Ngaba uhlala uziva ngathi izandla zakho neenyawo zakho ziyarhawuzelelwa, ziyarhawuzelelwa, okanye ziyatsha? Ngaba ngamanye amaxesha uziva ngathi ezi ndawo ziza kuba ndindisholo? Nangona ezi mpawu zisenokubonakala ziqhelekile, ngamanye amaxesha kunokubakho isizathu esibalulekileyo emva kwazo. Namhlanje sithetha ngamayeza afakwa ngemithambo yegazi aze asetyenziswe ukunyanga imeko ethile. YiPatisiran leyo.
Yintoni le Patisiran? Ithetha ukuthini?
Ngamafutshane, iPatisiran sisitofu sokugonya. Sisetyenziselwa ukunyanga iingxaki zemithambo-luvo kubantu abaneengxaki zemfuza ezibizwa ngokuba yi -hereditary transthyretin-mediated amyloidosis (hATTR) .
Ngoku usenokuba uzibuza ukuba yintoni i-hATTR. Kulula kakhulu. Sonke sineeproteni emizimbeni yethu. Kubantu abanesi simo se-hATTR, iproteni ebizwa ngokuba yi -transthyretin iyaqhekeka, ihlangane, ize izibeke njenge-mush. Le depositi ifumaneka kakhulu kwiimithambo-luvo, intliziyo, kunye nezinye izitho zomzimba. Xa oku kusenzeka, ezo zitho zomzimba, ingakumbi imithambo-luvo, ziqala ukonakala. Yiyo loo nto iimpawu ezikhankanyiweyo ngaphambili, ezinje ngokuba ndindisholo, iintlungu, kunye nokudumba kwamalungu omzimba, zivela.
Iyeza iPatisiran lisebenza ngokunciphisa ukuveliswa kweproteni egobileyo. Oko kukuthi, xa eli yeza lingena emzimbeni, lilawula ukuveliswa kweproteni eyingozi. Emva koko, ukuqokelelana kweproteni ejikeleze imithambo-luvo kuyancipha, kwaye iimpawu zilawulwa kancinci kancinci. Eli yeza lifumaneka kwimarike phantsi kwegama elithi ONPATTRO .
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza
Ngenxa yokuba eli liyeza elikhethekileyo, kubaluleke kakhulu ukwazisa ugqirha wakho ngemeko yakho yempilo epheleleyo ngaphambi kokuba uqale unyango. Qiniseka ukuba ubaxelela oku kulandelayo:
- Ii-Allergy: Ukuba une -allergies, kungekuphela nje kwiPatisiran, kodwa nakweminye imithi, ukutya, okanye izithinteli, nceda usixelele ngazo.
- Ukukhulelwa: Ukuba ukhulelwe, uzama ukukhulelwa, okanye ukrokrela ukuba ukhulelwe, xelela ugqirha wakho ngaphambi kokuba uqale unyango.
- Ukuba ungumama oncancisayo: Ukuba ungumama oncancisayo, kufuneka wazise ugqirha.
Ngokusekelwe kolu lwazi, ugqirha uya kugqiba ukuba olu nyango lufanelekile kuwe okanye akunjalo kunye nendlela yokuqhubeka.
Uza kunikwa njani eli yeza?
Eli asiloyeza onokulithatha ekhaya. I-Patisiran yi -intravenous infusion. Ngoko ke, inikwa kuphela esibhedlele okanye eklinikhi, phantsi kweliso labasebenzi bezonyango abaqeqeshiweyo.
Olu nyango ludla ngokwenziwa kanye kwiiveki ezintathu. Kuthatha malunga neyure enesiqingatha ukufaka iyeza emzimbeni.
Kubalulekile: Ukuba awukwazi ukuya kunyango olucwangcisiweyo, nceda wazise ugqirha wakho okanye ikliniki yakho ngoko nangoko. Akuyongcinga ilungileyo ukutsiba iidosi zonyango.
Kuthekani ukuba ndithatha amayeza amaninzi kakhulu?
Oku kunikwa kwindawo yesibhedlele ngoko ke amathuba okuba oku kwenzeke mancinci kakhulu. Nangona kunjalo, ukuba ucinga ukuba kukho into eyenzekileyo, yixele ngoko nangoko kwiZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke okanye kwiYunithi yoNyango oluNgxamisekileyo (ETU) kwisibhedlele esikufutshane.
Izinto ekufuneka uzikhumbule xa usebenzisa amayeza
Kubaluleke kakhulu ukunyamekela umzimba wakho kakuhle ngexesha lonyango.
- Iimpendulo zokufakwa kweyeza: Abanye abantu banokuba neempendulo ngelixa eli yeza linikwa emthanjeni okanye emva nje kokuba linikwe. Umzekelo, iintlungu zesifuba, ubunzima bokuphefumla, okanye ukuziva unesizungu. Ukunciphisa lo mngcipheko, ugqirha wakho unokukunika amanye amayeza (afana namayeza okulwa ne-allergy) ngaphambi kokuba ufumane inaliti yePatisiran. Ngoko ke landela imiyalelo kagqirha wakho ngokuchanekileyo. Abasebenzi bezonyango baya kukujonga ngokusondeleyo ngelixa eli yeza linikwa.
- Amanqanaba eVithamini A: I-Patisiran inokubangela ukwehla kwamanqanaba eVithamini A emzimbeni. IVithamini A ibalulekile kumbono wethu, impilo yolusu, kunye nokuzikhusela komzimba. Ke ngoko, ugqirha wakho unokucebisa ukuba uthathe ithebhulethi yeVithamini A yonke imihla. Kubaluleke kakhulu ukuyithatha kanye njengoko kuyalelwe. Kwakhona, thetha nogqirha wakho malunga nokutya okutyebileyo kwiVithamini A (iikaroti, iitapile ezimnandi, ispinatshi, ubisi).
- Utshintsho embonweni: Ukuba ufumana naluphi na utshintsho embonweni wakho, njengamehlo omileyo, xelela ugqirha wakho ngoko nangoko, kuba oku kunokuba luphawu lokungabikho kwevithamini A.
- Ukuhlolwa rhoqo: Ugqirha wakho uza kukujonga rhoqo ukuze abone ukuba iimpawu zakho ziyaphucuka okanye aziphucuki. Qiniseka ukuba uya rhoqo kwezi vavanyo.
Iziphumo ebezingalindelekanga ezinokubakho ngenxa yale yeza
Njengayo nayiphi na iyeza, iPatisiran inokubangela ezinye iziphumo ebezingalindelekanga. Nangona ingenguye wonke umntu ozifumanayo. Ezinye zazo ziyingozi kwaye ezinye zixhaphakile.
| Iziphumo ebezingalindelekanga ezinokubakho zePatisiran | |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha ngoko nangoko | |
| Iimpendulo ze-Allergic | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala. |
| Iimpendulo zokungenisa | Intlungu esifubeni, ubunzima bokuphefumla, ukuquleka, isiyezi. |
| Iimpawu zokunqongophala kwevithamini A | Utshintsho embonweni, amehlo omileyo, ulusu olomileyo, usulelo oluqhelekileyo. |
| Iziphumo ebezingalindelekanga eziqhelekileyo ekufuneka zixelwe kugqirha ukuba ziyaqhubeka okanye ziyakhathaza | |
| Iingxaki ngokubanzi | Intlungu yamalungu, iintlungu zemisipha, umphimbo obuhlungu, ukungonwabi esiswini. |
Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana naziphi na ezinye iimpawu ezingaqhelekanga, thetha nogqirha wakho ngazo.
Umyalezo Wokuya Ekhaya
- I-Patisiran sisitofu sokugonya esinyanga iingxaki zemithambo-luvo ezibangelwa sisifo esithile semfuza esibizwa ngokuba yi-hATTR.
- Oku kunikwa kuphela esibhedlele okanye ekliniki, phantsi kweliso likagqirha.
- Qaphela iimpembelelo zokufakwa kweyeza ezinokwenzeka ngelixa usela amayeza.
- Eli yeza linokunciphisa amanqanaba evithamini A emzimbeni, ngoko ke qiniseka ukuba uthatha ipilisi yevithamini A ecetyiswa ngugqirha wakho.
- Musa ukoyika ukuthetha nogqirha wakho malunga nazo naziphi na iimpawu ezingaqhelekanga, iziphumo ebezingalindelekanga, okanye iingxaki onokuzifumana. Unxibelelwano oluhle lubalulekile kunyango oluphumelelayo.
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