokuqaphela nangokulandela iingcebiso zonyango.

Ndifanele ndimbone nini ugqirha?

Ukuba une-MPN kodwa awunazo iimpawu, okanye ubona utshintsho emzimbeni wakho olubonisa iimpawu, bonana nogqirha wakho ngoko nangoko.

I-MPN ngokwenene yimfihlakalo. Abaphandi bayazi ukuba i-MPN inxulunyaniswa nokukhula okungaqhelekanga kweeseli zegazi. Bayazi nokuba ziingxaki zemfuza, kodwa imbangela echanekileyo yotshintsho lwemfuza olubangela i-MPN ayaziwa . Ngenxa yokuba ezi zizifo ezingaqhelekanga, abantu abaninzi abazi ukuba kunjani ukuhlala ne-MPN. Kodwa oogqirha nabaphandi bafunda ngakumbi nge-MPN, ngakumbi ngeendlela ezisebenzayo zokulawula iimpawu kunye nokunciphisa umngcipheko weengxaki ezinkulu zonyango. Ngoko ke, ungaze ulahle ithemba .

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